{"id":617,"date":"2024-12-02T03:19:46","date_gmt":"2024-12-02T03:19:46","guid":{"rendered":"http:\/\/60.204.213.123\/?page_id=617"},"modified":"2024-12-02T03:19:47","modified_gmt":"2024-12-02T03:19:47","slug":"%e5%b7%b2%e5%85%ac%e5%b8%83%e7%9a%84%e8%83%b0%e8%85%ba%e7%99%8c%e8%82%bf%e7%98%a4%e7%aa%81%e5%8f%98%e6%8a%97%e5%8e%9f%e6%b8%85%e5%8d%95","status":"publish","type":"page","link":"https:\/\/www.guixiong.com.cn\/?page_id=617","title":{"rendered":"\u5df2\u516c\u5e03\u7684\u80f0\u817a\u764c\u80bf\u7624\u7a81\u53d8\u6297\u539f\u6e05\u5355"},"content":{"rendered":"\n

\u80bf\u7624\u65b0\u6297\u539fmRNA\u75ab\u82d7\u5728\u52a0\u901f\u5ba1\u6279\u7684\u80cc\u666f\u4e0b\uff0c\u80bf\u7624\u7a81\u53d8\u6297\u539f\u7684\u7814\u7a76\u4ef7\u503c\u8d8a\u6765\u8d8a\u5927\uff0c\u4e3a\u6b64\uff0c\u6211\u4eec\u901a\u8fc7\u6587\u732e\u6316\u6398\uff0c\u4e3a\u8bfb\u8005\u6574\u7406\u4e86\u5404\u79cd\u80bf\u7624\u7684\u5df2\u9a8c\u8bc1\u80bf\u7624\u7a81\u53d8\u6297\u539f\u6e05\u5355\uff0c\u6211\u4eec\u5c06\u9646\u7eed\u53d1\u5e03<\/strong>\u3002<\/p>\n\n\n\n

\u4ee5\u4e0b\u662f\u76ee\u524d\u516c\u5e03\u7684\u80f0\u817a\u764c\u80bf\u7624\u7a81\u53d8\u6297\u539f\u80bd\u6e05\u5355\uff0c\u8be5\u6e05\u5355\u5747\u652f\u6301\u5b9a\u5236\u751f\u4ea7 (\u5b9a\u5236\u54a8\u8be2\u8bf7\u626b\u63cf\u672c\u9875\u53f3\u4fa7\u8054\u7cfb\u4eba\u4e8c\u7ef4\u7801)\u3002\u53ef\u5b9a\u5236\u751f\u4ea7\uff1a<\/p>\n\n\n\n

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  1. \u68c0\u6d4b\u6216\u5206\u9009\u6297\u539f\u7279\u5f02\u6027T\u7ec6\u80de\u7684\u6d41\u5f0f\u8bd5\u5242\u3001\u78c1\u73e0\u5206\u9009\u8bd5\u5242<\/li>\n\n\n\n
  2. \u6784\u5efa\u6297\u539f\u80bd\u548cMHC\u590d\u5408\u7269\uff0c\u7528\u4e8e\u5408\u6210\u4eba\u5de5\u5448\u9012\u7269\uff0c\u4ece\u800c\u523a\u6fc0T\u7ec6\u80de\u589e\u6b96<\/li>\n<\/ol>\n\n\n\n

