{"id":546,"date":"2024-10-11T03:28:44","date_gmt":"2024-10-11T03:28:44","guid":{"rendered":"http:\/\/60.204.213.123\/?page_id=546"},"modified":"2026-01-06T10:07:24","modified_gmt":"2026-01-06T10:07:24","slug":"%e5%b7%a5%e7%a8%8b%e5%8c%96%e5%91%88%e9%80%92%e7%bb%86%e8%83%9e","status":"publish","type":"page","link":"https:\/\/www.guixiong.com.cn\/?page_id=546","title":{"rendered":"\u5de5\u7a0b\u5316\u5448\u9012\u7ec6\u80de"},"content":{"rendered":"\n<p class=\"has-foreground-color has-text-color has-link-color wp-elements-57fc71eba2320a3e63f3f1189fc847dd\">T\u7ec6\u80de\u6297\u539f\u7b5b\u9009\u5728\u9776\u5411\u6297\u539f\u7684\u514d\u75ab\u6cbb\u7597\u9886\u57df\u662f\u91cd\u8981\u7684\u8d77\u70b9\uff0c\u5408\u9002\u7684\u5448\u9012\u7ec6\u80de\u5728\u6b64\u8fc7\u7a0b\u5f88\u5173\u952e\u3002<\/p>\n\n\n\n<p class=\"has-foreground-color has-text-color has-link-color wp-elements-aac276c0665c2e3b5559a8d1e5a1e5e9\">\u7136\u800c\uff0c\u65e0\u8bba\u662f\u6765\u81ea\u4e8e\u5065\u5eb7\u53d7\u8bd5\u8005PBMC\u8f6c\u5316\u7684\u5448\u9012\u7ec6\u80de\uff0c\u8fd8\u662fT2\u7b49\u5448\u9012\u7ec6\u80de\uff0c\u5728\u5f00\u53d1\u6297\u539f\u8fc7\u7a0b\u4e2d\u5747\u5b58\u5728\u4e0d\u5339\u914d\u3001\u6216\u8005\u5448\u9012\u6548\u7387\u65e0\u6cd5\u8c03\u8282\u7684\u60c5\u51b5\u3002\u8fd9\u4e9b\u60c5\u51b5\u4e0eHLA\u7279\u6027\u3001\u5448\u9012\u80fd\u529b\u3001\u5171\u523a\u6fc0-\u5171\u6291\u5236\u5206\u5b50\u7b49\u56e0\u7d20\u6709\u5173\u3002\u4e00\u79cd\u5373\u7528\u578b\u3001\u6807\u51c6\u5316\u3001\u53ef\u8c03\u63a7\u3001\u53ef\u4fee\u9970\u7684\u6297\u539f\u5448\u9012\u7ec6\u80de\u5bf9\u4e8e\u6297\u539f\u7b5b\u9009\u5177\u6709\u5e7f\u6cdb\u7684\u4ef7\u503c\u3002<\/p>\n\n\n\n<p class=\"has-foreground-color has-text-color has-link-color wp-elements-a7a8fa59ad1ba855a8e9dc8573b800cf\">\u300a<a href=\"https:\/\/www.nature.com\/articles\/srep31580\" data-type=\"link\" data-id=\"https:\/\/www.nature.com\/articles\/srep31580\">Creation of an engineered APC system to explore and optimize the presentation of immunodominant peptides of major allergens<\/a>\u300bScientific Reports. 2016 \u4e00\u6587\u9610\u91ca\u4e86\u9762\u5411\u8fc7\u654f\u6297\u539f\u7684\u5de5\u7a0b\u5316\u6297\u539f\u5448\u9012\u7ec6\u80de\u7684\u5e94\u7528\u4ef7\u503c\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u5de5\u7a0b\u5316\u6297\u539f\u5448\u9012\u7ec6\u80de\u7684\u4e3b\u8981\u7ec4\u4ef6<\/strong><\/h3>\n\n\n\n<p class=\"has-heading-color has-text-color has-link-color wp-elements-04ab34186648d60e7fde407b75e4ce6d\">\u4ee5K562\u7ec6\u80de\u6784\u5efa\u5de5\u7a0b\u5316\u6297\u539f\u5448\u9012\u7ec6\u80de\uff0c\u7528\u6765\u88c5\u8f7d\u8fc7\u654f\u539f\u6297\u539f\u3002\u5de5\u7a0b\u5316K562\u4e3b\u8981\u8868\u8fbe\uff1a<\/p>\n\n\n\n<p class=\"has-foreground-color has-text-color has-link-color