{"id":1102,"date":"2025-07-20T13:57:13","date_gmt":"2025-07-20T13:57:13","guid":{"rendered":"http:\/\/60.204.213.123\/?page_id=1102"},"modified":"2026-01-11T13:47:45","modified_gmt":"2026-01-11T13:47:45","slug":"%e8%83%b0%e8%85%ba%e5%af%bc%e7%ae%a1%e7%99%8c%e5%9f%ba%e5%9b%a0%e5%bc%82%e5%b8%b8%e5%89%aa%e5%88%87%e8%82%bd%e7%9a%84%e6%8a%97%e5%8e%9f%e7%89%b9%e5%bc%82%e6%80%a7t%e7%bb%86%e8%83%9e%e6%a3%80%e6%b5%8b","status":"publish","type":"page","link":"https:\/\/www.guixiong.com.cn\/?page_id=1102","title":{"rendered":"\u80f0\u817a\u5bfc\u7ba1\u764c\u57fa\u56e0\u5f02\u5e38\u526a\u5207\u80bd\u7684\u6297\u539f\u7279\u5f02\u6027T\u7ec6\u80de\u68c0\u6d4b\u8bd5\u5242+\u6297\u539f\u80bd\u5b9a\u91cfPCR\u5f15\u7269"},"content":{"rendered":"\r\n

\u4eba\u7c7b\u57fa\u56e0\u7ec4\u4e2d\u670995%\u7684\u533a\u57df\u66fe\u88ab\u8ba4\u4e3a\u662f\u5783\u573e\u533a\u57df\uff0c\u8be5\u533a\u57df\u7531\u201c\u975e\u7f16\u7801\u86cb\u767d\u201d\u7684\u57fa\u56e0\u7ec4\u6210\u3002\u8fd9\u91cc\u867d\u7136\u80fd\u4ea7\u751fRNA\uff0c\u4f46\u662f\u4e0d\u4ea7\u751f\u86cb\u767d\u8d28\u3002\u7136\u800c\uff0c2025\u5e745\u6708\u53d1\u8868\u4e8e\u300aScience\u300b\u6742\u5fd7\u7684\u201cPancreatic cancer\u2013restricted cryptic antigens are targets for T cell recognition<\/a>\u201d \u6311\u6218\u4e86\u8fd9\u4e00\u4f20\u7edf\u89c2\u5ff5\uff1a\u5728\u80f0\u817a\u764c\u4e2d\uff0c\u8fd9\u4e9b\u88ab\u89d2\u843d\u4f1a\u201c\u5f02\u5e38\u95ea\u5149\u201d\uff0c\u7ffb\u8bd1\u51fa\u53ea\u5728\u764c\u7ec6\u80de\u4e2d\u5b58\u5728\u7684\u7279\u6b8a\u80bd\u6bb5\u3002\u800c\u4e14\uff0c\u8fd9\u4e9b\u7279\u6b8a\u80bd\u6bb5\u8fd8\u53ef\u4ee5\u6d3b\u5316T\u7ec6\u80de\u514d\u75ab\uff0c\u6210\u4e3a\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u7684\u65b0\u9776\u70b9\u7fa4\u3002<\/p>\r\n\r\n\r\n\r\n

