{"id":749,"date":"2025-07-09T03:34:50","date_gmt":"2025-07-09T03:34:50","guid":{"rendered":"http:\/\/60.204.213.123\/?page_id=749"},"modified":"2026-02-28T09:52:44","modified_gmt":"2026-02-28T09:52:44","slug":"ul123-316-324-hla-a0201","status":"publish","type":"page","link":"https:\/\/www.guixiong.com.cn\/?page_id=749","title":{"rendered":"IE1 (316-324) HLA-A*02:01 \u6d41\u5f0f\u9a8c\u8bc1"},"content":{"rendered":"\r\n<h3 class=\"wp-block-heading\">\u9776\u70b9\u8bf4\u660e<\/h3>\r\n\r\n\r\n\r\n<p>\u86cb\u767d\u590d\u5408\u7269\uff1a<a href=\"https:\/\/www.iedb.org\/antigen\/UNIPROT:F5HCM1\" target=\"_blank\" rel=\"noopener\">IE1<\/a> (316-324) VLEETSVML HLA-A*02:01<\/p>\r\n<p><span data-pm-slice=\"0 0 []\">IE1\uff08Immediate Early Protein 1\uff09\u86cb\u767d<\/span>\u6765\u6e90\uff1a\u4eba\u7c7b\u5de8\u7ec6\u80de\u75c5\u6bd2\uff08Human cytomegalovirus, HCMV\uff09\uff0c\u4e00\u79cd\u53ef\u5efa\u7acb\u7ec8\u8eab\u6f5c\u4f0f\u611f\u67d3\u7684\u03b2\u75b1\u75b9\u75c5\u6bd2\uff0c\u5728\u514d\u75ab\u6291\u5236\u4eba\u7fa4\uff08\u5982\u5668\u5b98\u79fb\u690d\u53d7\u8005\u3001\u827e\u6ecb\u75c5\u60a3\u8005\uff09\u6216\u80ce\u513f\u4e2d\u53ef\u5f15\u53d1\u4e25\u91cd\u75be\u75c5\u3002<\/p>\r\n<p>\u529f\u80fd\u89d2\u8272\uff1aIE1\u662f\u75c5\u6bd2\u518d\u6fc0\u6d3b\u540e\u6700\u65e9\u8868\u8fbe\u7684\u5173\u952e\u8c03\u63a7\u86cb\u767d\u4e4b\u4e00\uff0c\u53c2\u4e0e\uff1a<\/p>\r\n<ul class=\"list-paddingleft-1\">\r\n<li>\r\n<p>\u6fc0\u6d3b\u75c5\u6bd2\u665a\u671f\u57fa\u56e0\u8f6c\u5f55<\/p>\r\n<\/li>\r\n<li>\r\n<p>\u5e72\u6270\u5bbf\u4e3b\u5e72\u6270\u7d20\u4fe1\u53f7\u901a\u8def\u4e0e\u6297\u75c5\u6bd2\u514d\u75ab<\/p>\r\n<\/li>\r\n<li>\r\n<p>\u8c03\u63a7\u75c5\u6bd2\u6f5c\u4f0f-\u518d\u6fc0\u6d3b\u8f6c\u6362<\/p>\r\n<\/li>\r\n<li>\r\n<p>\u4fc3\u8fdb\u75c5\u6bd2\u514d\u75ab\u9003\u9038<\/p>\r\n<\/li>\r\n<li>\r\n<p>\u56e0\u5176\u5728\u611f\u67d3\u65e9\u671f\u5373\u66b4\u9732\u4e8e\u514d\u75ab\u7cfb\u7edf\uff0c\u6210\u4e3aT\u7ec6\u80de\u514d\u75ab\u76d1\u89c6\u7684\u6838\u5fc3\u9776\u6807\uff0c\u4e5f\u662f\u75ab\u82d7\u4e0e\u514d\u75ab\u7597\u6cd5\u7814\u53d1\u7684\u91cd\u70b9\u6297\u539f\u3002<\/p>\r\n<\/li>\r\n<\/ul>\r\n<p>\u8be5\u9776\u70b9\u7684\u5e94\u7528\u4ef7\u503c<\/p>\r\n<p>1. \u514d\u75ab\u76d1\u6d4b\u6807\u5fd7\u7269\uff1aIE1 (316-324)\u7279\u5f02\u6027T\u7ec6\u80de\u53cd\u5e94\u5e38\u7528\u4e8e\u4e34\u5e8a\u8bc4\u4f30\u79fb\u690d\u60a3\u8005HCMV\u611f\u67d3\u98ce\u9669\u6216\u514d\u75ab\u91cd\u5efa\u72b6\u6001\u3002<\/p>\r\n<p>2. \u75ab\u82d7\u5f00\u53d1\u6838\u5fc3\u9776\u70b9\uff1a\u591a\u4e2aHCMV\u5019\u9009\u75ab\u82d7\uff08\u5982mRNA\u75ab\u82d7\u3001\u75c5\u6bd2\u8f7d\u4f53\u75ab\u82d7\uff09\u5c06IE1\u8868\u4f4d\u7eb3\u5165\u8bbe\u8ba1\uff0c\u4ee5\u6fc0\u53d1\u5f3a\u6548\u7ec6\u80de\u514d\u75ab\u3002<\/p>\r\n<p>3. \u57fa\u7840\u7814\u7a76\u6a21\u578b\uff1a\u5176\u4e30\u5bcc\u7684\u8868\u4f4d\u6570\u636e\u4e0e\u7ed3\u6784\u4fe1\u606f\uff0c\u52a9\u529b\u89e3\u6790\u75c5\u6bd2-\u5bbf\u4e3b\u4e92\u4f5c\u3001MHC\u63d0\u5448\u673a\u5236\u53ca\u514d\u75ab\u9003\u9038\u7b56\u7565\u3002<\/p>\r\n<p>4. \u6570\u636e\u5e93\u4ef7\u503c\uff1a\u6570\u636e\u6e90\u81eaIEDB\uff08\u514d\u75ab\u8868\u4f4d\u6570\u636e\u5e93\uff09\u7b49\u6743\u5a01\u5e73\u53f0\uff0c305\u4e2a\u8868\u4f4d\u53ca\u5343\u4f59\u6b21\u5b9e\u9a8c\u9a8c\u8bc1\uff0c\u4e3a\u5168\u7403\u7814\u7a76\u8005\u63d0\u4f9b\u53ef\u9760\u53c2\u8003\u3002<\/p>\r\n\r\n\r\n\r\n\r\n\r\n<h3 class=\"wp-block-heading\">HLA\u7c7b\u578b<\/h3>\r\n\r\n\r\n\r\n<p><a href=\"https:\/\/www.guixiong.com.cn\/?page_id=247\" data-type=\"page\" data-id=\"247\">HLA-A*02:01\uff0c \u4e2d\u56fd\u4eba\u5206\u5e03\u9891\u738712.036%<\/a><\/p>\r\n\r\n\r\n\r\n\r\n\r\n<h3 class=\"wp-block-heading\">\u6297\u539f\u548cHLA\u7684\u4eb2\u548c\u529b<\/h3>\r\n\r\n\r\n\r\n\r\n\r\n<p><a href=\"https:\/\/services.healthtech.dtu.dk\/services\/NetMHCpan-4.1\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>NetMHCpan 4.1<\/strong>\u00a0<\/a> \u8ba1\u7b97VLEETSVML\u4e0eHLA-A*02:01\u4eb2\u548c\u529b\u4e3a 89.11 nM\uff0c\u4e3a\u7a33\u5b9a\u7ed3\u5408\u3002<\/p>\r\n\r\n\r\n\r\n\r\n\r\n<h3 