{"id":1627,"date":"2026-01-30T14:10:22","date_gmt":"2026-01-30T14:10:22","guid":{"rendered":"https:\/\/www.guixiong.com.cn\/?page_id=1627"},"modified":"2026-01-30T14:16:33","modified_gmt":"2026-01-30T14:16:33","slug":"%e5%85%a8%e9%9d%a2%e8%ae%a4%e8%af%86-tcr-t-%e7%bb%86%e8%83%9e%e6%b2%bb%e7%96%97%ef%bc%9a%e4%bb%8e%e5%a4%96%e5%91%a8%e8%a1%80%e5%88%b0%e8%82%bf%e7%98%a4%e5%be%ae%e7%8e%af%e5%a2%83","status":"publish","type":"page","link":"https:\/\/www.guixiong.com.cn\/?page_id=1627","title":{"rendered":"\u5168\u9762\u8ba4\u8bc6 TCR-T \u7ec6\u80de\u6cbb\u7597\uff1a\u4ece\u5916\u5468\u8840\u5230\u80bf\u7624\u5fae\u73af\u5883\u2014\u2014\u5168\u6d41\u7a0b\u89e3\u6790\u4e0e\u5173\u952e\u5f71\u54cd\u56e0\u7d20"},"content":{"rendered":"<blockquote>\n<p data-pm-slice=\"3 2 []\"><span data-pm-slice=\"0 0 []\">TCR-T\u6cbb\u7597\u5168\u6d41\u7a0b\u793a\u610f\u56fe\u3002\u6807\u6ce8\u5173\u952e\u5de5\u827a\u8282\u70b9\uff08\u5982CD3\/CD28\u78c1\u73e0\u6bd4\u4f8b\u3001IL-2\u6d53\u5ea6\u3001\u6162\u75c5\u6bd2MOI\u3001\u6269\u589e\u500d\u6570\u3001\u6dcb\u5df4\u6e05\u9664\u65b9\u6848\u7b49\uff09\u3002<\/span><\/p>\n<p>TCR-T\u7597\u6548 = \uff08TCR\u7279\u5f02\u6027 \u00d7 T\u7ec6\u80de\u8d28\u91cf\uff09 \u00f7 \uff08\u514d\u75ab\u6291\u5236 + \u80bf\u7624\u9003\u9038\uff09\u3002\u672c\u6587\u5c06\u9010\u73af\u8282\u62c6\u89e3\u8fd9\u4e00\u516c\u5f0f\uff0c\u63ed\u793a\u6bcf\u4e00\u4e2a\u201c\u53d8\u91cf\u201d\u80cc\u540e\u7684\u79d1\u5b66\u903b\u8f91\u4e0e\u5de5\u7a0b\u4f18\u5316\u7a7a\u95f4\u3002<\/p><\/blockquote>\n<h3>\u4e00\u3001TCR-T\u7ec6\u80de\u6cbb\u7597\u5168\u6d41\u7a0b\u8be6\u89e3\uff08\u542bGMP\u7ea7\u5de5\u827a\u53c2\u6570\uff09<\/h3>\n<p>\u4e00\u4e2a\u6210\u529f\u7684TCR-T\u4ea7\u54c1\u9700\u7ecf\u5386\u4ece\u60a3\u8005\u91c7\u8840\u5230\u56de\u8f93\u76847\u4e2a\u6838\u5fc3\u6b65\u9aa4\uff0c\u6bcf\u4e00\u6b65\u5747\u9700\u4e25\u683c\u8d28\u63a7\uff1a<\/p>\n<section><strong>\u2460 \u5916\u5468\u8840\u91c7\u96c6\u4e0ePBMC\u5206\u79bb<\/strong><\/section>\n<section>\u2022 \u91c7\u8840\u91cf\uff1a\u901a\u5e3850\u2013100 mL\u5168\u8840\uff1b\u2022 \u5206\u79bb\u65b9\u6cd5\uff1aFicoll\u5bc6\u5ea6\u68af\u5ea6\u79bb\u5fc3\uff08\u56de\u6536\u7387&gt;85%\uff09\u6216\u5168\u81ea\u52a8\u7cfb\u7edf\uff08\u5982Sepax\u2122\uff09\uff1b\u2022 \u5173\u952e\u6307\u6807\uff1aCD3\u207a T\u7ec6\u80de\u5360\u6bd4 &gt;60%\uff0c\u6d3b\u7387 &gt;95%\u3002<\/section>\n<section><strong>\u2461 T\u7ec6\u80de\u6d3b\u5316<\/strong><\/section>\n<section>\u2022 \u6fc0\u6d3b\u5242\uff1a\u6297CD3\/CD28 Dynabeads\u2122\uff08\u78c1\u73e0:T\u7ec6\u80de = 1:1\u20133:1\uff09\uff1b\u2022 \u7ec6\u80de\u56e0\u5b50\uff1aIL-2\uff08300\u20131000 