{"id":1668,"date":"2026-02-10T14:06:45","date_gmt":"2026-02-10T14:06:45","guid":{"rendered":"https:\/\/www.guixiong.com.cn\/?page_id=1668"},"modified":"2026-02-10T14:07:37","modified_gmt":"2026-02-10T14:07:37","slug":"mhc-i%e5%88%86%e5%ad%90%e7%9a%84%e6%9f%94%e6%80%a7-%e4%b8%80%e4%b8%aa%e6%b0%a8%e5%9f%ba%e9%85%b8%e4%b9%8b%e5%b7%ae%e5%86%b3%e5%ae%9a%e5%85%8d%e7%96%ab%e7%b3%bb%e7%bb%9f%e8%83%bd","status":"publish","type":"page","link":"https:\/\/www.guixiong.com.cn\/?page_id=1668","title":{"rendered":"MHC-I\u5206\u5b50\u7684\u201c\u67d4\u6027\u201d: \u4e00\u4e2a\u6c28\u57fa\u9178\u4e4b\u5dee\u51b3\u5b9a\u514d\u75ab\u7cfb\u7edf\u80fd\u5426\u770b\u89c1\u764c\u7ec6\u80de\uff1f"},"content":{"rendered":"<blockquote>\n<pre data-pm-slice=\"2 1 []\">\u25b2 \u7814\u7a76\u63ed\u793a\uff0cMHC-I\u5206\u5b50\u5e76\u975e\u521a\u6027\u7ed3\u6784\uff0c\u5176\u5185\u5728\u7684\u201c\u53ef\u5851\u6027\u201d\uff08\u67d4\u6027\uff09\u51b3\u5b9a\u4e86\u5b83\u7b5b\u9009\u9ad8\u4eb2\u548c\u529b\u6297\u539f\u80bd\u7684\u80fd\u529b\u3002B*4405\uff08\u53f3\uff09\u6bd4B*4402\uff08\u5de6\uff09\u66f4\u5177\u67d4\u6027\uff0c\u56e0\u6b64\u80fd\u66f4\u9ad8\u6548\u5730\u5448\u9012\u80bf\u7624\u6297\u539f\u3002\r\n\r\n<strong>\u4e3a\u4ec0\u4e48\u6709\u4e9b\u4eba\u7684\u514d\u75ab\u7cfb\u7edf\u80fd\u6709\u6548\u8bc6\u522b\u5e76\u6e05\u9664\u764c\u7ec6\u80de\uff0c\u800c\u6709\u4e9b\u4eba\u5374\u4e0d\u80fd\uff1f<\/strong>\u00a0\u7b54\u6848\u53ef\u80fd\u5c31\u85cf\u5728\u6211\u4eec\u7ec6\u80de\u8868\u9762\u7684\u201c\u544a\u793a\u724c\u201d\u2014\u2014MHC-I\u5206\u5b50\u7684\u7ec6\u5fae\u5dee\u522b\u91cc\u3002\u8fd1\u65e5\uff0c\u4e00\u9879\u53d1\u8868\u4e8e<strong>\u300aScientific Reports\u300b<\/strong>\uff08Nature\u65d7\u4e0b\uff09\u7684\u7814\u7a76\uff0c\u901a\u8fc7\u7ed3\u5408\u8ba1\u7b97\u5efa\u6a21\u3001\u5206\u5b50\u52a8\u529b\u5b66\u6a21\u62df\u548c\u751f\u5316\u5b9e\u9a8c\uff0c\u9996\u6b21\u4ece\u539f\u5b50\u5c42\u9762\u63ed\u793a\u4e86MHC-I\u5206\u5b50\u7684\u5185\u5728\u201c\u67d4\u6027\u201d\uff08Protein Plasticity\uff09\u662f\u5176\u53d1\u6325\u6297\u539f\u9009\u62e9\u529f\u80fd\u7684\u6838\u5fc3\u5bc6\u7801\u3002\u8fd9\u9879\u7814\u7a76\u4e0d\u4ec5\u89e3\u91ca\u4e86\u514d\u75ab\u5e94\u7b54\u4e2a\u4f53\u5dee\u5f02\u7684\u6839\u6e90\uff0c\u66f4\u4e3a\u4f18\u5316\u764c\u75c7\u75ab\u82d7\u548cT\u7ec6\u80de\u7597\u6cd5\u63d0\u4f9b\u4e86\u5168\u65b0\u7684\u8bbe\u8ba1\u601d\u8def\u3002<\/pre>\n<\/blockquote>\n<h3>\u00a0\u8c1c\u9898\uff1a\u4ec5\u4e00\u4e2a\u6c28\u57fa\u9178\u4e4b\u5dee\uff0c\u5929\u58e4\u4e4b\u522b\u7684\u514d\u75ab\u6548\u679c<\/h3>\n<p><span data-pm-slice=\"0 0 []\">MHC I\u5206\u5b50\u5177\u6709\u9ad8\u5ea6\u591a\u6001\u6027\uff0c\u4f46\u5176\u4e09\u7ea7\u7ed3\u6784\u5374\u5341\u5206\u76f8\u4f3c\uff08\u56fe1\uff09\uff0c\u4e3b\u8981\u5305\u62ec\uff1a\u591a\u6001\u6027\u7684\u91cd\u94fe\u3001\u5355\u6001\u7684\u03b22\u5fae\u7403\u86cb\u767d\uff08\u03b22m\uff09\u4ee5\u53ca\u4e00\u6761\u901a\u5e38\u75318\u81f310\u4e2a\u6c28\u57fa\u9178\u7ec4\u6210\u7684\u80bd\u6bb5\u3002\u8fd9\u4e9b\u7ec4\u5206\u4ee5\u975e\u5171\u4ef7\u952e\u7684\u5f62\u5f0f\u7ed3\u5408\u4e8e\u80bd\u6bb5\u7ed3\u5408\u69fd\u4e2d\u3002\u5f53\u8f85\u52a9\u56e0\u5b50\u5206\u5b50tapasin\u529f\u80fd\u7f3a\u5931\u6216\u4e0d\u5b58\u5728\u65f6\uff0c\u4e0d\u540c\u7b49\u4f4d\u57fa\u56e0\u578bMHC I\u5206\u5b50\u5728\u80bd\u6bb5\u9009\u62e9\u529f\u80fd\u4e0a\u7684\u5185\u5728\u5dee\u5f02\u4fbf\u4f1a\u51f8\u663e\u51fa\u6765\u3002\u8fd9\u662f\u56e0\u4e3atapasin\u80fd\u591f\u901a\u8fc7\u4f18\u5148\u589e\u5f3a\u90a3\u4e9b\u80bd\u6bb5\u9009\u62e9\u6548\u7387\u8f83\u4f4e\u7684MHC I\u5206\u5b50\u7684\u9009\u62e9\u529f\u80fd\uff0c\u4ece\u800c\u63a9\u76d6\u8fd9\u4e9b\u5185\u5728\u5dee\u5f02\u3002\u800c\u5728tapasin\u7f3a\u5931\u7684\u60c5\u51b5\u4e0b\uff0cMHC I\u5206\u5b50\u4e00\u7ea7\u5e8f\u5217\u4e2d\u7684\u5dee\u5f02\u4fbf\u8db3\u4ee5\u663e\u8457\u5f71\u54cd\u5176\u80bd\u6bb5\u9009\u62e9\u529f\u80fd12\u3002\u4f8b\u5982\uff0c\u4e24\u79cd\u4eba\u7c7b\u7b49\u4f4d\u57fa\u56e0HLA-B<\/span><em>35:01\u548cHLA-B<\/em>52:01\u7684\u4e00\u7ea7\u5e8f\u5217\u4ec5\u76f8\u5dee12\u4e2a\u6c28\u57fa\u9178\u6b8b\u57fa\u3002\u5728\u7f3a\u4e4f<span data-pm-slice=\"0 0 []\">tapasin<\/span>\u7684\u60c5\u51b5\u4e0b\uff0cHLA-B<em>35:01\u5206\u5b50\u4f1a\u5728\u7ec6\u80de\u8868\u9762\u9ad8\u6c34\u5e73\u8868\u8fbe\uff0c\u800cHLA-B<\/em>52:01\u5206\u5b50\u5219\u4ec5\u4ee5\u4f4e\u6c34\u5e73\u5b58\u5728\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u5373\u4f7f\u4ec5\u4ec5\u4e00\u4e2a\u6c28\u57fa\u9178\u7684\u5dee\u5f02\u4e5f\u80fd\u6539\u53d8MHC I\u5206\u5b50\u7684\u56fa\u6709\u80bd\u6bb5\u9009\u62e9\u529f\u80fd\uff1aHLA-B<em>44:02\uff08B<\/em>4402\uff09\u4e0eHLA-B<em>44:05\uff08B<\/em>4405\uff09\u5728\u7b2c116\u4f4d\u4ec5\u76f8\u5dee\u4e00\u4e2a\u6c28\u57fa\u9178\u6b8b\u57fa\uff08\u56fe1A\uff09\uff0c\u7136\u800c\uff0c\u5728\u7f3a\u4e4f<span data-pm-slice=\"0 0 []\">tapasin<\/span>\u7684\u60c5\u51b5\u4e0b\uff0c\u4e8c\u8005\u5728\u9009\u62e9\u9ad8\u4eb2\u548c\u529b\u80bd\u6bb5\u7684\u80fd\u529b\u4e0a\u5374\u5904\u4e8e\u622a\u7136\u76f8\u53cd\u7684\u4e24\u7aef\u3002\u5728<span data-pm-slice=\"0 0 []\">tapasin<\/span>\u7f3a\u9677\u7684\u7ec6\u80de\u4e2d\uff0cB<em>4402\u96be\u4ee5\u6709\u6548\u91c7\u6837\u80bd\u6bb5\u5e93\uff0c\u56e0\u6b64\u5728\u5185\u8d28\u7f51\uff08ER\uff09\u4e2d\u88ab\u964d\u89e3\uff1b\u800cB<\/em>4405\u5219\u80fd\u9ad8\u6548\u5730\u9009\u62e9\u9ad8\u4eb2\u548c\u529b\u80bd\u6bb5\uff0c\u5e76\u5c06\u5176\u5448\u9012\u5230\u7ec6\u80de\u8868\u9762\u3002<\/p>\n<p>\u7814\u7a76\u805a\u7126\u4e8e\u4e24\u4e2a\u4eba\u7c7bMHC-I\u7b49\u4f4d\u57fa\u56e0\uff1a<strong>HLA-B*44:02 (B*4402)<\/strong>\u00a0\u548c\u00a0<strong>HLA-B*44:05 (B*4405)<\/strong>\u3002\u5b83\u4eec\u7684\u86cb\u767d\u8d28\u5e8f\u5217**\u4ec5\u5728\u7b2c116\u4f4d\u6709\u4e00\u4e2a\u6c28\u57fa\u9178\u4e0d\u540c**\uff08B*4402\u662f\u5929\u51ac\u6c28\u9178D\uff0cB*4405\u662f\u916a\u6c28\u9178Y\uff09\u3002<\/p>\n<p>\u7136\u800c\uff0c\u8fd9\u4e2a\u5fae\u5c0f\u7684\u5dee\u5f02\u5374\u5bfc\u81f4\u4e86\u5de8\u5927\u7684\u529f\u80fd\u9e3f\u6c9f\uff1a<\/p>\n<ul class=\"list-paddingleft-1\">\n<li><strong>B*4405<\/strong><br \/>\n<section>\u5728\u6ca1\u6709\u8f85\u52a9\u5206\u5b50tapasin\u7684\u5e2e\u52a9\u4e0b\uff0c\u4e5f\u80fd\u9ad8\u6548\u5730\u4ece\u6210\u5343\u4e0a\u4e07\u7684\u80bd\u6bb5\u4e2d\u7b5b\u9009\u51fa\u9ad8\u4eb2\u548c\u529b\u7684\u6297\u539f\u80bd\uff0c\u5e76\u7a33\u5b9a\u5730\u5448\u9012\u5230\u7ec6\u80de\u8868\u9762\uff0c\u8ba9T\u7ec6\u80de\u201c\u770b\u5f97\u89c1\u201d\u3002<\/section>\n<\/li>\n<li><strong>B*4402<\/strong><br \/>\n<section>\u81ea\u8eab\u7b5b\u9009\u80fd\u529b\u6781\u5dee\uff0c\u82e5\u65e0tapasin\u5e2e\u52a9\uff0c\u5927\u90e8\u5206\u4f1a\u56e0\u672a\u80fd\u7ed3\u5408\u7a33\u5b9a\u80bd\u6bb5\u800c\u5728\u5185\u8d28\u7f51\u4e2d\u88ab\u964d\u89e3\uff0c\u5bfc\u81f4\u7ec6\u80de\u8868\u9762\u51e0\u4e4e\u201c\u7a7a\u7a7a\u5982\u4e5f\u201d\uff0cT\u7ec6\u80de\u65e0\u6cd5\u8bc6\u522b\u3002<\/section>\n<\/li>\n<\/ul>\n<p>\u8fd9\u4e2a\u73b0\u8c61\u5f15\u51fa\u4e86\u4e00\u4e2a\u6839\u672c\u95ee\u9898\uff1a**\u9759\u6001\u7684\u6676\u4f53\u7ed3\u6784\u51e0\u4e4e\u5b8c\u5168\u76f8\u540c\uff08RMSD\u4ec50.3\u00c5\uff09\uff0c\u4e3a\u4f55\u529f\u80fd\u5374\u5982\u6b64\u8fe5\u5f02\uff1f**<\/p>\n<h3>\u6838\u5fc3\u53d1\u73b0\uff1aMHC-I\u662f\u4e2a\u201c\u52a8\u6001\u5f00\u5173\u201d\uff0c\u800c\u975e\u201c\u9759\u6001\u9501\u201d<\/h3>\n<p>\u7814\u7a76\u56e2\u961f\u63d0\u51fa\u5e76\u9a8c\u8bc1\u4e86\u4e00\u4e2a\u5173\u952e\u5047\u8bf4\uff1aMHC-I\u5206\u5b50\u5728\u6267\u884c\u529f\u80fd\u65f6\uff0c\u4f1a\u7ecf\u5386\u4e00\u4e2a**\u5f00\u653e\uff08open\uff09\u548c\u95ed\u5408\uff08closed\uff09\u7684\u6784\u8c61\u8f6c\u6362\u8fc7\u7a0b**\u3002<\/p>\n<ul class=\"list-paddingleft-1\">\n<li><strong>\u5f00\u653e\u6001<\/strong><br \/>\n<section>\u80bd\u7ed3\u5408\u69fd\u6253\u5f00\uff0c\u5141\u8bb8\u80bd\u6bb5\u8fdb\u5165\u6216\u79bb\u5f00\u3002<\/section>\n<\/li>\n<li><strong>\u95ed\u5408\u6001<\/strong><br \/>\n<section>\u80bd\u7ed3\u5408\u69fd\u5173\u95ed\uff0c\u5f62\u6210\u7a33\u5b9a\u7684\u590d\u5408\u7269\uff0c\u51c6\u5907\u5448\u9012\u5230\u7ec6\u80de\u8868\u9762\u3002<\/section>\n<\/li>\n<\/ul>\n<p>\u901a\u8fc7\u5efa\u7acb\u8ba1\u7b97\u7cfb\u7edf\u6a21\u578b\u5e76\u62df\u5408\u4f53\u5185\u5b9e\u9a8c\u6570\u636e\uff0c\u4ed6\u4eec\u53d1\u73b0\uff1a<strong>B*4405\u7684\u201c\u95ed\u5408\u901f\u7387\u201d\u8fdc\u5feb\u4e8eB*4402<\/strong>\u3002\u8fd9\u610f\u5473\u7740B*4405\u80fd\u66f4\u5feb\u5730\u201c\u9501\u4f4f\u201d\u4e00\u4e2a\u80bd\u6bb5\uff0c\u7136\u540e\u901a\u8fc7\u5176\u201c\u5f00\u653e\u901f\u7387\u201d\uff08\u8be5\u901f\u7387\u7531\u80bd\u6bb5\u4eb2\u548c\u529b\u51b3\u5b9a\uff09\u6765\u6d4b\u8bd5\u8fd9\u4e2a\u80bd\u6bb5\u7684\u597d\u574f\u3002\u5982\u679c\u4eb2\u548c\u529b\u4f4e\uff08\u5f00\u653e\u5feb\uff09\uff0c\u5c31\u8fc5\u901f\u91ca\u653e\uff0c\u518d\u53bb\u5c1d\u8bd5\u4e0b\u4e00\u4e2a\uff1b\u5982\u679c\u4eb2\u548c\u529b\u9ad8\uff08\u5f00\u653e\u6162\uff09\uff0c\u5c31\u80fd\u7a33\u5b9a\u4e0b\u6765\u3002\u8fd9\u79cd\u5feb\u901f\u7684\u201c\u8bd5\u9519-\u9501\u5b9a\u201d\u5faa\u73af\uff0c\u4f7f\u5176\u7b5b\u9009\u6548\u7387\u6781\u9ad8\u3002\u800cB*4402\u7531\u4e8e\u95ed\u5408\u592a\u6162\uff0c\u6574\u4e2a\u7b5b\u9009\u8fc7\u7a0b\u53d8\u5f97\u5f02\u5e38\u4f4e\u6548\u3002<\/p>\n<p><img fetchpriority=\"high\" decoding=\"async\" class=\"alignnone size-large wp-image-1670\" src=\"https:\/\/guixiong.com.cn\/wp-content\/uploads\/2026\/02\/MHC-I\u5206\u5b50\u7684\u67d4\u6027-1-1024x452.jpg\" alt=\"\" width=\"1024\" height=\"452\" srcset=\"https:\/\/guixiong.com.cn\/wp-content\/uploads\/2026\/02\/MHC-I\u5206\u5b50\u7684\u67d4\u6027-1-1024x452.jpg 1024w, https:\/\/guixiong.com.cn\/wp-content\/uploads\/2026\/02\/MHC-I\u5206\u5b50\u7684\u67d4\u6027-1-300x133.jpg 300w, https:\/\/guixiong.com.cn\/wp-content\/uploads\/2026\/02\/MHC-I\u5206\u5b50\u7684\u67d4\u6027-1-768x339.jpg 768w, https:\/\/guixiong.com.cn\/wp-content\/uploads\/2026\/02\/MHC-I\u5206\u5b50\u7684\u67d4\u6027-1.jpg 1227w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/p>\n<pre>\u6b64\u56fe\u63cf\u8ff0\u4e86\u4e09\u4e2a\u7279\u70b9\uff08A\u3001B\u3001C\uff09\uff0c\u5c55\u793a\u4e86\uff1a\r\nA-MHC I\u5206\u5b50\uff08HLA-B44:05\uff09\u7684\u6574\u4f53\u7ed3\u6784\u53ca\u5176\u7ec4\u6210\uff1b\r\nB-\u4e24\u4e2a\u6781\u5176\u76f8\u4f3c\u7684\u7b49\u4f4d\u57fa\u56e0\uff08B4402 vs B4405\uff09\u4ec5\u56e0\u4e00\u4e2a\u6c28\u57fa\u9178\uff08116\u4f4d\uff09\u4e0d\u540c\u800c\u4ea7\u751f\u529f\u80fd\u5dee\u5f02\uff08\u5982\u5f71\u54cdT\u7ec6\u80de\u8bc6\u522b\u6216\u81ea\u8eab\u514d\u75ab\u53cd\u5e94\uff09\uff1b\r\nC-\u80bd\u7ed3\u5408\u69fd\u7684\u7ed3\u6784\u7279\u5f81\uff0c\u8fd9\u662fMHC I\u5448\u9012\u6297\u539f\u7684\u5173\u952e\u90e8\u4f4d\u3002<\/pre>\n<p>\u4e0a\u56fe\u5448\u73b0\u5982\u4e0b\uff1a<\/p>\n<ul>\n<li>\uff08A\uff09\u90e8\u5206\uff1a<br \/>\n\u5e26\u72b6\u56fe\u201d\uff08ribbon