{"id":22,"date":"2024-07-30T14:03:53","date_gmt":"2024-07-30T14:03:53","guid":{"rendered":"http:\/\/60.204.213.123\/wordpress\/?page_id=22"},"modified":"2026-01-11T14:02:56","modified_gmt":"2026-01-11T14:02:56","slug":"tcr%e6%8c%87%e5%af%bc%e7%9a%84%e8%82%bf%e7%98%a4%e6%8a%97%e5%8e%9f%e5%8f%91%e7%8e%b0-%e4%bb%a5%e9%9d%9e%e5%b0%8f%e7%bb%86%e8%83%9e%e8%82%ba%e7%99%8ctcr%e6%8a%97%e5%8e%9f%e5%8f%91%e7%8e%b0%e4%b8%ba","status":"publish","type":"page","link":"https:\/\/www.guixiong.com.cn\/?page_id=22","title":{"rendered":"TCR\u6307\u5bfc\u7684\u80bf\u7624\u6297\u539f\u53d1\u73b0-\u4ee5\u975e\u5c0f\u7ec6\u80de\u80ba\u764cTCR\u6297\u539f\u53d1\u73b0\u4e3a\u4f8b"},"content":{"rendered":"\r\n<h3 class=\"wp-block-heading\">\u80cc\u666f<\/h3>\r\n\r\n\r\n\r\n<p>\u53d1\u8868\u4e8e2021\u5e74Immunity\u7684<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7960510\/\" target=\"_blank\" rel=\"noreferrer noopener\">Global analysis of shared T cell specificities in human non-small cell lung cancer enables HLA inference and antigen discovery<\/a>\u4e00\u6587\uff0c\u63d0\u4f9b\u4e86\u4e00\u79cd\u65b0\u9896\u7684\u80bf\u7624\u6297\u539f\u53d1\u73b0\u4e4b\u8def\u3002<\/p>\r\n\r\n\r\n\r\n<p>\u6297\u539f\u7684\u591a\u7ec4\u5b66\u68c0\u6d4b\u5f80\u5f80\u662f\u80bf\u7624\u65b0\u6297\u539f\u53d1\u73b0\u7684\u4e3b\u8981\u8def\u5f84\uff0c\u800c\u4eceT\u7ec6\u80de\u53d7\u4f53\u6d4b\u5e8f\u6570\u636e\u5165\u624b\u627e\u80bf\u7624\u6297\u539f\u5219\u662f\u8be5\u6587\u65b0\u9896\u4e4b\u5904:<\/p>\r\n\r\n\r\n\r\n<p>\u65b0\u9896\u70b9\u5728\u4e8e\uff1a\u80bf\u7624\u65b0\u751f\u6297\u539f\u53d1\u73b0\u662f\u4ee5TILs\u7684TCR\u53cd\u5411\u5bfb\u627e\u6297\u539f\u3002<\/p>\r\n\r\n\r\n\r\n<p>\u6b64\u6cd5\u7684\u6838\u5fc3\u6b65\u9aa4\u662f\u5408\u6210TCR\u86cb\u767d\u591a\u805a\u4f53\uff0c\u4ecepMHC\u7a81\u53d8\u80bd\u9175\u6bcd\u8868\u9762\u5c55\u793a\u6587\u5e93\u4e2d\u7b5b\u9009\u6297\u539f\u3002\u5728\u6b64\uff0c\u6211\u4eec\u5c31\u8be6\u7ec6\u5c55\u5f00\u6574\u4e2a\u8fc7\u7a0b\uff0c\u4e3b\u8981\u52063\u4e2a\u9636\u6bb5\uff1a<\/p>\r\n\r\n\r\n\r\n<ol class=\"wp-block-list\">\r\n<li>TCR\u6d4b\u5e8f\u6570\u636e\u6536\u96c6\u3001\u5206\u6790\u3001\u9a8c\u8bc1<\/li>\r\n\r\n\r\n\r\n<li>HLA-A*02:01\u7a81\u53d8\u80bd\u9175\u6bcd\u8868\u9762\u5c55\u793a\u5e93\u7b5b\u9009\u6297\u539f<\/li>\r\n\r\n\r\n\r\n<li>\u9a8c\u8bc1\u6297\u539f\u7279\u5f02\u6027T\u7ec6\u80de\u7684\u7279\u6027<\/li>\r\n<\/ol>\r\n\r\n\r\n\r\n<figure class=\"wp-block-image\"><img