{"id":1637,"date":"2026-02-01T13:17:08","date_gmt":"2026-02-01T13:17:08","guid":{"rendered":"https:\/\/www.guixiong.com.cn\/?page_id=1637"},"modified":"2026-02-01T13:22:12","modified_gmt":"2026-02-01T13:22:12","slug":"%e5%85%a8%e9%9d%a2%e8%ae%a4%e8%af%86-tcr-t-%e7%bb%86%e8%83%9e%e6%b2%bb%e7%96%97%ef%bc%9a%e4%bb%8e%e6%96%b0%e6%8a%97%e5%8e%9f%e5%88%b0%e9%95%bf%e6%95%88%e8%ae%b0%e5%bf%86-%e5%8d%81","status":"publish","type":"page","link":"https:\/\/www.guixiong.com.cn\/?page_id=1637","title":{"rendered":"\u5168\u9762\u8ba4\u8bc6 TCR-T \u7ec6\u80de\u6cbb\u7597\uff1a\u4ece\u65b0\u6297\u539f\u5230\u957f\u6548\u8bb0\u5fc6TCR-T\u7ec6\u80de\u7597\u6cd5-\u4e03\u9879\u5f00\u53d1\u4e4b\u9053"},"content":{"rendered":"<blockquote>\n<pre data-pm-slice=\"3 2 []\"><strong>TCR-T\u6cbb\u7597\u5341\u5927\u6280\u672f\u7a81\u7834\u65b9\u5411\uff1a\u65b0\u6297\u539f\u9274\u5b9a \u2192 TCR\u4eb2\u548c\u529b\u4f18\u5316 \u2192 T\u7ec6\u80de\u5e72\u6027\u7ef4\u6301 \u2192 \u8054\u5408\u7597\u6cd5<\/strong>\u3002\r\n\r\nTCR-T\u7684\u672a\u6765 = \uff08\u4e2a\u4f53\u5316\u65b0\u6297\u539f \u00d7 \u5de5\u7a0b\u5316T\u7ec6\u80de\uff09 \u00f7 \uff08\u8131\u9776\u98ce\u9669 + \u8017\u7aed\uff09\u3002\u672c\u6587\u5c06\u9010\u9879\u62c6\u89e3\u8fd9\u4e00\u516c\u5f0f\uff0c\u63ed\u793a\u6bcf\u4e00\u9879\u201c\u53d8\u91cf\u201d\u80cc\u540e\u7684\u79d1\u5b66\u903b\u8f91\u4e0e\u6280\u672f\u5b9e\u73b0\u8def\u5f84\u3002<\/pre>\n<\/blockquote>\n<h2>\u4e00\u3001\u65b0\u6297\u539f\u53cd\u5e94\u6027TCR\uff1a\u4ece\u201c\u901a\u7528\u9776\u70b9\u201d\u8d70\u5411\u201c\u4e2a\u4f53\u5316\u7cbe\u51c6\u201d<\/h2>\n<p><strong>\u65b0\u6297\u539f\u4f18\u52bf<\/strong>\uff1a\u6e90\u4e8e\u4f53\u7ec6\u80de\u7a81\u53d8\uff0c\u4ec5\u5728\u80bf\u7624\u8868\u8fbe\uff0c\u514d\u75ab\u539f\u6027\u5f3a\uff0c\u65e0\u4e2d\u67a2\u8010\u53d7\u3002<\/p>\n<p><strong>\u9274\u5b9a\u6d41\u7a0b<\/strong>\uff1a<\/p>\n<ol class=\"list-paddingleft-1\">\n<li><strong>WES\/RNA-seq\uff1a<\/strong><br \/>\n<section>\u80bf\u7624 vs \u6b63\u5e38\u7ec4\u7ec7\u914d\u5bf9\u6d4b\u5e8f\uff0c\u8bc6\u522b\u975e\u540c\u4e49\u7a81\u53d8\uff1b<\/section>\n<\/li>\n<li><strong>HLA\u5206\u578b\uff1a<\/strong><br \/>\n<section>NGS-based HLA typing\uff08\u7cbe\u5ea6\u81f34-digit\uff09\uff1b<\/section>\n<\/li>\n<li><strong>\u8868\u4f4d\u9884\u6d4b\uff1a<\/strong><br \/>\n<section>NetMHCpan 4.1 \/ MHCflurry 