{"id":48,"date":"2024-07-31T02:14:26","date_gmt":"2024-07-31T02:14:26","guid":{"rendered":"http:\/\/60.204.213.123\/wordpress\/?page_id=48"},"modified":"2024-10-11T05:57:18","modified_gmt":"2024-10-11T05:57:18","slug":"tcr%e5%a4%9a%e8%81%9a%e4%bd%93-%e7%94%a8%e4%ba%8e%e5%88%86%e6%9e%90%e5%85%8d%e7%96%ab%e7%bb%86%e8%83%9e%e8%af%86%e5%88%ab%e7%9a%84%e8%82%bf%e7%98%a4%e7%bb%86%e8%83%9e","status":"publish","type":"page","link":"https:\/\/www.guixiong.com.cn\/?page_id=48","title":{"rendered":"TCR\u86cb\u767d\u590d\u5408\u7269\u4e0e\u8367\u5149\u56db\u805a\u4f53"},"content":{"rendered":"\n<h3 class=\"wp-block-heading\">\u4ec0\u4e48\u662fTCR\u86cb\u767d\u590d\u5408\u7269<\/h3>\n\n\n\n<p class=\"has-foreground-color has-text-color has-link-color wp-elements-f583fc5262a12af4eec57720715d1643\">TCR\u86cb\u767d\u590d\u5408\u7269\u662f\u7531TCR\u7684alpha\u94fe\u548cbeta\u94fe\u5f62\u6210\u7684\u5f02\u4e8c\u805a\u4f53\u53ef\u6eb6\u6027\u86cb\u767d\u3002\u7531\u4e8e\u4f53\u5185TCR\u86cb\u767d\u590d\u5408\u7269\u662f\u951a\u5b9a\u4e8e\u7ec6\u80de\u819c\u8868\u9762\uff0cTCR\u5f02\u4e8c\u805a\u4f53\u9700\u8981\u7ec6\u80de\u819c\u8102\u7b4f\u624d\u80fd\u7ec4\u88c5\uff0c\u56e0\u6b64\u5929\u7136\u60c5\u51b5\u4e0b\u65e0\u6e38\u79bb\u72b6\u6001\u7684\u53ef\u6eb6\u6027TCR\u86cb\u767d\u590d\u5408\u7269\u3002\u53ef\u6eb6\u6027TCR\u86cb\u767d\u590d\u5408\u7269\u9700\u8981\u901a\u8fc7\u6539\u9020TCR\u975e\u6297\u539f\u8bc6\u522b\u533a\u7ed3\u6784\uff0c\u4ece\u800c\u5b9e\u73b0TCR\u7684alpha\u94fe\u548cbeta\u94fe\u7684\u6b63\u786e\u6298\u53e0\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-large is-resized\"><img fetchpriority=\"high\" decoding=\"async\" width=\"1024\" height=\"576\" src=\"https:\/\/www.guixiong.com.cn\/wp-content\/uploads\/2024\/10\/TCR-multimer-1024x576.jpg\" alt=\"\" class=\"wp-image-455\" style=\"width:500px\" srcset=\"https:\/\/guixiong.com.cn\/wp-content\/uploads\/2024\/10\/TCR-multimer-1024x576.jpg 1024w, https:\/\/guixiong.com.cn\/wp-content\/uploads\/2024\/10\/TCR-multimer-600x338.jpg 600w, https:\/\/guixiong.com.cn\/wp-content\/uploads\/2024\/10\/TCR-multimer-300x169.jpg 300w, https:\/\/guixiong.com.cn\/wp-content\/uploads\/2024\/10\/TCR-multimer-768x432.jpg 768w, https:\/\/guixiong.com.cn\/wp-content\/uploads\/2024\/10\/TCR-multimer-1536x864.jpg 1536w, https:\/\/guixiong.com.cn\/wp-content\/uploads\/2024\/10\/TCR-multimer.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\">\u4e3a\u4ec0\u4e48\u8981\u5408\u6210TCR\u86cb\u767d\u590d\u5408\u7269<\/h3>\n\n\n\n<p>1.  \u8bc4\u4f30TCR\u548cpMHC\u7684\u4eb2\u548c\u529b\uff0c\u4ece\u800c\u4e3a\u9009\u62e9TCR-T\u6216TCR\u6cbb\u7597\u6027\u86cb\u767d\u63d0\u4f9b\u6700\u4f73TCR\u7ed3\u6784\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image is-resized\"><img decoding=\"async\" width=\"891\" height=\"897\" src=\"https:\/\/www.guixiong.com.cn\/wp-content\/uploads\/2024\/10\/image-2.png\" alt=\"\u672c\u56fe\u7247\u4e3a\u6842\u828e\u751f\u7269\u7248\u6743\u6240\u6709\" class=\"wp-image-567\" style=\"width:400px\" srcset=\"https:\/\/guixiong.com.cn\/wp-content\/uploads\/2024\/10\/image-2.png 891w, https:\/\/guixiong.com.cn\/wp-content\/uploads\/2024\/10\/image-2-100x100.png 100w, https:\/\/guixiong.com.cn\/wp-content\/uploads\/2024\/10\/image-2-600x604.png 600w, https:\/\/guixiong.com.cn\/wp-content\/uploads\/2024\/10\/image-2-298x300.png 298w, https:\/\/guixiong.com.cn\/wp-content\/uploads\/2024\/10\/image-2-150x150.png 150w, https:\/\/guixiong.com.cn\/wp-content\/uploads\/2024\/10\/image-2-768x773.png 768w\" sizes=\"(max-width: 891px) 100vw, 891px\" \/><\/figure>\n\n\n\n<p>2. TCR\u86cb\u767d\u590d\u5408\u7269\u53ef\u4ee5\u5076\u8054\u8367\u5149\uff0c\u5f62\u6210TCR\u8367\u5149\u56db\u805a\u4f53\uff0c\u7528\u4e8e\u68c0\u6d4b<a href=\"https:\/\/www.guixiong.com.cn\/?page_id=546\" data-type=\"page\" data-id=\"546\" target=\"_blank\" rel=\"noreferrer noopener\">\u6297\u539f\u5448\u9012\u7ec6\u80de<\/a>\u8868\u9762\u7684pMHC\u542b\u91cf\uff0c\u5206\u6790\u80bf\u7624\u7ec6\u80de\u7b49\u6297\u539f\u5448\u9012\u7ec6\u80de\u7a7a\u95f4\u5b9a\u4f4d\u3002\u8fd9\u7c7bTCR\u86cb\u767d\u590d\u5408\u7269\u987b\u4e3apMHC\u9ad8\u4eb2\u548c\u529bTCR\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-large is-resized\"><img decoding=\"async\" width=\"1024\" height=\"768\" src=\"https:\/\/www.guixiong.com.cn\/wp-content\/uploads\/2024\/10\/K562-HLA01-N-72-1024x768.jpg\" alt=\"\u672c\u56fe\u7247\u4e3a\u6842\u828e\u751f\u7269\u7248\u6743\u6240\u6709\" class=\"wp-image-574\" style=\"width:400px\" srcset=\"https:\/\/guixiong.com.cn\/wp-content\/uploads\/2024\/10\/K562-HLA01-N-72-1024x768.jpg 1024w, https:\/\/guixiong.com.cn\/wp-content\/uploads\/2024\/10\/K562-HLA01-N-72-600x450.jpg 600w, https:\/\/guixiong.com.cn\/wp-content\/uploads\/2024\/10\/K562-HLA01-N-72-300x225.jpg 300w, https:\/\/guixiong.com.cn\/wp-content\/uploads\/2024\/10\/K562-HLA01-N-72-768x576.jpg 768w, https:\/\/guixiong.com.cn\/wp-content\/uploads\/2024\/10\/K562-HLA01-N-72.jpg 1280w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>3. \u7528\u4e8e\u7b5b\u9009\u6297\u539f\u80bd\uff1a\u5bf9\u4e8e\u6765\u81ea\u4e8e\u4e34\u5e8a\u6837\u672cPBMC\u7684TCR\uff0c\u5728\u4e0d\u786e\u5b9a\u76ee\u6807\u6297\u539f\u60c5\u51b5\u4e0b\uff0c\u4f7f\u7528TCR\u86cb\u767d\u590d\u5408\u7269\u5076\u8054\u78c1\u73e0\u53ef\u7b5b\u9009\u51fa\u76ee\u6807\u6297\u539f\u3002\u8be5\u7b5b\u9009\u987b\u914d\u5408\u4f7f\u7528<a href=\"https:\/\/www.guixiong.com.cn\/?page_id=128\" data-type=\"page\" data-id=\"128\" target=\"_blank\" rel=\"noreferrer