{"id":860,"date":"2025-07-09T04:10:40","date_gmt":"2025-07-09T04:10:40","guid":{"rendered":"http:\/\/60.204.213.123\/?page_id=860"},"modified":"2026-01-23T08:47:44","modified_gmt":"2026-01-23T08:47:44","slug":"mart1-27-35-hla-a0201-8","status":"publish","type":"page","link":"https:\/\/www.guixiong.com.cn\/?page_id=860","title":{"rendered":"EBNA1 (508-517) HLA-A*02:01"},"content":{"rendered":"\r\n<h3 class=\"wp-block-heading\">\u9776\u70b9\u8bf4\u660e<\/h3>\r\n\r\n\r\n\r\n<p>EBNA1 (508-517) HLA-A*02:01 \u662fEBV\u75c5\u6bd2 Epstein-Barr nuclear antigen 1 FVYGGSKTSL\uff0cEBNA1\u8d1f\u8d23\u5728\u6f5c\u4f0f\u611f\u67d3\u671f\u95f4\u590d\u5236\u548c\u7ef4\u62a4\u75c5\u6bd2\u8868\u89c2\u9057\u4f20\u5b66\u7684\u590d\u5236\u8d77\u70b9\u3002Epstein-Barr\u75c5\u6bd2\uff08EBV\uff09\u7f16\u7801\u7684\u6838\u6297\u539f1\uff08EBNA1\uff09\u662f\u9488\u5bf9EBV\u76f8\u5173\u6076\u6027\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u7684\u4e00\u4e2a\u6709\u5438\u5f15\u529b\u7684\u76ee\u6807\uff0c\u56e0\u4e3a\u5b83\u5728\u6240\u6709EBV\u9633\u6027\u7ec6\u80de\u4e2d\u8868\u8fbe\u3002\u5c3d\u7ba1CD8 +\u7ec6\u80de\u6bd2\u6027T\u6dcb\u5df4\u7ec6\u80de(CTL)\u8868\u4f4d\u5448\u73b0\u4e3b\u8981\u7531\u5176\u7518\u6c28\u9178-\u4e19\u6c28\u9178\u91cd\u590d\u57df(GAr)\u6240\u963b\u6b62\uff0c\u4f46\u4f7f\u7528mRNA\u8f6c\u5bfc\u6811\u7a81\u72b6\u7ec6\u80de(DCs)\u5c06\u63d0\u4f9b\u8bf1\u5bfcEBNA1\u7279\u5f02\u6027CTL\u7684\u4f18\u52bf\u3002<\/p>\r\n\r\n\r\n\r\n<p>\u901a\u8fc7\u7528\u542b\u6709GAr\u7684EBNA1\u8f6c\u5bfc\u5355\u6838\u7ec6\u80de\u6765\u6e90\u7684DC\u523a\u6fc0\u540e\uff0c\u4ece\u5065\u5eb7\u4f9b\u4f53\u6210\u529f\u5206\u79bb\u51fa\u4e24\u4e2aEBNA1\u7279\u5f02\u6027CTL\u514b\u9686B5\u548cC6\u3002\u8fd9\u4e9bCTL\u5206\u522b\u8bc6\u522bHLA-B * 3501\u548cHLA-Cw * 0303\u80cc\u666f\u4e0b\u7684\u80bd\u3002\u7136\u540e\u9274\u5b9a\u4e86\u4e00\u4e2a\u65b0\u7684\u8868\u4f4dFVYGGSKTSL\uff0c\u5b83\u88abHLA-Cw * 0303\u548c-Cw * 0304\u5448\u9012\uff0c\u8fd9\u4e24\u79cd\u5206\u5b50\u5206\u522b\u7531&gt;35\uff05\u7684\u65e5\u672c\u4eba\u3001&gt;20\uff05\u7684\u5317\u65b9\u6c49\u65cf\u4eba\u548c&gt;25\uff05\u7684\u9ad8\u52a0\u7d22\u4eba\u8868\u8fbe\u3002\u6df7\u5408\u6dcb\u5df4\u7ec6\u80de-\u80bd\u57f9\u517b\u65b9\u6cd5\u663e\u793a\uff0c\u5728HLA-Cw * 0303\u6216-Cw * 0304\u9633\u6027\u7684\u53d7\u8bd5\u8005\u4e2d\u3002<\/p>\r\n\r\n\r\n\r\n<p>FVYGGSKTSL\u7279\u5f02\u6027CTL\u4e3a\u6bcf\u767e\u4e07\u4e2aCD8 + T\u7ec6\u80de1\u81f310\u4e2a\u3002\u6b64\u5916\uff0c\u8fd9\u4e24\u4e2aCTL\u514b\u9686\u6291\u5236\u4e86HLA\u5339\u914d\u7684EBV\u8f6c\u5316B\u6dcb\u5df4\u7ec6\u80de\u7684\u751f\u957f\uff0c\u5e76\u4e14B5 CTL\u5bf9HLA-Cw * 0303\u80cc\u666f\u4e0bEBNA1\u8868\u8fbe\u80c3\u764c\u7ec6\u80de\u4ea7\u751f\u03b3\u5e72\u6270\u7d20\u53cd\u5e94\u3002\u8fd9\u4e9b\u6570\u636e\u8868\u660e\uff0cEBNA1 