桂芎生物

靶点说明

MOG(35-55) 来自髓鞘少突胶质细胞糖蛋白myelin/oligodendrocyte glycoprotein 的多肽序列MEVGWYRSPFSRVVHLYRNGK，在C57小鼠由MHC-II型H2-IA-a/b呈递。单次注射MOG 35-55足以在C57小鼠中诱导严重的临床实验性自身免疫性脑脊髓炎（EAE）。MOG 35-55特异性T细胞系在TCR Vβ基因使用方面具有多样性。

HLA类型

H2-IA-a/b，C57小鼠MHC-II型

抗原和HLA的亲和力

NetMHCpan II 4.0  计算MEVGWYRSPFSRVVHLYRNGK与H2-IA-a/b亲和力为 558.64nM

产品类型和应用

产品类型	规格	价格
流式检测与分选	MGP(35-55) H2-IA-a/b PE / APC / Alexa Fluor 488	7200元/50ug, 11800元/100ug
磁珠分选	MGP(35-55) H2-IA-a/b 磁珠	8200元/50ug, 12800元/100ug
生物素化复合物	MGP(35-55) H2-IA-a/b-biotin	6800元/50ug, 11400元/100ug

实测结果

肽刺激PBMC后检测抗原特异性CD4+T细胞

MEVGWYRSPFSRVVHLYRNGK多肽刺激H2-IA-a/b 限制性PBMC后，使用MGP(35-55) H2-IA-a/b 四聚体和抗CD4-FITC抗体检测。下图左图为抗原肽MEVGWYRSPFSRVVHLYRNGK刺激组，右图为未加抗原肽刺激组。

靶点结合的TCR序列

请查看IEDB数据库

Receptor – IEDB Receptor ID	Chain 1 – Calculated V Gene	Chain 1 – Calculated D Gene	Chain 1 – Calculated J Gene	Chain 1 – CDR3 Curated	Chain 2 – Calculated V Gene	Chain 2 – Calculated D Gene	Chain 2 – Calculated J Gene	Chain 2 – CDR3 Curated
1805	TRAV9D-4			VYFCALRSYNFGF	TRBV16*04			ASSLDCGANP

相关文章

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