{"id":1642,"date":"2026-02-02T15:15:23","date_gmt":"2026-02-02T15:15:23","guid":{"rendered":"https:\/\/www.guixiong.com.cn\/?page_id=1642"},"modified":"2026-02-02T15:15:23","modified_gmt":"2026-02-02T15:15:23","slug":"mrna%e7%96%ab%e8%8b%97%e5%a6%82%e4%bd%95%e6%bf%80%e6%b4%bbcd4%e2%81%ba-t%e7%bb%86%e8%83%9e%ef%bc%9f%e6%96%b0%e7%a0%94%e7%a9%b6%e9%a2%a0%e8%a6%86%e4%bc%a0%e7%bb%9f%e8%ae%a4%e7%9f%a5%ef%bc%9a%e4%b8%93","status":"publish","type":"page","link":"https:\/\/www.guixiong.com.cn\/?page_id=1642","title":{"rendered":"mRNA\u75ab\u82d7\u5982\u4f55\u6fc0\u6d3bCD4\u207a T\u7ec6\u80de\uff1f\u65b0\u7814\u7a76\u98a0\u8986\u4f20\u7edf\u8ba4\u77e5\uff1a\u4e13\u804c\u514d\u75ab\u7ec6\u80de\u624d\u662f\u4e3b\u89d2"},"content":{"rendered":"<blockquote>\n<pre data-pm-slice=\"2 2 []\">\u4f20\u7edf\u89c2\u70b9\u8ba4\u4e3a\u808c\u7ec6\u80de\u662f\u6297\u539f\u201c\u5de5\u5382\u201d\uff0c\u4f46\u65b0\u8bc1\u636e\u6307\u5411\u6811\u7a81\u72b6\u7ec6\u80de\uff08DCs\uff09\u624d\u662fCD4\u207a T\u7ec6\u80de\u6fc0\u6d3b\u7684\u6838\u5fc3\u3002\r\n\r\n\u957f\u671f\u4ee5\u6765\uff0c\u5b66\u754c\u666e\u904d\u8ba4\u4e3amRNA\u75ab\u82d7\u901a\u8fc7\u201c\u5916\u6e90\u6027\u6297\u539f\u5448\u9012\u201d\u6fc0\u6d3bCD4\u207a T\u7ec6\u80de\u2014\u2014\u5373\u808c\u7ec6\u80de\u751f\u4ea7\u6297\u539f\uff0c\u518d\u7531\u6811\u7a81\u72b6\u7ec6\u80de\u201c\u6361\u6765\u201d\u5448\u9012\u3002\u4f46\u6700\u65b0\u7814\u7a76\u53d1\u73b0\uff1a<strong>\u771f\u6b63\u9ad8\u6548\u6fc0\u6d3bT\u7ec6\u80de\u7684\uff0c\u662f\u6297\u539f\u5448\u9012\u7ec6\u80de\uff08APCs\uff09\u81ea\u5df1\u6444\u53d6mRNA\u3001\u81ea\u5df1\u5408\u6210\u6297\u539f\u3001\u81ea\u5df1\u5b8c\u6210\u5448\u9012\u7684\u201c\u5185\u6e90\u6027\u8def\u5f84\u201d<\/strong>\u3002<\/pre>\n<\/blockquote>\n<h3>\u4e00\u3001\u5185\u6e90\u6027\u5448\u9012\u6548\u7387\u8fdc\u8d85\u5916\u6e90\u6027<\/h3>\n<p>\u7814\u7a76\u4eba\u5458\u7528\u6d41\u611f\u75c5\u6bd2NP\u6216HA\u7684mRNA-LNP\u5904\u7406\u5c0f\u9f20\u9aa8\u9ad3\u6765\u6e90\u6811\u7a81\u72b6\u7ec6\u80de\uff08BMDCs\uff09\uff0c\u8bbe\u8ba1\u4e86\u4e24\u7ec4\u5171\u57f9\u517b\u5b9e\u9a8c\uff1a<\/p>\n<ul class=\"list-paddingleft-1\">\n<li><strong>\u5185\u6e90\u6027\u7ec4\uff1a<\/strong><br \/>\n<section>MHC II\u5339\u914d\u7684BMDCs \u81ea\u5df1\u6444\u53d6mRNA\u5e76\u8868\u8fbe\u6297\u539f\uff1b<\/section>\n<\/li>\n<li><strong>\u5916\u6e90\u6027\u7ec4\uff1a<\/strong><br \/>\n<section>MHC II\u4e0d\u5339\u914d\u7684BMDCs \u8868\u8fbe\u6297\u539f\u540e\uff0c\u91ca\u653e\u86cb\u767d\u4f9bMHC