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\u7b2c\u4e00\u7ae0\uff1a\u7814\u7a76\u80cc\u666f\u4e0e\u6838\u5fc3\u6311\u6218<\/h3>\n
T\u7ec6\u80de\u7684\u6fc0\u6d3b\u59cb\u4e8e\u5176\u8868\u9762T\u7ec6\u80de\u53d7\u4f53\uff08TCR\uff09\u5bf9\u7531MHC-I\u7c7b\u5206\u5b50\u5448\u9012\u7684\u6297\u539f\u80bd\uff08pMHC\uff09\u7684\u7279\u5f02\u6027\u8bc6\u522b\u3002\u7136\u800c\uff0c\u5355\u9760TCR-pMHC\u7684\u76f8\u4e92\u4f5c\u7528\u901a\u5e38\u975e\u5e38\u5fae\u5f31\uff08\u89e3\u79bb\u5e38\u6570KD\u5728\u03bcM\u7ea7\u522b\uff09\uff0c\u4e0d\u8db3\u4ee5\u89e6\u53d1\u6709\u6548\u7684\u4fe1\u53f7\u4f20\u5bfc\u3002<\/p>\n
\u6b64\u65f6\uff0cCD8\u5171\u53d7\u4f53<\/strong>\u767b\u573a\u3002\u4f5c\u4e3aT\u7ec6\u80de\u8868\u9762\u7684\u6807\u5fd7\u6027\u5206\u5b50\uff0cCD8\uff08\u4e3b\u8981\u4e3aCD8\u03b1\u03b2\u5f02\u6e90\u4e8c\u805a\u4f53\uff09\u901a\u8fc7\u5176\u03b1\u94fe\u7684IgV\u6837\u7ed3\u6784\u57df\uff0c\u7ed3\u5408MHC-I\u5206\u5b50\u9ad8\u5ea6\u4fdd\u5b88\u7684\u03b13\u7ed3\u6784\u57df\u3002\u8fd9\u4e00\u7ed3\u5408\u6709\u4e24\u4e2a\u516c\u8ba4\u7684\u529f\u80fd\uff1a<\/p>\n
    \n
  1. \u4fe1\u53f7\u8f6c\u5bfc<\/strong>
    \n
    CD8\u80de\u5185\u6bb5\u4e0eLck\u6fc0\u9176\u76f8\u8fde\uff0c\u5c06Lck\u62db\u52df\u81f3TCR\u590d\u5408\u7269\u9644\u8fd1\uff0c\u542f\u52a8\u4e0b\u6e38\u78f7\u9178\u5316\u7ea7\u8054\u53cd\u5e94\u3002<\/section>\n<\/li>\n
  2. \u7269\u7406\u7a33\u5b9a<\/strong>
    \n
    \u901a\u8fc7\u5f62\u6210TCR-CD8-pMHCI\u4e09\u5143\u590d\u5408\u7269\uff0c\u589e\u5f3a\u6574\u4f53\u7ed3\u5408\u7a33\u5b9a\u6027\u3002<\/section>\n<\/li>\n<\/ol>\n
    \u7136\u800c\uff0c\u57282005\u5e74\u4e4b\u524d\uff0cCD8\u7684\u201c\u7269\u7406\u7a33\u5b9a\u201d\u4f5c\u7528\u4e00\u76f4\u505c\u7559\u5728\u5047\u8bf4\u5c42\u9762\uff0c\u7f3a\u4e4f\u76f4\u63a5\u7684\u3001\u91cf\u5316\u7684\u8bc1\u636e\u3002\u4e3b\u8981\u96be\u70b9\u5728\u4e8e\uff1aCD8\u4e0eMHC-I\u7684\u4eb2\u548c\u529b\u6781\u4f4e<\/strong>\uff08KD > 100 \u03bcM\uff09\uff0c\u8fdc\u4f4e\u4e8eTCR-pMHC\u7684\u4eb2\u548c\u529b\uff0c\u4f7f\u5f97\u5728\u4f53\u5916\u76f4\u63a5\u6d4b\u91cf\u4e09\u5143\u590d\u5408\u7269\u7684\u7a33\u5b9a\u6027\u51e0\u4e4e\u4e0d\u53ef\u80fd\u3002<\/p>\n
    \u7b2c\u4e8c\u7ae0\uff1a\u5929\u624d\u7684\u5b9e\u9a8c\u8bbe\u8ba1\u2014\u2014\u7528HLA\u7a81\u53d8\u4f53\u5206\u79bb\u53d8\u91cf<\/h3>\n
    \u4e3a\u4e86\u89e3\u51b3\u8fd9\u4e2a\u96be\u9898\uff0cSewell\u56e2\u961f\u91c7\u7528\u4e86\u201c\u53cd\u5411\u9057\u4f20\u5b66\u201d\u7684\u601d\u8def\uff0c\u4e0d\u76f4\u63a5\u53bb\u6d4bCD8\uff0c\u800c\u662f\u6539\u9020MHC-I\u5206\u5b50\uff0c\u521b\u9020\u51fa\u4e00\u7cfb\u5217\u4e0eCD8\u4eb2\u548c\u529b\u4e0d\u540c\u3001\u4f46\u4e0eTCR\u7ed3\u5408\u80fd\u529b\u4e0d\u53d8\u7684HLA-A2\u7a81\u53d8\u4f53\u3002\u8fd9\u662f\u672c\u7814\u7a76\u6700\u7cbe\u5999\u4e4b\u5904\u3002<\/p>\n