diagram\uff09\u5c55\u793a\u86cb\u767d\u8d28\u7684\u4e09\u7ef4\u7ed3\u6784\uff0c\u7a81\u51fa\u5176\u4e8c\u7ea7\u7ed3\u6784\uff08\u5982\u03b1\u87ba\u65cb\u3001\u03b2\u6298\u53e0\uff09\u3002<br \/>\nMHC I molecule HLA-B44:05\uff1a\u8fd9\u662f\u4eba\u7c7bMHC I\u7c7b\u5206\u5b50\u7684\u4e00\u79cd\u4e9a\u578b\uff0c\u5c5e\u4e8eHLA-B\u57fa\u56e0\u5ea7\u7684\u4e00\u4e2a\u7b49\u4f4d\u57fa\u56e0\u4ea7\u7269\uff08HLA\u662f\u4eba\u7c7b\u7684MHC\uff09\u3002<br \/>\n\u5171\u6709\u4e09\u4e2a\u7ec4\u6210\u90e8\u5206\uff1a<br \/>\nPolymorphic heavy chain\uff08\u591a\u6001\u6027\u91cd\u94fe\uff09\uff1aMHC I\u7c7b\u5206\u5b50\u7684\u03b1\u94fe\uff0c\u5177\u6709\u9ad8\u5ea6\u591a\u6001\u6027\uff08\u4e0d\u540c\u4e2a\u4f53\u95f4\u5e8f\u5217\u5dee\u5f02\u5927\uff09\uff0c\u51b3\u5b9a\u6297\u539f\u7ed3\u5408\u7279\u5f02\u6027\u3002\u56fe\u4e2d\u4e3a\u9ec4\u8272\u3002<br \/>\nInvariant \u03b22m\uff08\u6052\u5b9a\u7684\u03b22\u5fae\u7403\u86cb\u767d\uff09\uff1a\u5373\u03b2\u2082-\u5fae\u7403\u86cb\u767d\uff08\u03b2\u2082-microglobulin\uff09\uff0c\u4e0d\u5177\u591a\u6001\u6027\uff0c\u4e0e\u91cd\u94fe\u975e\u5171\u4ef7\u7ed3\u5408\uff0c\u5bf9MHC I\u5206\u5b50\u7a33\u5b9a\u8868\u8fbe\u81f3\u5173\u91cd\u8981\u3002\u56fe\u4e2d\u4e5f\u6807\u4e3a\u9ec4\u8272\uff08\u53ef\u80fd\u4e0e\u91cd\u94fe\u540c\u8272\uff0c\u4f46\u5b9e\u9645\u662f\u4e0d\u540c\u86cb\u767d\uff09\u3002<br \/>\nPeptide\uff08\u80bd\u6bb5\uff09\uff1a\u88abMHC I\u5448\u9012\u7684\u6297\u539f\u80bd\uff0c\u901a\u5e38\u4e3a8\u201310\u4e2a\u6c28\u57fa\u9178\u957f\uff0c\u6765\u81ea\u7ec6\u80de\u5185\u964d\u89e3\u7684\u86cb\u767d\u8d28\uff08\u5982\u75c5\u6bd2\u86cb\u767d\uff09\u3002\u56fe\u4e2d\u4e3a\u7ea2\u8272\u3002<br \/>\nPolymorphic residue 116\uff1a\u6307\u5728HLA-B44:02\u548cHLA-B44:05\u8fd9\u4e24\u4e2a\u975e\u5e38\u76f8\u4f3c\u7684\u7b49\u4f4d\u57fa\u56e0\u4e4b\u95f4\uff0c\u7b2c116\u4f4d\u6c28\u57fa\u9178\u4e0d\u540c\uff08\u8fd9\u662f\u5b83\u4eec\u7684\u4e3b\u8981\u533a\u522b\uff09\u3002\u8be5\u6b8b\u57fa\u4f4d\u4e8e\u80bd\u7ed3\u5408\u69fd\u5e95\u90e8\uff0c\u5f71\u54cd\u80bd\u7684\u9009\u62e9\u548cT\u7ec6\u80de\u8bc6\u522b\u3002\u56fe\u4e2d\u7528\u84dd\u8272\u6807\u51fa\u3002<\/li>\n<li>\uff08B\uff09\u90e8\u5206\uff1a<br \/>\n\u8fd9\u662f\u5728\u6bd4\u8f83\u4e24\u4e2a\u9ad8\u5ea6\u76f8\u4f3c\u7684HLA-B44\u4e9a\u578b\u7684\u6676\u4f53\u7ed3\u6784\uff1a<br \/>\nB4402\uff1a\u6765\u81eaPDB\u6570\u636e\u5e93\u7f16\u53f7 1M6O\uff0c\u56fe\u4e2d\u7eff\u8272\u3002<br \/>\nB4405\uff1a\u6765\u81eaPDB\u7f16\u53f7 1SYV\uff0c\u56fe\u4e2d\u84dd\u8272\u3002<br \/>\nRMSD = 0.3 \u00c5\uff1aRMSD\uff08Root Mean Square Deviation\uff0c\u5747\u65b9\u6839\u504f\u5dee\uff09\u662f\u8861\u91cf\u4e24\u4e2a\u7ed3\u6784\u76f8\u4f3c\u5ea6\u7684\u6307\u6807\u30020.3\u57c3\uff08\u00c5\uff09\u662f\u975e\u5e38\u5c0f\u7684\u5dee\u5f02\uff081 \u00c5 = 0.1 \u7eb3\u7c73\uff09\uff0c\u8bf4\u660e\u8fd9\u4e24\u4e2a\u5206\u5b50\u7684\u6574\u4f53\u4e09\u7ef4\u7ed3\u6784\u51e0\u4e4e\u5b8c\u5168\u76f8\u540c\uff0c\u4ec5\u5728\u4e2a\u522b\u6b8b\u57fa\uff08\u5982116\u4f4d\uff09\u6709\u5dee\u5f02\u3002<\/li>\n<li>\uff08C\uff09\u90e8\u5206\uff1a<br \/>\n\u8fd9\u662fMHC I\u5206\u5b50\u80bd\u7ed3\u5408\u69fd\uff08peptide-binding groove\uff09 \u7684\u6df7\u5408\u5c55\u793a\u65b9\u5f0f\uff1a<br \/>\nRibbon\uff1a\u663e\u793a\u86cb\u767d\u8d28\u9aa8\u67b6\u7684\u4e8c\u7ea7\u7ed3\u6784\u3002<br \/>\nSurface\uff1a\u663e\u793a\u5206\u5b50\u8868\u9762\uff08\u901a\u5e38\u662f\u9759\u7535\u52bf\u6216\u5f62\u72b6\uff09\uff0c\u7a81\u51fa\u80bd\u7ed3\u5408\u69fd\u7684\u51f9\u69fd\u5f62\u72b6\u3002<br \/>\n\u80bd\u7ed3\u5408\u69fd\u7531\u91cd\u94fe\u7684\u03b11\u548c\u03b12\u7ed3\u6784\u57df\u6784\u6210\uff0c\u50cf\u4e00\u4e2a\u201c\u6c9f\u201d\uff0c\u4e2d\u95f4\u5bb9\u7eb3\u6297\u539f\u80bd\u3002\u8fd9\u4e2a\u533a\u57df\u7684\u591a\u6001\u6027\u51b3\u5b9a\u4e86\u80fd\u7ed3\u5408\u54ea\u4e9b\u80bd\u3002<\/li>\n<\/ul>\n<h3 data-pm-slice=\"2 2 []\">\u5206\u5b50\u52a8\u529b\u5b66\u6a21\u62df\uff1a\u770b\u89c1\u201c\u67d4\u6027\u201d\u7684\u529b\u91cf<\/h3>\n<p>\u4e3a\u4e86\u4ece\u7269\u7406\u5c42\u9762\u89e3\u91ca\u201c\u95ed\u5408\u901f\u7387\u201d\u7684\u5dee\u5f02\uff0c\u7814\u7a76\u56e2\u961f\u8fdb\u884c\u4e86\u957f\u8fbe420\u7eb3\u79d2\u7684\u5206\u5b50\u52a8\u529b\u5b66\uff08MD\uff09\u6a21\u62df\u3002<\/p>\n<p>\u6a21\u62df\u7ed3\u679c\u663e\u793a\uff0c\u5728**\u6ca1\u6709\u80bd\u6bb5\u7ed3\u5408**\u7684\u72b6\u6001\u4e0b\uff1a<\/p>\n<ul class=\"list-paddingleft-1\">\n<li><strong>B*4405<\/strong><br \/>\n<section>\u8868\u73b0\u51fa\u9ad8\u5ea6\u7684\u201c\u53ef\u5851\u6027\u201d\uff0c\u5176\u80bd\u7ed3\u5408\u69fd\uff08F-pocket\uff09\u80fd\u63a2\u7d22\u591a\u79cd\u4e0d\u540c\u7684\u6784\u8c61\uff0c\u6574\u4f53\u5206\u5b50\u5448\u73b0\u51fa\u4e00\u79cd\u534f\u8c03\u7684\u201c\u626d\u8f6c\u201d\u8fd0\u52a8\u3002<\/section>\n<\/li>\n<li><strong>B*4402<\/strong><br \/>\n<section>\u6784\u8c61\u53d8\u5316\u8303\u56f4\u975e\u5e38\u6709\u9650\uff0c\u663e\u5f97\u50f5\u786c\u800c\u8fdf\u949d\u3002<\/section>\n<\/li>\n<\/ul>\n<p>**\u7ed3\u8bba\u4e00\u76ee\u4e86\u7136\uff1aMHC-I\u5206\u5b50\u7684\u5185\u5728\u201c\u67d4\u6027\u201d\uff08\u53ef\u5851\u6027\uff09\u76f4\u63a5\u51b3\u5b9a\u4e86\u5176\u6784\u8c61\u8f6c\u6362\uff08\u95ed\u5408\uff09\u7684\u901f\u7387\uff0c\u8fdb\u800c\u51b3\u5b9a\u4e86\u5176\u6297\u539f\u9009\u62e9\u529f\u80fd\u7684\u5f3a\u5f31\u3002**<\/p>\n<p>\u66f4\u4ee4\u4eba\u4fe1\u670d\u7684\u662f\uff0c\u7814\u7a76\u8005\u901a\u8fc7\u5b9a\u70b9\u7a81\u53d8\uff08W147A\uff09\u4eba\u4e3a\u964d\u4f4e\u4e86B*4405\u7684\u67d4\u6027\uff0c\u7ed3\u679c\u5176\u6297\u539f\u9009\u62e9\u529f\u80fd\u679c\u7136\u53d8\u5f97\u548cB*4402\u4e00\u6837\u5dee\uff0c\u5b8c\u7f8e\u9a8c\u8bc1\u4e86\u8fd9\u4e00\u673a\u5236\u3002<\/p>\n<p><img