II\u5339\u914d\u7684BMDCs\u541e\u566c\u5448\u9012\u3002<\/section>\n<\/li>\n<\/ul>\n<p>\u7ed3\u679c\u4ee4\u4eba\u60ca\u8bb6\uff1a<strong>\u5373\u4f7f\u4e24\u7ec4\u6297\u539f\u603b\u91cf\u548cMHC II\u8868\u8fbe\u6c34\u5e73\u76f8\u5f53\uff0c\u5185\u6e90\u6027\u7ec4\u6fc0\u6d3bCD4\u207a T\u7ec6\u80de\u7684\u80fd\u529b\u4ecd\u663e\u8457\u66f4\u5f3a<\/strong>\u3002\u8fd9\u8bf4\u660e\uff0c\u201c\u81ea\u5df1\u751f\u4ea7\u3001\u81ea\u5df1\u5448\u9012\u201d\u7684\u6548\u7387\u8fdc\u9ad8\u4e8e\u201c\u4ee3\u5de5+\u8f6c\u4ea4\u201d\u6a21\u5f0f\u3002<\/p>\n<h3>\u00a0\u4e8c\u3001APCs\u662f\u6838\u5fc3\uff0c\u808c\u7ec6\u80de\u4f5c\u7528\u5fae\u5f31<\/h3>\n<p>\u4e3a\u9a8c\u8bc1\u4f53\u5185\u771f\u5b9e\u60c5\u51b5\uff0c\u7814\u7a76\u8005\u5de7\u5999\u5229\u7528miRNA\u9776\u5411\u6280\u672f\uff1a<\/p>\n<ul class=\"list-paddingleft-1\">\n<li><strong>miR-142\u9776\u5411\u7ec4\uff1a<\/strong><br \/>\n<section>\u7279\u5f02\u6027\u6c89\u9ed8<strong>\u9020\u8840\u7cfb\u7ec6\u80de<\/strong>\uff08\u5305\u62ecAPCs\uff09\u4e2d\u7684\u6297\u539f\u8868\u8fbe \u2192 APCs\u53ea\u80fd\u4f9d\u8d56\u5916\u6e90\u6297\u539f\uff1b<\/section>\n<\/li>\n<li><strong>miR-206\u9776\u5411\u7ec4\uff1a<\/strong><br \/>\n<section>\u7279\u5f02\u6027\u6c89\u9ed8<strong>\u808c\u8089\u7ec6\u80de<\/strong>\u4e2d\u7684\u6297\u539f\u8868\u8fbe \u2192 \u808c\u7ec6\u80de\u65e0\u6cd5\u4ea7\u6297\u539f\u3002<\/section>\n<\/li>\n<\/ul>\n<p>\u7ed3\u679c\u6e05\u6670\u663e\u793a\uff1a<\/p>\n<ul>\n<li><strong>miR-142\u7ec4<\/strong>\uff1a\u6297\u539f\u7279\u5f02\u6027CD4\u207a T\u7ec6\u80de\u3001\u6ee4\u6ce1\u8f85\u52a9T\u7ec6\u80de\uff08Tfh\uff09\u53ca\u6297\u4f53\u6ef4\u5ea6\u5747<strong>\u663e\u8457\u4e0b\u964d<\/strong>\uff1b<\/li>\n<li><strong>miR-206\u7ec4<\/strong>\uff1aCD4\u207a T\u7ec6\u80de\u5e94\u7b54\u548c\u6297\u4f53\u6c34\u5e73<strong>\u51e0\u4e4e\u4e0d\u53d7\u5f71\u54cd<\/strong>\u3002<\/li>\n<\/ul>\n<p>\u8fd9\u76f4\u63a5\u8bc1\u660e\uff1a<strong>mRNA-LNP\u75ab\u82d7\u8bf1\u5bfcCD4\u207a T\u7ec6\u80de\u5e94\u7b54\u7684\u5173\u952e\uff0c\u5728\u4e8eAPCs\u81ea\u8eab\u7684\u6297\u539f\u5408\u6210\u80fd\u529b\uff0c\u800c\u975e\u808c\u7ec6\u80de\u7684\u201c\u4ee3\u5de5\u201d<\/strong>\u3002<\/p>\n<h3>\u4e09\u3001\u7814\u7a76\u5c40\u9650\u4e0e\u672a\u89e3\u4e4b\u8c1c<\/h3>\n<ul class=\"list-paddingleft-1\">\n<li><strong>\u6a21\u578b\u5c40\u9650\uff1a<\/strong><br \/>\n<section>\u76ee\u524d\u6570\u636e\u57fa\u4e8e\u5c0f\u9f20\uff0c\u4eba\u4f53APC\u4e9a\u7fa4\u66f4\u590d\u6742\uff0c\u9700\u8c28\u614e\u5916\u63a8\uff1b<\/section>\n<\/li>\n<li><strong>\u5916\u6e90\u9014\u5f84\u4ecd\u6709\u8d21\u732e\uff1a<\/strong><br \/>\n<section>\u7ea620%\u7684Tfh\u6d3b\u5316\u4ecd\u4f9d\u8d56\u808c\u7ec6\u80de\u6765\u6e90\u6297\u539f\uff0c\u63d0\u793a\u5916\u6e90\u6027\u8def\u5f84\u5177\u8f85\u52a9\u4f5c\u7528\uff1b<\/section>\n<\/li>\n<li><strong>\u673a\u5236\u5f85\u6df1\u6316\uff1a<\/strong><br \/>\n<section>\u5185\u6e90\u6027\u6297\u539f\u5982\u4f55\u9ad8\u6548\u8fdb\u5165MHC II\u901a\u8def\uff1fIRE1\u03b1-XBP1\u7b49\u5185\u8d28\u7f51\u5e94\u6fc0\u901a\u8def\u662f\u5426\u53c2\u4e0e\uff1f\u5c1a\u65e0\u5b9a\u8bba\u3002<\/section>\n<\/li>\n<\/ul>\n<h3>\u56db\u3001\u672a\u6765\u65b9\u5411\uff1a\u4ece\u673a\u5236\u5230\u5e94\u7528<\/h3>\n<ul class=\"list-paddingleft-1\">\n<li><strong>\u9776\u5411APC\u7684\u9012\u9001\u7cfb\u7edf\uff1a<\/strong><br \/>\n<section>\u5f00\u53d1\u7ea2\u7ec6\u80de\u819c\u4f2a\u88c5LNP\u3001DC\u9776\u5411\u914d\u4f53\u4fee\u9970\u7b49\u7b56\u7565\uff0c\u63d0\u5347mRNA\u5728\u6811\u7a81\u72b6\u7ec6\u80de\u4e2d\u7684\u5bcc\u96c6\uff1b<\/section>\n<\/li>\n<li><strong>\u5185\u6e90\u6027\u52a0\u5de5\u589e\u5f3a\u5242\uff1a<\/strong><br \/>\n<section>\u7b5b\u9009\u8c03\u63a7\u81ea\u566c-\u6eb6\u9176\u4f53\u6216\u5185\u8d28\u7f51\u5e94\u6fc0\u901a\u8def\u7684\u5c0f\u5206\u5b50\uff08\u5982IRE1\u03b1\u8c03\u8282\u5242\uff09\uff0c\u4f18\u5316\u6297\u539f\u5448\u9012\u6548\u7387\uff1b<\/section>\n<\/li>\n<li><strong>\u4e2a\u6027\u5316\u8868\u4f4d\u8bbe\u8ba1\uff1a<\/strong><br \/>\n<section>\u57fa\u4e8e\u4e2a\u4f53HLA-II\u5206\u578b\uff0c\u5b9a\u5236\u9ad8\u4eb2\u548c\u529b\u5185\u6e90\u6027\u4f18\u52bf\u8868\u4f4d\u5e93\uff0c\u63d0\u5347\u75ab\u82d7\u5e7f\u8c31\u6027\u4e0e\u6548\u529b\u3002<\/section>\n<\/li>\n<\/ul>\n<p>\u53c2\u8003\u6587\u732e\uff1a <a href=\"https:\/\/www.nature.com\/articles\/s41467-025-68080-x\" target=\"_blank\" rel=\"noopener\">Optimal murine CD4&#8242; T cell priming by mRNA-lipidnanoparticle vaccines requires endogenous antigen processing<\/a><\/p>\n<h3><strong>\u4e94\u3001\u7ed3\u8bed<\/strong><\/h3>\n<ul class=\"list-paddingleft-1\">\n<li>mRNA\u75ab\u82d7\u7684\u6210\u529f\u4e0d\u4ec5\u5728\u4e8e\u5176\u5feb\u901f\u7814\u53d1\u80fd\u529b\uff0c\u66f4\u5728\u4e8e\u5176\u72ec\u7279\u7684\u514d\u75ab\u6fc0\u6d3b\u673a\u5236\u3002<\/li>\n<li>\u8fd9\u9879\u7814\u7a76\u63d0\u9192\u6211\u4eec\uff1a<strong>\u771f\u6b63\u7684\u514d\u75ab\u5f15\u64ce\uff0c\u85cf\u5728\u4e13\u804c\u6297\u539f\u5448\u9012\u7ec6\u80de\u4e4b\u4e2d<\/strong>\u3002<\/li>\n<li>\u672a\u6765\u75ab\u82d7\u8bbe\u8ba1\uff0c\u6216\u5c06\u4ece\u201c\u5e7f\u6492\u7f51\u201d\u8d70\u5411\u201c\u7cbe\u51c6\u6295\u9001\u201d\u3002<\/li>\n<\/ul>\n<h2 