mRNA\u8f6c\u5bfc\u7684DC\u53ef\u80fd\u662f\u8bf1\u5bfcEBNA1\u7279\u5f02\u6027CTL\u7684\u6709\u6548\u5de5\u5177\uff0c\u8fd9\u53ef\u80fd\u5bf9\u4e8eEBV\u76f8\u5173\u6076\u6027\u80bf\u7624\u7684CTL\u7597\u6cd5\u5177\u6709\u4e34\u5e8a\u610f\u4e49\u3002<\/p>\r\n\r\n\r\n\r\n<p>&nbsp;<\/p>\r\n\r\n\r\n\r\n<h3 class=\"wp-block-heading\">HLA\u7c7b\u578b<\/h3>\r\n\r\n\r\n\r\n<p><a href=\"https:\/\/www.guixiong.com.cn\/?page_id=247\" data-type=\"page\" data-id=\"247\">HLA-A*02:01\uff0c \u4e2d\u56fd\u4eba\u5206\u5e03\u9891\u738712.036%<\/a><\/p>\r\n\r\n\r\n\r\n<p>&nbsp;<\/p>\r\n\r\n\r\n\r\n<h3 class=\"wp-block-heading\">\u6297\u539f\u548cHLA\u7684\u4eb2\u548c\u529b<\/h3>\r\n\r\n\r\n\r\n<p>&nbsp;<\/p>\r\n\r\n\r\n\r\n<p><a href=\"https:\/\/services.healthtech.dtu.dk\/services\/NetMHCpan-4.1\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>NetMHCpan 4.1<\/strong>\u00a0<\/a> \u8ba1\u7b97FVYGGSKTSL\u4e0eHLA-A*02:01\u4eb2\u548c\u529b\u4e3a 380.61 nM\uff0c\u4e3a\u7a33\u5b9a\u7ed3\u5408\u3002<\/p>\r\n\r\n\r\n\r\n<p>&nbsp;<\/p>\r\n\r\n\r\n\r\n<h3 class=\"wp-block-heading\">\u4ea7\u54c1\u7c7b\u578b\u548c\u5e94\u7528<\/h3>\r\n\r\n\r\n\r\n<p>&nbsp;<\/p>\r\n\r\n\r\n\r\n<figure class=\"wp-block-table\">\r\n<table>\r\n<tbody>\r\n<tr>\r\n<td>\u4ea7\u54c1\u7c7b\u578b<\/td>\r\n<td>\u89c4\u683c<\/td>\r\n<td>\u4ef7\u683c<\/td>\r\n<\/tr>\r\n<tr>\r\n<td>\u6d41\u5f0f\u68c0\u6d4b\u4e0e\u5206\u9009<\/td>\r\n<td>EBNA1 (508-517) HLA-A*02:01 PE \/ APC \/ Alexa Fluor 488<\/td>\r\n<td>7200\u5143\/50ug, 11800\u5143\/100ug<\/td>\r\n<\/tr>\r\n<tr>\r\n<td>\u78c1\u73e0\u5206\u9009<\/td>\r\n<td>EBNA1 (508-517) HLA-A*02:01 HLA-A*02:01\u78c1\u73e0<\/td>\r\n<td>8200\u5143\/50ug, 12800\u5143\/100ug<\/td>\r\n<\/tr>\r\n<tr>\r\n<td>\u751f\u7269\u7d20\u5316\u590d\u5408\u7269<\/td>\r\n<td>EBNA1 (508-517) HLA-A*02:01 HLA-A*02:01-biotin<\/td>\r\n<td>6800\u5143\/50ug, 11400\u5143\/100ug<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>\r\n<\/figure>\r\n\r\n\r\n\r\n<div class=\"wp-block-columns wp-elements-be6581cecb17a9180dda1fb925477138\">\r\n\r\n\r\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\u00a0<\/div>\r\n<\/div>\r\n<!-- \/wp:post-content -->\r\n\r\n<!-- wp:heading {\"level\":3} -->\r\n<h3 class=\"wp-block-heading\">\u9776\u70b9\u7ed3\u5408\u7684TCR\u5e8f\u5217<\/h3>\r\n<!-- \/wp:heading -->\r\n\r\n<!-- wp:paragraph -->\r\n<p>\u8bf7\u67e5\u770b<a href=\"http:\/\/www.iedb.org\" target=\"_blank\" rel=\"noreferrer noopener\" data-type=\"link\" data-id=\"www.iedb.org\">IEDB\u6570\u636e\u5e93<\/a><\/p>\r\n<!-- \/wp:paragraph -->\r\n\r\n<!-- wp:paragraph -->\r\n<p>&nbsp;<\/p>\r\n<!-- \/wp:paragraph -->\r\n\r\n<!-- wp:heading {\"level\":3} -->\r\n<h3 class=\"wp-block-heading\">\u76f8\u5173\u6587\u7ae0<\/h3>\r\n<!-- \/wp:heading -->\r\n\r\n<!