2.0\uff08IC<sub>50<\/sub>\u00a0&lt; 50 nM\u4e3a\u9ad8\u4eb2\u548c\uff09\uff1b<\/section>\n<\/li>\n<li><strong>\u5b9e\u9a8c\u9a8c\u8bc1\uff1a<\/strong>\n<ul class=\"list-paddingleft-1\">\n<li>\n<section>TIL\u6269\u589e + IFN-\u03b3 ELISpot \u7b5b\u9009\u53cd\u5e94\u6027\u514b\u9686\uff1b<\/section>\n<\/li>\n<li>\n<section>PD-1\u207a CD39\u207a TIL\u5bcc\u96c6\u65b0\u6297\u539f\u7279\u5f02\u6027T\u7ec6\u80de\uff08Tran et al., Science 2014\uff09\uff1b<\/section>\n<\/li>\n<li>\n<section>\u5355\u7ec6\u80deTCR-seq + pMHC\u591a\u805a\u4f53\u67d3\u8272\u9501\u5b9a\u914d\u5bf9\u3002<\/section>\n<section><\/section>\n<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n<p><strong>\u00a0\u6311\u6218\u4e0e\u5bf9\u7b56<\/strong>\uff1a<\/p>\n<ul class=\"list-paddingleft-1\">\n<li><strong>\u6210\u672c\u9ad8\uff1a<\/strong><br \/>\n<section>\u5355\u4f8b\u7ea6 $ 50,000\u2013100,000 \uff1b<\/section>\n<\/li>\n<li><strong>\u5468\u671f\u957f\uff1a<\/strong><br \/>\n<section>6\u20138\u5468 \u2192 \u5efa\u7acb\u201c\u73b0\u8d27\u578b\u201d\u65b0\u6297\u539fTCR\u5e93\uff08\u8986\u76d6KRAS G12D\/V, TP53 R175H\u7b49\u70ed\u70b9\u7a81\u53d8\uff09\uff1b<\/section>\n<\/li>\n<li><strong>\u5448\u9012\u4e0d\u786e\u5b9a\u6027\uff1a<\/strong><br \/>\n<section>\u4ec55\u201310%\u7a81\u53d8\u88ab\u771f\u5b9e\u5448\u9012 \u2192 \u5fc5\u987b\u7ed3\u5408IP-MS\u9a8c\u8bc1\u3002<\/section>\n<\/li>\n<\/ul>\n<h2>\u4e8c\u3001CD4\u207a TCR-T\uff1a\u4ece\u201c\u8f85\u52a9\u8005\u201d\u5230\u201c\u76f4\u63a5\u6740\u4f24\u8005\u201d\u7684\u8303\u5f0f\u8f6c\u53d8<\/h2>\n<p><strong>\u4f20\u7edf\u8ba4\u77e5\u5c40\u9650<\/strong>\uff1aCD4\u207a T\u7ec6\u80de\u4ec5\u63d0\u4f9bIL-2\u3001IFN-\u03b3\u7b49\u8f85\u52a9\u4fe1\u53f7\u3002<\/p>\n<p><strong>\u98a0\u8986\u6027\u53d1\u73b0<\/strong>\uff1a<\/p>\n<ul class=\"list-paddingleft-1\">\n<li>\n<section>CD4\u207a TCR-T\u53ef\u76f4\u63a5\u6740\u4f24MHC-II\u207a\u80bf\u7624\uff08\u5982\u9ed1\u8272\u7d20\u7624\u3001\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\uff09\uff1b<\/section>\n<\/li>\n<li>\n<section>HLA-II\u9650\u5236\u6027TCR\uff08\u5982KRAS G12D\u2013DRB1*04:01\uff09\u8bf1\u5bfc\u5b8c\u5168\u7f13\u89e3\uff08Tran et al., NEJM 2016\uff09\uff1b<\/section>\n<\/li>\n<li>\n<section>MHC-I\u9650\u5236\u6027TCR\u8f6c\u5bfcCD4\u207a T\u7ec6\u80de\u540e\uff0c\u4ecd\u53ef\u5206\u6ccc\u7a7f\u5b54\u7d20\/granzyme