{"id":757,"date":"2025-07-09T03:44:12","date_gmt":"2025-07-09T03:44:12","guid":{"rendered":"http:\/\/60.204.213.123\/?page_id=757"},"modified":"2025-07-09T03:45:16","modified_gmt":"2025-07-09T03:45:16","slug":"mart1-27-35-hla-a0201-6","status":"publish","type":"page","link":"https:\/\/www.guixiong.com.cn\/?page_id=757","title":{"rendered":"Envelope protein (183-191) HLA-A*02:01 \u6d41\u5f0f\u9a8c\u8bc1"},"content":{"rendered":"\n<h3 class=\"wp-block-heading\">\u9776\u70b9\u8bf4\u660e<\/h3>\n\n\n\n<p>Envelope protein (183-191) FLLTRILTI HLA-A*02:01 \u6765\u81eaHBV\uff0c\u5176\u591a\u80bdFLLTRILTI\u662f\u4e00\u79cd\u7ebf\u6027\u80bd\u8868\u4f4d\uff08\u8868\u4f4dID 16755\uff09\uff0c\u4f5c\u4e3a\u4e59\u578b\u809d\u708e\u75c5\u6bd2\uff08\u4eba\u7c7b\u4e59\u578b\u809d\u708e\u75c5\u6bd2\uff09\u5305\u819c\u86cb\u767d\uff08UniProt\uff1aQ76R62\uff09\u7684\u4e00\u90e8\u5206\uff0c\u5177\u6709T\u7ec6\u80de\u7684\u514d\u75ab\u539f\u6027\u3002<\/p>\n\n\n\n<p><\/p>\n\n\n\n<h3 class=\"wp-block-heading\">HLA\u7c7b\u578b<\/h3>\n\n\n\n<p><a href=\"https:\/\/www.guixiong.com.cn\/?page_id=247\" data-type=\"page\" data-id=\"247\">HLA-A*02:01\uff0c \u4e2d\u56fd\u4eba\u5206\u5e03\u9891\u738712.036%<\/a><\/p>\n\n\n\n<p><\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u6297\u539f\u548cHLA\u7684\u4eb2\u548c\u529b<\/h3>\n\n\n\n<p><\/p>\n\n\n\n<p><a href=\"https:\/\/services.healthtech.dtu.dk\/services\/NetMHCpan-4.1\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>NetMHCpan 4.1<\/strong>&nbsp;<\/a> \u8ba1\u7b97FLLTRILTI\u4e0eHLA-A*02:01\u4eb2\u548c\u529b\u4e3a 4.93 nM\uff0c\u4e3a\u7a33\u5b9a\u7ed3\u5408\u3002<\/p>\n\n\n\n<p><\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u4ea7\u54c1\u7c7b\u578b\u548c\u5e94\u7528<\/h3>\n\n\n\n<p><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>\u4ea7\u54c1\u7c7b\u578b<\/td><td>\u89c4\u683c<\/td><td>\u4ef7\u683c<\/td><\/tr><tr><td>\u6d41\u5f0f\u68c0\u6d4b\u4e0e\u5206\u9009<\/td><td>Envelope protein (183-191) HLA-A*02:01 PE \/ APC \/ Alexa Fluor 488<\/td><td>7200\u5143\/50ug,  11800\u5143\/100ug<\/td><\/tr><tr><td>\u78c1\u73e0\u5206\u9009<\/td><td>Envelope protein (183-191) HLA-A*02:01 HLA-A*02:01\u78c1\u73e0<\/td><td>8200\u5143\/50ug,  12800\u5143\/100ug<\/td><\/tr><tr><td>\u751f\u7269\u7d20\u5316\u590d\u5408\u7269<\/td><td>Envelope protein (183-191) HLA-A*02:01 HLA-A*02:01-biotin<\/td><td>6800\u5143\/50ug,  11400\u5143\/100ug<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\">\u5b9e\u6d4b\u7ed3\u679c<\/h3>\n\n\n\n<p><\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u80bd\u523a\u6fc0PBMC\u540e\u68c0\u6d4b\u6297\u539f\u7279\u5f02\u6027CD8+T\u7ec6\u80de<\/h3>\n\n\n\n<p>FLLTRILTI\u591a\u80bd\u523a\u6fc0HLA-A*02:01\u9650\u5236\u6027PBMC\u540e\uff0c\u4f7f\u7528Envelope protein (183-191) HLA-A*02:01 PE \u56db\u805a\u4f53\u548c\u6297CD8-FITC\u6297\u4f53\u68c0\u6d4b\u3002\u4e0b\u56fe\u5de6\u56fe\u4e3a\u6297\u539f\u80bdFLLTRILTI\u523a\u6fc0\u7ec4\uff0c\u53f3\u56fe\u4e3a\u672a\u52a0\u6297\u539f\u80bd\u523a\u6fc0\u7ec4\u3002<\/p>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image size-full\"><img