IU\/mL\uff09\uff0c\u90e8\u5206\u65b9\u6848\u52a0\u5165IL-7\uff0810 ng\/mL\uff09\u548cIL-15\uff0810 ng\/mL\uff09\u4ee5\u7ef4\u6301\u5e72\u6027\uff1b\u2022 \u65f6\u95f4\u7a97\uff1a\u6fc0\u6d3b24\u201348\u5c0f\u65f6\u540e\u8fdb\u884c\u57fa\u56e0\u8f6c\u5bfc\uff0c\u6b64\u65f6T\u7ec6\u80de\u5904\u4e8eG1\/S\u671f\uff0c\u8f6c\u5bfc\u6548\u7387\u6700\u9ad8\u3002<\/section>\n<section><strong>\u2462 \u57fa\u56e0\u8f6c\u5bfc<\/strong><\/section>\n<section>\u2022 \u8f7d\u4f53\u9009\u62e9\uff1a\u6162\u75c5\u6bd2\uff08LV\uff09\u4e3a\u4e3b\uff08\u6574\u5408\u7a33\u5b9a\u3001\u6ef4\u5ea6\u9ad8\uff09\uff0cMOI\uff08\u611f\u67d3\u590d\u6570\uff09\u901a\u5e38\u4e3a3\u201310\uff1b\u2022 \u542f\u52a8\u5b50\uff1aEF-1\u03b1 &gt; CMV\uff08\u957f\u671f\u8868\u8fbe\u66f4\u7a33\u5b9a\uff09\uff1b\u2022 \u8f6c\u5bfc\u589e\u5f3a\uff1a\u6dfb\u52a0\u805a\u51dd\u80fa\uff08Polybrene, 4\u20138 \u03bcg\/mL\uff09\u6216Retronectin\u00ae\u5305\u88ab\u57f9\u517b\u677f\uff1b\u2022 \u8f6c\u5bfc\u6548\u7387\uff1a\u6d41\u5f0f\u68c0\u6d4bTCR V\u03b2\u6216\u6807\u7b7e\uff08\u5982MyC-tag\uff09\u8868\u8fbe\uff0c\u76ee\u6807 &gt;70%\u3002<\/section>\n<section><strong>\u2463 T\u7ec6\u80de\u6269\u589e<\/strong><\/section>\n<section>\u2022 \u57f9\u517b\u57fa\uff1aX-VIVO 15 \u6216 TexMACS\u2122\uff0c\u65e0\u8840\u6e05\u3001\u65e0\u52a8\u7269\u6e90\u6210\u5206\uff1b\u2022 \u7ec6\u80de\u56e0\u5b50\u7ec4\u5408\uff1a\u00a0 \u2013 \u77ed\u6548\u6269\u589e\uff1aIL-2\uff08300 IU\/mL\uff09\u2192 \u5feb\u901f\u6269\u589e\u4f46\u6613\u8017\u7aed\uff1b\u00a0 \u2013 \u957f\u6548\u8bb0\u5fc6\u578b\uff1aIL-7 + IL-15\uff08\u540410 ng\/mL\uff09\u2192 \u5bcc\u96c6Tscm\/Tcm\uff1b\u2022 \u6269\u589e\u500d\u6570\uff1a\u901a\u5e3810\u201314\u5929\u8fbe10\u00b2\u201310\u2074\u500d\uff0c\u7ec8\u4ea7\u54c1\u7ec6\u80de\u6570 \u22651\u00d710\u2079\uff1b\u2022 \u8d28\u63a7\u70b9\uff1a\u6d3b\u7387 &gt;80%\uff0cCD4:CD8 \u2248 1:1\u20131:3\uff0cTCR\u8868\u8fbe &gt;70%\u3002<\/section>\n<section><strong>\u2464 \u6dcb\u5df4\u6e05\u9664\u9884\u5904\u7406\uff08Lymphodepletion\uff09<\/strong><\/section>\n<section>\u2022 \u76ee\u7684\uff1a\u6e05\u9664\u8c03\u8282\u6027T\u7ec6\u80de\uff08Treg\uff09\u3001\u9ad3\u7cfb\u6765\u6e90\u6291\u5236\u7ec6\u80de\uff08MDSC\uff09\uff0c\u91ca\u653eIL-7\/IL-15\u201c\u751f\u6001\u4f4d\u201d\uff1b\u2022 \u5e38\u7528\u65b9\u6848\uff1a\u00a0 \u2013 \u73af\u78f7\u9170\u80fa\uff08Cy\uff09 60 mg\/kg\/day \u00d7 2\u5929 + \u6c1f\u8fbe\u62c9\u6ee8\uff08Flu\uff09 25 mg\/m\u00b2\/day \u00d7 5\u5929\uff08NCT01352286\uff09\uff1b\u00a0 \u2013 \u5355\u836fCy 750 mg\/m\u00b2 \u00d7 3\u5929\uff08\u66f4\u6e29\u548c\uff09\uff1b\u2022 \u6700\u4f73\u56de\u8f93\u7a97\u53e3\uff1a\u672b\u6b21\u5316\u7597\u540e24\u201348\u5c0f\u65f6\u3002<\/section>\n<section><strong>\u2465 \u7ec6\u80de\u56de\u8f93<\/strong><\/section>\n<section>\u2022 \u5242\u91cf\uff1a\u901a\u5e381\u201310\u00d710\u2079 cells\/m\u00b2\uff0c\u52061\u20133\u6b21\u9759\u8109\u8f93\u6ce8\uff1b\u2022 \u8f85\u52a9\u7528\u836f\uff1a\u56de\u8f93\u524d\u7ed9\u4e88\u5730\u585e\u7c73\u677e\uff08\u9884\u9632CRS\uff09\uff0c\u56de\u8f93\u540e\u76d1\u6d4bIL-6\u3001IFN-\u03b3\u3001\u94c1\u86cb\u767d\u7b49\u3002<\/section>\n<section><strong>\u2466 \u56de\u8f93\u540e\u7ba1\u7406<\/strong><\/section>\n<section>\u2022 \u76d1\u6d4b\uff1a\u5916\u5468\u8840TCR-T\u7ec6\u80de persistence\uff08qPCR\/ddPCR\u68c0\u6d4b\u8f6c\u57fa\u56e0\u62f7\u8d1d\u6570\uff09\uff1b\u2022 \u652f\u6301\u6cbb\u7597\uff1a\u5fc5\u8981\u65f6\u7ed9\u4e88IL-2\uff08\u4f4e\u5242\u91cf\uff0c60,000 IU\/m\u00b2\uff09\u7ef4\u6301T\u7ec6\u80de\u5b58\u6d3b\uff1b\u2022 \u4e0d\u826f\u53cd\u5e94\u5904\u7406\uff1a\u6309ASTCT\u6807\u51c6\u7ba1\u7406CRS\/ICANS\u3002<\/section>\n<h5><\/h5>\n<h1><span style=\"font-family: inherit; font-size: 24px;\">\u4e8c\u3001\u5f71\u54cdTCR-T\u7597\u6548\u7684\u56db\u5927\u7ef4\u5ea6\u6df1\u5ea6\u5256\u6790<\/span><\/h1>\n<section>\n<h5>\u7ef4\u5ea6\u4e00\uff5c\u8f93\u6ce8\u7ec6\u80de\u6570\u91cf\u4e0e\u52a8\u529b\u5b66<\/h5>\n<p><strong>\u2022 \u6709\u6548\u9608\u503c<\/strong>\uff1a\u4e34\u5e8a\u6570\u636e\u663e\u793a\uff0c\u5916\u5468\u8840\u4e2d\u8f6c\u57fa\u56e0T\u7ec6\u80de\u5cf0\u503c \u22651% of CD8\u207a T cells \u4e0e\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\u663e\u8457\u76f8\u5173\uff08Johnson et al., Blood 2009\uff09\u3002<\/p>\n<p><strong>\u2022 \u52a8\u529b\u5b66\u6a21\u578b<\/strong>\uff1a\u7406\u60f3\u66f2\u7ebf\u5e94\u5448\u73b0\u201c\u5feb\u901f\u6269\u589e \u2192 \u5e73\u7a33\u5e73\u53f0 \u2192 \u7f13\u6162\u8870\u51cf\u201d\u3002\u82e5\u65e9\u671f\u5373\u8870\u51cf\uff0c\u63d0\u793aT\u7ec6\u80de\u8017\u7aed\u6216\u514d\u75ab\u6392\u65a5\u3002<\/p>\n<p><strong>\u2022 \u4f18\u5316\u7b56\u7565<\/strong>\uff1a<\/p>\n<ul class=\"list-paddingleft-1\">\n<li>\n<section>\u5206\u6b21\u56de\u8f93\uff08Day 0 + Day 7\uff09\u53ef\u5ef6\u957f\u4f53\u5185\u5b58\u7eed\u65f6\u95f4\uff1b<\/section>\n<\/li>\n<li>\n<section>\u8054\u5408IL-15 superagonist\uff08\u5982N-803\uff09\u53ef\u63d0\u5347T\u7ec6\u80de\u6301\u4e45\u6027\uff08NCT04261439\uff09\u3002<\/section>\n<\/li>\n<\/ul>\n<h5>\u7ef4\u5ea6\u4e8c\uff5c\u514d\u75ab\u6291\u5236\u5fae\u73af\u5883\u7684\u7834\u89e3<\/h5>\n<p><strong>\u2022 \u4e3b\u8981\u6291\u5236\u673a\u5236<\/strong>\uff1a<\/p>\n<table>\n<thead>\n<tr>\n<th>\n<section>\u7c7b\u522b<\/section>\n<\/th>\n<th>\n<section>\u4ee3\u8868\u5206\u5b50\/\u7ec6\u80de<\/section>\n<\/th>\n<th>\n<section>\u4f5c\u7528\u673a\u5236<\/section>\n<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>\n<section>\u514d\u75ab\u68c0\u67e5\u70b9<\/section>\n<\/td>\n<td>\n<section>PD-1, CTLA-4, LAG-3, TIM-3<\/section>\n<\/td>\n<td>\n<section>\u6291\u5236T\u7ec6\u80de\u6d3b\u5316\u4fe1\u53f7<\/section>\n<\/td>\n<\/tr>\n<tr>\n<td>\n<section>\u6291\u5236\u6027\u7ec6\u80de<\/section>\n<\/td>\n<td>\n<section>Treg, MDSC, TAM\uff08M2\u578b\uff09<\/section>\n<\/td>\n<td>\n<section>\u5206\u6cccIL-10\u3001TGF-\u03b2\u3001IDO1<\/section>\n<\/td>\n<\/tr>\n<tr>\n<td>\n<section>\u4ee3\u8c22\u6291\u5236<\/section>\n<\/td>\n<td>\n<section>\u817a\u82f7\uff08CD73\/CD39\uff09\u3001\u72ac\u5c3f\u6c28\u9178\uff08IDO1\uff09<\/section>\n<\/td>\n<td>\n<section>\u6291\u5236mTOR\u901a\u8def\uff0c\u963b\u65ad\u7cd6\u9175\u89e3<\/section>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n<p><strong>\u2022 \u8054\u5408\u6cbb\u7597\u7b56\u7565<\/strong>\uff1a<\/p>\n<ul class=\"list-paddingleft-1\">\n<li>\n<section>\u6297PD-1\uff08\u5e15\u535a\u5229\u73e0\u5355\u6297\uff09 + TCR-T\uff1a\u5728\u6ed1\u819c\u8089\u7624\u4e2dORR\u4ece40%\u63d0\u5347\u81f360%\uff08NCT03462317\uff09\uff1b<\/section>\n<\/li>\n<li>\n<section>IDO1\u6291\u5236\u5242\uff08Epacadostat\uff09 + TCR-T\uff1a\u9006\u8f6c\u8272\u6c28\u9178\u8017\u7aed\uff0c\u6062\u590dT\u7ec6\u80de\u529f\u80fd\uff1b<\/section>\n<\/li>\n<li>\n<section>CD73\u6297\u4f53\uff08Oleclumab\uff09\uff1a\u963b\u65ad\u817a\u82f7\u751f\u6210\uff0c\u6539\u5584T\u7ec6\u80de\u6d78\u6da6\u3002<\/section>\n<\/li>\n<\/ul>\n<h5>\u7ef4\u5ea6\u4e09\uff5c\u80bf\u7624\u5f02\u8d28\u6027\u4e0e\u6297\u539f\u9003\u9038<\/h5>\n<p><strong>\u2022 \u6297\u539f\u4e22\u5931\u673a\u5236<\/strong>\uff1a<\/p>\n<ul class=\"list-paddingleft-1\">\n<li>\n<section>MHC-I\u4e0b\u8c03\uff08\u03b2\u2082m\u7a81\u53d8\u3001HLA LOH\uff09\uff1b<\/section>\n<\/li>\n<li>\n<section>\u6297\u539f\u52a0\u5de5\u901a\u8def\u7f3a\u9677\uff08TAP1\/2\u7f3a\u5931\u3001ERAP1\u7a81\u53d8\uff09\uff1b<\/section>\n<\/li>\n<li>\n<section>\u8868\u89c2\u6c89\u9ed8\uff08\u542f\u52a8\u5b50\u7532\u57fa\u5316\uff09\u3002<\/section>\n<\/li>\n<\/ul>\n<p><strong>\u2022 \u5e94\u5bf9\u7b56\u7565<\/strong>\uff1a<\/p>\n<ul class=\"list-paddingleft-1\">\n<li><strong>\u591a\u9776\u70b9TCR-T\uff1a<\/strong><br \/>\n<section>\u5171\u8868\u8fbe2\u4e2aTCR\uff08\u5982NY-ESO-1 + MAGE-A4\uff09\uff0c\u8986\u76d6\u6297\u539f\u5f02\u8d28\u6027\uff1b<\/section>\n<\/li>\n<li><strong>\u8868\u89c2\u836f\u7269\u8054\u7528\uff1a<\/strong><br \/>\n<section>\u5730\u897f\u4ed6\u6ee8\uff08\u53bb\u7532\u57fa\u5316\uff09 + HDAC\u6291\u5236\u5242\uff08\u4f0f\u7acb\u8bfa\u4ed6\uff09\u53ef\u91cd\u65b0\u6fc0\u6d3b\u6c89\u9ed8\u6297\u539f\uff1b<\/section>\n<\/li>\n<li><strong>HLA-II\u9776\u5411\uff1a<\/strong><br \/>\n<section>CD4\u207a TCR-T\u8bc6\u522bHLA-II\u5448\u9012\u80bd\uff0c\u63d0\u4f9b\u8f85\u52a9\u4fe1\u53f7\u5e76\u76f4\u63a5\u6740\u4f24\uff08\u5982KRAS G12D\u2013HLA-DR\uff09\u3002<\/section>\n<\/li>\n<\/ul>\n<h5>\u7ef4\u5ea6\u56db\uff5c\u6548\u5e94\u7ec6\u80de\u5185\u5728\u5c5e\u6027\u4f18\u5316<\/h5>\n<p><strong>1. T\u7ec6\u80de\u5206\u5316\u72b6\u6001\u7cbe\u51c6\u8c03\u63a7<\/strong><\/p>\n<table>\n<thead>\n<tr>\n<th>\n<section>\u4e9a\u7fa4<\/section>\n<\/th>\n<th>\n<section>\u6807\u5fd7\u7269<\/section>\n<\/th>\n<th>\n<section>\u529f\u80fd\u7279\u70b9<\/section>\n<\/th>\n<th>\n<section>\u57f9\u517b\u7b56\u7565<\/section>\n<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>\n<section>Tscm<\/section>\n<\/td>\n<td>\n<section>CD45RA\u207a CCR7\u207a CD62L\u207a CD95\u207a<\/section>\n<\/td>\n<td>\n<section>\u81ea\u6211\u66f4\u65b0\u5f3a\uff0c\u6301\u4e45\u6027\u6700\u4f73<\/section>\n<\/td>\n<td>\n<section>IL-7 + IL-15 + Wnt\u4fe1\u53f7\u6fc0\u6d3b<\/section>\n<\/td>\n<\/tr>\n<tr>\n<td>\n<section>Tcm<\/section>\n<\/td>\n<td>\n<section>CD45RO\u207a CCR7\u207a CD62L\u207a<\/section>\n<\/td>\n<td>\n<section>\u957f\u6548\u8bb0\u5fc6\uff0c\u53ef\u518d\u6269\u589e<\/section>\n<\/td>\n<td>\n<section>IL-15 + \u6297\u6c27\u5316\u5242\uff08NAC\uff09<\/section>\n<\/td>\n<\/tr>\n<tr>\n<td>\n<section>Tem\/Teff<\/section>\n<\/td>\n<td>\n<section>CD45RO\u207a CCR7\u207b<\/section>\n<\/td>\n<td>\n<section>\u5373\u65f6\u6740\u4f24\u5f3a\uff0c\u4f46\u6613\u8017\u7aed<\/section>\n<\/td>\n<td>\n<section>\u9ad8\u5242\u91cfIL-2<\/section>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<section><\/section>\n<section><strong>2. TCR\u9519\u914d\u4e0e\u4eb2\u548c\u529b\u5de5\u7a0b<\/strong><\/section>\n<ul class=\"list-paddingleft-1\">\n<li><strong>\u9519\u914d\u98ce\u9669\uff1a<\/strong><br \/>\n<section>\u5916\u6e90\u03b1\/\u03b2\u94fe\u4e0e\u5185\u6e90\u94fe\u5f62\u6210\u5f02\u6e90\u4e8c\u805a\u4f53\uff0c\u53ef\u80fd\u8bc6\u522b\u81ea\u8eab\u6297\u539f\uff08\u5982MAGE-A12\uff09\uff1b<\/section>\n<\/li>\n<li><strong>\u89e3\u51b3\u65b9\u6848\uff1a<\/strong>\n<ul class=\"list-paddingleft-1\">\n<li>\n<section>\u9f20\u6e90\u5316C\u533a\uff08murinized constant domain\uff09\u4fc3\u8fdb\u540c\u6e90\u914d\u5bf9\uff1b<\/section>\n<\/li>\n<li>\n<section>CRISPR\u6572\u9664TRAC\/TRBC\uff08\u6548\u7387&gt;95%\uff09\uff0c\u5f7b\u5e95\u6d88\u9664\u5185\u6e90TCR\uff1b<\/section>\n<\/li>\n<li>\n<section>\u5f15\u5165\u4e8c\u786b\u952e\uff08\u5982Cys in