桂芎生物

靶点说明

CMV病毒 pp65蛋白第495-503区域的多肽NLVPMVATV与HLA-A*02:01形成的复合物。该靶点具有明确活化T细胞的效应，已发布其结合的TCR序列。该靶点常被用于标准品，以测试抗原特异性活化T细胞的制备流程。由于CMV感染是血液肿瘤骨髓移植的主要防范目标，该靶点被用于检测血液肿瘤患者抗病毒免疫能力。

HLA类型

HLA-A*02:01， 中国人分布频率12.036%

抗原和HLA的亲和力

NetMHCpan 4.1  计算NLVPMVATV与HLA-A*02:01亲和力为17.92nM，肽与HLA稳定结合。

产品类型和应用

产品类型	规格	价格
流式检测与分选	CMV-pp65 (495-503) HLA-A*02:01 PE / APC / Alexa Fluor 488	7200元/50ug, 11800元/100ug
磁珠分选	CMV-pp65 (495-503) HLA-A*02:01 磁珠	8200元/50ug, 12800元/100ug
生物素化复合物	CMV-pp65 (495-503) HLA-A*02:01-biotin	6800元/50ug, 11400元/100ug

实测结果

实测1：肽刺激PBMC后检测抗原特异性CD8+T细胞

NLVPMVATV多肽刺激HLA-A*02:01限制性PBMC后，使用CMV-pp65 (495-503) HLA-A*02:01 PE 四聚体和抗CD8-FITC抗体检测。以未加抗原肽的细胞培养组为对照。

实测2：测试CMV-pp65 (495-503) HLA-A*02:01 PE/APC四聚体荧光标记细胞

针对NLVPMVATV多肽刺激后的HLA-A*02:01限制性PBMC，CMV-pp65 (495-503) HLA-A*02:01 PE四聚体和CMV-pp65 (495-503) HLA-A*02:01 APC四聚体同时标记抗原特异性T细胞。

