{"id":1624,"date":"2026-01-29T13:46:32","date_gmt":"2026-01-29T13:46:32","guid":{"rendered":"https:\/\/www.guixiong.com.cn\/?page_id=1624"},"modified":"2026-01-29T13:46:32","modified_gmt":"2026-01-29T13:46:32","slug":"%e5%85%a8%e9%9d%a2%e8%ae%a4%e8%af%86-tcr-t-%e7%bb%86%e8%83%9e%e6%b2%bb%e7%96%97%ef%bc%9a%e5%ae%9a%e4%b9%89%e3%80%81%e6%8a%97%e5%8e%9f%e9%80%92%e5%91%88%e6%9c%ba%e5%88%b6%e4%b8%8e%e9%9d%b6%e7%82%b9","status":"publish","type":"page","link":"https:\/\/www.guixiong.com.cn\/?page_id=1624","title":{"rendered":"\u5168\u9762\u8ba4\u8bc6 TCR-T \u7ec6\u80de\u6cbb\u7597\uff1a\u5b9a\u4e49\u3001\u6297\u539f\u9012\u5448\u673a\u5236\u4e0e\u9776\u70b9\u9009\u62e9"},"content":{"rendered":"<blockquote>\n<pre data-pm-slice=\"2 6 []\"><strong>TCR-T\u7ec6\u80de\u6cbb\u7597\u5168\u6d41\u7a0b\uff1a\u4ece\u80bf\u7624\u6297\u539f\u53d1\u73b0 \u2192 TCR\u514b\u9686 \u2192 \u57fa\u56e0\u5de5\u7a0b \u2192 \u529f\u80fd\u9a8c\u8bc1 \u2192 \u4e34\u5e8a\u56de\u8f93<\/strong>\r\n\r\nTCR-T\u7ec6\u80de\u7597\u6cd5\u901a\u8fc7\u5c06\u9ad8\u4eb2\u548c\u529b\u80bf\u7624\u7279\u5f02\u6027TCR\u57fa\u56e0\u5bfc\u5165\u60a3\u8005T\u7ec6\u80de\uff0c\u8d4b\u4e88\u5176\u7cbe\u51c6\u8bc6\u522bMHC-\u5448\u9012\u80bf\u7624\u6297\u539f\u7684\u80fd\u529b\u3002\u4e0eCAR-T\u4e0d\u540c\uff0cTCR-T\u53ef\u9776\u5411<strong>\u80de\u5185\u6297\u539f<\/strong>\uff0c\u5728\u5b9e\u4f53\u7624\u6cbb\u7597\u4e2d\u5177\u6709\u4e0d\u53ef\u66ff\u4ee3\u7684\u4f18\u52bf\uff0c\u4f46\u5176\u6210\u529f\u9ad8\u5ea6\u4f9d\u8d56\u4e8e\u6297\u539f\u52a0\u5de5\u4e0eMHC\u9012\u5448\u7684\u5b8c\u6574\u6027\u3002<\/pre>\n<\/blockquote>\n<h3>\u4e00\u3001TCR-T\u7ec6\u80de\u7684\u7cbe\u786e\u5b9a\u4e49\u4e0e\u4f5c\u7528\u539f\u7406<\/h3>\n<p>TCR-T\u7ec6\u80de\u662f\u6307\u901a\u8fc7\u75c5\u6bd2\u8f7d\u4f53\uff08\u5982\u6162\u75c5\u6bd2\u3001\u9006\u8f6c\u5f55\u75c5\u6bd2\uff09\u6216\u975e\u75c5\u6bd2\u65b9\u6cd5\uff08\u5982\u8f6c\u5ea7\u5b50\u3001mRNA\u7535\u8f6c\uff09\u5c06\u7f16\u7801\u7279\u5b9a\u03b1\u03b2 TCR\u7684\u57fa\u56e0\u5bfc\u5165\u81ea\u4f53\u5916\u5468\u8840T\u7ec6\u80de\u540e\u83b7\u5f97\u7684\u5de5\u7a0b\u5316T\u7ec6\u80de\u3002\u5176\u6838\u5fc3\u7279\u5f81\u5305\u62ec\uff1a<\/p>\n<ul class=\"list-paddingleft-1\">\n<li><strong>\u6297\u539f\u7279\u5f02\u6027\uff1a<\/strong><br \/>\n<section>\u7531\u5916\u6e90TCR\u51b3\u5b9a\uff0c\u901a\u5e38\u6765\u6e90\u4e8e\u80bf\u7624\u6d78\u6da6\u6dcb\u5df4\u7ec6\u80de\uff08TILs\uff09\u3001\u75ab\u82d7\u5e94\u7b54\u8005\u6216\u5065\u5eb7\u4f9b\u4f53\u4e2d\u7684\u9ad8\u4eb2\u548c\u529b\u514b\u9686\uff1b<\/section>\n<\/li>\n<li><strong>MHC\u9650\u5236\u6027\uff1a<\/strong><br \/>\n<section>\u5fc5\u987b\u8bc6\u522b\u7531\u7279\u5b9aHLA\u7b49\u4f4d\u57fa\u56e0\uff08\u5982HLA-A*02:01\uff09\u5448\u9012\u76848\u201310 aa\u80bd\u6bb5\uff1b<\/section>\n<\/li>\n<li><strong>\u4fe1\u53f7\u4f9d\u8d56\u5bbf\u4e3b\u901a\u8def\uff1a<\/strong><br \/>\n<section>TCR\u672c\u8eab\u65e0\u80de\u5185\u4fe1\u53f7\u57df\uff0c\u9700\u4e0e\u5185\u6e90CD3\u590d\u5408\u7269\uff08CD3\u03b5\u03b4\/\u03b5\u03b3\/\u03b6\u03b6\uff09\u7ec4\u88c5\u624d\u80fd\u542f\u52a8Zap-70\u78f7\u9178\u5316\u7ea7\u8054\uff1b<\/section>\n<\/li>\n<li><strong>\u5171\u53d7\u4f53\u534f\u540c\uff1a<\/strong><br \/>\n<section>CD8\u207a TCR-T\u7ec6\u80de\u4f9d\u8d56CD8\u03b1\u03b2\u7ed3\u5408MHC I\u7684\u03b13\u7ed3\u6784\u57df\uff0c\u63d0\u5347pMHC\u9a7b\u7559\u65f6\u95f4\u7ea610\u500d\uff08K<sub>D<\/sub>\u4ece\u03bcM\u7ea7\u6539\u5584\u81f3nM\u7ea7\uff09\u3002<\/section>\n<\/li>\n<\/ul>\n<p><strong>\u4e0eCAR-T\u7684\u5173\u952e\u533a\u522b<\/strong>\uff08\u89c1\u4e0b\u8868\uff09\uff1a<\/p>\n<table>\n<thead>\n<tr>\n<th>\n<section>\u7279\u6027<\/section>\n<\/th>\n<th>\n<section>TCR-T<\/section>\n<\/th>\n<th>\n<section>CAR-T<\/section>\n<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>\n<section>\u8bc6\u522b\u6297\u539f\u7c7b\u578b<\/section>\n<\/td>\n<td>\n<section>MHC-\u5448\u9012\u7684\u7ebf\u6027\u80bd\u6bb5\uff08\u80de\u5185\/\u80de\u5916\uff09<\/section>\n<\/td>\n<td>\n<section>\u5929\u7136\u6784\u8c61\u6297\u539f\uff08\u4ec5\u80de\u5916\/\u819c\u86cb\u767d\uff09<\/section>\n<\/td>\n<\/tr>\n<tr>\n<td>\n<section>MHC\u4f9d\u8d56<\/section>\n<\/td>\n<td>\n<section>\u662f\uff08HLA\u9650\u5236\uff09<\/section>\n<\/td>\n<td>\n<section>\u5426<\/section>\n<\/td>\n<\/tr>\n<tr>\n<td>\n<section>\u4fe1\u53f7\u7ed3\u6784<\/section>\n<\/td>\n<td>\n<section>\u4ec5TCR \u03b1\u03b2\u94fe\uff0c\u4f9d\u8d56\u5185\u6e90CD3<\/section>\n<\/td>\n<td>\n<section>scFv + CD3\u03b6 + \u5171\u523a\u6fc0\u57df\uff08CD28\/4-1BB\uff09<\/section>\n<\/td>\n<\/tr>\n<tr>\n<td>\n<section>\u9002\u7528\u80bf\u7624\u7c7b\u578b<\/section>\n<\/td>\n<td>\n<section>\u5b9e\u4f53\u7624\uff08\u9ed1\u8272\u7d20\u7624\u3001\u8089\u7624\u3001NSCLC\u7b49\uff09<\/section>\n<\/td>\n<td>\n<section>\u8840\u6db2\u7624\uff08B-ALL\u3001DLBCL\u7b49\uff09<\/section>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n<p><img decoding=\"async\" src=\"https:\/\/guixiong.com.cn\/wp-content\/uploads\/2026\/01\/TCR-vs-CAR.jpg\" \/><\/p>\n<h3 data-pm-slice=\"2 2 []\">\u4e8c\u3001\u6297\u539f\u9012\u5448\uff1aTCR-T\u8bc6\u522b\u7684\u5206\u5b50\u57fa\u7840<\/h3>\n<p>TCR-T\u80fd\u5426\u6709\u6548\u6740\u4f24\u80bf\u7624\uff0c\u53d6\u51b3\u4e8e\u9776\u7ec6\u80de\u662f\u5426\u80fd\u5c06\u80bf\u7624\u76f8\u5173\u6297\u539f\uff08TAA\uff09\u6216\u65b0\u6297\u539f\uff08NeoAg\uff09\u6b63\u786e\u52a0\u5de5\u5e76\u5448\u9012\u4e8eMHC I\u7c7b\u5206\u5b50\u8868\u9762\u3002\u8be5\u8fc7\u7a0b\u6d89\u53ca\u591a\u4e2a\u7cbe\u5bc6\u8c03\u63a7\u7684\u751f\u5316\u6b65\u9aa4\u3002<\/p>\n<h5>1. \u5185\u6e90\u6027\u6297\u539f\u7684MHC I\u7c7b\u9012\u5448\u901a\u8def\uff08\u7ecf\u5178\u9014\u5f84\uff09<\/h5>\n<p>\u8fd9\u662fTCR-T\u8bc6\u522b\u5b9e\u4f53\u7624\u7684\u4e3b\u8981\u901a\u8def\uff0c\u5177\u4f53\u6b65\u9aa4\u5982\u4e0b\uff1a<\/p>\n<ol class=\"list-paddingleft-1\">\n<li><strong>\u86cb\u767d\u9176\u4f53\u964d\u89e3\uff1a\u80bf\u7624\u7ec6\u80de\u5185\u5f02\u5e38\u86cb\u767d\uff08\u5982\u7a81\u53d8p53\u3001NY-ESO-1\uff09\u88ab\u6cdb\u7d20\u5316\u6807\u8bb0\uff0c\u9001\u516526S\u86cb\u767d\u9176\u4f53\u964d\u89e3\u4e3a5\u201325 aa\u80bd\u6bb5\uff1b<\/strong><\/li>\n<li><strong>TAP\u8f6c\u8fd0\uff1a\u80bd\u6bb5\u5728Hsp70\/Hsp90\u534f\u52a9\u4e0b\uff0c\u7ecf\u6297\u539f\u52a0\u5de5\u8f6c\u8fd0\u4f53\uff08TAP1\/TAP2\u5f02\u6e90\u4e8c\u805a\u4f53\uff09\u4ece\u80de\u8d28\u8f6c\u8fd0\u81f3\u5185\u8d28\u7f51\uff08ER\uff09\u8154\u3002TAP\u504f\u597d8\u201316 aa\u3001C\u7aef\u758f\u6c34\/\u78b1\u6027\u6b8b\u57fa\u7684\u80bd\u6bb5\uff1b<\/strong><\/li>\n<li><strong>MHC I\u7ec4\u88c5\uff1a\u5728ER\u4e2d\uff0c\u65b0\u751fMHC I\u91cd\u94fe\uff08\u03b1\u94fe\uff09\u4e0e\u03b2\u2082m\u7ed3\u5408\uff0c\u5e76\u5728\u4f34\u4fa3\u86cb\u767d\uff08calnexin \u2192 calreticulin\/ERp57\uff09\u8f85\u52a9\u4e0b\u5f62\u6210\u201c\u80bd\u88c5\u8f7d\u590d\u5408\u7269\u201d\uff08PLC\uff09\uff0c\u5305\u542bTAP\u3001tapasin\u7b49\uff1b<\/strong><\/li>\n<li><strong>\u80bd\u9009\u62e9\u4e0e\u7a33\u5b9a\uff1a\u4ec5\u4e0eMHC I\u7ed3\u5408\u69fd\u5339\u914d\u826f\u597d\u7684\u80bd\uff08\u901a\u5e388\u201310 aa\uff0c\u542b\u951a\u5b9a\u6b8b\u57fa\u5982P2\/P9\uff09\u88ab\u4fdd\u7559\uff0c\u5176\u4f59\u88abERAP1\/2\u8fdb\u4e00\u6b65\u4fee\u526a\u6216\u964d\u89e3\uff1b<\/strong><\/li>\n<li><strong>\u8868\u9762\u5448\u9012\uff1a\u7a33\u5b9apMHC I\u590d\u5408\u7269\u7ecf\u9ad8\u5c14\u57fa\u4f53\u8f6c\u8fd0\u81f3\u7ec6\u80de\u819c\uff0c\u5bc6\u5ea6\u901a\u5e38\u4e3a10\u00b3\u201310\u2075 copies\/cell\u3002<\/strong><\/li>\n<\/ol>\n<p><strong>\u4e34\u5e8a\u8b66\u793a<\/strong>\uff1a\u8bb8\u591a\u80bf\u7624\u901a\u8fc7\u4e0b\u8c03TAP\u3001\u03b2\u2082m\u6216MHC I\u8868\u8fbe\u9003\u907f\u514d\u75ab\u76d1\u89c6\uff0c\u5bfc\u81f4TCR-T\u5931\u6548\u3002\u56e0\u6b64\uff0c\u6cbb\u7597\u524d\u9700\u68c0\u6d4b\u9776\u7ec6\u80deMHC