{"id":1662,"date":"2026-02-07T14:48:48","date_gmt":"2026-02-07T14:48:48","guid":{"rendered":"https:\/\/www.guixiong.com.cn\/?page_id=1662"},"modified":"2026-02-07T14:51:03","modified_gmt":"2026-02-07T14:51:03","slug":"pd-1%e6%8a%91%e5%88%b6%e5%89%82%e8%b5%b7%e6%95%88%e7%9a%84%e5%85%b3%e9%94%ae%e7%a7%8d%e5%ad%90%e7%bb%86%e8%83%9e","status":"publish","type":"page","link":"https:\/\/www.guixiong.com.cn\/?page_id=1662","title":{"rendered":"PD-1\u6291\u5236\u5242\u8d77\u6548\u7684\u5173\u952e\u201c\u79cd\u5b50\u201d\u7ec6\u80de"},"content":{"rendered":"<blockquote>\n<pre data-pm-slice=\"2 2 []\">\u25b2 \u7814\u7a76\u63ed\u793a\uff0cHPV\u9633\u6027\u5934\u9888\u764c\u80bf\u7624\u5185\u5b58\u5728\u4e00\u7fa4\u5177\u6709\u5e72\u7ec6\u80de\u7279\u6027\u7684PD-1+TCF-1+ CD8+ T\u7ec6\u80de\uff0c\u5b83\u4eec\u662f\u514d\u75ab\u6cbb\u7597\u54cd\u5e94\u7684\u5e0c\u671b\u6240\u5728\u3002\r\n\r\n<strong>PD-1\u6291\u5236\u5242\u5e76\u975e\u5bf9\u6240\u6709\u60a3\u8005\u90fd\u6709\u6548\uff0c\u5176\u80cc\u540e\u7684\u539f\u56e0\u4e00\u76f4\u662f\u514d\u75ab\u6cbb\u7597\u9886\u57df\u7684\u6838\u5fc3\u8c1c\u9898\u3002<\/strong>\u00a0\u8fd1\u65e5\uff0c\u7531\u514d\u75ab\u5b66\u6cf0\u6597Rafi Ahmed\u6559\u6388\u9886\u8854\u7684\u56e2\u961f\u5728\u9876\u7ea7\u671f\u520a<strong>\u300aNature\u300b<\/strong>\u4e0a\u53d1\u8868\u4e86\u4e00\u9879\u91cc\u7a0b\u7891\u5f0f\u7684\u7814\u7a76\u3002\u4ed6\u4eec\u805a\u7126\u4e8eHPV\u75c5\u6bd2\u76f8\u5173\u7684\u5934\u9888\u764c\uff0c\u5728\u80bf\u7624\u5185\u90e8\u7cbe\u51c6\u5b9a\u4f4d\u5230\u4e00\u7fa4\u7f55\u89c1\u4f46\u81f3\u5173\u91cd\u8981\u7684\u201c\u79cd\u5b50\u201d\u7ec6\u80de\u2014\u2014<strong>\u529f\u80fd\u6027HPV\u7279\u5f02\u6027\u7684PD-1+TCF-1+\u5e72\u7ec6\u80de\u6837CD8+ T\u7ec6\u80de<\/strong>\u3002\u8fd9\u4e00\u53d1\u73b0\u4e0d\u4ec5\u89e3\u91ca\u4e86\u4e3a\u4f55\u90e8\u5206\u60a3\u8005\u80fd\u4ecePD-1\u7597\u6cd5\u4e2d\u83b7\u76ca\uff0c\u66f4\u4e3a\u672a\u6765\u7684\u7cbe\u51c6\u6cbb\u7597\u548c\u75ab\u82d7\u5f00\u53d1\u6307\u660e\u4e86\u65b0\u65b9\u5411\u3002<\/pre>\n<\/blockquote>\n<h3>\u6311\u6218\uff1a\u5982\u4f55\u5728\u832b\u832b\u201cT\u6d77\u201d\u4e2d\u627e\u5230\u771f\u6b63\u7684\u6297\u764c\u6218\u58eb\uff1f<\/h3>\n<p>\u5934\u9888\u764c\u80bf\u7624\u7ec4\u7ec7\u91cc\u5145\u65a5\u7740\u6210\u5343\u4e0a\u4e07\u7684T\u7ec6\u80de\uff0c\u4f46\u5176\u4e2d\u7edd\u5927\u591a\u6570\u662f\u201c\u65c1\u89c2\u8005\u201d\uff0c\u5bf9\u80bf\u7624\u6beb\u65e0\u4f5c\u7528\u3002\u8981\u627e\u5230\u771f\u6b63\u80fd\u8bc6\u522b\u5e76\u653b\u51fbHPV\u75c5\u6bd2\u6297\u539f\u7684\u7279\u5f02\u6027T\u7ec6\u80de\uff0c\u65e0\u5f02\u4e8e\u5927\u6d77\u635e\u9488\u3002<\/p>\n<p>\u8be5\u7814\u7a76\u7684\u9996\u8981\u7a81\u7834\uff0c\u5c31\u662f\u6210\u529f\u9274\u5b9a\u51fa\u4e86\u6765\u81eaHPV