靶点结合的TCR序列

T Cell Receptors – Group ID	T Cell Receptors – Chain 1 CDR3	T Cell Receptors – Chain 2 CDR3
823	AVNYGNMLT	ASSKTSGSPYNEQF
825	ILDNNNDMR	ASSLAPGATNEKLF
826	AVFFGNVLHC	ASSRTGGAPEKLF
827	AVGYGNQFY	ASIKTGGAPETQY
828	AFPYNNNDMR	ASSLEGYTEAF
829	AFPYNNNDMR	ASQIQGYTEAF
830	ALGWANNLF	ASSPGTGHTGELF
832	AVRDISARLM	ATAGTGGLF
833	AFVTGNQFY	ASSPVTGTGTYGYT
834	ILDRDGGGATNKLI	ATSPGLAGAYQETQY
835	ALRDDKII	ATSPGLAGAYQETQY
836	VPPYEKLT	ASSLLVEQF
837	VPPYEKLT	VPPYEKLT
838	AVVHNDMR	ASSQDVSRLAHLSTDTQN
839	ATDGDDYKLS	ASSPGLAGGWEQY
840	ATDGDDYKLS	SARDNLRANYGYT
841	AVSYGNMLT	ASNPVAGLPGEQY
1510	ASGNNARLM	ASSEDHTGFYEQY
1521	AFITGNQFY	ASSQTQLWETQY
1522	ARNTGNQFY	ASSPQTGVGNYGYT
1523	AVRDIIARLM	ASSSVNEQF
1538	ATDAPGGYQKVT	ASSPWTGTLNTEA
1539	AEISPSGGSYIPT	ATSDLKVHSGNYGYT
1540	AERLQTGANNLF	ASSPPAGSYNEQ
1541	APYTGTASKLT	AWSSRGQMTDTQ
1542	AVYGTASKLT	SAFSGAAFVTDTQY
1543	AARSNFGNEKLT	ASSAWDRSSGANVLT
1544	AMRVPRAQGGSEKLV	ASSQDPFAVLNTEA
1627	ARNTGNQ	ASSYVTGTGSYGYTG
1628	AYPYNNNDMR	ASSLEGYTEA
1629	AEYTGTASKLT	ACSLRSQGTDTQY
1630	AEYTGTASKLT	AWSSRDSMTDTQY
1631	AVDIETSGSRLT	ASSELGGAGTGEL
1632	AVYFGNVLHCG	ASSFLQVTEA
1633	AGPRQTSYDKVI	ASSSANYGYT
1634	AGPRKTSYDKVI	ASSSANYGYT
1635	AGPMKTSYDKVI	ASSSAHYGYT
1636	AGPMKTSYDKVI	ASSSAFYGYT
1637	AGPEKTSYDKVI	ASSSANYGYT
1638	ATKNTGNQFY	ASSVGLPYEQY
1639	AFIAGNQFY	ASSLFVGGPGNEQ
1640	AVAFGNQFY	ASTGTSGALYNEQ
1641	ARNTGNQFY	ASSETGATNYGYTG
1642	ARNTGNQFY	ASSYQTGAGGYGYTG
1643	ARNTGNQFY	ASSPVTGGIYGYTG
1644	ARNTGNQFY	ASSFQTGASYGYTFG
1645	ILLGTGANNLF	ASSPKLQGAWAEKL
1646	AKNTGNQFY	ASSPQTGTIYGYTG
1647	AFPYNNNDMR	ASSLEGYTEAFFG
1648	ILDNNNDMRFG	ASSLAPGATNEKL
1649	AGNTGNQFYFG	ASSLQTGATFNYGYT
1650	ILSPNNDMRFG	AWSVSDLAKNIQY
1651	ILPLWLTFG	ASSLEGYTEAFFG
1652	ARQDGNQFY	ASSPVAGGAYNEQ
1653	AVRIDYKLS	ASSYSTGAGETQY
1654	AVYYGQNFV	ASSFQGYTEA
1163	ARNTGNQFY	ASSPVTGGIYGYT
824	ILDNNNDMR	ASSLAPGTTNEKLF
1970	ARNTGNQFYFG	ASSETGATNYGYTG
1971	ARNTGNQFYFG	ASSYVTGTGSYGYTG
1972	ARNTGNQFYFG	ASSPVTGGIYGYTG
1973	ARNTGNQFYFG	ASSYQTGAGGYGYTFG
