{"id":80,"date":"2024-07-31T03:20:02","date_gmt":"2024-07-31T03:20:02","guid":{"rendered":"http:\/\/60.204.213.123\/wordpress\/?page_id=80"},"modified":"2024-07-31T10:24:48","modified_gmt":"2024-07-31T10:24:48","slug":"t2-cell%ef%bc%9a%e4%b8%80%e7%a7%8d%e5%8f%91%e7%8e%b0%e8%82%bf%e7%98%a4-%e7%97%85%e6%af%92%e6%8a%97%e5%8e%9f%e7%89%b9%e5%bc%82%e6%80%a7t%e7%bb%86%e8%83%9e%e7%9a%84%e7%b2%be%e7%a1%ae%e9%aa%8c%e8%af%81","status":"publish","type":"page","link":"https:\/\/www.guixiong.com.cn\/?page_id=80","title":{"rendered":"T2 Cell\uff1a\u4e00\u79cd\u53d1\u73b0\u80bf\u7624\/\u75c5\u6bd2\u6297\u539f\u7279\u5f02\u6027T\u7ec6\u80de\u7684\u7cbe\u786e\u9a8c\u8bc1\u5de5\u5177"},"content":{"rendered":"\n

\u76f8\u5173\u670d\u52a1\u53c2\u8003-\u201c\u9776\u5411\u6297\u539f\u7684\u7ec6\u80de\u6bd2T\u7ec6\u80de\u589e\u6b96\u670d\u52a1<\/a>\u201d<\/strong><\/em><\/p>\n\n\n\n

T2 Cell\u662f\u4ec0\u4e48\uff1f<\/strong>T2 Cell\u662f\u4e00\u79cd\u4eba\u6dcb\u5df4\u7ec6\u80de\u6742\u4ea4\u7624\u7ec6\u80de\uff0c\u8be5\u7ec6\u80de\u7f3a\u4e4f\u6297\u539f\u591a\u80bd\u8f6c\u8fd0\u86cb\u767d\uff0c\u5bfc\u81f4\u5185\u6e90\u6027\u6297\u539f\u65e0\u6cd5\u5b9a\u4f4d\u5230\u5185\u8d28\u7f51\u6838\u9ad8\u5c14\u57fa\u4f53\uff0c\u56e0\u6b64\u65e0\u6cd5\u88ab\u964d\u89e3\u6210\u6297\u539f\u80bd\u3002T2 \u7ec6\u80de\u7684HLA-A2\u4e3a\u9633\u6027\uff0c\u5e38\u7528\u4e8e\u7814\u7a76\u6297\u539f\u9012\u5448\u8fc7\u7a0b\u548cT\u7ec6\u80de\u4e0eMHC- \u5206\u5b50\u7684\u76f8\u4e92\u8bc6\u522b\u3002<\/p>\n\n\n\n

T2\u7ec6\u80de\u4e0e\u76ee\u6807\u6297\u539f\u80bd\u4ee5\u4e24\u79cd\u65b9\u5f0f\u7ed3\u5408\uff0c\u4e00\u79cd\u65b9\u5f0f\u662f\u901a\u8fc7\u5728T2\u7ec6\u80de\u57f9\u517b\u57fa\u4e2d\u4ee5pulsing\u6a21\u5f0f\u4f9b\u5e94\u76ee\u6807\u6297\u539f\u80bd\uff0c\u5bfc\u81f4T2\u7ec6\u80de\u5448\u9012\u6297\u539f\u80bd\u7ed9\u5bf9\u5e94T\u7ec6\u80de\uff1b\u7b2c\u4e8c\u79cd\u65b9\u5f0f\u662f\u901a\u8fc7\u8868\u8fbe\u6297\u539f\u80bd+\u4fe1\u53f7\u80bd\u7684\u8d28\u7c92\u8f7d\u4f53\u8f6c\u67d3T2\u7ec6\u80de\uff0c\u6297\u539f\u80bd\u5728T2\u7ec6\u80de\u8868\u9762\u4e0eHLA-A2\u5171\u8868\u8fbe\u3002<\/p>\n\n\n\n