E2\u3001E5\u548cE6\u86cb\u767d\u7684\u591a\u4e2a\u65b0\u8868\u4f4d\u3002\u5229\u7528\u8fd9\u4e9b\u8868\u4f4d\u5236\u5907\u7684MHC-I\u56db\u805a\u4f53\uff08Tetramer\uff09\uff0c\u7814\u7a76\u4eba\u5458\u7ec8\u4e8e\u80fd\u591f\u50cf\u7528\u201c\u78c1\u94c1\u201d\u4e00\u6837\uff0c\u4ece\u590d\u6742\u7684\u80bf\u7624\u6d78\u6da6\u6dcb\u5df4\u7ec6\u80de\uff08TILs\uff09\u4e2d\u76f4\u63a5\u5206\u9009\u51fa\u771f\u6b63\u7684HPV\u7279\u5f02\u6027CD8+ T\u7ec6\u80de\u3002<\/p>\n<p><strong>\u8fd9\u6b63\u662f\u6574\u4e2a\u7814\u7a76\u6700\u5173\u952e\u7684\u4e00\u6b65\uff0c\u4e5f\u662f\u6280\u672f\u96be\u5ea6\u6700\u9ad8\u7684\u4e00\u73af\u3002<\/strong>\u00a0\u6ca1\u6709\u7cbe\u51c6\u7684\u6297\u539f\u8868\u4f4d\u4fe1\u606f\u548c\u9ad8\u6548\u7684\u5206\u9009\u624b\u6bb5\uff0c\u540e\u7eed\u6240\u6709\u5173\u4e8e\u8fd9\u7fa4\u7ec6\u80de\u529f\u80fd\u7684\u6df1\u523b\u6d1e\u89c1\u90fd\u5c06\u65e0\u4ece\u8c08\u8d77\u3002<\/p>\n<h3>\u6838\u5fc3\u53d1\u73b0\uff1aT\u7ec6\u80de\u7684\u201c\u4e09\u91cd\u8eab\u4efd\u201d\u4e0e\u5206\u5316\u8f68\u8ff9<\/h3>\n<p>\u901a\u8fc7\u5bf9\u5206\u9009\u51fa\u7684HPV\u7279\u5f02\u6027T\u7ec6\u80de\u8fdb\u884c\u5355\u7ec6\u80deRNA\u6d4b\u5e8f\uff08scRNA-seq\uff09\uff0c\u7814\u7a76\u56e2\u961f\u63ed\u793a\u4e86\u4e00\u4e2a\u7cbe\u5999\u7684\u5206\u5316\u56fe\u8c31\uff1a<\/p>\n<ul class=\"list-paddingleft-1\">\n<li><strong>\u5e72\u7ec6\u80de\u6837\uff08Stem-like\uff09\u7ec6\u80de<\/strong><br \/>\n<section>\u8868\u8fbeTCF-1\u7b49\u5e72\u6027\u6807\u5fd7\u7269\uff0c\u5177\u6709\u5f3a\u5927\u7684\u81ea\u6211\u66f4\u65b0\u548c\u589e\u6b96\u6f5c\u80fd\u3002\u5b83\u4eec\u5b89\u9759\u5730\u9a7b\u7559\u5728\u80bf\u7624\u7684\u6dcb\u5df4\u6837\u57fa\u8d28\u533a\u57df\uff0c\u662f\u7ef4\u6301\u957f\u671f\u514d\u75ab\u5e94\u7b54\u7684\u201c\u50a8\u5907\u519b\u201d\u3002<\/section>\n<\/li>\n<li><strong>\u8fc7\u6e21\u6001\uff08Transitory\uff09\u7ec6\u80de<\/strong><br \/>\n<section>\u5f00\u59cb\u8868\u8fbe\u6548\u5e94\u5206\u5b50\uff0c\u5904\u4e8e\u4ece\u201c\u79cd\u5b50\u201d\u5411\u201c\u6218\u58eb\u201d\u8f6c\u53d8\u7684\u4e2d\u95f4\u72b6\u6001\u3002<\/section>\n<\/li>\n<li><strong>\u7ec8\u672b\u8017\u7aed\uff08Terminally exhausted\uff09\u7ec6\u80de<\/strong><br \/>\n<section>\u5931\u53bb\u4e86\u589e\u6b96\u80fd\u529b\uff0c\u529f\u80fd\u4e25\u91cd\u53d7\u635f\uff0c\u662f\u514d\u75ab\u5e94\u7b54\u7684\u201c\u7ec8\u70b9\u7ad9\u201d\u3002<\/section>\n<\/li>\n<\/ul>\n<p>\u66f4\u91cd\u8981\u7684\u662f\uff0c\u901a\u8fc7T\u7ec6\u80de\u53d7\u4f53\uff08TCR\uff09\u514b\u9686\u578b\u5206\u6790\u548c\u62df\u65f6\u5e8f\u5206\u6790\uff0c\u7814\u7a76\u8bc1\u5b9e\u4e86\u8fd9\u4e09\u79cd\u72b6\u6001\u7684\u7ec6\u80de\u6e90\u81ea\u540c\u4e00\u4e2a\u514b\u9686\uff0c\u5e76\u9075\u5faa\u7740<strong>\u201c\u5e72\u7ec6\u80de\u6837 \u2192 \u8fc7\u6e21\u6001 \u2192 \u7ec8\u672b\u8017\u7aed\u201d<\/strong>\u7684\u7ebf\u6027\u5206\u5316\u8f68\u8ff9\u3002<\/p>\n<h3>\u4e34\u5e8a\u610f\u4e49\uff1a\u4e3a\u4f55PD-1\u7597\u6cd5\u5728\u8fd9\u91cc\u53ef\u80fd\u6709\u6548\uff1f<\/h3>\n<p>\u7814\u7a76\u6700\u5173\u952e\u7684\u5b9e\u9a8c\u8bc1\u660e\uff1a<strong>\u8fd9\u7fa4HPV\u7279\u5f02\u6027\u7684PD-1+TCF-1+\u5e72\u7ec6\u80de\u6837T\u7ec6\u80de\u662f\u529f\u80fd\u5065\u5168\u7684\uff01<\/strong><\/p>\n<p>\u5f53\u5728\u4f53\u5916\u7528HPV\u6297\u539f\u80bd\u523a\u6fc0\u65f6\uff0c\u5b83\u4eec\u80fd\u591f\u8fc5\u901f\u589e\u6b96\uff0c\u5e76\u5206\u5316\u4e3a\u5177\u6709\u5f3a\u5927\u6740\u4f24\u529f\u80fd\u7684\u6548\u5e94T\u7ec6\u80de\u3002\u800c\u7ec8\u672b\u8017\u7aed\u7684\u7ec6\u80de\u5219\u5bf9\u6b64\u6beb\u65e0\u53cd\u5e94\u3002<\/p>\n<p>\u8fd9\u4e00\u53d1\u73b0\u5b8c\u7f8e\u89e3\u91ca\u4e86PD-1\u6291\u5236\u5242\u7684\u4f5c\u7528\u673a\u5236\uff1a\u5b83\u5e76\u975e\u201c\u590d\u6d3b\u201d\u5df2\u7ecf\u6b7b\u4ea1\u7684T\u7ec6\u80de\uff0c\u800c\u662f\u901a\u8fc7\u89e3\u9664\u5bf9\u201c\u79cd\u5b50\u201d\u7ec6\u80de\u7684\u6291\u5236\uff0c\u8ba9\u5b83\u4eec\u91cd\u65b0\u6fc0\u6d3b\u3001\u6269\u589e\u5e76\u8865\u5145\u524d\u7ebf\u7684\u201c\u6218\u58eb\u201d\u90e8\u961f\u3002\u56e0\u6b64\uff0c<strong>\u80bf\u7624\u5185\u662f\u5426\u5b58\u5728\u8fd9\u7fa4\u529f\u80fd\u6027\u5e72\u7ec6\u80de\u6837T\u7ec6\u80de\uff0c\u5f88\u53ef\u80fd\u6210\u4e3a\u9884\u6d4bPD-1\u7597\u6cd5\u7597\u6548\u7684\u5173\u952e\u751f\u7269\u6807\u5fd7\u7269\u3002<\/strong><\/p>\n<h3>\u672a\u6765\u5c55\u671b\uff1a\u8d85\u8d8aE6\/E7\uff0c\u62d3\u5bbd\u6cbb\u7597\u6027\u75ab\u82d7\u8fb9\u754c<\/h3>\n<p>\u6b64\u5916\uff0c\u8be5\u7814\u7a76\u8fd8\u5e26\u6765\u4e00\u4e2a\u610f\u5916\u4e4b\u559c\uff1a\u9664\u4e86\u5e7f\u4e3a\u4eba\u77e5\u7684E6\u548cE7\u86cb\u767d\uff0cHPV\u7684E2\u548cE5\u86cb\u767d\u540c\u6837\u80fd\u6fc0\u53d1\u5f3a\u70c8\u7684T\u7ec6\u80de\u53cd\u5e94\u3002\u8fd9\u610f\u5473\u7740\uff0c\u672a\u6765\u7684HPV\u6cbb\u7597\u6027\u75ab\u82d7\u82e5\u80fd\u5c06E2\u548cE5\u7eb3\u5165\u6297\u539f\u7ec4\u5408\uff0c\u5c06\u6709\u671b\u6fc0\u53d1\u66f4\u5e7f\u6cdb\u3001\u66f4\u5f3a\u5927\u7684\u6297\u80bf\u7624\u514d\u75ab\u5e94