wp-elements-91cb59228095097f884c621f06bc03cc\"><strong>\u9488\u5bf9MHC-I\u4f53\u7cfb\uff1a<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>HLA-I\u7c7b\u5206\u5b50<\/li>\n\n\n\n<li>CD80, \u4f5c\u4e3a\u5171\u523a\u6fc0\u5206\u5b50\uff0c\u4fc3\u8fdbT\u7ec6\u80de\u6d3b\u5316<\/li>\n\n\n\n<li>CD83\u819c\u86cb\u767d, \u53c2\u4e0e\u6297\u539f\u5448\u9012\uff0c\u6d3b\u5316\u6dcb\u5df4\u7ec6\u80de\uff0c\u662f\u6210\u719f\u7684\u6811\u7a81\u7ec6\u80de\u6807\u5fd7\u7269\u3002<\/li>\n<\/ul>\n\n\n\n<p class=\"has-foreground-color has-text-color has-link-color wp-elements-c5142189fd41010bc8bc27279f158e64\"><strong>\u9488\u5bf9MHC-II\u4f53\u7cfb\uff1a<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>HLA-II\u7c7b\u5206\u5b50<\/li>\n\n\n\n<li>CD80\uff0c\u4f5c\u4e3a\u5171\u523a\u6fc0\u5206\u5b50\uff0c\u4fc3\u8fdbT\u7ec6\u80de\u6d3b\u5316<\/li>\n\n\n\n<li>HLA-DM \u589e\u5f3a\u5916\u6e90\u80bd\u7684\u88c5\u8f7d\uff0c\u66f4\u52a0\u91cd\u8981\u7684\u662f\uff0c\u53ef\u4ee5\u589e\u5f3a\u6765\u81ea\u5168\u957f\u86cb\u767d\u7684\u6297\u539f\u80bd\u5448\u9012\u6548\u679c\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u5de5\u7a0b\u5316\u6297\u539f\u5448\u9012\u7ec6\u80de\u5404\u7ec4\u4ef6\u7684\u6d4b\u8bd5\u6548\u679c<\/strong><\/h3>\n\n\n\n<p class=\"has-foreground-color has-text-color has-link-color wp-elements-454dacae2185a0314e6e16cf7c77687c\"><strong>CD80<\/strong><strong>\u7ec4\u4ef6<\/strong><\/p>\n\n\n\n<p class=\"has-foreground-color has-text-color has-link-color wp-elements-fecc186ce9f5c00e8c023d3805260e1f\">CD80\u662f\u6297\u539f\u5448\u9012\u7ec6\u80de\u4e0a\u91cd\u8981\u7684\u5171\u523a\u6fc0\u5206\u5b50\uff0c\u4f7fK562\u589e\u5f3a\u6297\u539f\u80bd\u5448\u9012\u540e\u7684T\u7ec6\u80de\u53cd\u5e94\u6027\u3002\u65e0CD80\u4fee\u9970\u7684\u5448\u9012\u7ec6\u80de\u5bf9T\u7ec6\u80de\u7684\u53cd\u5e94\u6027\u5f31\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img fetchpriority=\"high\" decoding=\"async\" width=\"554\" height=\"249\" src=\"https:\/\/www.guixiong.com.cn\/wp-content\/uploads\/2024\/10\/image.png\" alt=\"\" class=\"wp-image-548\" srcset=\"https:\/\/guixiong.com.cn\/wp-content\/uploads\/2024\/10\/image.png 554w, https:\/\/guixiong.com.cn\/wp-content\/uploads\/2024\/10\/image-300x135.png 300w\" sizes=\"(max-width: 554px) 100vw, 554px\" \/><\/figure>\n\n\n\n<p class=\"has-foreground-color has-text-color has-link-color wp-elements-a056e846d296a713fce129ffb28650a3\"><strong>HLA-DM<\/strong><strong>\u7ec4\u4ef6<\/strong><\/p>\n\n\n\n<p class=\"has-foreground-color has-text-color has-link-color wp-elements-faf74bdb7813e8d1717135f222225135\">HLA-DM\u4fc3\u8fdb\u5916\u6e90\u80bd\u88c5\u8f7d\uff0c\u4f46\u662f\u5bf9\u5185\u6e90\u80bd\u6ca1\u6709\u589e\u5f3a\u5448\u9012\u7684\u4f5c\u7528\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" width=\"554\" height=\"494\" src=\"https:\/\/www.guixiong.com.cn\/wp-content\/uploads\/2024\/10\/image-1.png\" alt=\"\" class=\"wp-image-549\" srcset=\"https:\/\/guixiong.com.cn\/wp-content\/uploads\/2024\/10\/image-1.png 554w, https:\/\/guixiong.com.cn\/wp-content\/uploads\/2024\/10\/image-1-300x268.png 300w\" sizes=\"(max-width: 554px) 100vw, 