fetchpriority=\"high\" decoding=\"async\" width=\"321\" height=\"324\" src=\"https:\/\/www.guixiong.com.cn\/wp-content\/uploads\/2025\/07\/image-8.png\" alt=\"\" class=\"wp-image-1081\" srcset=\"https:\/\/guixiong.com.cn\/wp-content\/uploads\/2025\/07\/image-8.png 321w, https:\/\/guixiong.com.cn\/wp-content\/uploads\/2025\/07\/image-8-100x100.png 100w, https:\/\/guixiong.com.cn\/wp-content\/uploads\/2025\/07\/image-8-297x300.png 297w, https:\/\/guixiong.com.cn\/wp-content\/uploads\/2025\/07\/image-8-150x150.png 150w\" sizes=\"(max-width: 321px) 100vw, 321px\" \/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" width=\"325\" height=\"340\" src=\"https:\/\/www.guixiong.com.cn\/wp-content\/uploads\/2025\/07\/image-9.png\" alt=\"\" class=\"wp-image-1083\" srcset=\"https:\/\/guixiong.com.cn\/wp-content\/uploads\/2025\/07\/image-9.png 325w, https:\/\/guixiong.com.cn\/wp-content\/uploads\/2025\/07\/image-9-287x300.png 287w\" sizes=\"(max-width: 325px) 100vw, 325px\" \/><\/figure>\n<\/div>\n<\/div>\n\n\n\n<h3 class=\"wp-block-heading\">\u9776\u70b9\u7ed3\u5408\u7684TCR\u5e8f\u5217<\/h3>\n\n\n\n<p>\u8bf7\u67e5\u770b<a href=\"http:\/\/www.iedb.org\" data-type=\"link\" data-id=\"www.iedb.org\" target=\"_blank\" rel=\"noreferrer noopener\">IEDB\u6570\u636e\u5e93<\/a><\/p>\n\n\n\n<p><\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u76f8\u5173\u6587\u7ae0<\/h3>\n\n\n\n<table id=\"tablepress-20\" class=\"tablepress tablepress-id-20\">\n<thead>\n<tr class=\"row-1 odd\">\n\t<th class=\"column-1\">Reference - PMID<\/th><th class=\"column-2\">Reference - Journal<\/th><th class=\"column-3\">Reference - Date<\/th><th class=\"column-4\">Reference - Title<\/th>\n<\/tr>\n<\/thead>\n<tbody class=\"row-hover\">\n<tr class=\"row-2 even\">\n\t<td class=\"column-1\">7527444<\/td><td class=\"column-2\">J Immunol<\/td><td class=\"column-3\">1994<\/td><td class=\"column-4\">The relationship between class I binding affinity and immunogenicity of potential cytotoxic T cell epitopes.<\/td>\n<\/tr>\n<tr class=\"row-3 odd\">\n\t<td class=\"column-1\">9239396<\/td><td class=\"column-2\">J Clin Invest<\/td><td class=\"column-3\">1997<\/td><td class=\"column-4\">Human histocompatibility leukocyte antigen-binding supermotifs predict broadly cross-reactive cytotoxic T lymphocyte responses in patients with acute hepatitis.<\/td>\n<\/tr>\n<tr class=\"row-4 even\">\n\t<td class=\"column-1\">9780224<\/td><td class=\"column-2\">J Immunol<\/td><td class=\"column-3\">1998<\/td><td class=\"column-4\">Human class I supertypes and CTL repertoires extend to chimpanzees.<\/td>\n<\/tr>\n<tr class=\"row-5 odd\">\n\t<td class=\"column-1\">8837608<\/td><td class=\"column-2\">Nat Med<\/td><td class=\"column-3\">1996<\/td><td class=\"column-4\">The hepatitis B virus persists for decades after patients' recovery from acute viral hepatitis despite active maintenance of a cytotoxic T-lymphocyte response.<\/td>\n<\/tr>\n<tr class=\"row-6 even\">\n\t<td class=\"column-1\">8794355<\/td><td class=\"column-2\">J Virol<\/td><td class=\"column-3\">1996<\/td><td class=\"column-4\">Differential cytotoxic T-lymphocyte responsiveness to the hepatitis B and C viruses in chronically infected patients.