I\u8868\u8fbe\u6c34\u5e73\u3002<\/p>\n<h5>2. \u5916\u6e90\u6027\u6297\u539f\u7684MHC II\u7c7b\u9012\u5448\uff08\u5bf9CD4\u207a TCR-T\u7684\u610f\u4e49\uff09<\/h5>\n<p>\u867d\u7136\u591a\u6570TCR-T\u57fa\u4e8eCD8\u207a T\u7ec6\u80de\uff0c\u4f46\u8fd1\u5e74\u7814\u7a76\u53d1\u73b0\uff0cCD4\u207a TCR-T\u53ef\u901a\u8fc7\u8bc6\u522bMHC II-\u5448\u9012\u7684\u80bf\u7624\u6297\u539f\uff08\u5982MAGE-A3\u3001WT1\uff09\u63d0\u4f9b\u957f\u6548\u514d\u75ab\u8bb0\u5fc6\u548c\u8f85\u52a9\u529f\u80fd\u3002<\/p>\n<ul class=\"list-paddingleft-1\">\n<li>\n<section>\u6297\u539f\u88ab\u6811\u7a81\u72b6\u7ec6\u80de\uff08DC\uff09\u541e\u566c \u2192 \u5f62\u6210\u65e9\u671f\u5185\u4f53 \u2192 \u9178\u5316\u6210\u719f\u4e3a\u665a\u671f\u5185\u4f53\/\u6eb6\u9176\u4f53\uff1b<\/section>\n<\/li>\n<li>\n<section>\u86cb\u767d\u9176\uff08cathepsins\uff09\u964d\u89e3\u6297\u539f\u4e3a13\u201325 aa\u80bd\u6bb5\uff1b<\/section>\n<\/li>\n<li>\n<section>MHC II\u5728ER\u4e2d\u4e0e\u6052\u5b9a\u94fe\uff08Ii\uff09\u7ed3\u5408\uff0c\u9632\u6b62\u63d0\u524d\u7ed3\u5408\u80bd\uff1b\u8fdb\u5165\u5185\u4f53\u540e\uff0cIi\u88ab\u964d\u89e3\uff0c\u4ec5\u7559CLIP\u7247\u6bb5\uff1b<\/section>\n<\/li>\n<li>\n<section>H2-DM\u50ac\u5316CLIP\u66ff\u6362\u4e3a\u6297\u539f\u80bd\uff0c\u5f62\u6210pMHC II\u590d\u5408\u7269\uff0c\u8f6c\u8fd0\u81f3\u8868\u9762\u4f9bCD4\u207a T\u7ec6\u80de\u8bc6\u522b\u3002<\/section>\n<\/li>\n<\/ul>\n<h5>3. \u975e\u7ecf\u5178\u9012\u5448\u9014\u5f84\uff1a\u4ea4\u53c9\u5448\u9012\uff08Cross-presentation\uff09<\/h5>\n<p>\u6811\u7a81\u72b6\u7ec6\u80de\u53ef\u5c06\u5916\u6e90\u6027\u80bf\u7624\u6297\u539f\uff08\u5982\u51cb\u4ea1\u5c0f\u4f53\u3001\u5916\u6ccc\u4f53\uff09\u901a\u8fc7MHC I\u5448\u9012\u7ed9CD8\u207a T\u7ec6\u80de\uff0c\u8fd9\u4e00\u8fc7\u7a0b\u79f0\u4e3a\u4ea4\u53c9\u5448\u9012\u3002\u5176\u673a\u5236\u5305\u62ec\uff1a<\/p>\n<ul class=\"list-paddingleft-1\">\n<li><strong>\u6db2\u6ce1\u9014\u5f84\uff1a\u6297\u539f\u5728\u5185\u4f53\u4e2d\u76f4\u63a5\u52a0\u8f7d\u81f3MHC I\uff1b<\/strong><\/li>\n<li><strong>\u80de\u8d28\u9014\u5f84\uff1a\u6297\u539f\u4ece\u5185\u4f53\u9003\u9038\u81f3\u80de\u8d28\uff0c\u8fdb\u5165\u7ecf\u5178MHC I\u901a\u8def\u3002<\/strong><\/li>\n<\/ul>\n<p>\u6b64\u673a\u5236\u5bf9\u542f\u52a8\u521d\u59cbT\u7ec6\u80de\u5e94\u7b54\u81f3\u5173\u91cd\u8981\uff0c\u4e5f\u662fDC\u75ab\u82d7\u8054\u5408TCR-T\u6cbb\u7597\u7684\u7406\u8bba\u57fa\u7840\u3002<\/p>\n<h3>\u4e09\u3001TCR-T\u9776\u70b9\u9009\u62e9\u7684\u5173\u952e\u8003\u91cf<\/h3>\n<p>\u7406\u60f3\u7684TCR-T\u9776\u70b9\u9700\u6ee1\u8db3\u4ee5\u4e0b\u6761\u4ef6\uff1a<\/p>\n<ul