decoding=\"async\" class=\"alignnone size-large wp-image-1669\" src=\"https:\/\/guixiong.com.cn\/wp-content\/uploads\/2026\/02\/MHC-I\u5206\u5b50\u7684\u67d4\u6027-2-761x1024.jpg\" alt=\"\" width=\"761\" height=\"1024\" srcset=\"https:\/\/guixiong.com.cn\/wp-content\/uploads\/2026\/02\/MHC-I\u5206\u5b50\u7684\u67d4\u6027-2-761x1024.jpg 761w, https:\/\/guixiong.com.cn\/wp-content\/uploads\/2026\/02\/MHC-I\u5206\u5b50\u7684\u67d4\u6027-2-223x300.jpg 223w, https:\/\/guixiong.com.cn\/wp-content\/uploads\/2026\/02\/MHC-I\u5206\u5b50\u7684\u67d4\u6027-2-768x1034.jpg 768w, https:\/\/guixiong.com.cn\/wp-content\/uploads\/2026\/02\/MHC-I\u5206\u5b50\u7684\u67d4\u6027-2.jpg 821w\" sizes=\"(max-width: 761px) 100vw, 761px\" \/><\/p>\n<p>\u4e0a\u56fe\u7684\u610f\u601d\u662f\uff1a<\/p>\n<h6 class=\"qk-md-head\"><strong class=\"qk-md-strong complete\"><span class=\"qk-md-text complete\">(A) \u56fe \u65f6\u95f4\u4f9d\u8d56\u7684\u80bd\u9009\u62e9\uff08\u901a\u8fc7\u8109\u51b2\u8ffd\u8e2a + \u70ed\u7a33\u5b9a\u6027\u68c0\u6d4b\uff09<\/span><\/strong><\/h6>\n<ul class=\"qk-md-ul\">\n<li class=\"qk-md-li complete\"><strong class=\"qk-md-strong complete\"><span class=\"qk-md-text complete\">\u65b9\u6cd5<\/span><\/strong><span class=\"qk-md-text complete\">\uff1a\u7528\u653e\u5c04\u6027\u540c\u4f4d\u7d20\u00b3\u2075S-\u7532\u786b\u6c28\u9178\u5bf9tapasin\u7f3a\u5931\u7684721.220\u7ec6\u80de\u8fdb\u884c<\/span><strong class=\"qk-md-strong complete\"><span class=\"qk-md-text complete\">5\u5206\u949f\u8109\u51b2\u6807\u8bb0<\/span><\/strong><span class=\"qk-md-text complete\">\uff0c\u7136\u540e\u5728\u4e0d\u540c\u65f6\u95f4\u70b9\u201c\u8ffd\u8e2a\u201d\uff08chase\uff09\u3002<\/span><\/li>\n<li class=\"qk-md-li complete\"><span class=\"qk-md-text complete\">\u7ec6\u80de\u88c2\u89e3\u540e\uff0c\u5c06\u6837\u54c1\u52a0\u70ed\u5230\u4e0d\u540c\u6e29\u5ea6\uff084\u00b0C\u300137\u00b0C\u300150\u00b0C\uff09\uff0c\u53ea\u6709<\/span><strong class=\"qk-md-strong complete\"><span class=\"qk-md-text complete\">\u7ed3\u5408\u4e86\u9ad8\u4eb2\u548c\u529b\u80bd\u7684MHC I<\/span><\/strong><span class=\"qk-md-text complete\">\u624d\u80fd\u8010\u53d7\u9ad8\u6e29\u800c\u4e0d\u89e3\u805a\u3002<\/span><\/li>\n<li class=\"qk-md-li complete\"><strong class=\"qk-md-strong complete\"><span class=\"qk-md-text complete\">\u76ee\u7684<\/span><\/strong><span class=\"qk-md-text complete\">\uff1a\u901a\u8fc7\u70ed\u7a33\u5b9a\u6027\u95f4\u63a5\u53cd\u6620MHC I\u6240\u7ed3\u5408\u80bd\u7684\u4eb2\u548c\u529b\u968f\u65f6\u95f4\u7684\u53d8\u5316\u3002<\/span><\/li>\n<li class=\"qk-md-li complete\"><strong class=\"qk-md-strong complete\"><span class=\"qk-md-text complete\">\u7ed3\u679c\u91cf\u5316\u89c1(F)<\/span><\/strong><span class=\"qk-md-text complete\">\u3002<\/span><\/li>\n<\/ul>\n<h6 class=\"qk-md-head\"><strong class=\"qk-md-strong complete\"><span class=\"qk-md-text complete\">(B) \u56fe MHC I\u5411\u7ec6\u80de\u8868\u9762\u8f6c\u8fd0\u7684\u52a8\u529b\u5b66\uff08\u901a\u8fc7EndoH\u6297\u6027\u6d4b\u5b9a\uff09<\/span><\/strong><\/h6>\n<ul class=\"qk-md-ul\">\n<li class=\"qk-md-li complete\"><strong class=\"qk-md-strong complete\"><span class=\"qk-md-text complete\">EndoH\uff08\u5185\u5207\u7cd6\u82f7\u9176H\uff09<\/span><\/strong><span class=\"qk-md-text complete\">\uff1a\u53ea\u80fd\u5207\u5272<\/span><strong class=\"qk-md-strong complete\"><span class=\"qk-md-text complete\">\u672a\u7ecf\u8fc7\u9ad8\u5c14\u57fa\u4f53\u4fee\u9970<\/span><\/strong><span class=\"qk-md-text complete\">\u7684N-\u7cd6\u94fe\u3002\u56e0\u6b64\uff1a<\/span>\n<ul class=\"qk-md-ul\">\n<li class=\"qk-md-li complete\"><strong class=\"qk-md-strong complete\"><span class=\"qk-md-text complete\">EndoH\u654f\u611f\uff08ES\uff09<\/span><\/strong><span class=\"qk-md-text complete\">\u00a0\u2192 MHC I\u8fd8\u5728\u5185\u8d28\u7f51\u6216\u987a\u9762\u9ad8\u5c14\u57fa\u4f53\u524d\uff08\u672a\u6210\u719f\uff09\u3002<\/span><\/li>\n<li class=\"qk-md-li complete\"><strong class=\"qk-md-strong complete\"><span class=\"qk-md-text complete\">EndoH\u6297\u6027\uff08ER\uff09<\/span><\/strong><span class=\"qk-md-text complete\">\u00a0\u2192 MHC I\u5df2\u901a\u8fc7\u987a\u9762\u9ad8\u5c14\u57fa\u4f53\uff0c\u6b63\u5728\/\u5df2\u5230\u8fbe\u7ec6\u80de\u8868\u9762\uff08\u6210\u719f\uff09\u3002<\/span><\/li>\n<\/ul>\n<\/li>\n<li class=\"qk-md-li complete\"><span class=\"qk-md-text complete\">\u4f7f\u7528\u6297\u4f53W6\/32\u514d\u75ab\u6c89\u6dc0MHC I\uff0c\u5e76\u68c0\u6d4b\u5176EndoH\u6297\u6027\u6bd4\u4f8b\uff0c\u4ece\u800c\u63a8\u65ad<\/span><strong class=\"qk-md-strong complete\"><span class=\"qk-md-text complete\">MHC I\u79bb\u5f00\u5185\u8d28\u7f51\u3001\u8f6c\u8fd0\u5230\u8868\u9762\u7684\u901f\u5ea6<\/span><\/strong><span class=\"qk-md-text complete\">\u3002<\/span><\/li>\n<li class=\"qk-md-li complete\"><strong class=\"qk-md-strong complete\"><span class=\"qk-md-text complete\">\u7279\u522b\u8bf4\u660e<\/span><\/strong><span class=\"qk-md-text complete\">\uff1a\u5b9e\u9a8c\u8bbe\u8ba1\u53ea\u6355\u83b7<\/span><strong class=\"qk-md-strong complete\"><span class=\"qk-md-text complete\">\u7ed3\u5408\u4e86\u9ad8\u4eb2\u548c\u529b\u80bd\u7684MHC I<\/span><\/strong><span