class=\"wp-block-heading\">\u4ea7\u54c1\u7c7b\u578b\u548c\u5e94\u7528<\/h3>\r\n\r\n\r\n\r\n\r\n\r\n<figure class=\"wp-block-table\">\r\n<table>\r\n<tbody>\r\n<tr>\r\n<td>\u4ea7\u54c1\u7c7b\u578b<\/td>\r\n<td>\u89c4\u683c<\/td>\r\n<td>\u4ef7\u683c<\/td>\r\n<\/tr>\r\n<tr>\r\n<td>\u6d41\u5f0f\u68c0\u6d4b\u4e0e\u5206\u9009<\/td>\r\n<td>IE1 (316-324) HLA-A*02:01 PE \/ APC \/ Alexa Fluor 488<\/td>\r\n<td>7200\u5143\/50ug, 11800\u5143\/100ug<\/td>\r\n<\/tr>\r\n<tr>\r\n<td>\u78c1\u73e0\u5206\u9009<\/td>\r\n<td>IE1 (316-324) HLA-A*02:01 HLA-A*02:01\u78c1\u73e0<\/td>\r\n<td>8200\u5143\/50ug, 12800\u5143\/100ug<\/td>\r\n<\/tr>\r\n<tr>\r\n<td>\u751f\u7269\u7d20\u5316\u590d\u5408\u7269<\/td>\r\n<td>IE1 (316-324) HLA-A*02:01 HLA-A*02:01-biotin<\/td>\r\n<td>6800\u5143\/50ug, 11400\u5143\/100ug<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>\r\n<\/figure>\r\n\r\n\r\n\r\n<h3 class=\"wp-block-heading\">\u5b9e\u6d4b\u7ed3\u679c<\/h3>\r\n\r\n\r\n\r\n<p>&nbsp;<\/p>\r\n\r\n\r\n\r\n<h3 class=\"wp-block-heading\">\u80bd\u523a\u6fc0PBMC\u540e\u68c0\u6d4b\u6297\u539f\u7279\u5f02\u6027CD8+T\u7ec6\u80de<\/h3>\r\n\r\n\r\n\r\n<p>IE1 (316-324) VLEETSVML\u591a\u80bd\u523a\u6fc0HLA-A*02:01\u9650\u5236\u6027PBMC\u540e\uff0c\u4f7f\u7528IE1 (316-324)\u00a0 HLA-A*02:01 PE \u56db\u805a\u4f53\u548c\u6297CD8-FITC\u6297\u4f53\u68c0\u6d4b\u3002\u4e0b\u56fe\u5de6\u56fe\u4e3a\u6297\u539f\u80bdVLEETSVML\u523a\u6fc0\u7ec4\uff0c\u53f3\u56fe\u4e3a\u672a\u52a0\u6297\u539f\u80bd\u523a\u6fc0\u7ec4\u3002<\/p>\r\n\r\n\r\n\r\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\r\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\r\n<figure class=\"wp-block-image size-full\"><img fetchpriority=\"high\" decoding=\"async\" width=\"329\" height=\"331\" class=\"wp-image-1068\" src=\"https:\/\/www.guixiong.com.cn\/wp-content\/uploads\/2025\/07\/image-3.png\" alt=\"\" srcset=\"https:\/\/guixiong.com.cn\/wp-content\/uploads\/2025\/07\/image-3.png 329w, https:\/\/guixiong.com.cn\/wp-content\/uploads\/2025\/07\/image-3-100x100.png 100w, https:\/\/guixiong.com.cn\/wp-content\/uploads\/2025\/07\/image-3-298x300.png 298w, https:\/\/guixiong.com.cn\/wp-content\/uploads\/2025\/07\/image-3-150x150.png 150w\" sizes=\"(max-width: 329px) 100vw, 329px\" \/><\/figure>\r\n<\/div>\r\n\r\n\r\n\r\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\r\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" width=\"324\" height=\"337\" class=\"wp-image-1069\" src=\"https:\/\/www.guixiong.com.cn\/wp-content\/uploads\/2025\/07\/image-4.png\" alt=\"\" srcset=\"https:\/\/guixiong.com.cn\/wp-content\/uploads\/2025\/07\/image-4.png 324w, https:\/\/guixiong.com.cn\/wp-content\/uploads\/2025\/07\/image-4-288x300.png 288w\" sizes=\"(max-width: 324px) 100vw, 324px\" \/><\/figure>\r\n<\/div>\r\n<\/div>\r\n\r\n\r\n\r\n<h3 class=\"wp-block-heading\">\u9776\u70b9\u7ed3\u5408\u7684TCR\u5e8f\u5217<\/h3>\r\n\r\n\r\n\r\n<p>\u8bf7\u67e5\u770b<a href=\"http:\/\/www.iedb.org\" target=\"_blank\" rel=\"noreferrer noopener\" data-type=\"link\" data-id=\"www.iedb.org\">IEDB\u6570\u636e\u5e93<\/a><\/p>\r\n\r\n\r\n\n<table id=\"tablepress-32\" class=\"tablepress tablepress-id-32\">\n<thead>\n<tr class=\"row-1 odd\">\n\t<th class=\"column-1\">Receptor - IEDB Receptor ID<\/th><th class=\"column-2\">Chain 1 - Calculated V Gene<\/th><th class=\"column-3\">Chain 1 - Calculated D Gene<\/th><th class=\"column-4\">Chain 1 - Calculated J Gene<\/th><th class=\"column-5\">Chain 1 - CDR3 Curated<\/th><th class=\"column-6\">Chain 2 - Calculated V Gene<\/th><th class=\"column-7\">Chain 2 - Calculated D Gene<\/th><th class=\"column-8\">Chain 2 - Calculated J Gene<\/th><th class=\"column-9\">Chain 2 - CDR3 Curated<\/th>\n<\/tr>\n<\/thead>\n<tbody class=\"row-hover\">\n<tr class=\"row-2 even\">\n\t<td class=\"column-1\">209258<\/td><td class=\"column-2\"><\/td><td class=\"column-3\"><\/td><td class=\"column-4\"><\/td><td class=\"column-5\">CVVRTDKLIF<\/td><td class=\"column-6\"><\/td><td class=\"column-7\"><\/td><td class=\"column-8\"><\/td><td class=\"column-9\">CASSLDSQSSGNTIYF<\/td>\n<\/tr>\n<tr class=\"row-3 odd\">\n\t<td class=\"column-1\">225171<\/td><td