decoding=\"async\" class=\"wp-image-1672\" src=\"http:\/\/www.haoshengmed.com\/wp-content\/uploads\/2024\/03\/image-8.png\" alt=\"\" \/><\/figure>\r\n\r\n\r\n\r\n<h3 class=\"wp-block-heading\">\u5173\u952eTCR\u6765\u81ea\u6570\u636e\u6316\u6398<\/h3>\r\n\r\n\r\n\r\n<p>TCR\u6570\u636e\u4ece\u6765\u81ea178\u4e2a\u60a3\u8005\u7684TCR\u6d4b\u5e8f(\u542bPBMC\u548cTILs\u7ec6\u80de)\uff0c\u83b7\u5f97778,938\u79cdTCRbeta\u94fe 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Jurkat T\u3002\u8be5TCR\u5177\u6709\u5982\u4e0b\u7279\u5f81\uff1a<\/p>\r\n\r\n\r\n\r\n<p>1\u3001 \u8be5TCR\u662f\u80bf\u7624\u6d78\u6da6\u6dcb\u5df4\u7ec6\u80de\u7279\u5f02\u6027\u7684\uff1b<\/p>\r\n\r\n\r\n\r\n<p>2\u3001 \u5177\u6709TCR\u514b\u9686\u6269\u5f20\u6027<\/p>\r\n\r\n\r\n\r\n<p>3\u3001 \u88ab\u4e24\u79cdTCR\u6d4b\u5e8f\u65b9\u6cd5\u9274\u5b9a<\/p>\r\n\r\n\r\n\r\n<p>4\u3001 \u4eceTCR\u6297\u539f\u6ce8\u91ca\u6570\u636e\u5e93VDJdb\u4e2d\uff0c\u672a\u80fd\u53d1\u73b0\u5bf9\u5e94\u6297\u539f<\/p>\r\n\r\n\r\n\r\n<h3 class=\"wp-block-heading\">pMHC\u7a81\u53d8\u80bd\u9175\u6bcd\u8868\u9762\u5c55\u793a\u5e93\u7b5b\u9009\u6297\u539f<\/h3>\r\n\r\n\r\n\r\n<p>\u7528TCR2\u86cb\u767d\u53ca\u5176\u591a\u805a\u4f53\u505a\u8bf1\u9975\uff0c\u5728HLA-A:02:01\u7a81\u53d8\u80bd\u9175\u6bcd\u8868\u9762\u5c55\u793a\u5e93\u7b5b\u9009\u6297\u539f\uff0c\u8be5\u5e93\u542b\u670910\u76847\u6b21\u65b9\u79cd\u80bd\u6bb5\uff0c\u80bd\u6bb5\u957f\u5ea6\u8303\u56f4\u4e3a8-11\u4e2a\u6c28\u57fa\u9178\u3002<\/p>\r\n\r\n\r\n\r\n<p>\u7ecf\u8fc74\u8f6e\u7b5b\u9009\uff0c\u6700\u7ec8\u7b5b\u5f973\u79cd\u591a\u80bd\u5177\u6709\u88abTCR2\u5bcc\u96c6\u7684\u7279\u5f81\u3002<\/p>\r\n\r\n\r\n\r\n<p>\u7b5b\u9009\u83b7\u5f97TCR2\u5bcc\u96c6\u7684\u591a\u80bd\u4e3a\u80bf\u7624\u76f8\u5173\u6297\u539fTMEM161A\u3001EBV\u75c5\u6bd2\u6297\u539fLMP2\u3001\u5927\u80a0\u6746\u83cc\u80a0\u6746\u83cc\u7d20\u3002<\/p>\r\n\r\n\r\n\r\n<figure class=\"wp-block-image\"><img decoding=\"async\" class=\"wp-image-1673\" src=\"http:\/\/www.haoshengmed.com\/wp-content\/uploads\/2024\/03\/image-9.png\" alt=\"\" \/><\/figure>\r\n\r\n\r\n\r\n<p>\u901a\u8fc7HLA-A:02:01\u7a81\u53d8\u80bd\u9175\u6bcd\u8868\u9762\u5c55\u793a\u5e93\u7b5b\u9009\u6709\u5982\u4e0b\u51e0\u4e2a\u4f18\u70b9\uff1a<\/p>\r\n\r\n\r\n\r\n<p>1\u3001 HLA-A:02:01\u6d89\u53ca\u7684\u4eba\u7fa4\u5360\u6bd4\u572815%\uff0c\u662fHLA\u7c7b\u578b\u4e2d\u4eba\u7fa4\u5206\u5e03\u8f83\u5e7f\u7684\u7c7b\u578b\uff0c\u8be5HLA\u6355\u83b7\u7684\u80bd\u5177\u6709\u66f4\u5e7f\u6cdb\u7684\u9002\u7528\u6027\uff1b<\/p>\r\n\r\n\r\n\r\n<p>2\u3001 \u540c\u65f6\u6355\u83b7\u5230\u80bf\u7624\u3001\u75c5\u6bd2\u3001\u7ec6\u83cc\u6297\u539f\uff0c\u5bf9\u4e8e\u80bf\u7624\u514d\u75ab\u6297\u539f\u7684\u7b5b\u9009\u8303\u56f4\u6709\u5145\u5206\u6269\u5145\uff1b<\/p>\r\n\r\n\r\n\r\n<p>3\u3001 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class=\"wp-block-heading\">\u65b0\u53d1\u73b0\u6297\u539f\u53ca\u5176\u7279\u5f02\u6027T\u7ec6\u80de\u7684\u7ec4\u7ec7\u5206\u5e03\u7279\u6027<\/h3>\r\n\r\n\r\n\r\n<p>\u80bf\u7624\u76f8\u5173\u6297\u539fTMEM161A\u5728\u764c\u7ec4\u7ec7\u8868\u8fbe\u9ad8\u4e8e\u764c\u65c1\u7ec4\u7ec7\uff0c\u7ecfTCGA\u6570\u636e\u5e93\u9a8c\u8bc1\u4e00\u81f4\u3002<\/p>\r\n\r\n\r\n\r\n<p>TEME161A-HLA-A*02:01\u8367\u5149\u56db\u805a\u4f53\u68c0\u6d4b\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005TILs\uff0c\u53d1\u73b0\u9633\u6027\u7387\u536040%\uff1b<\/p>\r\n\r\n\r\n\r\n<p>\u8be5TCR\u514b\u9686\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u591a\u4e8e\u817a\u764c\uff0c\u8be5\u7279\u5f81\u4e0eTEME161A\u7684\u7ec4\u7ec7\u5206\u5e03\u4e00\u81f4<\/p>\r\n\r\n\r\n\r\n<p>TEME161A-HLA-A*02:01\u7279\u5f02\u6027T\u7ec6\u80de\u4e3b\u8981\u662feffector T cell\u3002<\/p>\r\n\r\n\r\n\r\n<h3 class=\"wp-block-heading\">\u5173\u4e8e\u4ea4\u53c9\u53cd\u5e94<\/h3>\r\n\r\n\r\n\r\n<p>TCR2\u7684\u6297\u539f\u7b5b\u9009\u540c\u65f6\u53d1\u73b0\u4e863\u79cd\u6765\u6e90\u8fe5\u5f02\u7684\u6297\u539f\uff0c\u90a3\u4e48\u8fd9\u4e09\u79cd\u6297\u539f\u662f\u5426\u5177\u6709\u4ea4\u53c9\u6fc0\u6d3b\u7279\u6027\u5462\uff1f<\/p>\r\n\r\n\r\n\r\n<p>\u901a\u8fc7TEME161A-HLA-A<em>02:01\u3001EBV\u75c5\u6bd2LMP2-HLA-A<\/em>02:01\u3001\u5927\u80a0\u6746\u83cc\u80a0\u6746\u83cc\u7d20-HLA-A*02:01 \u8367\u5149\u56db\u805a\u4f53\u68c0\u6d4bTCR2 \u4fee\u9970\u7684Jurkat-T\u7ec6\u80de\u53d1\u73b0\uff0c3\u79cd\u56db\u805a\u4f53\u5747\u68c0\u6d4b\u5747\u4e3a\u9633\u6027\u3002<\/p>\r\n\r\n\r\n\r\n<p>\u7136\u800c\uff0c\u5f53\u6539\u53d8TCR2\u7684a\u94fe\u540e\uff0c3\u79cd\u6297\u539f\u5bf9TCR2 Jurkat-T\u7ec6\u80de\u7684\u6fc0\u6d3b\u6548\u5e94\u5747\u5168\u90e8\u6d88\u5931\u3002<\/p>\r\n\r\n\r\n\r\n<p>\u6b64\u5916\uff0c\u6bd4\u8f833\u79cd\u6297\u539f\u523a\u6fc0TCR2 Jurkat-T\u7ec6\u80de\u540e\u5bf9\u80bf\u7624\u7ec6\u80deT2\u7684\u6740\u4f24\u6548\u679c\u5224\u65ad\uff0cEBV\u75c5\u6bd2\u6297\u539f\u56db\u805a\u4f53\u3001\u5927\u80a0\u6746\u83cc\u80a0\u6746\u83cc\u7d20\u7684\u523a\u6fc0\u6740\u4f24\u6548\u679c\u5f3a\u4e8eTEME161A\u3002<\/p>\r\n\r\n\r\n\r\n<h3 