class=\"qk-md-text complete\">\uff08\u56e0W6\/32\u53ea\u8bc6\u522b\u6b63\u786e\u6298\u53e0\u4e14\u80bd\u7ed3\u5408\u7a33\u5b9a\u7684MHC I\uff09\u3002<\/span><\/li>\n<li class=\"qk-md-li complete\"><strong class=\"qk-md-strong complete\"><span class=\"qk-md-text complete\">\u7ed3\u679c\u91cf\u5316\u89c1(G)<\/span><\/strong><span class=\"qk-md-text complete\">\u3002<\/span><\/li>\n<\/ul>\n<h6 class=\"qk-md-head\"><strong class=\"qk-md-strong complete\"><span class=\"qk-md-text complete\">(C) <\/span><\/strong><strong class=\"qk-md-strong complete\"><span class=\"qk-md-text complete\">\u56fe <\/span><\/strong><strong class=\"qk-md-strong complete\" style=\"font-family: inherit;\"><span class=\"qk-md-text complete\">\u65e0tapasin\u6761\u4ef6\u4e0b\u80bd\u9009\u62e9\u7684\u8ba1\u7b97\u7cfb\u7edf\u6a21\u578b<\/span><\/strong><\/h6>\n<ul class=\"qk-md-ul\">\n<li class=\"qk-md-li complete\"><span class=\"qk-md-text complete\">\u7528<\/span><strong class=\"qk-md-strong complete\"><span class=\"qk-md-text complete\">\u8ba1\u7b97\u6a21\u578b<\/span><\/strong><span class=\"qk-md-text complete\">\u6a21\u62dfMHC I\u5728\u5185\u8d28\u7f51\u4e2d\u5982\u4f55\u81ea\u4e3b\u9009\u62e9\u80bd\u3002<\/span><\/li>\n<li class=\"qk-md-li complete\"><span class=\"qk-md-text complete\">\u56fe\u4e2d\uff1a<\/span>\n<ul class=\"qk-md-ul\">\n<li class=\"qk-md-li complete\"><strong class=\"qk-md-strong complete\"><span class=\"qk-md-text complete\">\u5f62\u72b6\uff08shapes\uff09<\/span><\/strong><span class=\"qk-md-text complete\">\uff1a\u4ee3\u8868\u4e0d\u540c\u5206\u5b50\u72b6\u6001\uff08\u5982\u7a7a\u8f7dMHC I\u3001\u80bd-MHC\u590d\u5408\u7269\u7b49\uff09\u3002<\/span><\/li>\n<li class=\"qk-md-li complete\"><strong class=\"qk-md-strong complete\"><span class=\"qk-md-text complete\">\u5e26\u6807\u7b7e\u7684\u65b9\u6846<\/span><\/strong><span class=\"qk-md-text complete\">\uff1a\u4ee3\u8868\u5316\u5b66\u53cd\u5e94\u6b65\u9aa4\uff08\u5982\u80bd\u7ed3\u5408\u3001MHC\u6784\u8c61\u53d8\u5316\uff09\uff0c\u5e76\u6807\u6709\u901f\u7387\u53c2\u6570\uff08\u5982\u7ed3\u5408\u901f\u7387k_on\u3001\u89e3\u79bb\u901f\u7387k_off\u7b49\uff09\u3002<\/span><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h6 class=\"qk-md-head\"><strong class=\"qk-md-strong complete\"><span class=\"qk-md-text complete\">(D)<\/span><\/strong><strong class=\"qk-md-strong complete\"><span class=\"qk-md-text complete\">\u56fe\u00a0<\/span><\/strong><strong class=\"qk-md-strong complete\"><span class=\"qk-md-text complete\">\u4e24\u79cd\u53ef\u80fd\u7684\u7ed3\u5408\u673a\u5236\u6a21\u578b<\/span><\/strong><\/h6>\n<ul class=\"qk-md-ul\">\n<li class=\"qk-md-li complete\"><strong class=\"qk-md-strong complete\"><span class=\"qk-md-text complete\">\u5355\u6784\u8c61\u6a21\u578b\uff08one-conformation\uff09<\/span><\/strong><span class=\"qk-md-text complete\">\uff1a\u5047\u8bbeMHC I\u53ea\u6709\u4e00\u4e2a\u6784\u8c61\u72b6\u6001\uff0c\u80bd\u76f4\u63a5\u7ed3\u5408\u3002<\/span><\/li>\n<li class=\"qk-md-li complete\"><strong class=\"qk-md-strong complete\"><span class=\"qk-md-text complete\">\u53cc\u6784\u8c61\u6a21\u578b\uff08two-conformation\uff09<\/span><\/strong><span class=\"qk-md-text complete\">\uff1a\u5047\u8bbeMHC I\u53ef\u5728\u201c\u5f00\u653e\u201d\uff08open\uff0c\u6613\u7ed3\u5408\u80bd\uff09\u548c\u201c\u95ed\u5408\u201d\uff08closed\uff0c\u7a33\u5b9a\u80bd-MHC\uff09\u4e4b\u95f4\u8f6c\u6362\u3002<\/span><\/li>\n<li class=\"qk-md-li complete\"><strong class=\"qk-md-strong complete\"><span class=\"qk-md-text complete\">\u7ea2\u8272\u7c97\u7ebf\/\u7b26\u53f7<\/span><\/strong><span class=\"qk-md-text complete\">\uff1a\u8868\u793a<\/span><strong class=\"qk-md-strong complete\"><span class=\"qk-md-text complete\">\u80bd\u4f9d\u8d56\u7684\u53cd\u5e94\u6b65\u9aa4<\/span><\/strong><span class=\"qk-md-text complete\">\uff08\u5373\u53ea\u6709\u5728\u80bd\u5b58\u5728\u65f6\u624d\u53d1\u751f\uff0c\u5982MHC\u4ece\u5f00\u653e\u53d8\u4e3a\u95ed\u5408\uff09\u3002<\/span><\/li>\n<\/ul>\n<h6 class=\"qk-md-head\"><strong class=\"qk-md-strong complete\"><span class=\"qk-md-text complete\">(E) \u56fe \u6a21\u578b\u6bd4\u8f83\u4e0e\u6700\u4f18\u6a21\u578b\u9009\u62e9<\/span><\/strong><\/h6>\n<ul class=\"qk-md-ul\">\n<li class=\"qk-md-li complete\"><span class=\"qk-md-text complete\">\u4f7f\u7528<\/span><strong class=\"qk-md-strong complete\"><span class=\"qk-md-text complete\">\u8d1d\u53f6\u65af\u4fe1\u606f\u51c6\u5219\uff08BIC\uff09<\/span><\/strong><span class=\"qk-md-text complete\">\u00a0\u6bd4\u8f83\u4e0d\u540c\u6a21\u578b\u7684\u62df\u5408\u4f18\u5ea6\uff08BIC\u8d8a\u4f4e\u8d8a\u597d\uff09\u3002<\/span><\/li>\n<li class=\"qk-md-li complete\"><strong class=\"qk-md-strong complete\"><span class=\"qk-md-text complete\">\u6700\u4f18\u6a21\u578b<\/span><\/strong><span class=\"qk-md-text complete\">\uff1a<\/span><strong class=\"qk-md-strong complete\"><span class=\"qk-md-text complete\">\u53cc\u6784\u8c61\u6a21\u578b<\/span><\/strong><span class=\"qk-md-text complete\">\uff0c\u5176\u4e2d\uff1a<\/span>\n<ul class=\"qk-md-ul\">\n<li class=\"qk-md-li complete\"><strong class=\"qk-md-strong complete\"><span class=\"qk-md-text complete\">\u80bd\u4f9d\u8d56\u7684\u6b65\u9aa4\u662fMHC I\u7684\u201c\u6253\u5f00\u201d\uff08opening\uff09<\/span><\/strong><span class=\"qk-md-text complete\">\uff1b<\/span><\/li>\n<li class=\"qk-md-li complete\"><strong class=\"qk-md-strong complete\"><span class=\"qk-md-text