1974	AYPYNNNDMRFG	ASSLEGYTEAFFG
1975	AEYTGTASKLTFG	ACSLRSQGTDTQYFG
1976	AEYTGTASKLTFG	AWSSRDSMTDTQYFG
1977	AVDIETSGSRLTFG	ASSELGGAGTGELFFG
1978	AVYFGNVLHCG	ASSFLQVTEAFFG
1979	AGPRQTSYDKVIFG	ASSSANYGYTFG
1980	AGPRKTSYDKVIFG	ASSSANYGYTFG
1981	AGPMKTSYDKVIFG	ASSSAHYGYTFG
1982	AGPMKTSYDKVIFG	ASSSAFYGYTFG
1983	AGPEKTSYDKVIFG	ASSSANYGYTFG
1984	AVYGTASKLTFG	SAFSGAAFVTDTQYFG
1985	AEISPSGGSYIPTFG	ATSDLKVHSGNYGYTFG
1986	ATKNTGNQFYFG	ASSVGLPYEQYEQ
1987	AFIAGNQFYFG	ASSLFVGGPGNEQFFG
1988	AVAFGNQFYFG	ASTGTSGALYNEQFFG
1989	AERLQTGANNLFFG	ASSPPAGSYNEQFFG
1990	ILLGTGANNLFFG	ASSPKLQGAWAEKLFFG
1991	AMRVPRAQGGSEKLVFG	ASSQDPFAVLNTEAFFG
1992	APYTGTASKLTFG	AWSSRGQMTDTQYFG
1993	AKNTGNQFYFG	ASSPQTGTIYGYTG
1994	AFPYNNNDMRFG	ASSLEGYTEAFFG
1995	ILDNNNDMRFG	ASSLAPGATNEKLFFG
1996	AGNTGNQFYFG	ASSLQTGATFNYGYTFG
1997	ILSPNNDMRFG	AWSVSDLAKNIQYFG
1998	AARSNFGNEKLTFG	ASSAWDRSSGANVLTFG
1999	ARQDGNQFYFG	ASSPVAGGAYNEQFFG
2000	AVRIDYKLSFG	ASSYSTGAGETQYFG
2001	AVYYGQNFVFG	ASSFQGYTEAFFG
2002	ATDAPGGYQKVTFG	ASSPWTGTLNTEAFFG
18544	AFITGNQFY	ASSQTQLWETQY
18545	ILDNNNDMR	ASSLAPGTTNEKLF
20507	CARNTGNQFYF	CAWSISDLAKNIQYF
20508	CARNTGNQFYF	CASSAQTGASYGYTF
20509	CARNTGNQFYF	CASSPSTGVTFYGYTF
20510	CARNTGNQFYF	CASSWKTGTGGTGYTF
20511	CARNTGNQFYF	CASSYQTGTGVYGYTF
20538	CAGPMKTSYDKVIF	CASASANYGYTF
20713	CAAPGAGSYQLTF	CASTLWSATNEKLFF
20714	CAASDSNYQLIW	CASSEESGRAAEQYF
20715	CAASESGGSNYKLTF	CASSGRWTAYNEQFF
20716	CAASGGNNNDMRF	CASSVTPSSYNEQFF
20717	CAATDNARLMF	CATSRDLAEVNTEAFF
20718	CAEIPNYGGSQGNLIF	CASSFIGGVDGYTF
20719	CAEIQASGGSYIPTF	CATGRGGKIGEQYF
20720	CAEIQASGGSYIPTF	CATGRGGMIGEQYF
20721	CAEITGGGNKLTF	CSATDVTKGQLISGYTF
20722	CAENNSGDSSYKLIF	CASSFAHLSYNEQFF
20723	CAETPGPSYDKVIF	CAWSISDLAKNIQYF
20724	CAETRSRDYKLSF	CASSQEEGPGNQPQHF
20725	CAFELILGAQKLVF	CASSYSWTGSNYGYTF
20726	CAFPYNNNDMRF	CASSLEGYTEAFF
20727	CAGDNNARLMF	CASSSDPSGGGYNEQFF
20728	CAGKTSYDKVIF	CATEQGMHEQYF
20729	CAGPRETSYDKVIF	CASASANYGYTF
20730	CAGPRETSYDKVIF	CASSSAYYGYTF
20731	CAGQASQGNLIF	CASSIQALLTF