\u4f5c\u7528\u4e00\uff1a\u5916\u6e90\u6027\u6297\u539f\u80bd\u523a\u6fc0\u7684T2 Cell\u53ef\u7cbe\u786e\u5730\u627e\u5230\u9776\u5411\u6297\u539f\u7684T\u7ec6\u80de<\/strong><\/h3>\n\n\n\n

T2\u7ec6\u80de\u53ef\u4ee5\u5fe0\u5b9e\u5730\u5c06\u76ee\u6807\u6297\u539f\u80bd\u5448\u9012\u5230\u7ec6\u80de\u8868\u9762\uff0c\u4ece\u800c\u9776\u5411\u6027\u5730\u627e\u5230\u76ee\u6807\u6297\u539f\u80bd\u5bf9\u5e94\u7684T\u7ec6\u80de\u3002\u4e0e\u6b64\u76f8\u5bf9\uff0c\u4e00\u822cDC\u7ec6\u80de\u6216\u80bf\u7624\u7ec6\u80de\u7684\u80de\u5185\u6297\u539f\u7ecf\u81ea\u8eabTAP\u86cb\u767d\u8f6c\u8fd0\u81f3\u86cb\u767d\u9176\uff0c\u6297\u539f\u86cb\u767d\u964d\u89e3\u4e3a\u6297\u539f\u80bd\uff0c\u4ece\u800c\u65e0\u6cd5\u5fe0\u5b9e\u5730\u5448\u9012\u76ee\u6807\u6297\u539f\u80bd\u5230\u7ec6\u80de\u8868\u9762\uff0c\u8fdb\u800c\u65e0\u6cd5\u91cd\u590d\u9a8c\u8bc1\u76ee\u6807\u6297\u539f\u80bd\u7684T\u7ec6\u80de\u6fc0\u6d3b\u6548\u5e94\u3002T2\u7ec6\u80de\u643a\u5e26\u76ee\u6807\u6297\u539f\u80bd\u540e\uff0c\u7279\u5f02\u6027\u5730\u4e0e\u8bc6\u522b\u6297\u539f\u80bd+MHC-I\u590d\u5408\u7269\u7684TCR\u7ed3\u5408\uff0cTCR\u5bf9\u5e94T\u7ec6\u80de\u5c06\u88ab\u7cbe\u786e\u5b9a\u4f4d\u3002<\/p>\n\n\n\n

\u4f5c\u7528\u4e8c\uff1a\u76d1\u63a7\u7ec6\u80de\u6bd2T\u7ec6\u80de\u5bf9\u76ee\u6807\u6297\u539f\u7684\u53cd\u5e94<\/strong><\/h3>\n\n\n\n

\u7531\u4e8eT2\u7ec6\u80de\u65e0\u6cd5\u5904\u7406\u7ec6\u80de\u5185\u90e8\u6297\u539f\u5448\u9012\uff0c\u800c\u53ef\u4ee5\u5fe0\u5b9e\u5730\u5448\u9012\u5916\u6e90\u6027\u6297\u539f\u591a\u80bd\u3002\u56e0\u6b64\uff0cT2\u7ec6\u80de\u8868\u9762\u5177\u6709\u76ee\u6807\u6297\u539f\u80bd+MHC-I\u5206\u5b50\u7cbe\u786e\u76ee\u6807\u86cb\u767d\uff0c\u76ee\u6807\u6297\u539f\u7279\u5f02\u6027T\u7ec6\u80de\u5c06\u9776\u5411\u6740\u4f24T2\u7ec6\u80de\u3002\u56e0\u6b64\uff0c\u901a\u8fc7\u76ee\u6807\u6297\u539f\u5f02\u7279\u6027T\u7ec6\u80de+\u76ee\u6807\u6297\u539f\u80bd\u8868\u8fbe\u7279\u5f02\u6027T2\u7ec6\u80de\u5171\u8868\u8fbe\uff0c\u76d1\u6d4b\u76ee\u6807\u6297\u539f\u7684\u8017\u7aed\u60c5\u51b5\uff0c\u4ece\u800c\u5224\u65ad\u6297\u539f\u7279\u5f02\u6027T\u7ec6\u80de\u7684\u6740\u4f24\u6548\u679c\u3002<\/p>\n\n\n\n