complete\">\u7b49\u4f4d\u57fa\u56e0\u7279\u5f02\u6027\u53c2\u6570\u662f\u201c\u95ed\u5408\u901f\u7387c\u201d<\/span><\/strong><span class=\"qk-md-text complete\">\uff08\u5373\u4e0d\u540cHLA\u7b49\u4f4d\u57fa\u56e0\u5173\u95ed\u901f\u5ea6\u4e0d\u540c\uff0c\u5f71\u54cd\u80bd\u9009\u62e9\u6548\u7387\uff09\u3002<\/span><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h6 class=\"qk-md-head\"><strong class=\"qk-md-strong complete\"><span class=\"qk-md-text complete\">(F) \u56fe \u5b9e\u9a8c vs \u6a21\u578b\u6a21\u62df\uff1a\u70ed\u7a33\u5b9a\u6027\u6570\u636e<\/span><\/strong><\/h6>\n<ul class=\"qk-md-ul\">\n<li class=\"qk-md-li complete\"><strong class=\"qk-md-strong complete\"><span class=\"qk-md-text complete\">\u5706\u5708<\/span><\/strong><span class=\"qk-md-text complete\">\uff1a\u6765\u81ea(A)\u7684\u5b9e\u9a8c\u6570\u636e\uff08\u4e0d\u540c\u6e29\u5ea6\u4e0b\u5269\u4f59MHC I\u6bd4\u4f8b\uff09\u3002<\/span><\/li>\n<li class=\"qk-md-li complete\"><strong class=\"qk-md-strong complete\"><span class=\"qk-md-text complete\">\u5b9e\u7ebf<\/span><\/strong><span class=\"qk-md-text complete\">\uff1a\u6700\u4f18\u6a21\u578b\u7684\u6a21\u62df\u7ed3\u679c\u3002<\/span><\/li>\n<li class=\"qk-md-li complete\"><strong class=\"qk-md-strong complete\"><span class=\"qk-md-text complete\">\u989c\u8272\u542b\u4e49<\/span><\/strong><span class=\"qk-md-text complete\">\uff1a<\/span>\n<ul class=\"qk-md-ul\">\n<li class=\"qk-md-li complete\"><strong class=\"qk-md-strong complete\"><span class=\"qk-md-text complete\">\u84dd\u8272\uff084\u00b0C\uff09<\/span><\/strong><span class=\"qk-md-text complete\">\uff1a\u6240\u6709MHC I\uff08\u65e0\u8bba\u80bd\u4eb2\u548c\u529b\u9ad8\u4f4e\uff09\u90fd\u7a33\u5b9a\u3002<\/span><\/li>\n<li class=\"qk-md-li complete\"><strong class=\"qk-md-strong complete\"><span class=\"qk-md-text complete\">\u7eff\u8272\uff0837\u00b0C\uff09<\/span><\/strong><span class=\"qk-md-text complete\">\uff1a\u4e2d+\u9ad8\u4eb2\u548c\u529b\u80bd-MHC\u590d\u5408\u7269\u7a33\u5b9a\u3002<\/span><\/li>\n<li class=\"qk-md-li complete\"><strong class=\"qk-md-strong complete\"><span class=\"qk-md-text complete\">\u7ea2\u8272\uff0850\u00b0C\uff09<\/span><\/strong><span class=\"qk-md-text complete\">\uff1a\u4ec5\u9ad8\u4eb2\u548c\u529b\u80bd-MHC\u590d\u5408\u7269\u7a33\u5b9a\u3002<\/span><\/li>\n<\/ul>\n<\/li>\n<li class=\"qk-md-li complete\"><strong class=\"qk-md-strong complete\"><span class=\"qk-md-text complete\">\u9634\u5f71\u533a\u57df<\/span><\/strong><span class=\"qk-md-text complete\">\uff1a95%\u7f6e\u4fe1\u533a\u95f4\uff0c\u53cd\u6620\u6a21\u578b\u4e0d\u786e\u5b9a\u6027\u3002<\/span><\/li>\n<\/ul>\n<h6 class=\"qk-md-head\"><strong class=\"qk-md-strong complete\"><span class=\"qk-md-text complete\">(G) \u56fe \u5b9e\u9a8c vs \u6a21\u578b\u6a21\u62df\uff1a\u7ec6\u80de\u8868\u9762\u8f6c\u8fd0\uff08EndoH\u6297\u6027\uff09<\/span><\/strong><\/h6>\n<ul class=\"qk-md-ul\">\n<li class=\"qk-md-li complete\"><strong class=\"qk-md-strong complete\"><span class=\"qk-md-text complete\">\u5706\u5708<\/span><\/strong><span class=\"qk-md-text complete\">\uff1a\u6765\u81ea(B)\u7684EndoH\u6297\u6027\u767e\u5206\u6bd4\uff08\u5373\u5df2\u8f6c\u8fd0\u51fa\u5185\u8d28\u7f51\u7684MHC I\u6bd4\u4f8b\uff09\u3002<\/span><\/li>\n<li class=\"qk-md-li complete\"><strong class=\"qk-md-strong complete\"><span class=\"qk-md-text complete\">\u5b9e\u7ebf<\/span><\/strong><span class=\"qk-md-text complete\">\uff1a\u6a21\u578b\u9884\u6d4b\u7684\u8f6c\u8fd0\u52a8\u529b\u5b66\u3002<\/span><\/li>\n<li class=\"qk-md-li complete\"><span class=\"qk-md-text complete\">\u540c\u6837\u663e\u793a\u6a21\u578b\u80fd\u5f88\u597d\u5730\u62df\u5408\u5b9e\u9a8c\u6570\u636e\u3002<\/span><\/li>\n<\/ul>\n<h6 class=\"qk-md-head\"><strong class=\"qk-md-strong complete\"><span class=\"qk-md-text complete\">(H) \u56fe\u7b49\u4f4d\u57fa\u56e0\u7279\u5f02\u6027\u95ed\u5408\u901f\u7387c\u7684\u540e\u9a8c\u6982\u7387\u5206\u5e03<\/span><\/strong><\/h6>\n<ul class=\"qk-md-ul\">\n<li class=\"qk-md-li complete\"><span class=\"qk-md-text complete\">\u4f7f\u7528<\/span><strong class=\"qk-md-strong complete\"><span class=\"qk-md-text complete\">\u8d1d\u53f6\u65af\u63a8\u65ad<\/span><\/strong><span class=\"qk-md-text complete\">\uff0c\u6839\u636e\u5b9e\u9a8c\u6570\u636e\u53cd\u63a8\u53c2\u6570\u201cc\u201d\uff08MHC I\u95ed\u5408\u901f\u7387\uff09\u7684\u53ef\u80fd\u53d6\u503c\u3002<\/span><\/li>\n<li class=\"qk-md-li complete\"><strong class=\"qk-md-strong complete\"><span class=\"qk-md-text complete\">\u6a2a\u8f74<\/span><\/strong><span class=\"qk-md-text complete\">\uff1a\u95ed\u5408\u901f\u7387c\u7684\u6570\u503c\u3002<\/span><\/li>\n<li class=\"qk-md-li complete\"><strong class=\"qk-md-strong complete\"><span class=\"qk-md-text complete\">\u7eb5\u8f74<\/span><\/strong><span class=\"qk-md-text complete\">\uff1a\u8be5\u503c\u5728\u7ed9\u5b9a\u6570\u636e\u548c\u6a21\u578b\u4e0b\u7684<\/span><strong class=\"qk-md-strong complete\"><span class=\"qk-md-text complete\">\u540e\u9a8c\u6982\u7387\u5bc6\u5ea6<\/span><\/strong><span class=\"qk-md-text complete\">\u3002<\/span><\/li>\n<li class=\"qk-md-li complete\"><span class=\"qk-md-text complete\">\u5cf0\u503c\u4f4d\u7f6e\u8868\u793a\u6700\u53ef\u80fd\u7684c\u503c\uff0c\u5bbd\u5ea6\u53cd\u6620\u4e0d\u786e\u5b9a\u6027\u3002<\/span><\/li>\n<li class=\"qk-md-li complete\"><span class=\"qk-md-text complete\">\u4e0d\u540c\u7b49\u4f4d\u57fa\u56e0\uff08\u5982HLA-B<\/span><em