class=\"column-2\">TRAV23\/DV6<\/td><td class=\"column-3\"><\/td><td class=\"column-4\">TRAJ48<\/td><td class=\"column-5\">CAASIGAFGNEKLTF<\/td><td class=\"column-6\">TRBV3-1<\/td><td class=\"column-7\"><\/td><td class=\"column-8\">TRBJ1-5<\/td><td class=\"column-9\">CASSQVFGTPTPQHF<\/td>\n<\/tr>\n<tr class=\"row-4 even\">\n\t<td class=\"column-1\">225271<\/td><td class=\"column-2\">TRAV5<\/td><td class=\"column-3\"><\/td><td class=\"column-4\">TRAJ13<\/td><td class=\"column-5\">CAERGSGGYQKVTF<\/td><td class=\"column-6\">TRBV7-8<\/td><td class=\"column-7\"><\/td><td class=\"column-8\">TRBJ1-2<\/td><td class=\"column-9\">CASSLKSPGQANWYGYTF<\/td>\n<\/tr>\n<tr class=\"row-5 odd\">\n\t<td class=\"column-1\">225292<\/td><td class=\"column-2\">TRAV12-1<\/td><td class=\"column-3\"><\/td><td class=\"column-4\">TRAJ11<\/td><td class=\"column-5\">CVVRYSTLTF<\/td><td class=\"column-6\">TRBV5-1<\/td><td class=\"column-7\"><\/td><td class=\"column-8\">TRBJ1-3<\/td><td class=\"column-9\">CASSADSIGSGNTIYF<\/td>\n<\/tr>\n<tr class=\"row-6 even\">\n\t<td class=\"column-1\">225397<\/td><td class=\"column-2\">TRAV19<\/td><td class=\"column-3\"><\/td><td class=\"column-4\">TRAJ23<\/td><td class=\"column-5\">CALSEYNQGGKLIF<\/td><td class=\"column-6\">TRBV3-1<\/td><td class=\"column-7\"><\/td><td class=\"column-8\">TRBJ1-5<\/td><td class=\"column-9\">CASSQVFGTPTPQHF<\/td>\n<\/tr>\n<tr class=\"row-7 odd\">\n\t<td class=\"column-1\">225401<\/td><td class=\"column-2\">TRAV38-2\/DV8<\/td><td class=\"column-3\"><\/td><td class=\"column-4\">TRAJ43<\/td><td class=\"column-5\">CAYQWGGDMRF<\/td><td class=\"column-6\">TRBV3-1<\/td><td class=\"column-7\"><\/td><td class=\"column-8\">TRBJ1-5<\/td><td class=\"column-9\">CASSQVFGTPTPQHF<\/td>\n<\/tr>\n<tr class=\"row-8 even\">\n\t<td class=\"column-1\">225405<\/td><td class=\"column-2\">TRAV30<\/td><td class=\"column-3\"><\/td><td class=\"column-4\">TRAJ38<\/td><td class=\"column-5\">CGTEGAGNNRKLIW<\/td><td class=\"column-6\">TRBV3-1<\/td><td class=\"column-7\"><\/td><td class=\"column-8\">TRBJ1-5<\/td><td class=\"column-9\">CASSQVFGTPTPQHF<\/td>\n<\/tr>\n<tr class=\"row-9 odd\">\n\t<td class=\"column-1\">225405<\/td><td class=\"column-2\">TRAV30<\/td><td class=\"column-3\"><\/td><td class=\"column-4\">TRAJ38<\/td><td class=\"column-5\">CGTEGAGNNRKLIW<\/td><td class=\"column-6\">TRBV3-1<\/td><td class=\"column-7\"><\/td><td class=\"column-8\">TRBJ1-5<\/td><td class=\"column-9\">CASSQVFGTPTPQHF<\/td>\n<\/tr>\n<tr class=\"row-10 even\">\n\t<td class=\"column-1\">225405<\/td><td class=\"column-2\">TRAV30<\/td><td class=\"column-3\"><\/td><td class=\"column-4\">TRAJ38<\/td><td class=\"column-5\">CGTEGAGNNRKLIW<\/td><td class=\"column-6\">TRBV3-1<\/td><td class=\"column-7\"><\/td><td class=\"column-8\">TRBJ1-5<\/td><td class=\"column-9\">CASSQVFGTPTPQHF<\/td>\n<\/tr>\n<tr class=\"row-11 odd\">\n\t<td class=\"column-1\">225407<\/td><td class=\"column-2\">TRAV26-1<\/td><td class=\"column-3\"><\/td><td class=\"column-4\">TRAJ43<\/td><td class=\"column-5\">CIVRPRGDNDMRF<\/td><td class=\"column-6\">TRBV3-1<\/td><td class=\"column-7\"><\/td><td class=\"column-8\">TRBJ1-5<\/td><td class=\"column-9\">CASSQVFGTPTPQHF<\/td>\n<\/tr>\n<tr class=\"row-12 even\">\n\t<td class=\"column-1\">225408<\/td><td class=\"column-2\">TRAV4<\/td><td class=\"column-3\"><\/td><td class=\"column-4\">TRAJ28<\/td><td class=\"column-5\">CLVGDSGAGSYQLTF<\/td><td class=\"column-6\">TRBV3-1<\/td><td class=\"column-7\"><\/td><td class=\"column-8\">TRBJ1-5<\/td><td class=\"column-9\">CASSQVFGTPTPQHF<\/td>\n<\/tr>\n<tr class=\"row-13 odd\">\n\t<td class=\"column-1\">225420<\/td><td class=\"column-2\">TRAV38-1<\/td><td class=\"column-3\"><\/td><td class=\"column-4\">TRAJ20<\/td><td class=\"column-5\">CAFRGPNDYKLSF<\/td><td class=\"column-6\">TRBV13<\/td><td class=\"column-7\">TRBD1<\/td><td class=\"column-8\">TRBJ1-6<\/td><td class=\"column-9\">CASSPKGTDGNSPLHF<\/td>\n<\/tr>\n<tr class=\"row-14 even\">\n\t<td class=\"column-1\">225581<\/td><td class=\"column-2\">TRAV8-3<\/td><td class=\"column-3\"><\/td><td class=\"column-4\">TRAJ9<\/td><td