class=\"list-paddingleft-1\">\n<li><strong>\u80bf\u7624\u7279\u5f02\u6027\uff1a\u4f18\u5148\u9009\u62e9\u65b0\u6297\u539f\uff08NeoAg\uff09\u6216\u764c\u777e\u6297\u539f\uff08\u5982NY-ESO-1\u3001MAGE-A4\uff09\uff0c\u907f\u514d\u653b\u51fb\u6b63\u5e38\u7ec4\u7ec7\uff1b<\/strong><\/li>\n<li><strong>\u9ad8\u8868\u8fbe\u4e0e\u7a33\u5b9a\u5448\u9012\uff1a\u9776\u6297\u539f\u5728\u80bf\u7624\u4e2d\u9ad8\u8868\u8fbe\uff0c\u4e14\u52a0\u5de5\u901a\u8def\u5b8c\u6574\uff08TAP\u207a\/MHC I\u207a\uff09\uff1b<\/strong><\/li>\n<li><strong>HLA\u8986\u76d6\u5e7f\uff1a\u4f18\u9009\u4e2d\u56fd\u4eba\u7fa4\u9ad8\u9891HLA\u7b49\u4f4d\u57fa\u56e0\uff08\u5982HLA-A*02:01, *11:01, *24:02\uff09\u5bf9\u5e94\u7684\u8868\u4f4d\uff1b<\/strong><\/li>\n<li><strong>\u514d\u75ab\u539f\u6027\u5f3a\uff1a\u80fd\u8bf1\u5bfc\u9ad8\u4eb2\u548c\u529bTCR\uff08KD &lt; 10 \u03bcM\uff09\uff0c\u4e14\u65e0\u4e2d\u67a2\u8010\u53d7\u3002<\/strong><\/li>\n<\/ul>\n<p><strong>\u5386\u53f2\u6559\u8bad<\/strong>\uff1a2009\u5e74\u4e00\u9879MAGE-A3 TCR-T\u4e34\u5e8a\u8bd5\u9a8c\u56e0TCR\u4ea4\u53c9\u8bc6\u522b\u8111\u7ec4\u7ec7\u4e2dMAGE-A12\u5bfc\u81f42\u4f8b\u60a3\u8005\u6b7b\u4ea1\uff0c\u51f8\u663e\u8131\u9776\u6bd2\u6027\u98ce\u9669\u3002<\/p>\n<h3>\u6842\u828e\u751f\u7269\uff1a\u652f\u6491TCR-T\u7814\u53d1\u5168\u94fe\u6761\u7684\u6280\u672f\u5e73\u53f0<\/h3>\n<p>\u9488\u5bf9\u4e0a\u8ff0\u5173\u952e\u73af\u8282\uff0c\u6842\u828e\u63d0\u4f9b\u4ee5\u4e0b\u6df1\u5ea6\u6280\u672f\u670d\u52a1\uff1a<\/p>\n<p><strong><span data-pm-slice=\"1 1 [&quot;para&quot;,{&quot;tagName&quot;:&quot;p&quot;,&quot;attributes&quot;:{},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;node&quot;,{&quot;tagName&quot;:&quot;strong&quot;,&quot;attributes&quot;:{&quot;style&quot;:&quot;scrollbar-width: none;&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;}]\">1.\u00a0<a href=\"https:\/\/www.guixiong.com.cn\/?page_id=136\" target=\"_blank\" rel=\"noopener\">\u6297\u539f\u7279\u5f02\u6027T\u7ec6\u80de\u6269\u589e\uff1a<\/a><\/span><\/strong>\u6842\u828e\u7279\u6709\u7684DC\u5206\u5316\u6210\u719f\u6d41\u7a0b\uff0c\u63d0\u4f9b\u9ad8\u6bd4\u4f8bCD83\/CD86\u5448\u9012\u7ec6\u80de\uff0c\u4f53\u5916\u6269\u589e\u9ad8\u7eaf\u5ea6Tfh\/CD8\u207a T\u7ec6\u80de\u514b\u9686<\/p>\n<section><\/section>\n<section><\/section>\n<p><strong><span data-pm-slice=\"1 1 [&quot;para&quot;,{&quot;tagName&quot;:&quot;p&quot;,&quot;attributes&quot;:{},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;node&quot;,{&quot;tagName&quot;:&quot;strong&quot;,&quot;attributes&quot;:{&quot;style&quot;:&quot;scrollbar-width: none;&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;}]\">2.