class=\"qk-md-em\"><span class=\"qk-md-text complete\">44:02 vs B<\/span><\/em><span class=\"qk-md-text complete\">44:05\uff09\u4f1a\u6709\u4e0d\u540c\u7684c\u503c\uff0c\u89e3\u91ca\u5176\u80bd\u9009\u62e9\u6548\u7387\u5dee\u5f02\u3002<\/span><\/li>\n<\/ul>\n<div class=\"qk-md-paragraph\"><span class=\"qk-md-text complete\">\u8fd9\u9879\u7814\u7a76\u901a\u8fc7<\/span><strong class=\"qk-md-strong complete\"><span class=\"qk-md-text complete\">\u5b9e\u9a8c + \u8ba1\u7b97\u5efa\u6a21<\/span><\/strong><span class=\"qk-md-text complete\">\u63ed\u793a\uff1a<\/span><\/div>\n<ol class=\"qk-md-ol\" start=\"1\">\n<li class=\"qk-md-li complete\"><span class=\"qk-md-text complete\">\u5373\u4f7f\u5728<\/span><strong class=\"qk-md-strong complete\"><span class=\"qk-md-text complete\">\u6ca1\u6709tapasin<\/span><\/strong><span class=\"qk-md-text complete\">\u7684\u60c5\u51b5\u4e0b\uff0cMHC I\u4ecd\u80fd\u901a\u8fc7<\/span><strong class=\"qk-md-strong complete\"><span class=\"qk-md-text complete\">\u81ea\u8eab\u6784\u8c61\u52a8\u6001<\/span><\/strong><span class=\"qk-md-text complete\">\uff08\u5f00\u653e\u2194\u95ed\u5408\uff09\u9009\u62e9\u9ad8\u4eb2\u548c\u529b\u80bd\uff1b<\/span><\/li>\n<li class=\"qk-md-li complete\"><strong class=\"qk-md-strong complete\"><span class=\"qk-md-text complete\">\u4e0d\u540cHLA\u7b49\u4f4d\u57fa\u56e0\u7684\u5dee\u5f02<\/span><\/strong><span class=\"qk-md-text complete\">\u4e3b\u8981\u4f53\u73b0\u5728<\/span><strong class=\"qk-md-strong complete\"><span class=\"qk-md-text complete\">\u95ed\u5408\u901f\u7387\uff08c\uff09<\/span><\/strong><span class=\"qk-md-text complete\">\u00a0\u4e0a\u2014\u2014\u8fd9\u51b3\u5b9a\u4e86\u5b83\u4eec\u201c\u9501\u5b9a\u201d\u5408\u9002\u80bd\u7684\u901f\u5ea6\uff1b<\/span><\/li>\n<li class=\"qk-md-li complete\"><strong class=\"qk-md-strong complete\"><span class=\"qk-md-text complete\">\u53cc\u6784\u8c61\u6a21\u578b<\/span><\/strong><span class=\"qk-md-text complete\">\u6bd4\u4f20\u7edf\u5355\u6784\u8c61\u6a21\u578b\u66f4\u80fd\u89e3\u91ca\u5b9e\u9a8c\u89c2\u5bdf\u5230\u7684\u80bd\u9009\u62e9\u548c\u8f6c\u8fd0\u52a8\u529b\u5b66\uff1b<\/span><\/li>\n<li class=\"qk-md-li complete\"><span class=\"qk-md-text complete\">\u8fd9\u4e00\u673a\u5236\u53ef\u89e3\u91ca\u4e3a\u4f55\u67d0\u4e9bHLA\u7b49\u4f4d\u57fa\u56e0\uff08\u5982B<\/span><em class=\"qk-md-em\"><span class=\"qk-md-text complete\">44:02 vs B<\/span><\/em><span class=\"qk-md-text complete\">44:05\uff09\u5728\u514d\u75ab\u5e94\u7b54\u6216\u75be\u75c5\u6613\u611f\u6027\u4e0a\u8868\u73b0\u4e0d\u540c\u3002<\/span><\/li>\n<\/ol>\n<p><span data-pm-slice=\"2 2 [&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;style&quot;:&quot;scrollbar-width: none;color: rgb(51, 51, 51);font-family: -apple-system, BlinkMacSystemFont, \\&quot;Helvetica Neue\\&quot;, Helvetica, Arial, sans-serif;font-size: 16px;font-style: normal;font-variant-ligatures: normal;font-variant-caps: normal;font-weight: 400;letter-spacing: normal;orphans: 2;text-indent: 0px;text-transform: none;widows: 2;word-spacing: 0px;-webkit-text-stroke-width: 0px;white-space: normal;text-decoration-thickness: initial;text-decoration-style: initial;text-decoration-color: initial;margin-bottom: 15px;text-align: justify;&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;}]\">\u53c2\u8003\u6587\u732e\uff1a <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC5224517\/\" target=\"_blank\" rel=\"noopener\">Selector function of MHC I molecules is determined by protein plasticity<\/a>.\u00a0Sci Rep. 2015.\u00a0<\/span><\/p>\n<h3><span data-pm-slice=\"1 1 [&quot;heading&quot;,{&quot;tagName&quot;:&quot;h2&quot;,&quot;attributes&quot;:{&quot;style&quot;:&quot;-webkit-tap-highlight-color: rgba(0, 0, 0, 0);margin: 30px 0px 15px;padding: 0px 0px 6px;outline: 0px;font-weight: 400;font-size: 19px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;font-style: normal;font-variant-ligatures: normal;font-variant-caps: normal;orphans: 2;text-indent: 0px;text-transform: none;widows: 2;word-spacing: 0px;-webkit-text-stroke-width: 0px;white-space: normal;background-color: rgb(255, 255, 255);text-decoration-thickness: initial;text-decoration-style: initial;text-decoration-color: initial;scrollbar-width: none;font-family: \\&quot;PingFang SC\\&quot;, \\&quot;Helvetica Neue\\&quot;, Helvetica, Arial, sans-serif;letter-spacing: normal;text-align: start;color: rgb(25, 118, 210);border-bottom: 1px solid rgb(238, 238, 238);&quot;,&quot;data-pm-slice&quot;:&quot;2 1 []&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;,&quot;level&quot;:2}]\">\u5982\u4f55\u5c06\u8f6c\u5316\u4e3a\u7814\u7a76\u6210\u679c\uff1f<\/span><\/h3>\n<p>\u6842\u828e\u751f\u7269\u53ef\u63d0\u4f9b\u5173\u952e\u4ea7\u54c1\u652f\u6491\uff1a<\/p>\n<p data-pm-slice=\"0 0 []\"><strong>1.\u00a0<span data-pm-slice=\"1 1 [&quot;para&quot;,{&quot;tagName&quot;:&quot;p&quot;,&quot;attributes&quot;:{},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;node&quot;,{&quot;tagName&quot;:&quot;strong&quot;,&quot;attributes&quot;:{&quot;style&quot;:&quot;scrollbar-width: none;&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;}]\"><a href=\"https:\/\/www.guixiong.com.cn\/?page_id=1192\" target=\"_blank\" rel=\"noopener\">\u5fae\u91cfpMHC\u590d\u5408\u7269\u5408\u6210\u670d\u52a1<\/a>:\u00a0<\/span><\/strong>\u652f\u6301HLA-A*02:01\u7b4933\u79cd\u4e3b\u6d41HLA\u7b49\u4f4d\u57fa\u56e0\uff0c\u7528\u4e8e\u6297\u539f\u7279\u5f02\u6027T\u7ec6\u80de\u9a8c\u8bc1<\/p>\n<p><strong>2\u00a0<span data-pm-slice=\"1 1 [&quot;para&quot;,{&quot;tagName&quot;:&quot;p&quot;,&quot;attributes&quot;:{},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;node&quot;,{&quot;tagName&quot;:&quot;strong&quot;,&quot;attributes&quot;:{&quot;style&quot;:&quot;scrollbar-width: none;&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;}]\">.