    <\/h4>\n\n\n\n

    \u5df2\u9a8c\u8bc1\u7684\u80f0\u817a\u764c\u6297\u539f\u5217\u8868<\/h4>\n\n\n\n\n\n\n\t\n\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t
    \u6297\u539f\u80bd<\/th>\u6297\u539f\u86cb\u767d<\/th>\u5448\u9012\u7684HLA<\/th>\u9a8c\u8bc1\u6587\u732e<\/th>\n<\/tr>\n<\/thead>\n
    MQTSEREGSGPELSPSVM<\/td>Spastic paraplegia 33 protein, Zinc finger FYVE domain-containing protein 27, ZFYVE27, SPG33<\/td>HLA class I<\/td>Immunogenicity of somatic mutations in human gastrointestinal cancers.; Science; 2015 Unique Neoantigens Arise from Somatic Mutations in Patients with Gastrointestinal Cancers.; Cancer Discov; 2019<\/td>\n<\/tr>\n
    TLMDMRLSQVSDSVSGQTVVDPKGY<\/td>Androgen receptor N-terminal domain-transactivating protein 1, PRP6 homolog, U5 snRNP-associated 102 kDa protein, PRPF6, C20orf14<\/td>HLA class I<\/td>Unique Neoantigens Arise from Somatic Mutations in Patients with Gastrointestinal Cancers.; Cancer Discov; 2019<\/td>\n<\/tr>\n
    GPQETLDRTVHCQPAIFVASLAAVE<\/td>Mitochondrial malonyl CoA:ACP acyltransferase, Mitochondrial malonyltransferase, [Acyl-carrier-protein] malonyltransferase, MCAT, MT<\/td>HLA class I<\/td>Unique Neoantigens Arise from Somatic Mutations in Patients with Gastrointestinal Cancers.; Cancer Discov; 2019<\/td>\n<\/tr>\n
    LLMREVPLRCTIRLWDTYQSEPDGF<\/td>TBC1D22A, C22orf4<\/td>HLA-A*01:01<\/td>Optimized polyepitope neoantigen DNA vaccines elicit neoantigen-specific immune responses in preclinical models and in clinical translation.; Genome Med; 2021<\/td>\n<\/tr>\n
    LVRAVQFTETFLTERDKQSKWSGIP<\/td>Protein TAP1, TNF-receptor ubiquitous scaffolding\/signaling protein, TRPC4AP, C20orf188, TRRP4AP<\/td>HLA-B*44:03<\/td>Optimized polyepitope neoantigen DNA vaccines elicit neoantigen-specific immune responses in preclinical models and in clinical translation.; Genome Med; 2021<\/td>\n<\/tr>\n
    HTGEKPYRCKVCDTAFTWHSQLARH<\/td>ZNF611<\/td>HLA-A*32:01<\/td>Optimized polyepitope neoantigen DNA vaccines elicit neoantigen-specific immune responses in preclinical models and in clinical translation.; Genome Med; 2021<\/td>\n<\/tr>\n
    VVVGAGGVG<\/td>KRAS<\/td>HLA-B35<\/td>Cytotoxic CD4+ and CD8+ T lymphocytes, generated by mutant p21-ras (12Val) peptide vaccination of a patient, recognize 12Val-dependent nested epitopes present within the vaccine peptide and kill autologous tumour cells carrying this mutation.; Int J Cancer; 1997<\/td>\n<\/tr>\n
    VVGAGGVGK<\/td>KRAS<\/td>HLA-A*11:01<\/td>Expansion of KRAS hotspot mutations reactive T cells from human pancreatic tumors using autologous T cells as the antigen-presenting cells.; Cancer Immunol Immunother; 2022<\/td>\n<\/tr>\n
    VVVGAGGVGK<\/td>KRAS<\/td>HLA-A*11:01<\/td>Expansion of KRAS hotspot mutations reactive T cells from human pancreatic tumors using autologous T cells as the antigen-presenting cells.; Cancer Immunol Immunother; 2022<\/td>\n<\/tr>\n
    GADGVGKSA <\/td>KRAS<\/td>HLA-C*08:02<\/td>Neoantigen T-Cell Receptor Gene Therapy in Pancreatic Cancer. N Engl J Med
    \n. 2022<\/td>\n<\/tr>\n
    GADGVGKSAL<\/td>KRAS<\/td>HLA-C*08:02<\/td>Neoantigen T-Cell Receptor Gene Therapy in Pancreatic Cancer. N Engl J Med
    \n. 2022<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n\n\n\n

    \u80bf\u7624\u7a81\u53d8\u6297\u539f\u6e05\u5355\u4f7f\u7528\u65b9\u6cd5\uff1a<\/strong><\/h4>\n\n\n\n