\u7b54\uff0c\u4e3a\u60a3\u8005\u5e26\u6765\u66f4\u591a\u5e0c\u671b\u3002<\/p>\n<p><strong>\u603b\u7ed3\u6765\u8bf4<\/strong>\uff0c\u8fd9\u9879Nature\u7814\u7a76\u4e0d\u4ec5\u6df1\u5316\u4e86\u6211\u4eec\u5bf9T\u7ec6\u80de\u8017\u7aed\u4e0e\u518d\u751f\u7684\u7406\u89e3\uff0c\u66f4\u4ee5HPV\u9633\u6027\u5934\u9888\u764c\u4e3a\u8303\u4f8b\uff0c\u5c55\u793a\u4e86\u5982\u4f55\u901a\u8fc7\u7cbe\u7ec6\u7684\u514d\u75ab\u5b66\u5206\u6790\uff0c\u627e\u5230\u51b3\u5b9a\u514d\u75ab\u6cbb\u7597\u6210\u8d25\u7684\u5173\u952e\u7ec6\u80de\u4e9a\u7fa4\u3002\u8fd9\u4e3a\u5f00\u53d1\u65b0\u578b\u751f\u7269\u6807\u5fd7\u7269\u3001\u4f18\u5316\u73b0\u6709\u7597\u6cd5\u4ee5\u53ca\u8bbe\u8ba1\u4e0b\u4e00\u4ee3\u764c\u75c7\u75ab\u82d7\u63d0\u4f9b\u4e86\u5b9d\u8d35\u7684\u7406\u8bba\u57fa\u7840\u548c\u5b9e\u8df5\u8def\u5f84\u3002<\/p>\n<section>\u53c2\u8003\u6587\u732e:\u00a0 \u00a0<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10201342\/\" target=\"_blank\" rel=\"noopener\">Functional HPV-specific PD-1<sup>+<\/sup> stem-like CD8 T cells in head and neck cancer<\/a>. Nature, 2021.<\/section>\n<h3><span data-pm-slice=\"1 1 [&quot;heading&quot;,{&quot;tagName&quot;:&quot;h2&quot;,&quot;attributes&quot;:{&quot;style&quot;:&quot;-webkit-tap-highlight-color: rgba(0, 0, 0, 0);margin: 30px 0px 15px;padding: 0px 0px 6px;outline: 0px;font-weight: 400;font-size: 19px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;font-style: normal;font-variant-ligatures: normal;font-variant-caps: normal;orphans: 2;text-indent: 0px;text-transform: none;widows: 2;word-spacing: 0px;-webkit-text-stroke-width: 0px;white-space: normal;background-color: rgb(255, 255, 255);text-decoration-thickness: initial;text-decoration-style: initial;text-decoration-color: initial;scrollbar-width: none;font-family: \\&quot;PingFang SC\\&quot;, \\&quot;Helvetica Neue\\&quot;, Helvetica, Arial, sans-serif;letter-spacing: normal;text-align: start;color: rgb(25, 118, 210);border-bottom: 1px solid rgb(238, 238, 238);&quot;,&quot;data-pm-slice&quot;:&quot;2 1 []&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;,&quot;level&quot;:2}]\"> \u5982\u4f55\u5c06\u8f6c\u5316\u4e3a\u7814\u7a76\u6210\u679c\uff1f<\/span><\/h3>\n<p>\u6842\u828e\u751f\u7269\u53ef\u63d0\u4f9b\u5173\u952e\u4ea7\u54c1\u652f\u6491\uff1a<\/p>\n<section>\n<p data-pm-slice=\"0 0 []\"><strong>1.