554px\" \/><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u5de5\u7a0b\u5316\u6297\u539f\u5448\u9012\u7ec6\u80de\u4ea7\u54c1<\/strong><\/h3>\n\n\n\n<p class=\"has-foreground-color has-text-color has-link-color wp-elements-ce0c214e2a3470abb4d50258c4de1e14\">\u5f53\u524d\uff0c\u6211\u4eec\u63d0\u4f9b\u4ee5\u4e0bHLA\u7684\u5de5\u7a0b\u5316\u6297\u539f\u5448\u9012\u7ec6\u80de\u73b0\u8d27\u4ea7\u54c1\uff1a<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><tbody><tr><td class=\"has-text-align-center\" data-align=\"center\">HLA\u7c7b\u578b<\/td><td class=\"has-text-align-center\" data-align=\"center\">\u7ec4\u6210\u6027\u9ad8\u8868\u8fbe\u57fa\u56e0<\/td><td class=\"has-text-align-center\" data-align=\"center\">\u7ec6\u80de\u7c7b\u578b<\/td><td class=\"has-text-align-center\" data-align=\"center\">\u662f\u5426\u7a33\u8f6c<\/td><\/tr><tr><td class=\"has-text-align-center\" data-align=\"center\">HLA-A*02:01<\/td><td class=\"has-text-align-center\" data-align=\"center\">HLA-A*02:01<br>CD80<br>mCD83<\/td><td class=\"has-text-align-center\" data-align=\"center\">K562<\/td><td class=\"has-text-align-center\" data-align=\"center\">\u7a33\u8f6c<\/td><\/tr><tr><td class=\"has-text-align-center\" data-align=\"center\">HLA-B*40:01<\/td><td class=\"has-text-align-center\" data-align=\"center\">HLA-B*40:01<br>CD80<br>mCD83<\/td><td class=\"has-text-align-center\" data-align=\"center\">K562<\/td><td class=\"has-text-align-center\" data-align=\"center\">\u7a33\u8f6c<\/td><\/tr><tr><td class=\"has-text-align-center\" data-align=\"center\">HLA-C*07:02<\/td><td class=\"has-text-align-center\" data-align=\"center\">HLA-C*07:02<br>CD80<br>mCD83<\/td><td class=\"has-text-align-center\" data-align=\"center\">K562<\/td><td class=\"has-text-align-center\" data-align=\"center\">\u7a33\u8f6c<\/td><\/tr><tr><td class=\"has-text-align-center\" data-align=\"center\">HLA-DRB1*15:01<\/td><td class=\"has-text-align-center\" data-align=\"center\">HLA-DRB1*15:01<br>CD80<br>HLA-DRA1*01:01<br>HLA-DMA<br>HLA-DMB<\/td><td class=\"has-text-align-center\" data-align=\"center\">K562<\/td><td class=\"has-text-align-center\" data-align=\"center\">\u7a33\u8f6c<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u5de5\u7a0b\u5316\u5448\u9012\u7ec6\u80de\u7684\u5e94\u7528<\/strong><\/h3>\n\n\n\n<h4 class=\"wp-block-heading has-primary-color has-text-color has-link-color has-barlow-condensed-font-family has-regular-font-size wp-elements-243e39585552cba1ad20da1895ecd613\">\u957f\u671f\u6d3b\u5316\u6297\u539f\u7279\u5f02\u6027T\u7ec6\u80de<\/h4>\n\n\n\n<p class=\"has-foreground-color has-text-color has-link-color 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116<\/p>","protected":false},"excerpt":{"rendered":"<p>T\u7ec6\u80de\u6297\u539f\u7b5b\u9009\u5728\u9776\u5411\u6297\u539f\u7684\u514d\u75ab\u6cbb\u7597\u9886\u57df\u662f\u91cd\u8981\u7684\u8d77\u70b9\uff0c\u5408\u9002\u7684\u5448\u9012\u7ec6\u80de\u5728\u6b64\u8fc7\u7a0b\u5f88\u5173\u952e\u3002 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