\u00a0<a href=\"https:\/\/www.guixiong.com.cn\/?page_id=133\" target=\"_blank\" rel=\"noopener\">pMHC\u8367\u5149\u56db\u805a\u4f53\u5408\u6210\u4ee5\u53ca\u7b5b\u9009<\/a>:\u00a0<\/span><\/strong>\u73b0\u8d27\u8986\u76d6\u591a\u79cd\u80bf\u7624\u6297\u539f\uff08\u5982HPV\/CMV\/EBV\/KRAS\u7b49\uff09\uff0c\u5feb\u901f\u5206\u9009\u6297\u539f\u7279\u5f02\u6027T\u7ec6\u80de<\/p>\n<p><strong>3.\u00a0<span data-pm-slice=\"1 1 [&quot;para&quot;,{&quot;tagName&quot;:&quot;p&quot;,&quot;attributes&quot;:{},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;node&quot;,{&quot;tagName&quot;:&quot;strong&quot;,&quot;attributes&quot;:{&quot;style&quot;:&quot;scrollbar-width: none;&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;}]\"><a href=\"https:\/\/www.guixiong.com.cn\/?page_id=546\" target=\"_blank\" rel=\"noopener\">\u5de5\u7a0b\u5316\u5448\u9012\u7ec6\u80de\u6784\u5efa<\/a>:\u00a0<\/span><\/strong>K562-HLA\u7cfb\u5217\uff0c\u6a21\u62df\u4f53\u5185\u6297\u539f\u5448\u9012\uff0c\u7528\u4e8eDC\u529f\u80fd\u6a21\u62df<\/p>\n<p><strong>4.\u00a0<span data-pm-slice=\"1 1 [&quot;para&quot;,{&quot;tagName&quot;:&quot;p&quot;,&quot;attributes&quot;:{},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;node&quot;,{&quot;tagName&quot;:&quot;strong&quot;,&quot;attributes&quot;:{&quot;style&quot;:&quot;scrollbar-width: none;&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;}]\"><a href=\"https:\/\/www.guixiong.com.cn\/?page_id=1489\" target=\"_blank\" rel=\"noopener\">\u5355\u514b\u9686TCR\u6d4b\u5e8f<\/a>:\u00a0<\/span><\/strong>\u4ece\u56db\u805a\u4f53\u9633\u6027T\u7ec6\u80de\u4e2d\u83b7\u53d6\u914d\u5bf9\u94fe\u7684TCR\u4e3b\u514b\u9686<\/p>\n<p><strong>5.\u00a0<span data-pm-slice=\"1 1 [&quot;para&quot;,{&quot;tagName&quot;:&quot;p&quot;,&quot;attributes&quot;:{},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;node&quot;,{&quot;tagName&quot;:&quot;strong&quot;,&quot;attributes&quot;:{&quot;style&quot;:&quot;scrollbar-width: none;&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;}]\"><a href=\"https:\/\/www.guixiong.com.cn\/?page_id=1197\" target=\"_blank\" rel=\"noopener\">\u6297\u539f\u80bd-MHC\u4eb2\u548c\u529b\u9ad8\u901a\u91cfELISA\u626b\u63cf\u670d\u52a1<\/a>:\u00a0<\/span><\/strong>\u9ad8\u901a\u91cf\u7b5b\u9009\u6700\u4f18\u8868\u4f4d\uff0c\u6307\u5bfcDC\u75ab\u82d7\u8bbe\u8ba1<\/p>\n<p><strong>6.\u00a0<span data-pm-slice=\"1 1 [&quot;para&quot;,{&quot;tagName&quot;:&quot;p&quot;,&quot;attributes&quot;:{&quot;data-pm-slice&quot;:&quot;3 3 []&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;node&quot;,{&quot;tagName&quot;:&quot;strong&quot;,&quot;attributes&quot;:{&quot;style&quot;:&quot;scrollbar-width: none;&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;}]\"><a href=\"https:\/\/www.guixiong.com.cn\/?page_id=136\" target=\"_blank\" rel=\"noopener\">\u6297\u539f\u7279\u5f02\u6027T\u7ec6\u80de\u6269\u589e<\/a>:\u00a0<\/span><\/strong>\u6842\u828e\u62e5\u6709\u7a33\u5b9a\u7684\u6297\u539f\u7279\u5f02\u6027DC\u7684\u5206\u5316\u6210\u719f\u5de5\u827a\uff0c\u662f\u6297\u539f\u7279\u5f02\u6027T\u7ec6\u80de\u6269\u589e\u548c\u68c0\u6d4b\u7684\u57fa\u77f3\u3002<\/p>\n<p>\u70b9\u51fb\u7f51\u9875\u53f3\u4fa7\u201d\u5feb\u901f\u8054\u7cfb\u4eba\u201c\u626b\u7801\uff0c\u83b7\u53d6<strong>\u670d\u52a1\u65b9\u6848 + \u6210\u529f\u6848\u4f8b.<\/strong><\/p>\n<p>Views: 5<\/p>","protected":false},"excerpt":{"rendered":"<p>\u25b2 \u7814\u7a76\u63ed\u793a\uff0cMHC-I\u5206\u5b50\u5e76\u975e\u521a\u6027\u7ed3\u6784\uff0c\u5176\u5185\u5728\u7684\u201c\u53ef\u5851\u6027\u201d\uff08\u67d4\u6027\uff09\u51b3\u5b9a\u4e86\u5b83\u7b5b\u9009\u9ad8\u4eb2\u548c\u529b\u6297\u539f\u80bd\u7684\u80fd\u529b\u3002B*44&#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_kadence_starter_templates_imported_post":false,"_kad_post_transparent":"default","_kad_post_title":"default","_kad_post_layout":"default","_kad_post_sidebar_id":"","_kad_post_content_style":"default","_kad_post_vertical_padding":"default","_kad_post_feature":"","_kad_post_feature_position":"","_kad_post_header":false,"_kad_post_footer":false,"_kad_post_classname":"","footnotes":""},"class_list":["post-1668","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.guixiong.com.cn\/index.php?rest_route=\/wp\/v2\/pages\/1668","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.guixiong.com.cn\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.guixiong.com.cn\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.guixiong.com.cn\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.guixiong.com.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1668"}],"version-history":[{"count":2,"href":"https:\/\/www.guixiong.com.cn\/index.php?rest_route=\/wp\/v2\/pages\/1668\/revisions"}],"predecessor-version":[{"id":1672,"href":"https:\/\/www.guixiong.com.cn\/index.php?rest_route=\/wp\/v2\/pages\/1668\/revisions\/1672"}],"wp:attachment":[{"href":"https:\/\/www.guixiong.com.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1668"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}