-- wp:shortcode -->\r\n\n<table id=\"tablepress-57\" class=\"tablepress tablepress-id-57\">\n<thead>\n<tr class=\"row-1 odd\">\n\t<th class=\"column-1\">Reference - PMID<\/th><th class=\"column-2\">Reference - Journal<\/th><th class=\"column-3\">Reference - Date<\/th><th class=\"column-4\">Reference - Title<\/th>\n<\/tr>\n<\/thead>\n<tbody class=\"row-hover\">\n<tr class=\"row-2 even\">\n\t<td class=\"column-1\">17325349<\/td><td class=\"column-2\">J Gen Virol<\/td><td class=\"column-3\">2007<\/td><td class=\"column-4\">Full-length EBNA1 mRNA-transduced dendritic cells stimulate cytotoxic T lymphocytes recognizing a novel HLA-Cw*0303- and -Cw*0304-restricted epitope on EBNA1-expressing cells.<\/td>\n<\/tr>\n<tr class=\"row-3 odd\">\n\t<td class=\"column-1\">23280567<\/td><td class=\"column-2\">Eur J Immunol<\/td><td class=\"column-3\">2013<\/td><td class=\"column-4\">Conditional ligands for Asian HLA variants facilitate the definition of CD8+ T-cell responses in acute and chronic viral diseases.<\/td>\n<\/tr>\n<tr class=\"row-4 even\">\n\t<td class=\"column-1\">38608022<\/td><td class=\"column-2\">Sci Adv<\/td><td class=\"column-3\">2024<\/td><td class=\"column-4\">Simultaneous analysis of pMHC binding and reactivity unveils virus-specific CD8 T cell immunity to a concise epitope set.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<!-- #tablepress-57 from cache -->\r\n<!-- \/wp:shortcode -->\r\n\r\n<!-- wp:paragraph -->\r\n<p>&nbsp;<\/p>\r\n<!-- \/wp:paragraph -->\r\n\r\n<!-- wp:paragraph -->\r\n<p>&nbsp;<\/p>\r\n<!-- \/wp:paragraph --><p>Views: 6<\/p>","protected":false},"excerpt":{"rendered":"<p>\u9776\u70b9\u8bf4\u660e EBNA1 (508-517) HLA-A*02:01 \u662fEBV\u75c5\u6bd2 Epstein-Barr nu&#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_kadence_starter_templates_imported_post":false,"_kad_post_transparent":"default","_kad_post_title":"default","_kad_post_layout":"default","_kad_post_sidebar_id":"","_kad_post_content_style":"default","_kad_post_vertical_padding":"default","_kad_post_feature":"","_kad_post_feature_position":"","_kad_post_header":false,"_kad_post_footer":false,"_kad_post_classname":"","footnotes":""},"class_list":["post-860","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.guixiong.com.cn\/index.php?rest_route=\/wp\/v2\/pages\/860","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.guixiong.com.cn\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.guixiong.com.cn\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.guixiong.com.cn\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.guixiong.com.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=860"}],"version-history":[{"count":8,"href":"https:\/\/www.guixiong.com.cn\/index.php?rest_route=\/wp\/v2\/pages\/860\/revisions"}],"predecessor-version":[{"id":1577,"href":"https:\/\/www.guixiong.com.cn\/index.php?rest_route=\/wp\/v2\/pages\/860\/revisions\/1577"}],"wp:attachment":[{"href":"https:\/\/www.guixiong.com.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=860"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}