    \u80bf\u7624\u5fae\u73af\u5883\u7814\u7a76\uff1a<\/strong><\/p>\n\n\n\n

    \u68c0\u6d4b\u80bf\u7624\u6d78\u6da6\u6dcb\u5df4\u7ec6\u80de\u4e2d\uff0c\u80bf\u7624\u6297\u539f\u7279\u5f02\u6027\u6dcb\u5df4\u7ec6\u80de\u7684\u6570\u91cf\u5b9e\u73b0\u3002\u5177\u4f53\u65b9\u5f0f\u662f\uff1a\u6839\u636e\u6e05\u5355\u5185\u5bb9\uff0c\u5c06\u6297\u539f\u80bd\u548cHLA\u5408\u6210\u4e3a\u6297\u539f\u80bdMHC\u590d\u5408\u7269\u8367\u5149\u56db\u805a\u4f53\uff0c\u901a\u8fc7\u6d41\u5f0f\u7ec6\u80de\u68c0\u6d4b\u65b9\u6cd5\uff0c\u68c0\u6d4b\u80bf\u7624\u6d78\u6da6\u6dcb\u5df4\u7ec6\u80de\u7684\u542b\u91cf\u3002<\/p>\n\n\n\n

    \u80bf\u7624\u514d\u75ab\u7ec6\u80de\u7684\u5168\u8eab\u5206\u5e03\uff1a<\/strong><\/p>\n\n\n\n

    \u901a\u8fc7\u68c0\u6d4b\u5916\u5468\u8840\u4e2d\u80bf\u7624\u6297\u539f\u7279\u5f02\u6027\u6dcb\u5df4\u7ec6\u80de\u7684\u6570\u91cf\u5b9e\u73b0\u3002\u5177\u4f53\u65b9\u6cd5\u540c\u4e0a\u3002<\/p>\n\n\n\n

    \u8fc7\u7ee7\u6027\u80bf\u7624\u514d\u75ab\u7ec6\u80de\u6cbb\u7597\uff1a<\/strong><\/p>\n\n\n\n

    \u4f7f\u7528\u6e05\u5355\u4e2d\u6297\u539f\u80bd\uff0c\u523a\u6fc0\u6dcb\u5df4\u7ec6\u80de\uff0c\u800c\u540e\u4f7f\u7528\u6297\u539f\u80bdMHC\u590d\u5408\u7269\u8367\u5149\u56db\u805a\u4f53\u6216\u78c1\u73e0\u56db\u805a\u4f53\uff0c\u901a\u8fc7\u6d41\u5f0f\u5206\u9009\u6216\u78c1\u73e0\u5206\u9009\u7ec6\u80de\uff0c\u7ecf\u4f53\u5916\u7ec6\u80de\u589e\u6b96\u540e\uff0c\u56de\u8f93\u4f53\u5185\uff0c\u8bc4\u4f30\u80bf\u7624\u6291\u5236\u6548\u679c\u3002<\/p>\n\n\n\n

    \u80bf\u7624\u6297\u539f\u7279\u5f02\u6027TCR\u6d4b\u5e8f\uff1a<\/strong><\/p>\n\n\n\n

    \u901a\u8fc7\u80bf\u7624\u6d78\u6da6\u6dcb\u5df4\u7ec6\u80de\u3001\u6216\u5916\u5468\u8840\u6dcb\u5df4\u7ec6\u80de\uff0c\u901a\u8fc7\u5206\u9009\u540e\u8fdb\u884c\u5355\u7ec6\u80deTCR\u6d4b\u5e8f\uff0c\u83b7\u5f97\u6297\u539f\u7279\u5f02\u6027T\u7ec6\u80de\u7684TCR\u5e8f\u5217\uff0c\u8fdb\u4e00\u6b65\u8fdb\u884cTCR-T\u7597\u6cd5\u7814\u7a76\u3002<\/p>\n\n\n\n

    \u80bf\u7624\u75ab\u82d7\u7247\u6bb5\u7b5b\u9009\uff1a<\/strong><\/p>\n\n\n\n

    \u7efc\u5408\u4e0a\u8ff0\u8fc7\u7a0b\uff0c\u83b7\u5f97\u5177\u6709\u6fc0\u6d3bT\u7ec6\u80de\u6740\u4f24\u80bf\u7624\u7ec6\u80de\u7684\u7ecf\u9a8c\u8bc1\u6297\u539f\u80bdMHC\u590d\u5408\u7269\uff0c\u7528\u4e8e\u80bf\u7624\u75ab\u82d7\u6784\u5efa\u3002<\/p>\n

    Views: 4<\/p>","protected":false},"excerpt":{"rendered":"

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