class=\"wp-block-heading\">\u542f\u793a<\/h3>\r\n\r\n\r\n\r\n<p>\u4f20\u7edf\u53d1\u73b0\u80bf\u7624\u65b0\u6297\u539f\u662f\u9700\u8981\u7ecf\u5386\u91cd\u91cd\u98ce\u9669\u3002\u4ece\u8f6c\u5f55\u7ec4\u3001\u86cb\u767d\u8d28\u7ec4\u3001\u5916\u663e\u5b50\u7ec4\u3001\u5b8f\u57fa\u56e0\u7ec4\u6d4b\u5e8f\u6570\u636e\u4e2d\uff0c\u7ecf\u5386\u7ec4\u5b66\u68c0\u6d4b\u3001\u5927\u91cf\u591a\u80bd\u523a\u6fc0\u3001T\u7ec6\u80de\u9a8c\u8bc1\uff0c\u624d\u6709\u53ef\u80fd\u7b5b\u9009\u5230\u4e00\u79cdT\u7ec6\u80de\u6297\u539f\u3002\u7136\u800c\uff0c\u5373\u4fbf\u5982\u6b64\uff0c\u4f53\u5185\u6b64\u6297\u539f\u7684TCR\u514b\u9686\u5206\u5e03\u7279\u70b9\u5374\u672a\u5fc5\u4e0e\u80bf\u7624\u8fdb\u5c55\u76f8\u5173\u3002<\/p>\r\n\r\n\r\n\r\n<p>\u4f46\u662f\uff0c\u6362\u4e2a\u89d2\u5ea6\u6765\u770b\uff0c\u4eceTILs\u53d8\u5316\u6700\u5927\u7684TCR\u5165\u624b\u5bfb\u627e\u6297\u539f\uff0c\u53ef\u4ee5\u76f4\u63a5\u53d1\u73b0\u80bf\u7624\u514d\u75ab\u76f8\u5e94\u6700\u5f3a\u70c8\u7684\u9776\u6297\u539f\uff0c\u65e2\u5168\u9762\u53c8\u4fbf\u6377\u3002\u968f\u7740\u5355\u7ec6\u80deTCR\u6d4b\u5e8f\u7684\u666e\u904d\u6d41\u884c\uff0c\u76f4\u63a5\u53d1\u73b0\u80bf\u7624\u6297\u539f\u7684\u6570\u636e\u548c\u6280\u672f\u5c06\u5feb\u901f\u53d1\u5c55\u3002<\/p>\r\n<hr 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href=\"https:\/\/www.guixiong.com.cn\/?page_id=558\">\u7a33\u8f6cTCR-T\u539f\u4ee3\u7ec6\u80de<\/a><\/blockquote><iframe class=\"wp-embedded-content\" sandbox=\"allow-scripts\" security=\"restricted\" style=\"position: absolute; visibility: hidden;\" title=\"\u300a \u7a33\u8f6cTCR-T\u539f\u4ee3\u7ec6\u80de \u300b\u2014\u6842\u828e\u751f\u7269\" src=\"https:\/\/www.guixiong.com.cn\/?page_id=558&#038;embed=true#?secret=fZdRThvUyz#?secret=xC8PXTiHXd\" data-secret=\"xC8PXTiHXd\" width=\"600\" height=\"338\" frameborder=\"0\" marginwidth=\"0\" marginheight=\"0\" scrolling=\"no\"><\/iframe><\/p>\r\n<p><blockquote class=\"wp-embedded-content\" data-secret=\"zw5JgECgJM\"><a href=\"https:\/\/www.guixiong.com.cn\/?page_id=128\">TCR\u9776\u6297\u539f\u7b5b\u9009\u670d\u52a1<\/a><\/blockquote><iframe class=\"wp-embedded-content\" sandbox=\"allow-scripts\" security=\"restricted\" style=\"position: absolute; visibility: hidden;\" title=\"\u300a TCR\u9776\u6297\u539f\u7b5b\u9009\u670d\u52a1 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