20732	CAGSGTASKLTF	CASGEGGELFF
20733	CAHLGGSSNTGKLIF	CAVNGGSNYGYTF
20734	CAIDTGGFKTIF	CASSGTDSNQPQHF
20735	CALSDAYNFNKFYF	CASSDDRVRYGYTF
20736	CALSDVGMNRDDKIIF	CASSQGLGREGASEQFF
20737	CALSGDDYKLSF	CASSVASGRAHEQYF
20738	CASSSVNEQYF	CASSPITGTGAYGYTF
20739	CATDAPSNYQLIW	CASSSSGRDYEQYF
20740	CAVADTGNQFYF	CATAITSTQYF
20741	CAVAFGNQFYF	CASSMTSGALYNEQFF
20742	CAVAFGNQLYF	CASSMTSGALYNEQFF
20743	CAVEDYGQNFVF	CSARDRNTQGPETQYF
20744	CAVNAAGNDYKLSF	CASSTRTGQETQYF
20745	CAVRATDSSYKLIF	CASSFPKDGSTYEQYF
20746	CAVRDNFITGGFKTIF	CASSYFDEKLFF
20747	CAVRDNQAGTALIF	CASSAGSGSGYNEQFF
20748	CAVRDNSITGGFKTIF	CASSYFDEKLFF
20749	CAVRDSNYQLIW	CASSDAENTEAFF
20750	CAVRDSNYQLIW	CASSKGEVTEAFF
20751	CAVREDNAGNMLTF	CASGPLLLMTNEQFF
20752	CAVREGGQKLLF	CATSDRTSATEAFF
20753	CAVRNNNARLMF	CASSIVNEAFF
20754	CAVRNNNARLMF	CASSVVNEAFF
20755	CAVRPGYSSASKIIF	CASSETSGRSPYEQYF
20756	CAVRQDYQLIW	CASGPGTSATDTQYF
20757	CAVRQGYQLIW	CASGPGTSATDTQYF
20758	CAVRSWSTDKLIF	CASSVEGTSGRSYNEQFF
20759	CAVRVLMEYGNKLVF	CASSPGLASPYSYNEQFF
20760	CAVSGSYNTDKLIF	CSARDGLAGHYEQYF
20761	CAVSGSYNTDKLIF	CSARDGLTGHYEQYF
20762	CAVTPPPSYDKVIF	CASSSVSGYTF
20763	CAVVDQAGTALIF	CASSAGGGSYNEQFF
20764	CILSNNNDMCF	CAWSISDLAKNIQYF
20765	CILSNNNDMRF	CAWSISDLAKNIQYF
20766	CILSNNNDMRF	CASSPSTGVTFYGYTF
20767	CILSNNNDMRF	CAWSVSDVANTEAFF
20768	CILSNNNDMRF	CSAPPAGEYSNQPQHF
20769	CILSNNNDMRF	CSARDPSGLAGGLAETQYF
20770	CLVGGIGFGNVLHC	CAWSISDLAKNIQYF
20771	CVVSENYGGSQGNLIF	CASSLPPGRGYTEAFF
20772	CVVSRRTTGANNLFF	CASSYTLASYEQYF
20773	CAGAGSEGSGAGSYQLTF	CATSRPTVGSRLRDGYTF
20774	CILPLAGGTSYGKLTF	CAWSVADTQYF
20775	CILPLAGGTSYGKLTF	CSVEYRDNEQFF
20776	CILPLAGGTSYGKLTF	CAISESYEQYF
20779	CAASINRMDNDMRF	CSAFDREGVDGYTF
20780	CALSEAGGYSTLTF	CSAKVEGYEQYF
20781	CAHYYGNNRLAF	CSAPPDSLNTEAFF
20782	CGADPEGDDKIIF	CSARAEGARDSPLHF
20783	CIVRVGAAGNKLTF	CSARDVPGTTLGGELFF
20784	CAVRDLNARLMF	CSAREEGTQAWETQYF
20785	CAVRDLNARLMF	CASSSVNEQYF
20786	CAVRDQEGNTPLVF	CSAREEGTQAWETQYF
20787	CAVRDQEGNTPLVF	CAISAGTGVRNEQYF
20788	CAVRDQEGNTPLVF	CASMGGSNEQFF
