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CD8+ T\u7ec6\u80de\u5df2\u88ab\u8bc1\u5b9e\u662fICI\u589e\u5f3a\u6297\u80bf\u7624\u514d\u75ab\u7684\u4e3b\u8981\u8d21\u732e\u8005\u3002 \u4e3a\u4e86\u6210\u529f\u5730\u5bf9\u80bf\u7624\u7ec6\u80de\u53d1\u8d77\u514d\u75ab\u653b\u51fb\uff0cCD8+ T\u7ec6\u80de\u5fc5\u987b\u8bc6\u522b\u9776\u7ec6\u80de\u4e0a\u7531MHC-I\u5206\u5b50\u5448\u9012\u7684\u6297\u539f\u3002 \u6b63\u5982MHC-I\u5728CD8+ T\u7ec6\u80de\u4ecb\u5bfc\u7684\u6297\u80bf\u7624\u514d\u75ab\u4e2d\u6240\u53d1\u6325\u7684\u5173\u952e\u4f5c\u7528\uff0c\u7814\u7a76\u53d1\u73b0\uff0c\u5728\u9ed1\u8272\u7d20\u7624\u7684\u764c\u75c7\u8fdb\u5c55\u8fc7\u7a0b\u4e2d\uff0cMHC-I\u529f\u80fd\u7684\u7834\u574f\u5df2\u6210\u4e3a\u4e00\u79cd\u514d\u75ab\u9003\u9038\u7b56\u7565\u3002 \u6b64\u5916\uff0c\u65e9\u671f\u7684\u7814\u7a76\u8fd8\u62a5\u9053\uff0c\u4f5c\u4e3a\u5bf9\u9ed1\u8272\u7d20\u7624\u8fc7\u7ee7\u7ec6\u80de\u7597\u6cd5\u514d\u75ab\u6cbb\u7597\u4ea7\u751f\u8010\u836f\u6027\u7684\u673a\u5236\u4e4b\u4e00\uff0cMHC-I\u5206\u5b50\u7684\u91cd\u8981\u7ec4\u6210\u90e8\u5206\u03b22\u5fae\u7403\u86cb\u767d\u51fa\u73b0\u4e86\u7f3a\u5931\u73b0\u8c61\u3002 \u7c7b\u4f3c\u5730\uff0c\u9ed1\u8272\u7d20\u7624\u7ec6\u80de\u4e2dMHC-I\u8868\u8fbe\u7684\u4e0b\u8c03\u4e5f\u88ab\u786e\u8ba4\u4e3a\u5bf9ICI\u6cbb\u7597\u4ea7\u751f\u8010\u836f\u6027\u7684\u673a\u5236\u4e4b\u4e00\uff0c\u8fd9\u51f8\u663e\u4e86CD8+ T\u7ec6\u80de\u4ecb\u5bfc\u7684\u514d\u75ab\u53cd\u5e94\u5bf9\u4e8eICI\u7597\u6548\u7684\u91cd\u8981\u6027\u3002 \u5c3d\u7ba1MHC-I\u4ecb\u5bfc\u7684\u6297\u539f\u5448\u9012\u5bf9\u4e8e\u6709\u6548\u6297\u80bf\u7624\u514d\u75ab\u7684\u91cd\u8981\u6027\u5df2\u5f97\u5230\u5145\u5206\u8bc1\u5b9e\uff0c\u4f46\u5728\u80bf\u7624\u6f14\u8fdb\u65e9\u671fMHC-I\u4e0b\u8c03\u7684\u53d1\u751f\u9891\u7387\u548c\u65f6\u95f4\u5374\u4ecd largely \u4e0d\u660e\u3002 \u8fc7\u53bb\u51e0\u5341\u5e74\u7684\u6280\u672f\u8fdb\u6b65\u663e\u8457\u62d3\u5c55\u4e86\u7ec4\u7ec7\u75c5\u7406\u5b66\u5206\u6790\u7684\u65b9\u6cd5\u5b66\u624b\u6bb5\u3002\u6700\u521d\uff0c\u514d\u75ab\u7ec4\u7ec7\u5316\u5b66\uff08IHC\uff09\u67d3\u8272\u9700\u8981\u4f7f\u7528\u51b7\u51bb\u5207\u7247\uff0c\u5e76\u4e14\u5b8c\u5168\u4f9d\u9760\u624b\u5de5\u64cd\u4f5c\u3002\u5982\u4eca\uff0c\u81ea\u52a8\u5316\u67d3\u8272\u8bbe\u5907\u4e0e\u5408\u9002\u7684\u5355\u514b\u9686\u6297\u4f53\u4f7f\u5f97\u5373\u4f7f\u5728\u798f\u5c14\u9a6c\u6797\u56fa\u5b9a\u3001\u77f3\u8721\u5305\u57cb\u7684\u7ec4\u7ec7\u5207\u7247\u4e0a\u4e5f\u80fd\u5b9e\u73b0\u53ef\u91cd\u590d\u7684IHC\u5206\u6790\u3002 \u6b64\u5916\uff0c\u5168\u5207\u7247\u626b\u63cf\u4eea\u7684\u5f15\u5165\u5c06\u6574\u4e2a\u5207\u7247\u56fe\u50cf\u6570\u5b57\u5316\uff0c\u63a8\u52a8\u4e86\u6570\u5b57\u75c5\u7406\u7b97\u6cd5\u7684\u53d1\u5c55\uff0c\u8fdb\u4e00\u6b65\u63d0\u9ad8\u4e86\u56fe\u50cf\u5206\u6790\u7684\u53ef\u91cd\u590d\u6027\u3002\u5728\u672c\u7814\u7a76\u4e2d\uff0c\u6211\u4eec\u65e8\u5728\u5229\u7528\u73b0\u4ee3\u81ea\u52a8\u5316IHC\u67d3\u8272\u6280\u672f\u548c\u6570\u5b57\u75c5\u7406\u5b66\u5de5\u5177\uff0c\u63a2\u7a76MHC-I\u5728\u771f\u5b9e\u4e16\u754c\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u961f\u5217\u4e2d\u80bf\u7624\u6f14\u8fdb\u8fc7\u7a0b\u4e2d\u7684\u4e0b\u8c03\u9891\u7387\u4e0e\u65f6\u95f4\u7279\u5f81\u3002\u6211\u4eec\u6bd4\u8f83\u4e86\u539f\u53d1\u80bf\u7624\u3001\u65e9\u671f\u8f6c\u79fb\u7076\u4ee5\u53ca\u514d\u75ab\u6cbb\u7597\u540e\u590d\u53d1\u7684\u8f6c\u79fb\u7076\uff0c\u5e76\u5c06MHC-I\u7684\u8868\u8fbe\u6c34\u5e73\u4e0eCD8+ T\u7ec6\u80de\u6d78\u6da6\u6a21\u5f0f\u76f8\u5173\u8054\u3002\u6211\u4eec\u5047\u8bbe\uff0c\u5728\u80bf\u7624\u6f14\u8fdb\u65e9\u671f\u8bc4\u4f30MHC-I\u8868\u8fbe\u6c34\u5e73\u53caT\u7ec6\u80de\u6d78\u6da6\u6a21\u5f0f\uff0c\u53ef\u80fd\u6210\u4e3a\u6f5c\u5728\u7684\u751f\u7269\u6807\u5fd7\u7269\uff0c\u6709\u52a9\u4e8e\u6307\u5bfc\u65e5\u5e38\u4e34\u5e8a\u8bca\u7597\u4e2d\u7684\u6cbb\u7597\u51b3\u7b56\u3002<\/span><\/p>\n
\u7b2c\u4e00\u7ae0\uff1a\u514d\u75ab\u8bc6\u522b\u7684\u57fa\u77f3\u2014\u2014MHC-I\u4e3a\u4f55\u81f3\u5173\u91cd\u8981\uff1f<\/h3>\n
\u8981\u7406\u89e3\u8fd9\u9879\u7814\u7a76\u7684\u610f\u4e49\uff0c\u9996\u5148\u5fc5\u987b\u56de\u987eT\u7ec6\u80de\u4ecb\u5bfc\u7684\u9002\u5e94\u6027\u514d\u75ab\u5e94\u7b54\u7684\u57fa\u672c\u539f\u7406\u3002CD8+ T\u7ec6\u80de\u662f\u673a\u4f53\u6e05\u9664\u75c5\u6bd2\u611f\u67d3\u7ec6\u80de\u548c\u80bf\u7624\u7ec6\u80de\u7684\u4e3b\u529b\u519b\u3002\u5176\u6740\u4f24\u529f\u80fd\u7684\u542f\u52a8\uff0c\u4f9d\u8d56\u4e8e\u4e00\u4e2a\u7cbe\u5bc6\u7684\u201c\u4e09\u5143\u8bc6\u522b\u201d\u8fc7\u7a0b\uff1a<\/p>\n
    \n
  1. \u6297\u539f\u52a0\u5de5\u4e0e\u5448\u9012<\/strong>
    \n