B\uff08\u4f46\u6548\u7387\u4f4e\u4e8eCD8\u207a\uff09\u3002<\/section>\n<\/li>\n<\/ul>\n<p><strong>\u00a0\u5de5\u7a0b\u5316\u589e\u5f3a\u7b56\u7565<\/strong>\uff1a<\/p>\n<ul class=\"list-paddingleft-1\">\n<li>\n<section>\u5171\u8868\u8fbeCD8\u03b1\u540c\u6e90\u4e8c\u805a\u4f53\uff08CD8\u03b1\u03b1\uff09\uff0c\u7a33\u5b9aMHC-I\u2013TCR\u76f8\u4e92\u4f5c\u7528\uff1b<\/section>\n<\/li>\n<li>\n<section>\u5f15\u5165IL-12\u81ea\u5206\u6ccc\u56de\u8def\uff0c\u589e\u5f3aTh1\u6781\u5316\u4e0e\u7ec6\u80de\u6bd2\u6027\u3002<\/section>\n<\/li>\n<\/ul>\n<h2>\u4e09\u3001TCR\u8868\u8fbe\u4e0e\u7ec4\u88c5\u7684\u5de5\u7a0b\u5316\u4f18\u5316\uff08\u542b\u5173\u952e\u53c2\u6570\uff09<\/h2>\n<p><strong>1. \u03b1\/\u03b2\u94fe\u8fde\u63a5\u7b56\u7565\u5bf9\u6bd4<\/strong><\/p>\n<table>\n<thead>\n<tr>\n<th>\n<section>\u7b56\u7565<\/section>\n<\/th>\n<th>\n<section>\u8868\u8fbe\u6bd4 (\u03b1:\u03b2)<\/section>\n<\/th>\n<th>\n<section>\u9519\u914d\u7387<\/section>\n<\/th>\n<th>\n<section>\u63a8\u8350\u5ea6<\/section>\n<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>\n<section>\u53cc\u542f\u52a8\u5b50<\/section>\n<\/td>\n<td>\n<section>1:0.3\u20133.0<\/section>\n<\/td>\n<td>\n<section>\u9ad8<\/section>\n<\/td>\n<td>\n<section>\u2605\u2606\u2606<\/section>\n<\/td>\n<\/tr>\n<tr>\n<td>\n<section>IRES<\/section>\n<\/td>\n<td>\n<section>1:0.2\u20130.5<\/section>\n<\/td>\n<td>\n<section>\u4e2d\u9ad8<\/section>\n<\/td>\n<td>\n<section>\u2605\u2605\u2606<\/section>\n<\/td>\n<\/tr>\n<tr>\n<td>\n<section>P2A\/T2A<\/section>\n<\/td>\n<td>\n<section>1:0.9\u20131.1<\/section>\n<\/td>\n<td>\n<section>\u4f4e<\/section>\n<\/td>\n<td>\n<section>\u2605\u2605\u2605<\/section>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<section><strong>2. CD3\u5171\u8868\u8fbe<\/strong>\uff1a\u6162\u75c5\u6bd2\u5171\u8f6c\u5bfcCD3\u03b6\uff08\u6216\u5168CD3\u590d\u5408\u7269\uff09\uff0c\u819c\u8868\u9762TCR\u8868\u8fbe\u63d0\u53475\u201310\u500d\uff08Zhao et al., J Immunother 2010\uff09\u3002<\/section>\n<p><strong>3. C\u533a\u5de5\u7a0b\u5316<\/strong>\uff1a<\/p>\n<ul class=\"list-paddingleft-1\">\n<li><strong>\u9f20\u6e90C\u533a\uff1a<\/strong><br \/>\n<section>\u4ebaV\u533a + \u9f20C\u533a \u2192 \u540c\u6e90\u914d\u5bf9\u4f18\u5148\uff0c\u8868\u8fbe\u2191\uff0c\u4f46\u9700\u4eba\u6e90\u5316\u964d\u4f4e\u514d\u75ab\u539f\u6027\uff08\u5982\u66ff\u6362H55Q, K66E\uff09\uff1b<\/section>\n<\/li>\n<li><strong>\u4e8c\u786b\u952e\u5de5\u7a0b\uff1a<\/strong><br \/>\n<section>\u03b1Cys48 + \u03b2Cys57 \u2192 \u989d\u5916\u4e8c\u786b\u952e\uff0c\u9519\u914d\u7387\u219350%\uff0c\u529f\u80fd\u21912\u500d\uff08Schmitt et al., Blood 2009\uff09\u3002<\/section>\n<\/li>\n<\/ul>\n<h2>\u56db\u3001TCR\u4eb2\u548c\u529b\u5de5\u7a0b\uff1a\u5728\u7597\u6548\u4e0e\u5b89\u5168\u95f4\u8d70\u94a2\u4e1d<\/h2>\n<p><strong>\u2022 \u4e09\u5927\u6280\u672f\u8def\u5f84<\/strong>\uff1a<\/p>\n<ol class=\"list-paddingleft-1\">\n<li><strong>\u4eba\u6e90\u5316\u5c0f\u9f20\uff1a<\/strong><br \/>\n<section>HLA-A2\u8f6c\u57fa\u56e0\u5c0f\u9f20\u514d\u75ab \u2192 \u83b7\u5f97\u9ad8\u4eb2\u548cTCR\uff08\u5982p53, CEA\uff09\uff1b<\/section>\n<\/li>\n<li><strong>\u5f02\u4f53\u4f9b\u8005\u7b5b\u9009\uff1a<\/strong><br \/>\n<section>HLA-A2\u207b\u4f9b\u8005T\u7ec6\u80de\u5e93\u4e2d\u7b5b\u9009HLA-A2\u9650\u5236\u6027\u9ad8\u4eb2\u548cTCR\uff08\u5982WT1\uff09\uff1b<\/section>\n<\/li>\n<li><strong>\u4f53\u5916\u5b9a\u5411\u8fdb\u5316\uff1a<\/strong><br \/>\n<section>\u9175\u6bcd\u5c55\u793a + FACS\u5206\u9009 \u2192 K<sub>D<\/sub>\u4ece50 \u03bcM\u4f18\u5316\u81f31\u20135 \u03bcM\u3002<\/section>\n<\/li>\n<\/ol>\n<p><strong>\u2022 \u5b89\u5168\u8fb9\u754c<\/strong>\uff1a<\/p>\n<ul class=\"list-paddingleft-1\">\n<li>\n<section>K<sub>D<\/sub>\u00a0&lt; 1 \u03bcM \u2192 \u8131\u9776\u98ce\u9669\u5267\u589e\uff08\u5982CEA TCR\u81f4\u6b7b\u6027\u7ed3\u80a0\u708e\uff09\uff1b<\/section>\n<\/li>\n<li>\n<section>\u5fc5\u987b\u8fdb\u884c\uff1a\u00a0 \u2013 \u5168\u86cb\u767d\u7ec4BLASTp\uff08E-value &lt; 0.01\uff09\uff1b\u00a0 \u2013 SPOT array\uff0810\u2075\u80bd\u6bb5\uff09\uff1b\u00a0 \u2013 \u6b63\u5e38\u7ec4\u7ec7\u7c7b\u5668\u5b98\u5171\u57f9\u517b\uff08\u7ed3\u80a0\u3001\u8111\u3001\u5fc3\u808c\uff09\u3002<\/section>\n<\/li>\n<\/ul>\n<h2>\u4e94\u3001\u5185\u6e90TCR\u6e05\u9664\uff1a\u6839\u9664\u9519\u914d\u7684\u7ec8\u6781\u65b9\u6848<\/h2>\n<p><strong>\u2022 CRISPR\/Cas9\u6572\u9664TRAC\/TRBC<\/strong>\uff1a<\/p>\n<ul class=\"list-paddingleft-1\">\n<li>\n<section>\u6548\u7387 &gt;95%\uff08RNP\u7535\u8f6c\uff09\uff1b<\/section>\n<\/li>\n<li>\n<section>\u5916\u6e90TCR\u8868\u8fbe\u5747\u4e00\u6027 &gt;90%\uff1b<\/section>\n<\/li>\n<li>\n<section>\u4f53\u5185\u6301\u4e45\u6027\u63d0\u53472\u20133\u500d\uff08Stadtmauer et al., Science 