20789	CAVRDQEGNTPLVF	CASSSVNEQYF
20790	CAVRDQEGNTPLVF	CASSYSRSDGHLGNTIYF
20792	CVVNDGQNFVF	CSARRTGSTYNEQFF
20793	CAVKGAGSYQLTF	CSARYGSTCEQYF
20794	CAVRFLTDSWGKLQF	CSATTESNQPQHF
20795	CAVRFLTDSWGKLQF	CASSQRMGLSETQYF
20796	CAVDKDGGATNKLIF	CSDGQAFF
20797	CVVSARNTGNQFYF	CSVGLAGSYNEQFF
20798	CVVSAGSIVSGGYNKLIF	CAIRDKMNTEAFF
20799	CAVRGRSNYGGSQGNLI	CASRDTSGTAYEQYF
20800	CAVSEGVVWDLYGGSQGNLIF	CASREDGTEAFF
20801	CALSDGYSGGGADGLTF	CASRPDGRETQYF
20802	CAVRDSNYQLIW	CASSDRETYEQYF
20803	CALSGEGGSEKLVF	CASSETGFGNQPQHF
20804	CAVTYSGAGSYQLTF	CASSFLQGNQPQHF
20807	CAVRRAGNDMRF	CASSGTNSPLHF
20808	CILDNNNDMRF	CASSLAPGATNEKLFF
20809	CIRDNNNDMRF	CASSLAPGATNEKLFF
20810	CIKDNNNDMRF	CASSLAPGTTNEKLFF
20811	CILIPTGTYKYIF	CASSLEGFTEAFF
20812	CAPGNTGKLIF	CASSLGRDLNQPQHF
20813	CAGQLWTGTASKLTF	CASSLGRGIYEQYF
20814	CVVVAYSGAGSYQLTF	CASSLTGTTYGGYTF
20815	CAGRNNNARLMF	CASSLVGSGGEQYF
20816	CAVNSGYSTLTF	CASSPGQGGDEQYF
20817	CALSEGVFNDYKLSF	CASSPRQSNQPQHF
20818	CAASRSNSGYALNF	CASSQDISRGQTLFGNSPLHF
20819	CVVSEWAAGNKLTF	CASSQEQGDIQYF
20820	CALSEANQAGTALIF	CASSQERGGKWAYEQYF
20821	CALSDRNQGGKLIF	CASSQGKDTQYF
20822	CALSGQGGSEKLVF	CASSQTGFGNQPQHF
20823	CAVEQGFNKFYF	CASSRLGDGDSNQPQHF
20824	CAARTRGSTLGRLYF	CASSSANYGYTF
20825	CATWNSWGKFQF	CASSSETTSPLHF
20826	CAVRDYGSGGYNKLIF	CASSSRTSGINEQFF
20827	CAVMTTDSWGKLQF	CASSTPGAKLGDTGELFF
20828	CAVSNNNDMRF	CASSVVERAFF
20829	CAMREVFNDYKLSF	CASSVVERAFF
20830	CAVRDISARLMF	CASSVVERAFF
20831	CAVRGQTGFQKLVF	CASSYFRDRVGDQPQHF
20832	CAVMDSNYQLIW	CASSYSSSTGELFF
25125	CADYYGQNFVFG	CASSFQGYTEAFFG
25126	CASNTGNQFYFG	CASSPVTGTGHYGYTFG
26540	CAMNGARLMFGD	CSARDVLAGGSDTQYFG
26541	CARNTGNQFYFGT	CASSSVTGTGNYGYTFG
26542	CAFNFGNEKLTFGT	CASSLFGGFTEAFFG
26543	CAVRSNFGNEKLTFGT	CASSFWDRVSGANVLTFG
26969	AFPINHSGGSNYKLT	ASSSTNGYT
26970	ARNTGNQFY	ASSLVTGTGWGYT
26971	ASNTGNQFY	ASSPITGTGIYGYT
26972	ILGWGKLQ	ASSLDRVTGECF
26973	ILGWGKLQ	ASSLDRVTGELF
27759	CADYYGQNFVF	CASSFQGYTEAFF
27760	CAGPMKTSYDKVIF	CASSSANYGYTF
27761	CARNTGNQFYF	CASSYSTGTAYGYTF