<\/td>\n<\/tr>\n<tr class=\"row-7 odd\">\n\t<td class=\"column-1\">11035120<\/td><td class=\"column-2\">J Immunol<\/td><td class=\"column-3\">2000<\/td><td class=\"column-4\">Multiepitopic HLA-A*0201-restricted immune response against hepatitis B surface antigen after DNA-based immunization.<\/td>\n<\/tr>\n<tr class=\"row-8 even\">\n\t<td class=\"column-1\">17942551<\/td><td class=\"column-2\">J Virol<\/td><td class=\"column-3\">2008<\/td><td class=\"column-4\">Rational design of a multiepitope vaccine encoding T-lymphocyte epitopes for treatment of chronic hepatitis B virus infections.<\/td>\n<\/tr>\n<tr class=\"row-9 odd\">\n\t<td class=\"column-1\">18234055<\/td><td class=\"column-2\">Clin Exp Immunol<\/td><td class=\"column-3\">2008<\/td><td class=\"column-4\">A mutant HBs antigen (HBsAg)183-191 epitope elicits specific cytotoxic T lymphocytes in acute hepatitis B patients.<\/td>\n<\/tr>\n<tr class=\"row-10 even\">\n\t<td class=\"column-1\">18612271<\/td><td class=\"column-2\">Mol Ther<\/td><td class=\"column-3\">2008<\/td><td class=\"column-4\">The immunogenicity of adenovirus vectors limits the multispecificity of CD8 T-cell responses to vector-encoded transgenic antigens.<\/td>\n<\/tr>\n<tr class=\"row-11 odd\">\n\t<td class=\"column-1\">19542448<\/td><td class=\"column-2\">J Immunol<\/td><td class=\"column-3\">2009<\/td><td class=\"column-4\">Elimination of immunodominant epitopes from multispecific DNA-based vaccines allows induction of CD8 T cells that have a striking antiviral potential.<\/td>\n<\/tr>\n<tr class=\"row-12 even\">\n\t<td class=\"column-1\">19734234<\/td><td class=\"column-2\">J Immunol<\/td><td class=\"column-3\">2009<\/td><td class=\"column-4\">Quantitating T cell cross-reactivity for unrelated peptide antigens.<\/td>\n<\/tr>\n<tr class=\"row-13 odd\">\n\t<td class=\"column-1\">23251518<\/td><td class=\"column-2\">PLoS One<\/td><td class=\"column-3\">2012<\/td><td class=\"column-4\">Binding of TCR multimers and a TCR-like antibody with distinct fine-specificities is dependent on the surface density of HLA complexes.<\/td>\n<\/tr>\n<tr class=\"row-14 even\">\n\t<td class=\"column-1\">16537621<\/td><td class=\"column-2\">J Virol<\/td><td class=\"column-3\">2006<\/td><td class=\"column-4\">Expression of the interleukin-7 receptor alpha chain (CD127) on virus-specific CD8+ T cells identifies functionally and phenotypically defined memory T cells during acute resolving hepatitis B virus infection.<\/td>\n<\/tr>\n<tr class=\"row-15 odd\">\n\t<td class=\"column-1\">23908113<\/td><td class=\"column-2\">J Clin Invest<\/td><td class=\"column-3\">2013<\/td><td class=\"column-4\">Mobilizing monocytes to cross-present circulating viral antigen in chronic infection.<\/td>\n<\/tr>\n<tr class=\"row-16 even\">\n\t<td class=\"column-1\">25051027<\/td><td class=\"column-2\">PLoS One<\/td><td class=\"column-3\">2014<\/td><td class=\"column-4\">A whole recombinant yeast-based therapeutic vaccine elicits HBV X, S and Core specific T cells in mice and activates human T cells recognizing epitopes linked to viral clearance.