C\u03b1\/C\u03b2\uff09\u7a33\u5b9a\u5916\u6e90TCR\u3002<\/section>\n<\/li>\n<\/ul>\n<\/li>\n<li><strong>\u4eb2\u548c\u529b\u4f18\u5316\uff1a<\/strong><br \/>\n<section>\u901a\u8fc7\u9175\u6bcd\u5c55\u793a\u7b5b\u9009CDR3\u7a81\u53d8\u4f53\uff0cK<sub>D<\/sub>\u4ece50 \u03bcM\u63d0\u5347\u81f31\u20135 \u03bcM\uff0c\u4f46\u9700SPOT array\u9a8c\u8bc1\u8131\u9776\uff08\u5982CEA\u9776\u70b9\u66fe\u81f4\u7ed3\u80a0\u708e\uff09\u3002<\/section>\n<section><\/section>\n<\/li>\n<\/ul>\n<section><strong>3. \u8d8b\u5316\u56e0\u5b50\u53d7\u4f53\u5de5\u7a0b\u5316<\/strong><\/section>\n<ul class=\"list-paddingleft-1\">\n<li>\n<section>\u5375\u5de2\u764c\u9ad8\u8868\u8fbeCXCL12 \u2192 TCR-T\u8868\u8fbeCXCR4\uff1b<\/section>\n<\/li>\n<li>\n<section>\u9ed1\u8272\u7d20\u7624\u5206\u6cccCCL17\/22 \u2192 TCR-T\u8868\u8fbeCCR4\uff1b<\/section>\n<\/li>\n<li>\n<section>\u809d\u764c\u5fae\u73af\u5883\u5bcc\u96c6CXCL16 \u2192 TCR-T\u8868\u8fbeCXCR6\u3002<\/p>\n<hr \/>\n<\/section>\n<\/li>\n<\/ul>\n<h2>\u6842\u828e\u751f\u7269\uff1a\u63d0\u4f9b\u6297\u539f\u7279\u5f02\u6027T\u7ec6\u80de\u5168\u94fe\u6761\u89e3\u51b3\u65b9\u6848<\/h2>\n<p data-pm-slice=\"0 0 []\">\u8981\u590d\u73b0\u6216\u8d85\u8d8a\u8be5\u7814\u7a76\uff0c\u60a8\u9700\u8981\uff1a<strong>\u9ad8\u8986\u76d6\u56db\u805a\u4f53 + \u7cbe\u51c6T\u7ec6\u80de\u5206\u9009 + \u529f\u80fd\u9a8c\u8bc1\u4f53\u7cfb<\/strong>\u3002\u6842\u828e\u751f\u7269\u5df2\u6784\u5efa\u5b8c\u6574\u5e73\u53f0\uff1a<\/p>\n<p data-pm-slice=\"3 3 []\"><strong>1.\u00a0<span data-pm-slice=\"1 1 [&quot;para&quot;,{&quot;tagName&quot;:&quot;p&quot;,&quot;attributes&quot;:{},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;node&quot;,{&quot;tagName&quot;:&quot;strong&quot;,&quot;attributes&quot;:{&quot;style&quot;:&quot;scrollbar-width: none;&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;}]\"><a class=\"normal_text_link mp_article_text_link\" href=\"https:\/\/www.guixiong.com.cn\/?page_id=133\" target=\"_blank\" rel=\"noopener\" data-itemshowtype=\"0\" data-linktype=\"2\">pMHC\u8367\u5149\u56db\u805a\u4f53\u5408\u6210\u4ee5\u53ca\u7b5b\u9009<\/a>: <\/span><\/strong>\u8986\u76d6\u9ed1\u8272\u7d20\u7624\u6838\u5fc3\u6297\u539f\uff08MART-1\/gp100\/NY-ESO-1\u7b49\uff09\uff0c\u652f\u6301HLA-A*02:01\u7b49\u4e3b\u6d41\u7b49\u4f4d\u57fa\u56e0<\/p>\n<p><strong>2.\u00a0<span data-pm-slice=\"1 1 [&quot;para&quot;,{&quot;tagName&quot;:&quot;p&quot;,&quot;attributes&quot;:{},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;node&quot;,{&quot;tagName&quot;:&quot;strong&quot;,&quot;attributes&quot;:{&quot;style&quot;:&quot;scrollbar-width: none;&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;}]\"><a