2020\uff09\u3002<\/section>\n<\/li>\n<\/ul>\n<p><strong>\u2022 \u66ff\u4ee3\u65b9\u6848<\/strong>\uff1a\u03b3\u03b4 T\u7ec6\u80de\uff08\u65e0\u5185\u6e90\u03b1\u03b2TCR\uff09\uff0c\u4f46\u9700\u5171\u8868\u8fbeCD8\u4ee5\u589e\u5f3aMHC-I\u8bc6\u522b\u3002<\/p>\n<h2>\u00a0\u516d\u3001\u4fe1\u53f7\u589e\u5f3a\u4e0e\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad<\/h2>\n<p><strong>\u4fe1\u53f7\u57df\u878d\u5408<\/strong>\uff1a<\/p>\n<ul class=\"list-paddingleft-1\">\n<li>\n<section>TCR-CD28\u878d\u5408\uff1a\u8de8\u819c\u533a\u66ff\u6362\uff0c\u4fe1\u53f7\u2191\uff0c\u4f46\u7ed3\u6784\u7834\u574f\u98ce\u9669\u9ad8\uff1b<\/section>\n<\/li>\n<li>\n<section>4-1BB\u5171\u8868\u8fbe\uff1a\u63d0\u5347\u8bb0\u5fc6\u5f62\u6210\uff0c\u964d\u4f4e\u8017\u7aed\u3002<\/section>\n<\/li>\n<\/ul>\n<p><strong>\u00a0PD-1\u963b\u65ad<\/strong>\uff1a<\/p>\n<ul class=\"list-paddingleft-1\">\n<li>\n<section>CRISPR\u6572\u9664PDCD1 \u2192 \u6301\u4e45\u6027\u2191\uff0c\u4f46\u53ef\u80fd\u589e\u52a0\u81ea\u8eab\u514d\u75ab\u98ce\u9669\uff1b<\/section>\n<\/li>\n<li>\n<section>\u5206\u6ccc\u578b\u6297PD-1 scFv\uff08\u201c\u88c5\u7532TCR-T\u201d\uff09\u2192 \u5c40\u90e8\u963b\u65ad\uff0c\u5168\u8eab\u6bd2\u6027\u2193\u3002<\/section>\n<\/li>\n<\/ul>\n<h2>\u4e03\u3001\u5ef6\u957f\u4f53\u5185\u5b58\u7eed\uff1a\u4eceTscm\u5230HSC\u5de5\u7a0b\u5316<\/h2>\n<p><strong>T\u7ec6\u80de\u4e9a\u7fa4\u9009\u62e9<\/strong>\uff1a<\/p>\n<ul class=\"list-paddingleft-1\">\n<li>\n<section>Tscm\uff08CD45RA\u207aCCR7\u207aCD95\u207a\uff09\uff1a\u81ea\u6211\u66f4\u65b0\u5f3a\uff0c\u6301\u4e45\u6027\u6700\u4f73\uff1b<\/section>\n<\/li>\n<li>\n<section>\u57f9\u517b\u6761\u4ef6\uff1aIL-7 + IL-15 + Wnt\u6fc0\u6d3b\u5242\uff08CHIR99021\uff09\u3002<\/section>\n<\/li>\n<\/ul>\n<p><strong>\u9020\u8840\u5e72\u7ec6\u80de\uff08HSC\uff09\u5de5\u7a0b\u5316<\/strong>\uff1a<\/p>\n<ul class=\"list-paddingleft-1\">\n<li>\n<section>\u6162\u75c5\u6bd2\u8f6c\u5bfcCD34\u207a HSC \u2192 \u4f53\u5185\u6301\u7eed\u8f93\u51fa\u6297\u539f\u7279\u5f02\u6027T\u7ec6\u80de\uff1b<\/section>\n<\/li>\n<li>\n<section>\u5c0f\u9f20\u6a21\u578b\u4e2d\u5b58\u7eed &gt;6\u4e2a\u6708\uff08Ma et al., Cell Stem Cell 2019\uff09\u3002<\/section>\n<\/li>\n<\/ul>\n<h2>\u00a0\u6842\u828e\u751f\u7269\uff1aTCR-T\u7814\u53d1\u5e73\u53f0<\/h2>\n<p>\u6211\u4eec\u63d0\u4f9b\u4ece\u9776\u70b9\u53d1\u73b0\u5230GMP\u751f\u4ea7\u7684\u5168\u94fe\u6761\u89e3\u51b3\u65b9\u6848\uff1a<\/p>\n<p