noopener\">pMHC\u9175\u6bcd\u8868\u9762\u5c55\u793a\u7cfb\u7edf<\/a>\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"472\" src=\"https:\/\/www.guixiong.com.cn\/wp-content\/uploads\/2024\/10\/image-3-1024x472.png\" alt=\"\" class=\"wp-image-575\" srcset=\"https:\/\/guixiong.com.cn\/wp-content\/uploads\/2024\/10\/image-3-1024x472.png 1024w, https:\/\/guixiong.com.cn\/wp-content\/uploads\/2024\/10\/image-3-600x276.png 600w, https:\/\/guixiong.com.cn\/wp-content\/uploads\/2024\/10\/image-3-300x138.png 300w, https:\/\/guixiong.com.cn\/wp-content\/uploads\/2024\/10\/image-3-768x354.png 768w, https:\/\/guixiong.com.cn\/wp-content\/uploads\/2024\/10\/image-3-1536x707.png 1536w, https:\/\/guixiong.com.cn\/wp-content\/uploads\/2024\/10\/image-3.png 1987w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u670d\u52a1\u5185\u5bb9<\/strong><\/h3>\n\n\n\n<p class=\"has-foreground-color has-text-color has-link-color wp-elements-0279178edacea492c6be5cf1dc9f6661\">\u6839\u636e\u7528\u6237\u63d0\u4f9b\u7684TCR\u7684alpha\u94fe\u548cbeta\u94fe\u6838\u9178\u5e8f\u5217\uff0c\u5408\u6210\u76ee\u6807TCR\u86cb\u767d\u590d\u5408\u7269\u3001TCR\u86cb\u767d\u590d\u5408\u7269\u8367\u5149\u56db\u805a\u4f53\u3002\u5408\u6210\u91cf\u572850ug-10mg\u4e4b\u95f4\uff0c\u6839\u636e\u7528\u6237\u9700\u6c42\u800c\u5b9a\u3002\u8367\u5149\u6807\u8bb0\u53ef\u9009\u4e3aPE\u6216APC\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u7528\u6237\u63d0\u4f9b<\/strong><\/h3>\n\n\n\n<p class=\"has-foreground-color has-text-color has-link-color wp-elements-84580db177139d7c4c0764d789fd82e3\">1.\u7528\u6237\u63d0\u4f9b\u7684TCR\u7684V\u533a\u7684alpha\u94fe\u548cbeta\u94fe\u6838\u9178\u5e8f\u5217<\/p>\n\n\n\n<p class=\"has-foreground-color has-text-color has-link-color wp-elements-f936fe5031a7ea6df4dc5116fa176e65\">2. \u7528\u6237\u63d0\u4f9b\u5448\u9012\u6297\u539f\u80bd\u7684\u5448\u9012\u7ec6\u80de(\u53ef\u9009)\uff0c\u53ef\u7528\u4e8eTCR\u86cb\u767d\u590d\u5408\u7269\u8367\u5149\u56db\u805a\u4f53\u68c0\u6d4b\u5448\u9012\u7ec6\u80de\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u670d\u52a1\u5468\u671f<\/strong><\/h3>\n\n\n\n<p>21\u5929<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u53c2\u8003\u6587\u732e\uff1a<\/h3>\n\n\n\n<p><a href=\"https:\/\/www.science.org\/doi\/10.1126\/science.270.5243.1821\" data-type=\"link\" data-id=\"https:\/\/www.science.org\/doi\/10.1126\/science.270.5243.1821\">Crystal structure of the V alpha domain of a T cell antigen receptor<\/a>. Science. 1995<\/p>\n\n\n\n<p><a href=\"https:\/\/www.nature.com\/articles\/nbt1024\" data-type=\"link\" data-id=\"https:\/\/www.nature.com\/articles\/nbt1024\" target=\"_blank\" rel=\"noreferrer noopener\">Engineered T-cell receptor tetramers bind MHC-peptide complexes with high affinity<\/a>. Nat Biotechnol. 