\u4f5c\u7528\u4e09\uff1a \u8bc4\u4f30\u9776\u5411\u80bf\u7624\u7ec6\u80de\u80de\u5185\u6297\u539f\u7684\u7ec6\u80de\u6740\u4f24\u6548\u5e94\u8bc4\u4f30\u5de5\u5177<\/strong><\/h3>\n\n\n\n
\"\u6765\u81ea\u80bf\u7624\u7ec6\u80de\u7684TP53
\u6765\u81ea\u80bf\u7624\u7ec6\u80de\u7684TP53 524G>A\u7a81\u53d8\u86cb\u767d(R175H)\uff0c\u7ecf\u8fc7\u86cb\u767d\u9176\u4f53\u964d\u89e3\u6210\u4e3a\u80bd\u6bb5\u540e\uff0c\u88ab\u8fd0\u8f93\u81f3\u80de\u819c\u4e0eHLA-A2\u5f62\u6210\u590d\u5408\u7269\uff0c\u9776\u5411\u590d\u5408\u7269\u7684\u6297\u4f53H2-scDb\u6a21\u62dfTCR\u7684\u529f\u80fd\uff0c\u4e0eTP53 524G>A\u7a81\u53d8\u86cb\u767d(R175H)+HLA-A2\u590d\u5408\u7269\u7ed3\u5408\u540e\uff0c\u6297\u4f53\u7684CD3\u7ed3\u5408\u90e8\u4f4d\u8fde\u63a5T\u7ec6\u80de\u7684CD3\u86cb\u767d\uff0c\u523a\u6fc0T\u7ec6\u80de\u91ca\u653e\u4e00\u7cfb\u5217\u7ec6\u80de\u56e0\u5b50\uff0c\u9776\u5411\u6740\u4f24\u80bf\u7624\u7ec6\u80de\u3002T2\u7ec6\u80de\u5728\u6b64\u5c31\u662fTP53 524G>A\u7a81\u53d8\u86cb\u767d(R175H)+HLA-A2\u7684\u7ec6\u80de\u6765\u6e90\u3002\u56fe\u7247\u6765\u6e90\u4e8eTargeting a neoantigen derived from a common TP53 mutation. Science<\/a><\/figcaption><\/figure>\n\n\n\n

\u9a8c\u8bc1\u9776\u5411\u76ee\u6807\u6297\u539f\u7684\u6297\u4f53\u6740\u4f24\u6548\u679c\uff0c\u9776\u5411\u76ee\u6807\u6297\u539f+MHC\u590d\u5408\u7269\u7684TCR\u6837\u6297\u4f53\u4ecb\u5bfcCD8+T\u7ec6\u80de\u9776\u5411\u6740\u4f24T2\u7ec6\u80de\u3002T2\u7ec6\u80de\u4f5c\u4e3a\u6297\u4f53\u6865\u63a5CD8+T\u7ec6\u80de\u7684\u6548\u5e94\u8bc4\u4f30\u5de5\u5177\u3002<\/p>\n\n\n\n

T2 Cell\u5e94\u7528\u7684\u4ee3\u8868\u6027\u6848\u4f8b<\/strong><\/h3>\n\n\n\n

1. \u9488\u5bf9\u6297\u539f\u7279\u5f02\u6027TCR\u6539\u9020\u540e\u7ec6\u80de\u6bd2T\u7ec6\u80de\uff0cT2\u7ec6\u80de\u7528\u4e8e\u76d1\u63a7\u8fd9\u4e9bCTL\u5bf9\u80f0\u817a\u5bfc\u7ba1\u764c\u6297\u539f\u7684\u53cd\u5e94<\/p>\n\n\n\n