data-pm-slice=\"2 3 []\">\u8981\u590d\u73b0\u6216\u8d85\u8d8a\u8be5\u7814\u7a76\uff0c\u60a8\u9700\u8981\uff1a<strong>\u9ad8\u8986\u76d6\u56db\u805a\u4f53 + \u7cbe\u51c6T\u7ec6\u80de\u5206\u9009 + \u529f\u80fd\u9a8c\u8bc1\u4f53\u7cfb\uff0c<\/strong>\u6842\u828e\u751f\u7269\u5df2\u6784\u5efa\u5b8c\u6574\u5e73\u53f0\uff1a<\/p>\n<p><strong>1.\u00a0<span data-pm-slice=\"1 1 [&quot;para&quot;,{&quot;tagName&quot;:&quot;p&quot;,&quot;attributes&quot;:{},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;node&quot;,{&quot;tagName&quot;:&quot;strong&quot;,&quot;attributes&quot;:{&quot;style&quot;:&quot;scrollbar-width: none;&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;}]\"><a href=\"https:\/\/www.guixiong.com.cn\/?page_id=133\" target=\"_blank\" rel=\"noopener\">pMHC\u8367\u5149\u56db\u805a\u4f53\u5408\u6210\u4ee5\u53ca\u7b5b\u9009<\/a>: <\/span><\/strong>\u8986\u76d62000\u591a\u79cd\u6297\u539f\uff0c\u652f\u630130\u591a\u79cd\u7b49\u4e3b\u6d41HLA\u7b49\u4f4d\u57fa\u56e0<\/p>\n<p><strong>2.\u00a0<span data-pm-slice=\"1 1 [&quot;para&quot;,{&quot;tagName&quot;:&quot;p&quot;,&quot;attributes&quot;:{},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;node&quot;,{&quot;tagName&quot;:&quot;strong&quot;,&quot;attributes&quot;:{&quot;style&quot;:&quot;scrollbar-width: none;&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;}]\"><a href=\"https:\/\/www.guixiong.com.cn\/?page_id=1192\" target=\"_blank\" rel=\"noopener\">\u5fae\u91cfpMHC\u590d\u5408\u7269\u5408\u6210\u670d\u52a1<\/a>: <\/span><\/strong>\u5feb\u901f\u5b9a\u5236\uff0c\u5c11\u91cf\u9a8c\u8bc1\uff0c\u540c\u6b65\u8ffd\u8e2a\u591a\u4e2a\u6297\u539f\u7279\u5f02\u6027T\u7ec6\u80de\u514b\u9686<\/p>\n<p><strong>3.\u00a0<span data-pm-slice=\"1 1 [&quot;para&quot;,{&quot;tagName&quot;:&quot;p&quot;,&quot;attributes&quot;:{},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;node&quot;,{&quot;tagName&quot;:&quot;strong&quot;,&quot;attributes&quot;:{&quot;style&quot;:&quot;scrollbar-width: none;&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;}]\"><a href=\"https:\/\/www.guixiong.com.cn\/?page_id=136\" target=\"_blank\" rel=\"noopener\">\u6297\u539f\u7279\u5f02\u6027T\u7ec6\u80de\u6269\u589e<\/a>: <\/span><\/strong>\u57fa\u4e8e\u56db\u805a\u4f53\u5206\u9009\u7ec6\u80de\uff0c\u6269\u589e\u957f\u6548\u8bb0\u5fc6\u578bCD62L\u9633\u6027\u6297\u539f\u7279\u5f02\u6027T\u7ec6\u80de<\/p>\n<p><strong>4.