27812	CATNTGNQFYF	CASSPTTRTRYYGYTF
27813	CAAPRETSYDKVIF	CASSSANYGYTF
27814	CAGPTKTSYDKVIF	CASSSANYGYTF
27815	CAVNYGNMLTF	CASSYATEVAGETQYF
27816	CAVFYGNKLVF	CASSYATGIPDTQYF
27817	CILSNNNDMRF	CAWSISDSSRVEAFF
30282	CAGPMKTSYDKVIFG	CASSSANYGYTFG
30283	CAVFFG	CASSPTGGSPSPLHFG
34640	CAVNDRGSTLGRLYF	CSVWSFGDRDGYTF
34641	CAVNDRGSTLGRLYF	CASSSANYGYTF
34642	CAVNDRGSTLGRLYF	CASSSSPGLDNEQFF
34643	CAVNDRGSTLGRLYF	CASSYITGTGSYGYTF
34644	CAVNFGGGKLIF	CASSSANYGYTF
34645	CPREEGGSQGNLIF	CASSSANYGYTF
34646	CTSPNTNAGKSTF	CSARDRIGNTIYF
45963	CAVWMDSSYKLIF	ASSQEAADNEKLF
59000	CAVRGTNARLMF	ASSSVNEAF
59001	CAVRNNNARLMF	ASSIVNEAF
181933	CILDNNNDMRF	CASSLAPGTTNEKLFF
182875	CARNTGNQFYF	CASSPVTGGIYGYTF
185996	ILDNNNDMR	ASSLAPGATNEKLF
185997	ILSNNNDMR	AWTISDLAKNIQY
185998	AASGGPSYDKVI	ASSPGNILGGYT
188864	CAGYYGQNFVF	CASSFQGYTEAFF
188865	CARNTGNQFYF	CASSFQTGTGTYGYTF
188866	CTRGSQGNLIF	CASSFQTGTGTYGYTF
189729	CASGNAGNMLTF	CASSPGTGAVFFYGYTF
189811	CAVNYGNKLVF	CASSPFSGAPYEQYF
190022	CASQTGDSWGKFQF	CASSQEFPGQGSYEQYF
190232	CAEIPPNSGNTPLVF	CSADPGQGLGYGYTF
190378	CALSENTDKLIF	CSARAELAADFISSYNEQFF
190421	CAGGGSSNTGKLIF	CASTPFASTEAFF
190760	CVVNPTGGFQKLVF	CASSYFSGPYEQYF
190777	CAVGSQGNLIF	CATSDPLAAAYEQYF
191008	CAVRDVSARLMF	CASSSVNEQYF
191011	CAVRDISARLMF	CASSSVTEAFF
198235	CACPPGDYKLSF	CASSLDIPSYNEQFF
201202	CAATNAGGTSYGKLTF	CASSYFGSHDEQFF
201203	CAEYTGTASKLTF	CAWSSRGAMTDTQYF
201205	CAFPYNNNDMRF	CASSLEGYTEAFF
201206	CAFPYNNNDMRF	CASRTTTGVRTDTQYF
201211	CARNTGNQFYF	CASRGGGTQPWOEQFF
201217	CAVNGAGSYQLTF	CATSTETGEAFF
201286	EGGNQF	RLLAGGRSAQ
201287	EPENSGGSNYKL	SSANYGY
201289	IAGNQF	SLLLGTAAEA
201335	KNFNKF	SVYGGAGNSPL
201351	NTGNQF	SLVSGSGSYGY
201352	NTGNQF	SPTTGTGYFGY
201353	NTGNQF	SRQTGAAYGY
201354	NTGNQF	SYATGTAYGY
201355	PMKTSYDKV	SVVGLWTDTQ
201357	PRETSYDKV	SSANYGY
201358	REGIIQGAQKL	SPLGGAGLADTQ
201373	YYGQNF	SFLGYTEA
204876	CAGPLKTSYDKVIF	ASSSAHYGYT
204993	CILDNNNDMRF	ASSLAPGATNEKLF
204994	CIRDNNNDMRF	ASSLAPGATNEKLF
205632	CAVVLREYGNKLVF	SVGDGRGGEQY