data-pm-slice=\"2 3 []\">\u6842\u828e\u751f\u7269\uff1a<span data-pm-slice=\"1 1 [&quot;para&quot;,{&quot;tagName&quot;:&quot;p&quot;,&quot;attributes&quot;:{&quot;style&quot;:&quot;scrollbar-width: none; margin: 0px; font-size: 17px; color: rgb(1, 87, 155); font-weight: bold; line-height: 1.5;&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;}]\">mRNA\u75ab\u82d7<\/span>\u6297\u539f\u6d4b\u8bd5\u5e73\u53f0<\/h2>\n<p>\u6211\u4eec\u63d0\u4f9b\u4ece\u9776\u70b9\u53d1\u73b0\u5230\u75ab\u82d7\u6d4b\u8bd5\u89e3\u51b3\u65b9\u6848\uff0c\u8981\u590d\u73b0\u6216\u8d85\u8d8a\u8be5\u7814\u7a76\uff0c\u60a8\u9700\u8981\uff1a<strong>\u9ad8\u8986\u76d6\u56db\u805a\u4f53 + \u7cbe\u51c6T\u7ec6\u80de\u5206\u9009 + \u529f\u80fd\u9a8c\u8bc1\u4f53\u7cfb<\/strong>\u3002\u6842\u828e\u751f\u7269\u5df2\u6784\u5efa\u5b8c\u6574\u5e73\u53f0\uff1a<\/p>\n<p><strong>1.\u00a0<span data-pm-slice=\"1 1 [&quot;para&quot;,{&quot;tagName&quot;:&quot;p&quot;,&quot;attributes&quot;:{},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;node&quot;,{&quot;tagName&quot;:&quot;strong&quot;,&quot;attributes&quot;:{&quot;style&quot;:&quot;scrollbar-width: none;&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;}]\"><a href=\"https:\/\/www.guixiong.com.cn\/?page_id=133\" target=\"_blank\" rel=\"noopener\">pMHC\u8367\u5149\u56db\u805a\u4f53\u5408\u6210\u4ee5\u53ca\u7b5b\u9009<\/a>: <\/span><\/strong>\u8986\u76d62000\u591a\u79cd\u6297\u539f\uff0c\u652f\u630130\u591a\u79cd\u7b49\u4e3b\u6d41HLA\u7b49\u4f4d\u57fa\u56e0<\/p>\n<p><strong>2.\u00a0<span data-pm-slice=\"1 1 [&quot;para&quot;,{&quot;tagName&quot;:&quot;p&quot;,&quot;attributes&quot;:{},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;node&quot;,{&quot;tagName&quot;:&quot;strong&quot;,&quot;attributes&quot;:{&quot;style&quot;:&quot;scrollbar-width: none;&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;}]\"><a href=\"https:\/\/www.guixiong.com.cn\/?page_id=1192\" target=\"_blank\" rel=\"noopener\">\u5fae\u91cfpMHC\u590d\u5408\u7269\u5408\u6210\u670d\u52a1<\/a>: <\/span><\/strong>\u5feb\u901f\u5b9a\u5236\uff0c\u5c11\u91cf\u9a8c\u8bc1\uff0c\u540c\u6b65\u8ffd\u8e2a\u591a\u4e2a\u6297\u539f\u7279\u5f02\u6027T\u7ec6\u80de\u514b\u9686<\/p>\n<p><strong>3.