    \u80bf\u7624\u7ec6\u80de\u5185\u7684\u5f02\u5e38\u86cb\u767d\uff08\u5982\u7a81\u53d8\u4ea7\u751f\u7684\u65b0\u6297\u539f\uff09\u88ab\u86cb\u767d\u9176\u4f53\u964d\u89e3\u6210\u77ed\u80bd\uff08\u901a\u5e388-11\u4e2a\u6c28\u57fa\u9178\uff09\uff0c\u8fd9\u4e9b\u80bd\u6bb5\u88ab\u8f6c\u8fd0\u81f3\u5185\u8d28\u7f51\uff0c\u4e0e\u65b0\u5408\u6210\u7684MHC-I\u5206\u5b50\u7ed3\u5408\uff0c\u5f62\u6210\u7a33\u5b9a\u7684pMHC-I\u590d\u5408\u7269\u3002<\/section>\n
    <\/section>\n<\/li>\n
  2. \u8868\u9762\u5c55\u793a<\/strong>
    \n
    pMHC-I\u590d\u5408\u7269\u88ab\u8f6c\u8fd0\u81f3\u7ec6\u80de\u819c\u8868\u9762\uff0c\u5982\u540c\u4e00\u4e2a\u201c\u8eab\u4efd\u6807\u7b7e\u201d\uff0c\u5411\u5de1\u903b\u7684T\u7ec6\u80de\u5c55\u793a\u5176\u5185\u90e8\u72b6\u6001\u3002<\/section>\n
    <\/section>\n<\/li>\n
  3. TCR\u7279\u5f02\u6027\u8bc6\u522b<\/strong>
    \n
    CD8+ T\u7ec6\u80de\u901a\u8fc7\u5176\u8868\u9762\u7684T\u7ec6\u80de\u53d7\u4f53\uff08TCR\uff09\u7279\u5f02\u6027\u5730\u8bc6\u522b\u8fd9\u4e2a\u201c\u8eab\u4efd\u6807\u7b7e\u201d\u3002\u4e00\u65e6\u8bc6\u522b\u6210\u529f\uff0cCD8\u5171\u53d7\u4f53\uff08\u7ed3\u5408MHC-I\u7684\u03b13\u7ed3\u6784\u57df\uff09\u4f1a\u63d0\u4f9b\u5173\u952e\u7684\u7a33\u5b9a\u5316\u4fe1\u53f7\u548cLck\u6fc0\u9176\u6d3b\u6027\uff0c\u5171\u540c\u89e6\u53d1T\u7ec6\u80de\u7684\u6fc0\u6d3b\u3001\u589e\u6b96\u548c\u6548\u5e94\u529f\u80fd\uff08\u5982\u91ca\u653e\u7a7f\u5b54\u7d20\u3001\u9897\u7c92\u9176\uff09\u3002<\/section>\n<\/li>\n<\/ol>\n
    \u56e0\u6b64\uff0cMHC-I\u5206\u5b50\u662f\u8fde\u63a5\u80bf\u7624\u5185\u5728\u5f02\u5e38\u4e0e\u5916\u5728\u514d\u75ab\u76d1\u89c6\u7684\u6865\u6881<\/strong>\u3002\u5982\u679c\u8fd9\u5ea7\u6865\u6881\u88ab\u7834\u574f\uff0c\u518d\u5f3a\u5927\u7684T\u7ec6\u80de\u4e5f\u65e0\u6cd5\u201c\u770b\u89c1\u201d\u80bf\u7624\u3002<\/p>\n
    \"\"<\/a><\/p>\n
    <\/section>\n
    \u7b2c\u4e8c\u7ae0\uff1a\u201c\u53cc\u91cd\u67b7\u9501\u201d\u7684\u5f62\u6210\uff1a\u4ece\u7814\u7a76\u53d1\u73b0\u5230\u673a\u5236\u89e3\u6790<\/h3>\n
    \u8be5\u7814\u7a76\u56e2\u961f\u6536\u96c6\u4e86\u6db5\u76d6\u539f\u53d1\u7076\u3001\u4e0d\u540c\u90e8\u4f4d\u8f6c\u79fb\u7076\u4ee5\u53ca\u63a5\u53d7ICI\u6cbb\u7597\u524d\u540e\u7684\u9ed1\u8272\u7d20\u7624\u7ec4\u7ec7\u6837\u672c\uff0c\u5e76\u8fd0\u7528\u4e86\u5305\u62ec\u591a\u91cd\u514d\u75ab\u8367\u5149\uff08mIF\uff09\u3001\u6d41\u5f0f\u7ec6\u80de\u672f\u3001RNA\u6d4b\u5e8f\u548c\u6570\u5b57\u75c5\u7406\u5b66\u5728\u5185\u7684\u591a\u79cd\u5148\u8fdb\u6280\u672f\u8fdb\u884c\u7efc\u5408\u5206\u6790\u3002<\/p>\n
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