class=\"column-5\">CAVVVRNTGGFKTIF<\/td><td class=\"column-6\">TRBV12-4<\/td><td class=\"column-7\">TRBD2<\/td><td class=\"column-8\">TRBJ2-1<\/td><td class=\"column-9\">CASTTGTSGRDYNEQFF<\/td>\n<\/tr>\n<tr class=\"row-15 odd\">\n\t<td class=\"column-1\">225581<\/td><td class=\"column-2\">TRAV8-3<\/td><td class=\"column-3\"><\/td><td class=\"column-4\">TRAJ9<\/td><td class=\"column-5\">CAVVVRNTGGFKTIF<\/td><td class=\"column-6\">TRBV12-4<\/td><td class=\"column-7\">TRBD2<\/td><td class=\"column-8\">TRBJ2-1<\/td><td class=\"column-9\">CASTTGTSGRDYNEQFF<\/td>\n<\/tr>\n<tr class=\"row-16 even\">\n\t<td class=\"column-1\">225581<\/td><td class=\"column-2\">TRAV8-3<\/td><td class=\"column-3\"><\/td><td class=\"column-4\">TRAJ9<\/td><td class=\"column-5\">CAVVVRNTGGFKTIF<\/td><td class=\"column-6\">TRBV12-4<\/td><td class=\"column-7\">TRBD2<\/td><td class=\"column-8\">TRBJ2-1<\/td><td class=\"column-9\">CASTTGTSGRDYNEQFF<\/td>\n<\/tr>\n<tr class=\"row-17 odd\">\n\t<td class=\"column-1\">225581<\/td><td class=\"column-2\">TRAV8-3<\/td><td class=\"column-3\"><\/td><td class=\"column-4\">TRAJ9<\/td><td class=\"column-5\">CAVVVRNTGGFKTIF<\/td><td class=\"column-6\">TRBV12-4<\/td><td class=\"column-7\">TRBD2<\/td><td class=\"column-8\">TRBJ2-1<\/td><td class=\"column-9\">CASTTGTSGRDYNEQFF<\/td>\n<\/tr>\n<tr class=\"row-18 even\">\n\t<td class=\"column-1\">225622<\/td><td class=\"column-2\">TRAV41<\/td><td class=\"column-3\"><\/td><td class=\"column-4\">TRAJ48<\/td><td class=\"column-5\">CAVRGEFGNEKLTF<\/td><td class=\"column-6\">TRBV7-3<\/td><td class=\"column-7\"><\/td><td class=\"column-8\">TRBJ2-1<\/td><td class=\"column-9\">CASSLLPYNEQFF<\/td>\n<\/tr>\n<tr class=\"row-19 odd\">\n\t<td class=\"column-1\">225687<\/td><td class=\"column-2\">TRAV9-2<\/td><td class=\"column-3\"><\/td><td class=\"column-4\">TRAJ49<\/td><td class=\"column-5\">CALSVSNQFYF<\/td><td class=\"column-6\">TRBV4-1<\/td><td class=\"column-7\"><\/td><td class=\"column-8\">TRBJ2-1<\/td><td class=\"column-9\">CASSRDRSSYNEQFF<\/td>\n<\/tr>\n<tr class=\"row-20 even\">\n\t<td class=\"column-1\">225727<\/td><td class=\"column-2\">TRAV1-2<\/td><td class=\"column-3\"><\/td><td class=\"column-4\">TRAJ12<\/td><td class=\"column-5\">CVLMDSSYKLIF<\/td><td class=\"column-6\">TRBV6-2<\/td><td class=\"column-7\">TRBD1<\/td><td class=\"column-8\">TRBJ2-3<\/td><td class=\"column-9\">CASSTPPDRADTQYF<\/td>\n<\/tr>\n<tr class=\"row-21 odd\">\n\t<td class=\"column-1\">225739<\/td><td class=\"column-2\">TRAV8-1<\/td><td class=\"column-3\"><\/td><td class=\"column-4\">TRAJ36<\/td><td class=\"column-5\">CAVILTGANNLFF<\/td><td class=\"column-6\">TRBV11-1<\/td><td class=\"column-7\"><\/td><td class=\"column-8\">TRBJ2-3<\/td><td class=\"column-9\">CASSQQRGRTDTQYF<\/td>\n<\/tr>\n<tr class=\"row-22 even\">\n\t<td class=\"column-1\">225742<\/td><td class=\"column-2\">TRAV5<\/td><td class=\"column-3\"><\/td><td class=\"column-4\">TRAJ10<\/td><td class=\"column-5\">CAEILTGGGNKLTF<\/td><td class=\"column-6\">TRBV11-2<\/td><td class=\"column-7\"><\/td><td class=\"column-8\">TRBJ2-3<\/td><td class=\"column-9\">CASSLQTGRTDTQYF<\/td>\n<\/tr>\n<tr class=\"row-23 odd\">\n\t<td class=\"column-1\">225742<\/td><td class=\"column-2\">TRAV5<\/td><td class=\"column-3\"><\/td><td class=\"column-4\">TRAJ10<\/td><td class=\"column-5\">CAEILTGGGNKLTF<\/td><td class=\"column-6\">TRBV11-2<\/td><td class=\"column-7\"><\/td><td class=\"column-8\">TRBJ2-3<\/td><td class=\"column-9\">CASSLQTGRTDTQYF<\/td>\n<\/tr>\n<tr class=\"row-24 even\">\n\t<td class=\"column-1\">225815<\/td><td class=\"column-2\">TRAV29\/DV5<\/td><td class=\"column-3\"><\/td><td class=\"column-4\">TRAJ33<\/td><td class=\"column-5\">CAARLINYQLIW<\/td><td class=\"column-6\">TRBV4-3<\/td><td class=\"column-7\"><\/td><td class=\"column-8\">TRBJ2-2<\/td><td class=\"column-9\">CASSQDPAWGGANTGELFF<\/td>\n<\/tr>\n<tr class=\"row-25 odd\">\n\t<td class=\"column-1\">225815<\/td><td class=\"column-2\">TRAV29\/DV5<\/td><td class=\"column-3\"><\/td><td class=\"column-4\">TRAJ33<\/td><td class=\"column-5\">CAARLINYQLIW<\/td><td class=\"column-6\">TRBV4-3<\/td><td