\u00a0<a href=\"https:\/\/www.guixiong.com.cn\/?page_id=1192\" target=\"_blank\" rel=\"noopener\">\u5fae\u91cfpMHC\u590d\u5408\u7269\u5408\u6210\u670d\u52a1\uff1a<\/a><\/span><\/strong>\u652f\u6301\u4f4e\u81f3\u03bcg\u7ea7\u5b9a\u5236\uff0c\u9002\u7528\u4e8e\u5c0f\u9f20\/\u4eba\u6e90HLA\u7b49\u4f4d\u57fa\u56e0<\/p>\n<section><\/section>\n<section><\/section>\n<p><strong><span data-pm-slice=\"1 1 [&quot;para&quot;,{&quot;tagName&quot;:&quot;p&quot;,&quot;attributes&quot;:{},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;node&quot;,{&quot;tagName&quot;:&quot;strong&quot;,&quot;attributes&quot;:{&quot;style&quot;:&quot;scrollbar-width: none;&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;}]\">3.\u00a0<a href=\"https:\/\/www.guixiong.com.cn\/?page_id=133\" target=\"_blank\" rel=\"noopener\">pMHC\u8367\u5149\u56db\u805a\u4f53\u5408\u6210\u4ee5\u53ca\u7b5b\u9009\uff1a<\/a><\/span><\/strong>\u73b0\u8d272000+\u79cd\uff0c\u8986\u76d6HLA-A*02:01\/A*11:01\/A*24:02\u7b4930\u591a\u79cd\u4e3b\u6d41HLA\u4e9a\u578b\u57fa\u56e0<\/p>\n<section><\/section>\n<section><\/section>\n<p><strong><span data-pm-slice=\"1 1 [&quot;para&quot;,{&quot;tagName&quot;:&quot;p&quot;,&quot;attributes&quot;:{},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;node&quot;,{&quot;tagName&quot;:&quot;strong&quot;,&quot;attributes&quot;:{&quot;style&quot;:&quot;scrollbar-width: none;&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;}]\">4.\u00a0<a href=\"https:\/\/www.guixiong.com.cn\/?page_id=1489\" target=\"_blank\" rel=\"noopener\">\u5355\u514b\u9686TCR\u6d4b\u5e8f\uff1a\u00a0<\/a><\/span><\/strong>\u4ece\u5206\u9009T\u7ec6\u80de\u4e2d\u83b7\u53d6\u914d\u5bf9\u5168\u957fTCR\u03b1\/\u03b2\u4e3b\u514b\u9686<\/p>\n<section><\/section>\n<section><\/section>\n<p><strong><span data-pm-slice=\"1 1 [&quot;para&quot;,{&quot;tagName&quot;:&quot;p&quot;,&quot;attributes&quot;:{},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;node&quot;,{&quot;tagName&quot;:&quot;strong&quot;,&quot;attributes&quot;:{&quot;style&quot;:&quot;scrollbar-width: none;&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;}]\">5.