\u00a0<span data-pm-slice=\"1 1 [&quot;para&quot;,{&quot;tagName&quot;:&quot;p&quot;,&quot;attributes&quot;:{},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;node&quot;,{&quot;tagName&quot;:&quot;strong&quot;,&quot;attributes&quot;:{&quot;style&quot;:&quot;scrollbar-width: none;&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;}]\"><a href=\"https:\/\/www.guixiong.com.cn\/?page_id=136\" target=\"_blank\" rel=\"noopener\">\u6297\u539f\u7279\u5f02\u6027T\u7ec6\u80de\u6269\u589e<\/a>: <\/span><\/strong>\u57fa\u4e8e\u56db\u805a\u4f53\u5206\u9009\u7ec6\u80de\uff0c\u6269\u589e\u957f\u6548\u8bb0\u5fc6\u578bCD62L\u9633\u6027\u6297\u539f\u7279\u5f02\u6027T\u7ec6\u80de<\/p>\n<p><strong>4.\u00a0<span data-pm-slice=\"1 1 [&quot;para&quot;,{&quot;tagName&quot;:&quot;p&quot;,&quot;attributes&quot;:{},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;node&quot;,{&quot;tagName&quot;:&quot;strong&quot;,&quot;attributes&quot;:{&quot;style&quot;:&quot;scrollbar-width: none;&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;}]\"><a href=\"https:\/\/www.guixiong.com.cn\/?page_id=1489\" target=\"_blank\" rel=\"noopener\">\u5355\u514b\u9686TCR\u6d4b\u5e8f<\/a>: <\/span><\/strong>\u4ece\u56db\u805a\u4f53\u207aT\u7ec6\u80de\u4e2d\u83b7\u53d6\u914d\u5bf9TCR\u4e3b\u514b\u9686<\/p>\n<p><strong>5.\u00a0<span data-pm-slice=\"1 1 [&quot;para&quot;,{&quot;tagName&quot;:&quot;p&quot;,&quot;attributes&quot;:{},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;node&quot;,{&quot;tagName&quot;:&quot;strong&quot;,&quot;attributes&quot;:{&quot;style&quot;:&quot;scrollbar-width: none;&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;}]\"><a href=\"https:\/\/www.guixiong.com.cn\/?page_id=546\" target=\"_blank\" rel=\"noopener\">\u5de5\u7a0b\u5316\u5448\u9012\u7ec6\u80de\u6784\u5efa<\/a>: <\/span><\/strong>HLA-CD80-CD83 K562\u7ec6\u80de\u8bbe\u8ba1 12\u79cdHLA\u4e9a\u578b\uff0c\u7528\u4e8eT\u7ec6\u80de\u529f\u80fd\u9a8c\u8bc1<\/p>\n<p><strong>6.\u00a0<span data-pm-slice=\"1 1 [&quot;para&quot;,{&quot;tagName&quot;:&quot;p&quot;,&quot;attributes&quot;:{},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;node&quot;,{&quot;tagName&quot;:&quot;strong&quot;,&quot;attributes&quot;:{&quot;style&quot;:&quot;scrollbar-width: none;&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;}]\"><a href=\"https:\/\/www.guixiong.com.cn\/?page_id=1197\" target=\"_blank\" rel=\"noopener\">\u6297\u539f\u80bd-MHC\u4eb2\u548c\u529b\u9ad8\u901a\u91cfELISA\u626b\u63cf\u670d\u52a1<\/a>: 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