class=\"column-7\"><\/td><td class=\"column-8\">TRBJ2-2<\/td><td class=\"column-9\">CASSQDPAWGGANTGELFF<\/td>\n<\/tr>\n<tr class=\"row-26 even\">\n\t<td class=\"column-1\">225847<\/td><td class=\"column-2\">TRAV20<\/td><td class=\"column-3\"><\/td><td class=\"column-4\">TRAJ52<\/td><td class=\"column-5\">CAVQAVKLGGTSYGKLTF<\/td><td class=\"column-6\">TRBV7-2<\/td><td class=\"column-7\">TRBD1<\/td><td class=\"column-8\">TRBJ2-5<\/td><td class=\"column-9\">CASSAGQGGVETQYF<\/td>\n<\/tr>\n<tr class=\"row-27 odd\">\n\t<td class=\"column-1\">226027<\/td><td class=\"column-2\">TRAV38-2\/DV8<\/td><td class=\"column-3\"><\/td><td class=\"column-4\">TRAJ32<\/td><td class=\"column-5\">CALPLHGGATNKLIF<\/td><td class=\"column-6\">TRBV19<\/td><td class=\"column-7\"><\/td><td class=\"column-8\">TRBJ2-6<\/td><td class=\"column-9\">CAGRQAGANVLTF<\/td>\n<\/tr>\n<tr class=\"row-28 even\">\n\t<td class=\"column-1\">226102<\/td><td class=\"column-2\">TRAV27<\/td><td class=\"column-3\"><\/td><td class=\"column-4\">TRAJ44<\/td><td class=\"column-5\">CAGNTGTASKLTF<\/td><td class=\"column-6\">TRBV9<\/td><td class=\"column-7\"><\/td><td class=\"column-8\">TRBJ2-7<\/td><td class=\"column-9\">CASSPKYSYEQYF<\/td>\n<\/tr>\n<tr class=\"row-29 odd\">\n\t<td class=\"column-1\">226148<\/td><td class=\"column-2\">TRAV19<\/td><td class=\"column-3\"><\/td><td class=\"column-4\">TRAJ24<\/td><td class=\"column-5\">CALGPWGKLQF<\/td><td class=\"column-6\">TRBV3-1<\/td><td class=\"column-7\"><\/td><td class=\"column-8\">TRBJ2-7<\/td><td class=\"column-9\">CASSQVGGSSREQYF<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<!-- #tablepress-32 from cache -->\n\r\n\r\n\r\n<h3 class=\"wp-block-heading\">\u76f8\u5173\u6587\u7ae0<\/h3>\r\n\r\n\r\n\n<table id=\"tablepress-36\" class=\"tablepress tablepress-id-36\">\n<thead>\n<tr class=\"row-1 odd\">\n\t<th class=\"column-1\">Reference - PMID<\/th><th class=\"column-2\">Reference - Journal<\/th><th class=\"column-3\">Reference - Date<\/th><th class=\"column-4\">Reference - Title<\/th>\n<\/tr>\n<\/thead>\n<tbody class=\"row-hover\">\n<tr class=\"row-2 even\">\n\t<td class=\"column-1\">17092434<\/td><td class=\"column-2\">Cell Mol Immunol<\/td><td class=\"column-3\">2006<\/td><td class=\"column-4\">Preparation and characterization of HLA-A*0201 tetramer loaded with IE-1316-324 antigenic peptide of human cytomegalovirus.<\/td>\n<\/tr>\n<tr class=\"row-3 odd\">\n\t<td class=\"column-1\">16275592<\/td><td class=\"column-2\">Biol Blood Marrow Transplant<\/td><td class=\"column-3\">2005<\/td><td class=\"column-4\">Cytomegalovirus immune reconstitution occurs in recipients of allogeneic hematopoietic cell transplants irrespective of detectable cytomegalovirus infection.<\/td>\n<\/tr>\n<tr class=\"row-4 even\">\n\t<td class=\"column-1\">14550813<\/td><td class=\"column-2\">Exp Hematol<\/td><td class=\"column-3\">2003<\/td><td class=\"column-4\">A CTL epitope from human cytomegalovirus IE1 defined by combining prediction of HLA binding and proteasomal processing is the target of dominant immune responses in patients after allogeneic stem cell transplantation.<\/td>\n<\/tr>\n<tr class=\"row-5 odd\">\n\t<td class=\"column-1\">12634406<\/td><td class=\"column-2\">J Virol<\/td><td class=\"column-3\">2003<\/td><td class=\"column-4\">Use of transgenic HLA A*0201\/Kb and HHD II mice to evaluate frequency of cytomegalovirus IE1-derived peptide usage in eliciting human CD8 cytokine response.<\/td>\n<\/tr>\n<tr class=\"row-6 even\">\n\t<td class=\"column-1\">11930311<\/td><td class=\"column-2\">J Infect Dis<\/td><td class=\"column-3\">2002<\/td><td class=\"column-4\">Comparative analysis of CD8+ T cell responses against human cytomegalovirus proteins pp65 and immediate early 1 shows similarities in precursor frequency, oligoclonality, and phenotype.<\/td>\n<\/tr>\n<tr class=\"row-7 odd\">\n\t<td class=\"column-1\">15619009<\/td><td class=\"column-2\">Cell Mol Life Sci<\/td><td class=\"column-3\">2005<\/td><td class=\"column-4\">Major contribution of codominant CD8 and CD4 T cell epitopes to the human cytomegalovirus-specific T cell repertoire.