{"id":1614,"date":"2026-01-27T03:49:43","date_gmt":"2026-01-27T03:49:43","guid":{"rendered":"https:\/\/www.guixiong.com.cn\/?page_id=1614"},"modified":"2026-01-27T03:49:43","modified_gmt":"2026-01-27T03:49:43","slug":"ivac%e5%b0%86%e5%86%b7%e8%82%bf%e7%98%a4%e5%8f%98%e7%83%ad%ef%bc%8c%e9%87%8d%e5%a1%91%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e6%b2%bb%e7%96%97%e8%8c%83%e5%bc%8f","status":"publish","type":"page","link":"https:\/\/www.guixiong.com.cn\/?page_id=1614","title":{"rendered":"iVAC\u5c06\u201c\u51b7\u80bf\u7624\u201d\u53d8\u201c\u70ed\u201d\uff0c\u91cd\u5851\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u8303\u5f0f"},"content":{"rendered":"
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\u5317\u4eac\u5927\u5b66\u9648\u9e4f\u3001\u5e2d\u5efa\u5fe0\u56e2\u961f\u8054\u5408\u6df1\u5733\u6e7e\u5b9e\u9a8c\u5ba4\u5728\u300aNature\u300b\u53d1\u8868\u91cd\u78c5\u7814\u7a76\uff0c\u5f00\u53d1\u51fa\u65b0\u578b\u7624\u5185\u75ab\u82d7\u5d4c\u5408\u4f53\uff08iVAC\uff09\u2014\u2014\u901a\u8fc7\u201c\u964d\u89e3PD-L1 + \u5448\u9012\u5916\u6e90\u6297\u539f\u201d\u53cc\u529f\u80fd\u8bbe\u8ba1\uff0c\u5c06\u80bf\u7624\u7ec6\u80de\u91cd\u7f16\u7a0b\u4e3a\u7c7bAPC\uff0c\u6fc0\u6d3b\u9884\u5b58\u75c5\u6bd2\u7279\u5f02\u6027T\u7ec6\u80de\uff0c\u5b9e\u73b0\u5bf9\u201c\u51b7\u80bf\u7624\u201d\u7684\u9ad8\u6548\u6740\u4f24\u3002\r\n\r\n\u53c2\u8003\u6587\u732e<\/span>Intratumoural vaccination via checkpoint degradation-coupled antigen presentation<\/a>\u00a0 \u2014\u2014 Nature, 2026.1<\/pre>\n<\/blockquote>\n
iVAC\uff1a\u5316\u5b66\u91cd\u7f16\u7a0b\u7684\u201c\u53cc\u5203\u5251\u201d<\/h3>\n
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\u2461 \u5f3a\u5236\u5448\u9012\u5916\u6e90\u6297\u539f\uff1a\u643a\u5e26CMV\/OVA\u7b49\u75c5\u6bd2\u6297\u539f\u80bd\uff0c\u5728\u80bf\u7624\u7ec6\u80de\u5185\u52a0\u5de5\u540e\u901a\u8fc7MHC-I\u5448\u9012\uff0c\u6fc0\u6d3b\u9884\u5b58\u8bb0\u5fc6T\u7ec6\u80de\u3002<\/strong><\/section>\n
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\u8981\u590d\u73b0\u6216\u4f18\u5316iVAC\u7b56\u7565\uff0c\u60a8\u9700\u8981\u7cbe\u51c6\u7684\u6297\u539f-MHC\u5de5\u5177\u4e0e\u529f\u80fd\u9a8c\u8bc1\u5e73\u53f0\u3002\u6842\u828e\u751f\u7269\u5df2\u6784\u5efa\u8986\u76d6\u201c\u6297\u539f\u7b5b\u9009\u2014\u5448\u9012\u9a8c\u8bc1\u2014T\u7ec6\u80de\u76d1\u6d4b\u201d\u5168\u94fe\u6761\u7684\u6280\u672f\u4f53\u7cfb\uff1a<\/p>\n