<\/td>\n<\/tr>\n<tr class=\"row-17 odd\">\n\t<td class=\"column-1\">25016223<\/td><td class=\"column-2\">J Hepatol<\/td><td class=\"column-3\">2014<\/td><td class=\"column-4\">Restoration of HBV-specific CD8+ T cell function by PD-1 blockade in inactive carrier patients is linked to T cell differentiation.<\/td>\n<\/tr>\n<tr class=\"row-18 even\">\n\t<td class=\"column-1\">28792537<\/td><td class=\"column-2\">PLoS One<\/td><td class=\"column-3\">2017<\/td><td class=\"column-4\">Isolation and functional characterization of hepatitis B virus-specific T-cell receptors as new tools for experimental and clinical use.<\/td>\n<\/tr>\n<tr class=\"row-19 odd\">\n\t<td class=\"column-1\">29180767<\/td><td class=\"column-2\">Sci Rep<\/td><td class=\"column-3\">2017<\/td><td class=\"column-4\">Frequency and reactivity of antigen-specific T cells were concurrently measured through the combination of artificial antigen-presenting cell, MACS and ELISPOT.<\/td>\n<\/tr>\n<tr class=\"row-20 even\">\n\t<td class=\"column-1\">30006605<\/td><td class=\"column-2\">Nat Commun<\/td><td class=\"column-3\">2018<\/td><td class=\"column-4\">Nonstimulatory peptide-MHC enhances human T-cell antigen-specific responses by amplifying proximal TCR signaling.<\/td>\n<\/tr>\n<tr class=\"row-21 odd\">\n\t<td class=\"column-1\">15726541<\/td><td class=\"column-2\">Hepatology<\/td><td class=\"column-3\">2005<\/td><td class=\"column-4\">Acute phase HBV-specific T cell responses associated with HBV persistence after HBV\/HCV coinfection.<\/td>\n<\/tr>\n<tr class=\"row-22 even\">\n\t<td class=\"column-1\">30518652<\/td><td class=\"column-2\">J Virol<\/td><td class=\"column-3\">2019<\/td><td class=\"column-4\">Spatiotemporal Differences in Presentation of CD8 T Cell Epitopes during Hepatitis B Virus Infection.<\/td>\n<\/tr>\n<tr class=\"row-23 odd\">\n\t<td class=\"column-1\">30580250<\/td><td class=\"column-2\">Gut<\/td><td class=\"column-3\">2019<\/td><td class=\"column-4\">Phenotype and function of HBV-specific T cells is determined by the targeted epitope in addition to the stage of infection.<\/td>\n<\/tr>\n<tr class=\"row-24 even\">\n\t<td class=\"column-1\">30622109<\/td><td class=\"column-2\">Gut<\/td><td class=\"column-3\">2019<\/td><td class=\"column-4\">Phenotypic and functional differences of HBV core-specific versus HBV polymerase-specific CD8+ T cells in chronically HBV-infected patients with low viral load.<\/td>\n<\/tr>\n<tr class=\"row-25 odd\">\n\t<td class=\"column-1\">30711630<\/td><td class=\"column-2\">Gastroenterology<\/td><td class=\"column-3\">2019<\/td><td class=\"column-4\">Use of Expression Profiles of HBV-DNA Integrated Into Genomes of Hepatocellular Carcinoma Cells to Select T Cells for Immunotherapy.<\/td>\n<\/tr>\n<tr class=\"row-26 even\">\n\t<td class=\"column-1\">23011082<\/td><td class=\"column-2\">J Gastroenterol<\/td><td class=\"column-3\">2013<\/td><td class=\"column-4\">Kinetics of peripheral hepatitis B virus-specific CD8+ T cells in patients with onset of viral reactivation.<\/td>\n<\/tr>\n<tr class=\"row-27 odd\">\n\t<td class=\"column-1\">33205065<\/td><td class=\"column-2\">Cell Rep Med<\/td><td class=\"column-3\">2020<\/td><td class=\"column-4\">Hepatitis Delta Virus Acts as an Immunogenic Adjuvant in Hepatitis B Virus-Infected Hepatocytes.