<\/td>\n<\/tr>\n<tr class=\"row-8 even\">\n\t<td class=\"column-1\">17492595<\/td><td class=\"column-2\">J Infect Dis<\/td><td class=\"column-3\">2007<\/td><td class=\"column-4\">Cytomegalovirus (CMV) IE1- and pp65-specific CD8+ T cell responses broaden over time after primary CMV infection in infants.<\/td>\n<\/tr>\n<tr class=\"row-9 odd\">\n\t<td class=\"column-1\">16388983<\/td><td class=\"column-2\">J Clin Virol<\/td><td class=\"column-3\">2006<\/td><td class=\"column-4\">Attenuated poxvirus expressing three immunodominant CMV antigens as a vaccine strategy for CMV infection.<\/td>\n<\/tr>\n<tr class=\"row-10 even\">\n\t<td class=\"column-1\">14764694<\/td><td class=\"column-2\">J Immunol<\/td><td class=\"column-3\">2004<\/td><td class=\"column-4\">Human cytomegalovirus proteins pp65 and immediate early protein 1 are common targets for CD8+ T cell responses in children with congenital or postnatal human cytomegalovirus infection.<\/td>\n<\/tr>\n<tr class=\"row-11 odd\">\n\t<td class=\"column-1\">18982061<\/td><td class=\"column-2\">PLoS One<\/td><td class=\"column-3\">2008<\/td><td class=\"column-4\">Levels of CMV specific CD4 T cells are dynamic and correlate with CMV viremia after allogeneic stem cell transplantation.<\/td>\n<\/tr>\n<tr class=\"row-12 even\">\n\t<td class=\"column-1\">18706443<\/td><td class=\"column-2\">Immunol Lett<\/td><td class=\"column-3\">2008<\/td><td class=\"column-4\">A novel approach to evaluate the immunogenicity of viral antigens of clinical importance in HLA transgenic murine models.<\/td>\n<\/tr>\n<tr class=\"row-13 odd\">\n\t<td class=\"column-1\">14670917<\/td><td class=\"column-2\">Blood<\/td><td class=\"column-3\">2004<\/td><td class=\"column-4\">Rapid generation of combined CMV-specific CD4+ and CD8+ T-cell lines for adoptive transfer into recipients of allogeneic stem cell transplants.<\/td>\n<\/tr>\n<tr class=\"row-14 even\">\n\t<td class=\"column-1\">22197248<\/td><td class=\"column-2\">Antiviral Res<\/td><td class=\"column-3\">2012<\/td><td class=\"column-4\">The development of Chinese specific human cytomegalovirus polyepitope recombinant vaccine.<\/td>\n<\/tr>\n<tr class=\"row-15 odd\">\n\t<td class=\"column-1\">23100361<\/td><td class=\"column-2\">J Gen Virol<\/td><td class=\"column-3\">2013<\/td><td class=\"column-4\">Suppression of CD8+ T-cell recognition in the immediate-early phase of human cytomegalovirus infection.<\/td>\n<\/tr>\n<tr class=\"row-16 even\">\n\t<td class=\"column-1\">23267020<\/td><td class=\"column-2\">J Immunol<\/td><td class=\"column-3\">2013<\/td><td class=\"column-4\">CD8+ TCR repertoire formation is guided primarily by the peptide component of the antigenic complex.<\/td>\n<\/tr>\n<tr class=\"row-17 odd\">\n\t<td class=\"column-1\">15597326<\/td><td class=\"column-2\">Eur J Immunol<\/td><td class=\"column-3\">2005<\/td><td class=\"column-4\">Contemporaneous fluctuations in T cell responses to persistent herpes virus infections.<\/td>\n<\/tr>\n<tr class=\"row-18 even\">\n\t<td class=\"column-1\">23717207<\/td><td class=\"column-2\">PLoS Pathog<\/td><td class=\"column-3\">2013<\/td><td class=\"column-4\">Presentation of an immunodominant immediate-early CD8+ T cell epitope resists human cytomegalovirus immunoevasion.<\/td>\n<\/tr>\n<tr class=\"row-19 odd\">\n\t<td class=\"column-1\">23748502<\/td><td class=\"column-2\">Nat Biotechnol<\/td><td class=\"column-3\">2013<\/td><td class=\"column-4\">Combinatorial tetramer staining and mass cytometry analysis facilitate T-cell epitope mapping and characterization.<\/td>\n<\/tr>\n<tr class=\"row-20 even\">\n\t<td class=\"column-1\">24760079<\/td><td class=\"column-2\">PLoS One<\/td><td class=\"column-3\">2014<\/td><td class=\"column-4\">Identification and HLA-tetramer-validation of human CD4+ and CD8+ T cell responses against HCMV proteins IE1 and IE2.<\/td>\n<\/tr>\n<tr class=\"row-21 odd\">\n\t<td class=\"column-1\">25108651<\/td><td class=\"column-2\">Cytotherapy<\/td><td class=\"column-3\">2014<\/td><td class=\"column-4\">Clinical-scale isolation of 'minimally manipulated' cytomegalovirus-specific donor lymphocytes for the treatment of refractory cytomegalovirus disease.