1.\u00a0\u6297\u539f\u7279\u5f02\u6027T\u7ec6\u80de\u6269\u589e\uff1a\u00a0<\/a><\/span><\/strong>\u57fa\u4e8eLNP\u9012\u9001\u6297\u539f\u80bd\/MHC\u590d\u5408\u7269\uff0c\u4f53\u5916\u6269\u589e\u9ad8\u7eaf\u5ea6Tfh\/CD8\u207a T\u7ec6\u80de\u514b\u9686\u3002\u6842\u828e\u7279\u6709\u7684DC\u5206\u5316\u6210\u719f\u6d41\u7a0b\uff0c\u63d0\u4f9b\u9ad8\u6bd4\u4f8bCD83\/CD86\u5448\u9012\u7ec6\u80de<\/p>\n
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2.\u00a0\u5fae\u91cfpMHC\u590d\u5408\u7269\u5408\u6210\u670d\u52a1\uff1a\u00a0<\/a><\/span><\/strong>\u8986\u76d6CMV\/EBV\/\u6d41\u611f\u7b49\u9ad8\u514d\u75ab\u539f\u6027\u8868\u4f4d\uff0c\u652f\u6301HLA-A*02:01\/*11:01\/*24:02\u7b49\u4e2d\u56fd\u4e3b\u6d41\u5206\u578b<\/p>\n
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3.\u00a0pMHC\u8367\u5149\u56db\u805a\u4f53\u5408\u6210\u4ee5\u53ca\u7b5b\u9009\uff1a\u00a0<\/a><\/span><\/strong>\u73b0\u8d27\u63d0\u4f9bCMV-NLV\u3001EBV-GLC\u7b49\u75c5\u6bd2\u7279\u5f02\u6027\u56db\u805a\u4f53\uff0c\u7528\u4e8eT\u7ec6\u80de\u5206\u9009\u4e0e\u529f\u80fd\u9a8c\u8bc1<\/p>\n
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4.\u00a0\u5355\u514b\u9686TCR\u6d4b\u5e8f\uff1a\u00a0<\/a><\/span><\/strong>\u4ece\u56db\u805a\u4f53\u207a T\u7ec6\u80de\u4e2d\u83b7\u53d6\u4e3b\u514b\u9686\u914d\u5bf9TCR<\/p>\n
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5.<\/span><\/strong>\u6297\u539f\u80bd-MHC\u4eb2\u548c\u529b\u9ad8\u901a\u91cfELISA\u626b\u63cf\u670d\u52a1\uff1a<\/a><\/span><\/strong>\u9ad8\u901a\u91cf\u7b5b\u9009\u6700\u4f18\u591a\u80bd\u8fde\u63a5\u5b50\u5bf9\u5e94\u7684\u6297\u539f\u5448\u9012\u6548\u7387<\/p>\n
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7.\u00a0\u5de5\u7a0b\u5316\u5448\u9012\u7ec6\u80de\u6784\u5efa\uff1a<\/a><\/span><\/strong>\u6a21\u62dfiVAC\u91cd\u7f16\u7a0b\u540e\u7684HLA\u4e9a\u578b\u5bf9\u5e94\u7684\u80bf\u7624\u7ec6\u80de\uff0c\u7528\u4e8e\u4f53\u5916T\u7ec6\u80de\u6fc0\u6d3b\u5b9e\u9a8c<\/p>\n
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  • \n
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    IND\u7533\u62a5\u652f\u6301<\/strong>\uff1a\u63d0\u4f9bGMP\u7ea7\u6297\u539f\u80bd\u3001\u56db\u805a\u4f53\u53caT\u7ec6\u80de\u529f\u80fd\u6570\u636e\u5305\u3002<\/section>\n<\/li>\n<\/ul>\n
    Views: 30<\/p>","protected":false},"excerpt":{"rendered":"
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