2004<\/p>\n\n\n\n<p><a href=\"https:\/\/academic.oup.com\/intimm\/article-abstract\/14\/1\/39\/734423?redirectedFrom=fulltext&amp;login=false\" data-type=\"link\" data-id=\"https:\/\/academic.oup.com\/intimm\/article-abstract\/14\/1\/39\/734423?redirectedFrom=fulltext&amp;login=false\" target=\"_blank\" rel=\"noreferrer noopener\">Human CD8 co-receptor is strictly involved in MHC-peptide tetramer-TCR binding and T cell activation<\/a>. Int Immunol. 2002<\/p>\n\n\n\n<p><a href=\"https:\/\/journals.plos.org\/plosone\/article?id=10.1371\/journal.pone.0051397\" data-type=\"link\" data-id=\"https:\/\/journals.plos.org\/plosone\/article?id=10.1371\/journal.pone.0051397\" target=\"_blank\" rel=\"noreferrer noopener\">Binding of TCR multimers and a TCR-like antibody with distinct fine-specificities is dependent on the surface density of HLA complexes<\/a>. PLoS One. 2012<\/p>\n<p>Views: 56<\/p>","protected":false},"excerpt":{"rendered":"<p>\u4ec0\u4e48\u662fTCR\u86cb\u767d\u590d\u5408\u7269 TCR\u86cb\u767d\u590d\u5408\u7269\u662f\u7531TCR\u7684alpha\u94fe\u548cbeta\u94fe\u5f62\u6210\u7684\u5f02\u4e8c\u805a\u4f53\u53ef\u6eb6\u6027\u86cb\u767d\u3002\u7531\u4e8e\u4f53\u5185&#8230;<\/p>\n","protected":false},"author":2,"featured_media":455,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_kadence_starter_templates_imported_post":false,"_kad_post_transparent":"","_kad_post_title":"","_kad_post_layout":"","_kad_post_sidebar_id":"","_kad_post_content_style":"","_kad_post_vertical_padding":"","_kad_post_feature":"","_kad_post_feature_position":"","_kad_post_header":false,"_kad_post_footer":false,"_kad_post_classname":"","footnotes":""},"class_list":["post-48","page","type-page","status-publish","has-post-thumbnail","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.guixiong.com.cn\/index.php?rest_route=\/wp\/v2\/pages\/48","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.guixiong.com.cn\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.guixiong.com.cn\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.guixiong.com.cn\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.guixiong.com.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=48"}],"version-history":[{"count":11,"href":"https:\/\/www.guixiong.com.cn\/index.php?rest_route=\/wp\/v2\/pages\/48\/revisions"}],"predecessor-version":[{"id":584,"href":"https:\/\/www.guixiong.com.cn\/index.php?rest_route=\/wp\/v2\/pages\/48\/revisions\/584"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.guixiong.com.cn\/index.php?rest_route=\/wp\/v2\/media\/455"}],"wp:attachment":[{"href":"https:\/\/www.guixiong.com.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=48"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}