{"id":1666,"date":"2026-02-08T13:40:39","date_gmt":"2026-02-08T13:40:39","guid":{"rendered":"https:\/\/www.guixiong.com.cn\/?page_id=1666"},"modified":"2026-02-08T13:40:39","modified_gmt":"2026-02-08T13:40:39","slug":"%e7%bb%95%e8%bf%87%e6%8a%97%e5%8e%9f%e8%bf%b7%e9%9b%be%ef%bc%8c%e8%83%b0%e8%85%ba%e7%99%8c%e8%87%aa%e4%bd%93%e7%b1%bb%e5%99%a8%e5%ae%98%e5%8d%95%e7%bb%86%e8%83%9etcr%e6%b5%8b","status":"publish","type":"page","link":"https:\/\/www.guixiong.com.cn\/?page_id=1666","title":{"rendered":"\u7ed5\u8fc7\u201c\u6297\u539f\u8ff7\u96fe\u201d\uff0c\u80f0\u817a\u764c\u81ea\u4f53\u7c7b\u5668\u5b98+\u5355\u7ec6\u80deTCR\u6d4b\u5e8f\u9769\u65b0PDAC\u60a3\u8005TCR\u53d1\u73b0\u8303\u5f0f"},"content":{"rendered":"
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\u7b2c\u4e00\u7ae0\uff1aPDAC\u514d\u75ab\u6cbb\u7597\u7684\u56f0\u5883\u4e0e\u4f20\u7edfTCR\u53d1\u73b0\u7684\u5c40\u9650<\/h3>\n
TCR-T\u7ec6\u80de\u7597\u6cd5\u7684\u6210\u529f\uff0c\u9ad8\u5ea6\u4f9d\u8d56\u4e8e\u80fd\u5426\u627e\u5230\u4e00\u4e2a\u7406\u60f3\u7684TCR\uff1a\u5b83\u65e2\u80fd\u9ad8\u4eb2\u548c\u529b\u3001\u9ad8\u7279\u5f02\u6027\u5730\u8bc6\u522b\u80bf\u7624\u7ec6\u80de\u8868\u9762\u7684pMHC\u590d\u5408\u7269\uff0c\u53c8\u4e0d\u4f1a\u4e0e\u6b63\u5e38\u7ec4\u7ec7\u53d1\u751f\u4ea4\u53c9\u53cd\u5e94\u3002<\/p>\n
\u4f20\u7edf\u7684TCR\u53d1\u73b0\u8def\u5f84\u4e3b\u8981\u6709\u4e24\u6761\uff1a<\/p>\n
    \n
  1. \u57fa\u4e8e\u5df2\u77e5\u6297\u539f\u7684\u7b5b\u9009<\/strong>
    \n
    \u5229\u7528\u8367\u5149\u6807\u8bb0\u7684pMHC\u591a\u805a\u4f53\uff08\u5982\u56db\u805a\u4f53\uff09\u4ece\u60a3\u8005TILs\u6216\u5916\u5468\u8840\u4e2d\u76f4\u63a5\u5206\u9009\u51fa\u7279\u5f02\u6027T\u7ec6\u80de\u3002\u8fd9\u79cd\u65b9\u6cd5\u7684\u524d\u63d0\u662f\u5fc5\u987b\u9884\u5148\u77e5\u9053\u76ee\u6807\u6297\u539f\u80bd\u53ca\u5176\u5bf9\u5e94\u7684HLA\u9650\u5236\u6027\u3002\u7136\u800c\uff0c\u5728PDAC\u4e2d\uff0c\u9a71\u52a8\u7a81\u53d8\uff08\u5982KRAS G12D\/V\/R\uff09\u867d\u666e\u904d\uff0c\u4f46\u7531\u5176\u4ea7\u751f\u7684\u65b0\u6297\u539f\u5177\u6709\u6781\u5f3a\u7684HLA\u7b49\u4f4d\u57fa\u56e0\u9650\u5236\u6027\u548c\u4e2a\u4f53\u72ec\u7279\u6027\uff0c\u51e0\u4e4e\u4e0d\u5b58\u5728\u9002\u7528\u4e8e\u8d85\u8fc710%\u60a3\u8005\u7684\u201c\u516c\u5171\u65b0\u6297\u539f\u201d\u3002<\/section>\n
