桂芎生物

靶点说明

OVA (258-265)多肽SIINFEKL与H2Kb形成的复合物，是抗原特异性T细胞免疫的经典模型。OVA (257-264) SIINFEKL抗原性肽与小鼠MHC I类H-2Kb分子以2.5-A分辨率形成的复合物晶体结构。疏水性的肽残基Ile-P2和Phe-P5紧密地包装在一起，从MHC肽结合的结晶学和免疫学研究中证实OVA (258-265)多肽SIINFEKL与H2Kb可形成稳定复合物。

HLA类型

H2kb，C57小鼠的MHC-I亚型

抗原和HLA的亲和力

NetMHCpan 4.1  计算SIINFEKL与H2Kb 亲和力为 22.14nM，为稳定结合。

产品类型和应用

产品类型	规格	价格
流式检测与分选	OVA (258-265)H2Kb PE / APC / Alexa Fluor 488	7200元/50ug, 11800元/100ug
磁珠分选	OVA (258-265)H2Kb磁珠	8200元/50ug, 12800元/100ug
生物素化复合物	OVA (258-265)H2Kb -biotin	6800元/50ug, 11400元/100ug

实测结果

肽刺激PBMC后检测抗原特异性CD8+T细胞

SIINFEKL多肽刺激H2Kb 限制性PBMC后，使用OVA (258-265) H2Kb 四聚体和抗CD8-FITC抗体检测。下图左图为抗原肽SIINFEKL刺激组，右图为未加抗原肽刺激组。

靶点结合的TCR序列

请查看IEDB数据库

Receptor – IEDB Receptor ID	Chain 1 – CDR3 Curated	Chain 2 – CDR3 Curated
28799	DNYQLIWGSGTKLIIKPD	RANYEQYFGPGTRLTVL

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