\u00a0<span data-pm-slice=\"1 1 [&quot;para&quot;,{&quot;tagName&quot;:&quot;p&quot;,&quot;attributes&quot;:{},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;node&quot;,{&quot;tagName&quot;:&quot;strong&quot;,&quot;attributes&quot;:{&quot;style&quot;:&quot;scrollbar-width: none;&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;}]\"><a href=\"https:\/\/www.guixiong.com.cn\/?page_id=1489\" target=\"_blank\" rel=\"noopener\">\u5355\u514b\u9686TCR\u6d4b\u5e8f<\/a>: <\/span><\/strong>\u4ece\u56db\u805a\u4f53\u207aT\u7ec6\u80de\u4e2d\u83b7\u53d6\u914d\u5bf9TCR\u4e3b\u514b\u9686<\/p>\n<p><strong>5.\u00a0<span data-pm-slice=\"1 1 [&quot;para&quot;,{&quot;tagName&quot;:&quot;p&quot;,&quot;attributes&quot;:{},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;node&quot;,{&quot;tagName&quot;:&quot;strong&quot;,&quot;attributes&quot;:{&quot;style&quot;:&quot;scrollbar-width: none;&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;}]\"><a href=\"https:\/\/www.guixiong.com.cn\/?page_id=546\" target=\"_blank\" rel=\"noopener\">\u5de5\u7a0b\u5316\u5448\u9012\u7ec6\u80de\u6784\u5efa<\/a>: <\/span><\/strong>HLA-CD80-CD83 K562\u7ec6\u80de\u8bbe\u8ba1 12\u79cdHLA\u4e9a\u578b\uff0c\u7528\u4e8eT\u7ec6\u80de\u529f\u80fd\u9a8c\u8bc1<\/p>\n<p><strong>6.\u00a0<span data-pm-slice=\"1 1 [&quot;para&quot;,{&quot;tagName&quot;:&quot;p&quot;,&quot;attributes&quot;:{},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;node&quot;,{&quot;tagName&quot;:&quot;strong&quot;,&quot;attributes&quot;:{&quot;style&quot;:&quot;scrollbar-width: none;&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;}]\"><a href=\"https:\/\/www.guixiong.com.cn\/?page_id=1197\" target=\"_blank\" rel=\"noopener\">\u6297\u539f\u80bd-MHC\u4eb2\u548c\u529b\u9ad8\u901a\u91cfELISA\u626b\u63cf\u670d\u52a1<\/a>: <\/span><\/strong>\u9ad8\u901a\u91cf\u7b5b\u9009\u60a3\u8005\u4e2a\u4f53\u5316\u65b0\u6297\u539f\u8868\u4f4d<\/p>\n<p><strong>7. <a href=\"https:\/\/www.guixiong.com.cn\/?page_id=558\" target=\"_blank\" rel=\"noopener\">\u7a33\u8f6c\u539f\u4ee3TCR-T\u6784\u5efa<\/a>: <\/strong><span data-pm-slice=\"2 2 [&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;}]\">\u6574\u5408murine