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class=\"wp-block-list\">\n<li>\u5177\u6709\u6210\u719f\u4f18\u5316\u7684\u6297\u539f\u7279\u5f02\u6027T\u7ec6\u80de\u523a\u6fc0\u6d41\u7a0b\u3002\u8be5\u523a\u6fc0\u6d41\u7a0b\u5df2\u7ecf\u8fc7\u5927\u91cf\u9879\u76ee\u9a8c\u8bc1\uff0c\u540c\u65f6\u4e5f\u662f\u6211\u65b9pMHC\u8367\u5149\u56db\u805a\u4f53\u9633\u6027\u7ec6\u80de\u6210\u719f\u751f\u4ea7\u6d41\u7a0b\u3002<\/li>\n\n\n\n<li>\u5177\u6709\u6297\u539f\u80bd-MHC\u590d\u5408\u7269\u8367\u5149\u6d41\u5f0f\u68c0\u6d4b\u8bd5\u5242\u7684\u5408\u6210\u80fd\u529b\uff0c\u76ee\u524d\u5df2\u6210\u529f\u5408\u62105100\u79cd\u6297\u539f\u80bd-MHC\u590d\u5408\u7269\u8367\u5149\u6d41\u5f0f\u68c0\u6d4b\u8bd5\u5242\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">\u5e94\u7528\u6848\u4f8b<\/h3>\n\n\n\n<p>1.\u901a\u8fc7HLA\u7279\u5f02\u6027K562\u5448\u9012\u7ec6\u80de\u53d7\u6297\u539f\u80bd\u523a\u6fc0\u540e\uff0c\u4e0eT\u7ec6\u80de\u5171\u5b75\u80b2\uff0c\u5206\u79bb\u90a3\u4e9b\u8bc6\u522b\u5448\u9012\u7ec6\u80de\u7684T\u7ec6\u80de\u53d7\u4f53\u5e8f\u5217\uff0c\u5e76\u901a\u8fc7\u4e34\u5e8a\u9a8c\u8bc1\u786e\u5b9a\u4e86\u80bf\u7624\u65b0\u751f\u6297\u539f\u7279\u5f02\u6027TCR<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30700903\/\" target=\"_blank\" rel=\"noreferrer noopener\">T cell antigen discovery via trogocytosis.&nbsp;<\/a>Nat Methods. 2019<\/p>\n<\/blockquote>\n\n\n\n<p>2. \u9488\u5bf9\u6297\u539f\u7279\u5f02\u6027TCR\u6539\u9020\u540e\u7ec6\u80de\u6bd2T\u7ec6\u80de\uff0cT2\u7ec6\u80de\u7528\u4e8e\u76d1\u63a7\u8fd9\u4e9bCTL\u5bf9\u80f0\u817a\u5bfc\u7ba1\u764c\u6297\u539f\u7684\u53cd\u5e94<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p><em><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/pmid\/28710313\/\" target=\"_blank\" rel=\"noreferrer noopener\">Ex Vivo PD-L1\/PD-1 Pathway Blockade Reverses Dysfunction of Circulating CEA-Specific T Cells in Pancreatic Cancer Patients.<\/a><\/em>&nbsp;<em>Clin Cancer Res. 2017<\/em><\/p>\n<\/blockquote>\n\n\n\n<p>3. \u901a\u8fc7\u5448\u9012\u7ec6\u80de\u8868\u8fbe\u7684\u80bf\u7624\u6297\u539f\u80bd\uff0c\u5224\u65adTCR\u6837\u6297\u4f53\u7684\u7ed3\u5408\u80fd\u529b<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p><em><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/pmid\/28273004\/\" target=\"_blank\" rel=\"noreferrer noopener\">TCR-like antibody drug conjugates mediate killing of tumor cells with low peptide\/HLA targets<\/a>. MAbs. 2017<\/em><\/p>\n<\/blockquote>\n\n\n\n<p>4. \u80de\u5185\u6297\u539f\u7279\u5f02\u6027CAR-T\u7ec6\u80de\u653b\u51fb\u4eba\u5de5\u6297\u539f\u5448\u9012\u7ec6\u80de\uff0c\u8be5\u4eba\u5de5\u6297\u539f\u5448\u9012\u7ec6\u80de\u7279\u5f02\u6027\u8868\u8fbe\u80de\u5185\u6297\u539f+MHC\u590d\u5408\u7269<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p><em><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/pmid\/33046866\/\" target=\"_blank\" rel=\"noreferrer noopener\">CAR-T cells targeting a nucleophosmin neoepitope exhibit potent specific activity in mouse models of acute myeloid leukaemia<\/a>.<\/em>&nbsp;<em>Nat Biomed Eng. 2020<\/em><\/p>\n<\/blockquote>\n\n\n\n<p>5. \u5448\u9012p53\u7a81\u53d8\u6297\u539f\u4e0e\u91ce\u751f\u578b\u6297\u539f\u7684HLA-A2\u578b\u4eba\u5de5\u6297\u539f\u5448\u9012\u7ec6\u80de\uff0c\u88ab\u53cc\u7279\u5f02\u6027\u5355\u94fe\u6297\u4f53\u7279\u5f02\u6027\u6740\u4f24\u3002\u4eba\u5de5\u6297\u539f\u5448\u9012\u7ec6\u80de\u4f5c\u4e3a\u53cc\u7279\u5f02\u6027\u5355\u94fe\u6297\u4f53\u6740\u4f24\u6548\u5e94\u7684\u76d1\u63a7\u7ec6\u80de\u3002<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p><em><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8208645\/#S11title\" target=\"_blank\" rel=\"noreferrer noopener\">Targeting a neoantigen derived from a common TP53 mutation<\/a>.<\/em>&nbsp;<em>Science. 2021<\/em><\/p>\n<\/blockquote>\n<p>Views: 112<\/p>","protected":false},"excerpt":{"rendered":"<p>\u670d\u52a1\u4ef7\u503c \u4ecePBMC\u4e2d\u523a\u6fc0\u51fa\u6297\u539f\u7279\u5f02\u6027T\u7ec6\u80de\uff0c\u672c\u670d\u52a1\u5c06\u4ea4\u4ed8\u523a\u6fc0\u540e\u7ec6\u80de\u3001\u6d41\u5f0f\u68c0\u6d4b\u8bd5\u5242\u3001\u6297\u539f\u80bd\u3001\u6d41\u5f0f\u9274\u5b9a\u62a5\u544a\u3002 \u670d&#8230;<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_kadence_starter_templates_imported_post":false,"_kad_post_transparent":"","_kad_post_title":"","_kad_post_layout":"","_kad_post_sidebar_id":"","_kad_post_content_style":"","_kad_post_vertical_padding":"","_kad_post_feature":"","_kad_post_feature_position":"","_kad_post_header":false,"_kad_post_footer":false,"_kad_post_classname":"","footnotes":""},"class_list":["post-136","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.guixiong.com.cn\/index.php?rest_route=\/wp\/v2\/pages\/136","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.guixiong.com.cn\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.guixiong.com.cn\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.guixiong.com.cn\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.guixiong.com.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=136"}],"version-history":[{"count":4,"href":"https:\/\/www.guixiong.com.cn\/index.php?rest_route=\/wp\/v2\/pages\/136\/revisions"}],"predecessor-version":[{"id":557,"href":"https:\/\/www.guixiong.com.cn\/index.php?rest_route=\/wp\/v2\/pages\/136\/revisions\/557"}],"wp:attachment":[{"href":"https:\/\/www.guixiong.com.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=136"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}