    <\/section>\n<\/li>\n
  2. \u57fa\u4e8eHLA\u7684\u9884\u6d4b\u4e0e\u9a8c\u8bc1<\/strong>
    \n
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    \u8fd9\u4e24\u79cd\u65b9\u6cd5\u90fd\u9677\u5165\u4e86\u540c\u4e00\u4e2a\u6b7b\u80e1\u540c\uff1a\u5b83\u4eec\u90fd\u9700\u8981\u4e00\u4e2a\u660e\u786e\u7684\u201c\u9776\u70b9\u5047\u8bbe\u201d\u3002\u800c\u5728PDAC\u8fd9\u4e2a\u9776\u70b9\u6a21\u7cca\u3001\u5f02\u8d28\u6027\u6781\u9ad8\u7684\u80bf\u7624\u9762\u524d\uff0c\u8fd9\u79cd\u201c\u5148\u6709\u9e21\u8fd8\u662f\u5148\u6709\u86cb\u201d\u7684\u56f0\u5883\uff0c\u6781\u5927\u5730\u963b\u788d\u4e86\u6709\u6548TCR\u7684\u53d1\u73b0\u3002<\/p>\n
    \u7b2c\u4e8c\u7ae0\uff1a\u9769\u547d\u6027\u7b56\u7565\u2014\u2014\u201c\u4ee5\u7624\u5bfbT\u201d\u7684\u529f\u80fd\u5bfc\u5411\u7b5b\u9009<\/h3>\n
    \u65b0\u53d1\u8868\u7684\u8fd9\u9879\u7814\u7a76\uff0c\u5176\u6838\u5fc3\u601d\u60f3\u662f\u5f7b\u5e95\u6452\u5f03\u201c\u9776\u70b9\u5047\u8bbe\u201d\uff0c\u8f6c\u800c\u91c7\u7528\u4e00\u79cd\u201c\u529f\u80fd\u5bfc\u5411\u201d\u7684\u7b5b\u9009\u903b\u8f91\uff1a\u8ba9\u80bf\u7624\u81ea\u5df1\u6765\u544a\u8bc9\u6211\u4eec\uff0c\u54ea\u4e9bT\u7ec6\u80de\u662f\u5b83\u7684\u201c\u5929\u654c\u201d<\/strong>\u3002<\/p>\n
    \u4e3a\u4e86\u5b9e\u73b0\u8fd9\u4e00\u76ee\u6807\uff0c\u7814\u7a76\u8005\u6784\u5efa\u4e86\u4e00\u4e2a\u9ad8\u5ea6\u4eff\u751f\u7684\u4f53\u5916\u7cfb\u7edf\uff0c\u5176\u5173\u952e\u7ec4\u4ef6\u662f\u81ea\u4f53\u80bf\u7624\u7c7b\u5668\u5b98<\/strong>\uff08Autologous Tumor Organoid\uff09\u3002\u7c7b\u5668\u5b98\u662f\u4ece\u60a3\u8005\u65b0\u9c9c\u80bf\u7624\u7ec4\u7ec7\u4e2d\u5206\u79bb\u51fa\u7684\u5e72\u7ec6\u80de\u6216\u7956\u7ec6\u80de\uff0c\u5728\u7279\u5b9a3D\u57f9\u517b\u6761\u4ef6\u4e0b\u5f62\u6210\u7684\u5fae\u578b\u5668\u5b98\u3002\u5b83\u80fd\u591f\uff1a<\/p>\n