<\/td>\n<\/tr>\n<tr class=\"row-28 even\">\n\t<td class=\"column-1\">35224746<\/td><td class=\"column-2\">Aliment Pharmacol Ther<\/td><td class=\"column-3\">2022<\/td><td class=\"column-4\">Model to predict on-treatment restoration of functional HBV-specific CD8&lt;sup&gt;+&lt;\/sup&gt; cell response foresees off-treatment HBV control in eAg-negative chronic hepatitis B.<\/td>\n<\/tr>\n<tr class=\"row-29 odd\">\n\t<td class=\"column-1\">35464415<\/td><td class=\"column-2\">Front Immunol<\/td><td class=\"column-3\">2022<\/td><td class=\"column-4\">Screening and Identification of HBV Epitopes Restricted by Multiple Prevalent HLA-A Allotypes.<\/td>\n<\/tr>\n<tr class=\"row-30 even\">\n\t<td class=\"column-1\">34377970<\/td><td class=\"column-2\">JHEP Rep<\/td><td class=\"column-3\">2021<\/td><td class=\"column-4\">Human MAIT cells endowed with HBV specificity are cytotoxic and migrate towards HBV-HCC while retaining antimicrobial functions.<\/td>\n<\/tr>\n<tr class=\"row-31 odd\">\n\t<td class=\"column-1\">36211805<\/td><td class=\"column-2\">Oncoimmunology<\/td><td class=\"column-3\">2022<\/td><td class=\"column-4\">Systemic T-cell and humoral responses against cancer testis antigens in hepatocellular carcinoma patients.<\/td>\n<\/tr>\n<tr class=\"row-32 even\">\n\t<td class=\"column-1\">38808361<\/td><td class=\"column-2\">Clin Mol Hepatol<\/td><td class=\"column-3\">2024<\/td><td class=\"column-4\">Genetically-modified, redirected T cells target hepatitis B surface antigen-positive hepatocytes and hepatocellular carcinoma lesions in a clinical setting.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<!-- #tablepress-20 from cache -->\n\n\n\n<p><\/p>\n\n\n\n<p><\/p>\n<p>Views: 6<\/p>","protected":false},"excerpt":{"rendered":"<p>\u9776\u70b9\u8bf4\u660e Envelope protein (183-191) FLLTRILTI HLA-A*02:01 \u6765&#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_kadence_starter_templates_imported_post":false,"_kad_post_transparent":"","_kad_post_title":"","_kad_post_layout":"","_kad_post_sidebar_id":"","_kad_post_content_style":"","_kad_post_vertical_padding":"","_kad_post_feature":"","_kad_post_feature_position":"","_kad_post_header":false,"_kad_post_footer":false,"_kad_post_classname":"","footnotes":""},"class_list":["post-757","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.guixiong.com.cn\/index.php?rest_route=\/wp\/v2\/pages\/757","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.guixiong.com.cn\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.guixiong.com.cn\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.guixiong.com.cn\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.guixiong.com.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=757"}],"version-history":[{"count":8,"href":"https:\/\/www.guixiong.com.cn\/index.php?rest_route=\/wp\/v2\/pages\/757\/revisions"}],"predecessor-version":[{"id":1084,"href":"https:\/\/www.guixiong.com.cn\/index.php?rest_route=\/wp\/v2\/pages\/757\/revisions\/1084"}],"wp:attachment":[{"href":"https:\/\/www.guixiong.com.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=757"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}