\u00a0<a href=\"https:\/\/www.guixiong.com.cn\/?page_id=558\" target=\"_blank\" rel=\"noopener\">\u7a33\u8f6c\u539f\u4ee3TCR-T\u6784\u5efa\uff1a\u00a0<\/a><\/span><\/strong>\u6574\u5408<span data-pm-slice=\"2 2 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href=\"https:\/\/www.guixiong.com.cn\/?page_id=1197\" target=\"_blank\" rel=\"noopener\">\u6297\u539f\u80bd-MHC\u4eb2\u548c\u529b\u9ad8\u901a\u91cfELISA\u626b\u63cf\u670d\u52a1\uff1a\u00a0<\/a><\/span><\/strong>\u9ad8\u901a\u91cf\u8bc4\u4f30\u6570\u767e\u79cd\u80bd\u6bb5\u4e0eHLA\u7ed3\u5408\u80fd\u529b\uff0c\u4f18\u9009\u75ab\u82d7\u8868\u4f4d<\/p>\n<section><\/section>\n<section><\/section>\n<p><strong><span data-pm-slice=\"1 1 [&quot;para&quot;,{&quot;tagName&quot;:&quot;p&quot;,&quot;attributes&quot;:{},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;node&quot;,{&quot;tagName&quot;:&quot;strong&quot;,&quot;attributes&quot;:{&quot;style&quot;:&quot;scrollbar-width: none;&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;}]\">7.\u00a0<a href=\"https:\/\/www.guixiong.com.cn\/?page_id=546\" target=\"_blank\" rel=\"noopener\">\u5de5\u7a0b\u5316\u5448\u9012\u7ec6\u80de\u6784\u5efa\uff1a\u00a0<\/a><\/span><\/strong>K562-HLA\u7cfb\u5217\u7ec6\u80de\uff0c\u7528\u4e8e\u6301\u4e45\u6297\u539f\u5448\u9012<\/p>\n<p>Views: 11<\/p>","protected":false},"excerpt":{"rendered":"<p>TCR-T\u7ec6\u80de\u6cbb\u7597\u5168\u6d41\u7a0b\uff1a\u4ece\u80bf\u7624\u6297\u539f\u53d1\u73b0 \u2192 TCR\u514b\u9686 \u2192 \u57fa\u56e0\u5de5\u7a0b \u2192 \u529f\u80fd\u9a8c\u8bc1 \u2192 \u4e34\u5e8a\u56de\u8f93 TCR-T&#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_kadence_starter_templates_imported_post":false,"_kad_post_transparent":"default","_kad_post_title":"default","_kad_post_layout":"default","_kad_post_sidebar_id":"","_kad_post_content_style":"default","_kad_post_vertical_padding":"default","_kad_post_feature":"","_kad_post_feature_position":"","_kad_post_header":false,"_kad_post_footer":false,"_kad_post_classname":"","footnotes":""},"class_list":["post-1624","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.guixiong.com.cn\/index.php?rest_route=\/wp\/v2\/pages\/1624","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.guixiong.com.cn\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.guixiong.com.cn\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.guixiong.com.cn\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.guixiong.com.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1624"}],"version-history":[{"count":1,"href":"https:\/\/www.guixiong.com.cn\/index.php?rest_route=\/wp\/v2\/pages\/1624\/revisions"}],"predecessor-version":[{"id":1626,"href":"https:\/\/www.guixiong.com.cn\/index.php?rest_route=\/wp\/v2\/pages\/1624\/revisions\/1626"}],"wp:attachment":[{"href":"https:\/\/www.guixiong.com.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1624"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}