href=\"https:\/\/www.guixiong.com.cn\/?page_id=1192\" target=\"_blank\" rel=\"noopener\">\u5fae\u91cfpMHC\u590d\u5408\u7269\u5408\u6210\u670d\u52a1<\/a>\u00a0:<\/span><\/strong><strong data-pm-slice=\"0 0 []\"><span data-pm-slice=\"1 1 [&quot;para&quot;,{&quot;tagName&quot;:&quot;p&quot;,&quot;attributes&quot;:{},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;node&quot;,{&quot;tagName&quot;:&quot;strong&quot;,&quot;attributes&quot;:{&quot;style&quot;:&quot;scrollbar-width: none;&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;}]\">\u5feb\u901f\u5b9a\u5236\uff0c\u5c11\u91cf\u9a8c\u8bc1\uff0c\u540c\u6b65\u8ffd\u8e2a\u591a\u4e2a\u6297\u539f\u7279\u5f02\u6027T\u7ec6\u80de\u514b\u9686<\/span><\/strong><\/p>\n<p><strong>3.\u00a0<span data-pm-slice=\"1 1 [&quot;para&quot;,{&quot;tagName&quot;:&quot;p&quot;,&quot;attributes&quot;:{},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;node&quot;,{&quot;tagName&quot;:&quot;strong&quot;,&quot;attributes&quot;:{&quot;style&quot;:&quot;scrollbar-width: none;&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;}]\"><a href=\"https:\/\/www.guixiong.com.cn\/?page_id=136\" target=\"_blank\" rel=\"noopener\">\u6297\u539f\u7279\u5f02\u6027T\u7ec6\u80de\u6269\u589e:<\/a> <\/span><\/strong>\u57fa\u4e8e\u56db\u805a\u4f53\u5206\u9009\u7ec6\u80de\uff0c\u6269\u589e\u9ad8\u7eaf\u5ea6T-bet\u207a\u529f\u80fd\u6027T\u7ec6\u80de<\/p>\n<p><strong>4.\u00a0<a href=\"https:\/\/www.guixiong.com.cn\/?page_id=1489\" target=\"_blank\" rel=\"noopener\"><span data-pm-slice=\"1 1 [&quot;para&quot;,{&quot;tagName&quot;:&quot;p&quot;,&quot;attributes&quot;:{},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;node&quot;,{&quot;tagName&quot;:&quot;strong&quot;,&quot;attributes&quot;:{&quot;style&quot;:&quot;scrollbar-width: none;&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;}]\">\u5355\u514b\u9686TCR\u6d4b\u5e8f: <\/span><\/a><\/strong>\u4ece\u56db\u805a\u4f53\u207aT\u7ec6\u80de\u4e2d\u83b7\u53d6\u914d\u5bf9TCR\u4e3b\u514b\u9686<\/p>\n<p><strong>5.\u00a0<span data-pm-slice=\"1 1 [&quot;para&quot;,{&quot;tagName&quot;:&quot;p&quot;,&quot;attributes&quot;:{},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;node&quot;,{&quot;tagName&quot;:&quot;strong&quot;,&quot;attributes&quot;:{&quot;style&quot;:&quot;scrollbar-width: none;&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;}]\"><a href=\"https:\/\/www.guixiong.com.cn\/?page_id=546\" target=\"_blank\" rel=\"noopener\">\u5de5\u7a0b\u5316\u5448\u9012\u7ec6\u80de\u6784\u5efa<\/a>: <\/span><\/strong>K562-HLA-A*02:01-MART-1\u7b49\uff0c\u7528\u4e8eT\u7ec6\u80de\u529f\u80fd\u9a8c\u8bc1<\/p>\n<p><strong>6.