\u00a0<span data-pm-slice=\"1 1 [&quot;para&quot;,{&quot;tagName&quot;:&quot;p&quot;,&quot;attributes&quot;:{},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;node&quot;,{&quot;tagName&quot;:&quot;strong&quot;,&quot;attributes&quot;:{&quot;style&quot;:&quot;scrollbar-width: none;&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;}]\"><a href=\"https:\/\/www.guixiong.com.cn\/?page_id=1192\" target=\"_blank\" rel=\"noopener\">\u5fae\u91cfpMHC\u590d\u5408\u7269\u5408\u6210\u670d\u52a1<\/a>:\u00a0<\/span><\/strong>\u652f\u6301HLA-A*02:01\u7b4933\u79cd\u4e3b\u6d41HLA\u7b49\u4f4d\u57fa\u56e0\uff0c\u7528\u4e8e\u6297\u539f\u7279\u5f02\u6027T\u7ec6\u80de\u9a8c\u8bc1<\/p>\n<p><strong>2\u00a0<span data-pm-slice=\"1 1 [&quot;para&quot;,{&quot;tagName&quot;:&quot;p&quot;,&quot;attributes&quot;:{},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;node&quot;,{&quot;tagName&quot;:&quot;strong&quot;,&quot;attributes&quot;:{&quot;style&quot;:&quot;scrollbar-width: none;&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;}]\">.\u00a0<a href=\"https:\/\/www.guixiong.com.cn\/?page_id=133\" target=\"_blank\" rel=\"noopener\">pMHC\u8367\u5149\u56db\u805a\u4f53\u5408\u6210\u4ee5\u53ca\u7b5b\u9009<\/a>:\u00a0<\/span><\/strong>\u73b0\u8d27\u8986\u76d6\u591a\u79cd\u80bf\u7624\u6297\u539f\uff08\u5982HPV\/CMV\/EBV\/KRAS\u7b49\uff09\uff0c\u5feb\u901f\u5206\u9009\u6297\u539f\u7279\u5f02\u6027T\u7ec6\u80de<\/p>\n<p><strong>3.\u00a0<span data-pm-slice=\"1 1 [&quot;para&quot;,{&quot;tagName&quot;:&quot;p&quot;,&quot;attributes&quot;:{},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;node&quot;,{&quot;tagName&quot;:&quot;strong&quot;,&quot;attributes&quot;:{&quot;style&quot;:&quot;scrollbar-width: none;&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;}]\"><a href=\"https:\/\/www.guixiong.com.cn\/?page_id=546\" target=\"_blank\" rel=\"noopener\">\u5de5\u7a0b\u5316\u5448\u9012\u7ec6\u80de\u6784\u5efa<\/a>:\u00a0<\/span><\/strong>K562-HLA\u7cfb\u5217\uff0c\u6a21\u62df\u4f53\u5185\u6297\u539f\u5448\u9012\uff0c\u7528\u4e8eDC\u529f\u80fd\u6a21\u62df<\/p>\n<p><strong>4.\u00a0<span data-pm-slice=\"1 1 [&quot;para&quot;,{&quot;tagName&quot;:&quot;p&quot;,&quot;attributes&quot;:{},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;node&quot;,{&quot;tagName&quot;:&quot;strong&quot;,&quot;attributes&quot;:{&quot;style&quot;:&quot;scrollbar-width: none;&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;}]\"><a href=\"https:\/\/www.guixiong.com.cn\/?page_id=1489\" target=\"_blank\" rel=\"noopener\">\u5355\u514b\u9686TCR\u6d4b\u5e8f<\/a>:\u00a0<\/span><\/strong>\u4ece\u56db\u805a\u4f53\u9633\u6027T\u7ec6\u80de\u4e2d\u83b7\u53d6\u914d\u5bf9\u94fe\u7684TCR\u4e3b\u514b\u9686<\/p>\n<p><strong>5.\u00a0<span data-pm-slice=\"1 1 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