\u201c\u975e\u7f16\u7801\u86cb\u767d\u201d\u7684\u57fa\u56e0\u5305\u62ec\u957f\u975e\u7f16\u7801RNA\uff08long noncoding RNAs, lncRNAs\uff09\u3001\u57fa\u56e0\u76845’\u7aef\u548c3’\u7aef\u7684\u975e\u7ffb\u8bd1\u533a\u57df\uff085′ and 3′ Untranslated Regions, UTRs\uff09\uff0c\u4ee5\u53ca\u57fa\u56e0\u5185\u90e8\u7684\u5185\u542b\u5b50\uff08intORFs\uff09\u3002\u4f46\u662f\uff0c\u8fd9\u4e9b\u533a\u57df\u5728\u7279\u5b9a\u6761\u4ef6\u4e0b\uff0c\u6bd4\u5982\u975e\u5178\u578b\u8d77\u59cb\u4f4d\u70b9\u3001\u79fb\u7801\uff08Frameshift\uff09\u7b49\u5f02\u5e38\u673a\u5236\u4e0b\u4f1a\u542f\u52a8\u8868\u8fbe\uff0c\u88ab\u7ffb\u8bd1\u6210\u80bd\u6bb5\u3002\u8fd9\u4e9b\u80bd\u6bb5\u79f0\u4e3a\u201c\u975e\u7ecf\u5178\u80bd\u6bb5\u201d\uff08noncanonical peptides\uff09\u3002\u5176\u8868\u8fbe\u7279\u5f81\u5305\u62ec\u5982\u4e0b\u7c7b\u578b\uff1a<\/p>\r\n\r\n\r\n\r\n

\"\"\r\n
\u56fe\u7247\u6765\u81ea\u300aPancreatic cancer\u2013restricted cryptic antigens are targets for T cell recognition<\/a>\u300b (Science 2025), Canonical ORF = \u7ecf\u5178\u5f00\u653e\u8bfb\u7801\u6846; 5′ uORF = 5′ unannotated ORF; 5′ overlap uORF = 5′ overlap unannotated ORF; intORFs = alternative reading frames; 3’dORF = 3′ downstream ORF; 3′ overlap dORF = 3′ overlap downstream ORF; lnRNA = long nocoding RNA<\/figcaption>\r\n<\/figure>\r\n\r\n\r\n\r\n\r\n\r\n

Pancreatic cancer\u2013restricted cryptic antigens are targets for T cell recognition<\/a> \u7ecf\u8fc7\u4e25\u5bc6\u7684\u9a8c\u8bc1\uff0c\u4ece\u201c\u975e\u7ecf\u5178\u80bd\u6bb5\u201d\u4e2d\uff0c\u53d1\u73b0\u4e86\u80f0\u817a\u764c\u7ec4\u7ec7\u7279\u5f02\u6027\u76847\u6bb5\u591a\u80bd\u3002\u6839\u636e\u9002\u5e94\u6027\u514d\u75ab\u7406\u8bba\uff0c\u5982\u679c\u8fd9\u4e9b\u795e\u79d8\u6297\u539f\u53ea\u5728\u764c\u7ec6\u80de\u4e2d\u4ea7\u751f\uff0c\u6b63\u5e38\u7ec6\u80de\u4e2d\u4e0d\u8868\u8fbe\uff0c\u5b83\u4eec\u5c31\u53ef\u4ee5\u6210\u4e3a\u975e\u5e38\u7406\u60f3\u7684T\u7ec6\u80de\u9776\u70b9\uff0c\u8be5\u7814\u7a76\u786e\u8ba4\u4e86\u8fd97\u6bb5\u591a\u80bd\u5177\u6709\u6d3b\u5316T\u7ec6\u80de\u7684\u80fd\u529b\u3002<\/p>\r\n\r\n\r\n\r\n

7\u6bb5\u591a\u80bd\u7684\u53d1\u73b0\u8fc7\u7a0b\u53ef\u770b\u5168\u6587\u4e86\u89e3\uff0c\u5728\u6b64\u4e0d\u518d\u8d58\u8ff0\u3002<\/p>\r\n\r\n\r\n\r\n

\u8fd97\u6bb5\u591a\u80bd\u7684\u6297\u539f\u7279\u5f02\u6027T\u7ec6\u80de\u6d3b\u6027\u7ecf\u8fc7\u4e86\u4ee5\u4e0b\u65b9\u6cd5\u9a8c\u8bc1\uff0c\u8bc1\u660e\u4e86\u8fd9\u4e9b\u591a\u80bd\u5177\u6709\u80f0\u817a\u764c\u514d\u75ab\u6cbb\u7597\u6f5c\u529b\uff1a<\/p>\r\n\r\n\r\n\r\n