TCR\u6052\u5b9a\u533a\u7684\u975e\u75c5\u6bd2TCR\u7a33\u8f6c\u7cfb\u7edf\uff0c\u66f4\u5b89\u5168\u7684\u4e34\u5e8a\u524d\u7814\u7a76\u5e94\u7528<\/span><\/p>\n<h2>\u7ed3\u8bed\uff1aTCR-T\u7684\u672a\u6765\u5df2\u6765<\/h2>\n<p>TCR-T\u6b63\u4ece\u201c\u901a\u7528\u9776\u70b9\u3001\u6279\u91cf\u751f\u4ea7\u201d\u8fc8\u5411\u201c\u65b0\u6297\u539f\u9a71\u52a8\u3001\u4e2a\u4f53\u5316\u5b9a\u5236\u201d\u3002\u968f\u7740\u57fa\u56e0\u7f16\u8f91\u3001\u5408\u6210\u751f\u7269\u5b66\u3001AI\u9884\u6d4b\u7684\u6df1\u5ea6\u878d\u5408\uff0c\u6211\u4eec\u6709\u671b\u57285\u5e74\u5185\u770b\u5230\u9996\u4e2a\u83b7\u6279\u7684TCR-T\u4ea7\u54c1\u3002\u6842\u828e\u751f\u7269\u5c06\u6301\u7eed\u6df1\u8015TCR-T\u5e95\u5c42\u6280\u672f\uff0c\u52a9\u529b\u5168\u7403\u521b\u65b0\u836f\u4f01\u52a0\u901f\u4e34\u5e8a\u8f6c\u5316\u3002<\/p>\n<p>Views: 8<\/p>","protected":false},"excerpt":{"rendered":"<p>TCR-T\u6cbb\u7597\u5341\u5927\u6280\u672f\u7a81\u7834\u65b9\u5411\uff1a\u65b0\u6297\u539f\u9274\u5b9a \u2192 TCR\u4eb2\u548c\u529b\u4f18\u5316 \u2192 T\u7ec6\u80de\u5e72\u6027\u7ef4\u6301 \u2192 \u8054\u5408\u7597\u6cd5\u3002 TCR-&#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_kadence_starter_templates_imported_post":false,"_kad_post_transparent":"default","_kad_post_title":"default","_kad_post_layout":"default","_kad_post_sidebar_id":"","_kad_post_content_style":"default","_kad_post_vertical_padding":"default","_kad_post_feature":"","_kad_post_feature_position":"","_kad_post_header":false,"_kad_post_footer":false,"_kad_post_classname":"","footnotes":""},"class_list":["post-1637","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.guixiong.com.cn\/index.php?rest_route=\/wp\/v2\/pages\/1637","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.guixiong.com.cn\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.guixiong.com.cn\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.guixiong.com.cn\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.guixiong.com.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1637"}],"version-history":[{"count":4,"href":"https:\/\/www.guixiong.com.cn\/index.php?rest_route=\/wp\/v2\/pages\/1637\/revisions"}],"predecessor-version":[{"id":1640,"href":"https:\/\/www.guixiong.com.cn\/index.php?rest_route=\/wp\/v2\/pages\/1637\/revisions\/1640"}],"wp:attachment":[{"href":"https:\/\/www.guixiong.com.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1637"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}