\u00a0<span data-pm-slice=\"1 1 [&quot;para&quot;,{&quot;tagName&quot;:&quot;p&quot;,&quot;attributes&quot;:{},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;node&quot;,{&quot;tagName&quot;:&quot;strong&quot;,&quot;attributes&quot;:{&quot;style&quot;:&quot;scrollbar-width: none;&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;}]\"><a href=\"https:\/\/www.guixiong.com.cn\/?page_id=1197\" target=\"_blank\" rel=\"noopener\">\u6297\u539f\u80bd-MHC\u4eb2\u548c\u529b\u9ad8\u901a\u91cfELISA\u626b\u63cf\u670d\u52a1<\/a>: <\/span><\/strong>\u9ad8\u901a\u91cf\u7b5b\u9009\u60a3\u8005\u4e2a\u4f53\u5316\u65b0\u6297\u539f\u8868\u4f4d<\/p>\n<p><strong>7.\u00a0<a href=\"https:\/\/www.guixiong.com.cn\/?page_id=558\" target=\"_blank\" rel=\"noopener\">\u7a33\u8f6c\u539f\u4ee3TCR-T\u6784\u5efa<\/a>: <\/strong><span data-pm-slice=\"2 2 [&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;}]\">\u6574\u5408murine TCR\u6052\u5b9a\u533a\u7684\u975e\u75c5\u6bd2TCR\u7a33\u8f6c\u7cfb\u7edf\uff0c\u66f4\u5b89\u5168\u7684\u4e34\u5e8a\u524d\u7814\u7a76\u5e94\u7528<\/span><\/p>\n<\/section>\n<p>Views: 37<\/p>","protected":false},"excerpt":{"rendered":"<p>TCR-T\u6cbb\u7597\u5168\u6d41\u7a0b\u793a\u610f\u56fe\u3002\u6807\u6ce8\u5173\u952e\u5de5\u827a\u8282\u70b9\uff08\u5982CD3\/CD28\u78c1\u73e0\u6bd4\u4f8b\u3001IL-2\u6d53\u5ea6\u3001\u6162\u75c5\u6bd2MOI\u3001\u6269\u589e\u500d\u6570&#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_kadence_starter_templates_imported_post":false,"_kad_post_transparent":"default","_kad_post_title":"default","_kad_post_layout":"default","_kad_post_sidebar_id":"","_kad_post_content_style":"default","_kad_post_vertical_padding":"default","_kad_post_feature":"","_kad_post_feature_position":"","_kad_post_header":false,"_kad_post_footer":false,"_kad_post_classname":"","footnotes":""},"class_list":["post-1627","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.guixiong.com.cn\/index.php?rest_route=\/wp\/v2\/pages\/1627","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.guixiong.com.cn\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.guixiong.com.cn\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.guixiong.com.cn\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.guixiong.com.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1627"}],"version-history":[{"count":7,"href":"https:\/\/www.guixiong.com.cn\/index.php?rest_route=\/wp\/v2\/pages\/1627\/revisions"}],"predecessor-version":[{"id":1634,"href":"https:\/\/www.guixiong.com.cn\/index.php?rest_route=\/wp\/v2\/pages\/1627\/revisions\/1634"}],"wp:attachment":[{"href":"https:\/\/www.guixiong.com.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1627"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}