<\/td>\n<\/tr>\n<tr class=\"row-22 even\">\n\t<td class=\"column-1\">25339770<\/td><td class=\"column-2\">J Virol<\/td><td class=\"column-3\">2015<\/td><td class=\"column-4\">Clonal evolution of CD8+ T cell responses against latent viruses: relationship among phenotype, localization, and function.<\/td>\n<\/tr>\n<tr class=\"row-23 odd\">\n\t<td class=\"column-1\">26603974<\/td><td class=\"column-2\">Am J Transplant<\/td><td class=\"column-3\">2016<\/td><td class=\"column-4\">Virus-Specific CD8(+) T Cells Cross-Reactive to Donor-Alloantigen Are Transiently Present in the Circulation of Kidney Transplant Recipients Infected With CMV and\/or EBV.<\/td>\n<\/tr>\n<tr class=\"row-24 even\">\n\t<td class=\"column-1\">26800118<\/td><td class=\"column-2\">Clin Exp Immunol<\/td><td class=\"column-3\">2016<\/td><td class=\"column-4\">Abundant cytomegalovirus (CMV) reactive clonotypes in the CD8(+) T cell receptor alpha repertoire following allogeneic transplantation.<\/td>\n<\/tr>\n<tr class=\"row-25 odd\">\n\t<td class=\"column-1\">26509579<\/td><td class=\"column-2\">PLoS One<\/td><td class=\"column-3\">2015<\/td><td class=\"column-4\">Multiplex Identification of Antigen-Specific T Cell Receptors Using a Combination of Immune Assays and Immune Receptor Sequencing.<\/td>\n<\/tr>\n<tr class=\"row-26 even\">\n\t<td class=\"column-1\">26033882<\/td><td class=\"column-2\">Cytometry A<\/td><td class=\"column-3\">2015<\/td><td class=\"column-4\">Design and validation of conditional ligands for HLA-B*08:01, HLA-B*15:01, HLA-B*35:01, and HLA-B*44:05.<\/td>\n<\/tr>\n<tr class=\"row-27 odd\">\n\t<td class=\"column-1\">28818566<\/td><td class=\"column-2\">Vaccine<\/td><td class=\"column-3\">2017<\/td><td class=\"column-4\">A synthetic human cytomegalovirus pp65-IE1 fusion antigen efficiently induces and expands virus specific T cells.<\/td>\n<\/tr>\n<tr class=\"row-28 even\">\n\t<td class=\"column-1\">29666167<\/td><td class=\"column-2\">J Exp Med<\/td><td class=\"column-3\">2018<\/td><td class=\"column-4\">A flexible MHC class I multimer loading system for large-scale detection of antigen-specific T cells.<\/td>\n<\/tr>\n<tr class=\"row-29 odd\">\n\t<td class=\"column-1\">26314621<\/td><td class=\"column-2\">Arthritis Rheumatol<\/td><td class=\"column-3\">2016<\/td><td class=\"column-4\">Latent Cytomegalovirus Infection in Rheumatoid Arthritis and Increased Frequencies of Cytolytic LIR-1+CD8+ T Cells.<\/td>\n<\/tr>\n<tr class=\"row-30 even\">\n\t<td class=\"column-1\">24512815<\/td><td class=\"column-2\">J Immunol Methods<\/td><td class=\"column-3\">2014<\/td><td class=\"column-4\">In vitro expansion of antigen-specific CD8(+) T cells distorts the T-cell repertoire.<\/td>\n<\/tr>\n<tr class=\"row-31 odd\">\n\t<td class=\"column-1\">31324690<\/td><td class=\"column-2\">Sci Immunol<\/td><td class=\"column-3\">2019<\/td><td class=\"column-4\">Empty peptide-receptive MHC class I molecules for efficient detection of antigen-specific T cells.<\/td>\n<\/tr>\n<tr class=\"row-32 even\">\n\t<td class=\"column-1\">31398327<\/td><td class=\"column-2\">Cell<\/td><td class=\"column-3\">2019<\/td><td class=\"column-4\">T-Scan: A Genome-wide Method for the Systematic Discovery of T Cell Epitopes.<\/td>\n<\/tr>\n<tr class=\"row-33 odd\">\n\t<td class=\"column-1\">32393905<\/td><td class=\"column-2\">Nat Biotechnol<\/td><td class=\"column-3\">2020<\/td><td class=\"column-4\">Massively parallel interrogation and mining of natively paired human TCR&alpha;&beta; repertoires.<\/td>\n<\/tr>\n<tr class=\"row-34 even\">\n\t<td class=\"column-1\">33329532<\/td><td class=\"column-2\">Front Immunol<\/td><td class=\"column-3\">2020<\/td><td class=\"column-4\">Cytomegalovirus-Specific T Cell Epitope Recognition in Congenital Cytomegalovirus Mother-Infant Pairs.<\/td>\n<\/tr>\n<tr class=\"row-35 odd\">\n\t<td class=\"column-1\">33427749<\/td><td class=\"column-2\">J Clin Invest<\/td><td class=\"column-3\">2021<\/td><td class=\"column-4\">SARS-CoV-2-specific CD8+ T cell responses in convalescent COVID-19 individuals.