\n

Ex Vivo PD-L1\/PD-1 Pathway Blockade Reverses Dysfunction of Circulating CEA-Specific T Cells in Pancreatic Cancer Patients.<\/a><\/em> Clin Cancer Res. 2017<\/em><\/p>\n<\/blockquote>\n\n\n\n

2. \u901a\u8fc7T2\u7ec6\u80de\u8868\u8fbe\u7684\u80bf\u7624\u6297\u539f\u80bd\uff0c\u5224\u65adTCR\u6837\u6297\u4f53\u7684\u7ed3\u5408\u80fd\u529b<\/p>\n\n\n\n

\n

TCR-like antibody drug conjugates mediate killing of tumor cells with low peptide\/HLA targets<\/a>. MAbs. 2017<\/em><\/p>\n<\/blockquote>\n\n\n\n

3. \u80de\u5185\u6297\u539f\u7279\u5f02\u6027CAR-T\u7ec6\u80de\u653b\u51fbT2\u7ec6\u80de\uff0c\u8be5T2\u7ec6\u80de\u7279\u5f02\u6027\u8868\u8fbe\u80de\u5185\u6297\u539f+MHC\u590d\u5408\u7269<\/p>\n\n\n\n

\n

CAR-T cells targeting a nucleophosmin neoepitope exhibit potent specific activity in mouse models of acute myeloid leukaemia<\/a>.<\/em> Nat Biomed Eng. 2020<\/em><\/p>\n<\/blockquote>\n\n\n\n

4. \u5448\u9012p53\u7a81\u53d8\u6297\u539f\u4e0e\u91ce\u751f\u578b\u6297\u539f\u7684HLA-A2\u578bT2\u7ec6\u80de\uff0c\u88ab\u53cc\u7279\u5f02\u6027\u5355\u94fe\u6297\u4f53\u7279\u5f02\u6027\u6740\u4f24\u3002T2\u7ec6\u80de\u4f5c\u4e3a\u53cc\u7279\u5f02\u6027\u5355\u94fe\u6297\u4f53\u6740\u4f24\u6548\u5e94\u7684\u76d1\u63a7\u7ec6\u80de\u3002<\/p>\n\n\n\n

\n

Targeting a neoantigen derived from a common TP53 mutation<\/a>.<\/em> Science. 2021<\/em><\/p>\n<\/blockquote>\n\n\n\n

\u5e94\u7528T2 Cell\u8fdb\u7684\u4e0a\u6e38\u73af\u8282<\/strong><\/h2>\n\n\n\n

\u5177\u6709\u4ee5\u4e0b\u6570\u636e\u7684\u7814\u7a76\u8005\uff0cT2 Cell\u80fd\u591f\u5e2e\u52a9\u60a8\u6df1\u5316\u7814\u7a76\u601d\u8def\uff0c\u521b\u9020\u5177\u6709\u624e\u5b9e\u8bc1\u636e\u7684\u7814\u7a76\u6210\u679c\u3002<\/p>\n\n\n\n

    \n
  1. \u5916\u663e\u5b50\u6d4b\u5e8f\uff1a\u901a\u8fc7\u5168\u57fa\u56e0\u6216\u9776\u5411\u57fa\u56e0\u7684\u80bf\u7624\u7ec4\u7ec7\u3001ctDNA\u6d4b\u5e8f\u7ed3\u679c\uff0c\u53d1\u73b0\u5177\u6709\u80bf\u7624\u65b0\u751f\u6297\u539f\u7279\u8d28\u7684\u80bd\u6bb5\uff1b<\/li>\n\n\n\n
  2. HLA\u6d4b\u5e8f\uff1a\u786e\u5b9a\u60a3\u8005\u7684HLA\u5206\u578b<\/li>\n\n\n\n
  3. HLA\u86cb\u767d\u6d4b\u5e8f\uff1a\u786e\u5b9a\u60a3\u8005\u6807\u672c\u4e2dHLA\u7ed3\u5408\u591a\u80bd\u7684\u86cb\u767d\u5e8f\u5217<\/li>\n<\/ol>\n

    Views: 148<\/p>","protected":false},"excerpt":{"rendered":"

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