<\/td>\n<\/tr>\n<tr class=\"row-36 even\">\n\t<td class=\"column-1\">33853928<\/td><td class=\"column-2\">Sci Immunol<\/td><td class=\"column-3\">2021<\/td><td class=\"column-4\">SARS-CoV-2 genome-wide T cell epitope mapping reveals immunodominance and substantial CD8&lt;sup&gt;+&lt;\/sup&gt; T cell activation in COVID-19 patients.<\/td>\n<\/tr>\n<tr class=\"row-37 odd\">\n\t<td class=\"column-1\">36980230<\/td><td class=\"column-2\">Cells<\/td><td class=\"column-3\">2023<\/td><td class=\"column-4\">Persistent CD8 T Cell Marks Caused by the HCMV Infection in Seropositive Adults: Prevalence of HLA-E-Reactive CD8 T Cells.<\/td>\n<\/tr>\n<tr class=\"row-38 even\">\n\t<td class=\"column-1\">36121440<\/td><td class=\"column-2\">Blood Adv<\/td><td class=\"column-3\">2023<\/td><td class=\"column-4\">Tracking the progeny of adoptively transferred virus-specific T cells in patients posttransplant using TCR sequencing.<\/td>\n<\/tr>\n<tr class=\"row-39 odd\">\n\t<td class=\"column-1\">37586765<\/td><td class=\"column-2\">J Immunother Cancer<\/td><td class=\"column-3\">2023<\/td><td class=\"column-4\">TCR-engaging scaffolds selectively expand antigen-specific T-cells with a favorable phenotype for adoptive cell therapy.<\/td>\n<\/tr>\n<tr class=\"row-40 even\">\n\t<td class=\"column-1\">35401538<\/td><td class=\"column-2\">Front Immunol<\/td><td class=\"column-3\">2022<\/td><td class=\"column-4\">Public T-Cell Receptors (TCRs) Revisited by Analysis of the Magnitude of Identical and Highly-Similar TCRs in Virus-Specific T-Cell Repertoires of Healthy Individuals.<\/td>\n<\/tr>\n<tr class=\"row-41 odd\">\n\t<td class=\"column-1\">38053994<\/td><td class=\"column-2\">Front Immunol<\/td><td class=\"column-3\">2023<\/td><td class=\"column-4\">Overall avidity declines in TCR repertoires during latent CMV but not EBV infection.<\/td>\n<\/tr>\n<tr class=\"row-42 even\">\n\t<td class=\"column-1\">38608022<\/td><td class=\"column-2\">Sci Adv<\/td><td class=\"column-3\">2024<\/td><td class=\"column-4\">Simultaneous analysis of pMHC binding and reactivity unveils virus-specific CD8 T cell immunity to a concise epitope set.<\/td>\n<\/tr>\n<tr class=\"row-43 odd\">\n\t<td class=\"column-1\">37133356<\/td><td class=\"column-2\">Elife<\/td><td class=\"column-3\">2023<\/td><td class=\"column-4\">Improved T cell receptor antigen pairing through data-driven filtering of sequencing information from single cells.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<!-- #tablepress-36 from cache -->\n\r\n\r\n\r\n<p>&nbsp;<\/p>\r\n\r\n\r\n\r\n<p>&nbsp;<\/p>\r\n<p>Views: 13<\/p>","protected":false},"excerpt":{"rendered":"<p>\u9776\u70b9\u8bf4\u660e \u86cb\u767d\u590d\u5408\u7269\uff1aIE1 (316-324) VLEETSVML HLA-A*02:01 IE1\uff08Imme&#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_kadence_starter_templates_imported_post":false,"_kad_post_transparent":"default","_kad_post_title":"default","_kad_post_layout":"default","_kad_post_sidebar_id":"","_kad_post_content_style":"default","_kad_post_vertical_padding":"default","_kad_post_feature":"","_kad_post_feature_position":"","_kad_post_header":false,"_kad_post_footer":false,"_kad_post_classname":"","footnotes":""},"class_list":["post-749","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.guixiong.com.cn\/index.php?rest_route=\/wp\/v2\/pages\/749","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.guixiong.com.cn\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.guixiong.com.cn\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.guixiong.com.cn\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.guixiong.com.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=749"}],"version-history":[{"count":9,"href":"https:\/\/www.guixiong.com.cn\/index.php?rest_route=\/wp\/v2\/pages\/749\/revisions"}],"predecessor-version":[{"id":1687,"href":"https:\/\/www.guixiong.com.cn\/index.php?rest_route=\/wp\/v2\/pages\/749\/revisions\/1687"}],"wp:attachment":[{"href":"https:\/\/www.guixiong.com.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=749"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}