数据来源：IEDB数据库

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36532017	Amélie Rousselière; Nathalie Gérard; Laurence Delbos; Pierrick Guérif; Magali Giral; Céline Bressollette-Bodin; Béatrice Charreau	Front Immunol	2022	Distinctive phenotype for HLA-E- versus HLA-A2-restricted memory CD8 αβT cells in the course of HCMV infection discloses features shared with NKG2C<sup>+</sup>CD57<sup>+</sup>NK and δ2<sup>-</sup>γδT cell subsets.
36980230	Amélie Rousselière; Béatrice Charreau	Cells	2023	Persistent CD8 T Cell Marks Caused by the HCMV Infection in Seropositive Adults: Prevalence of HLA-E-Reactive CD8 T Cells.
36121440	W Huisman; M C J Roex; L Hageman; E A S Koster; S A J Veld; C Hoogstraten; P van Balen; H M van Egmond; C A M van Bergen; H Einsele; L Germeroth; D Amsen; J H F Falkenburg; I Jedema	Blood Adv	2023	Tracking the progeny of adoptively transferred virus-specific T cells in patients posttransplant using TCR sequencing.
37261346	Willemijn van der Wulp; Anna M Gram; Boris Bleijlevens; Renate S Hagedoorn; Can Araman; Robbert Q Kim; Jan Wouter Drijfhout; Paul W H I Parren; Richard G Hibbert; Rob C Hoeben; Sander I van Kasteren; Janine Schuurman; Maaike E Ressing; Mirjam H M Heemskerk	Front Immunol	2023	Comparison of methods generating antibody-epitope conjugates for targeting cancer with virus-specific T cells.
37193826	William Chour; Jongchan Choi; Jingyi Xie; Mary E Chaffee; Thomas M Schmitt; Kathryn Finton; Diana C DeLucia; Alexander M Xu; Yapeng Su; Daniel G Chen; Rongyu Zhang; Dan Yuan; Sunga Hong; Alphonsus H C Ng; Jonah Z Butler; Rick A Edmark; Lesley C Jones; Kim M Murray; Songming Peng; Guideng Li; Roland K Strong; John K Lee; Jason D Goldman; Philip D Greenberg; James R Heath	Commun Biol	2023	Large libraries of single-chain trimer peptide-MHCs enable antigen-specific CD8+ T cell discovery and analysis.
31941832	Minsuk Kwon; Chang Gon Kim; Hoyoung Lee; Hyunsoo Cho; Youngun Kim; Eung Chang Lee; Seong Jin Choi; Junsik Park; In-Ho Seo; Bjarne Bogen; Ik-Chan Song; Deog-Yeon Jo; Jin Seok Kim; Su-Hyung Park; Inhak Choi; Yoon Seok Choi; Eui-Cheol Shin	Clin Cancer Res	2020	PD-1 Blockade Reinvigorates Bone Marrow CD8<sup>+</sup> T Cells from Patients with Multiple Myeloma in the Presence of TGFβ Inhibitors.
32299815	Shiao-Pei Weathers; Marta Penas-Prado; Be-Lian Pei; Xiaoyang Ling; Cynthia Kassab; Pinaki Banerjee; Mustafa Bdiwi; Hila Shaim; Abdullah Alsuliman; Mayra Shanley; John F de Groot; Barbara J O’Brien; Rebecca Harrison; Nazanin Majd; Carlos Kamiya-Matsuoka; Gregory N Fuller; Jason T Huse; Linda Chi; Ganesh Rao; Jeffrey S Weinberg; Frederick F Lang; Raymond Sawaya; Elizabeth J Shpall; Katayoun Rezvani; Amy B Heimberger	Clin Cancer Res	2020	Glioblastoma-mediated Immune Dysfunction Limits CMV-specific T Cells and Therapeutic Responses: Results from a Phase I/II Trial.
37586765	Siri Amanda Tvingsholm; Marcus Svensson Frej; Vibeke Mindahl Rafa; Ulla Kring Hansen; Maria Ormhøj; Alexander Tyron; Agnete W P Jensen; Mohammad Kadivar; Amalie Kai Bentzen; Kamilla K Munk; Gitte N Aasbjerg; Jeppe S H Ternander; Christina Heeke; Tripti Tamhane; Christian Schmess; Samuel A Funt; Julie Westerlin Kjeldsen; Anders Handrup Kverneland; Özcan Met; Arianna Draghi; Søren Nyboe Jakobsen; Marco Donia; Inge Marie Svane; Sine Reker Hadrup	J Immunother Cancer	2023	TCR-engaging scaffolds selectively expand antigen-specific T-cells with a favorable phenotype for adoptive cell therapy.
37280206	Julien Schmidt; Johanna Chiffelle; Marta A S Perez; Morgane Magnin; Sara Bobisse; Marion Arnaud; Raphael Genolet; Julien Cesbron; David Barras; Blanca Navarro Rodrigo; Fabrizio Benedetti; Alexandra Michel; Lise Queiroz; Petra Baumgaertner; Philippe Guillaume; Michael Hebeisen; Olivier Michielin; Tu Nguyen-Ngoc; Florian Huber; Melita Irving; Stéphanie Tissot-Renaud; Brian J Stevenson; Sylvie Rusakiewicz; Denarda Dangaj Laniti; Michal Bassani-Sternberg; Nathalie Rufer; David Gfeller; Lana E Kandalaft; Daniel E Speiser; Vincent Zoete; George Coukos; Alexandre Harari	Nat Commun	2023	Neoantigen-specific CD8 T cells with high structural avidity preferentially reside in and eliminate tumors.
37761976	Eunjung Cho; Seongeun Han; Hyeon Seok Eom; Sang-Jin Lee; Chungyong Han; Rohit Singh; Seon-Hee Kim; Bo-Mi Park; Byoung-Gie Kim; Young H Kim; Byoung S Kwon; Ki Taek Nam; Beom K Choi	Int J Mol Sci	2023	Cross-Activation of Regulatory T Cells by Self Antigens Limits Self-Reactive and Activated CD8<sup>+</sup> T Cell Responses.
35401538	Wesley Huisman; Lois Hageman; Didier A T Leboux; Alexandra Khmelevskaya; Grigory A Efimov; Marthe C J Roex; Derk Amsen; J H Frederik Falkenburg; Inge Jedema	Front Immunol	2022	Public T-Cell Receptors (TCRs) Revisited by Analysis of the Magnitude of Identical and Highly-Similar TCRs in Virus-Specific T-Cell Repertoires of Healthy Individuals.
37751288	Daphne M Hullegie-Peelen; Hector Tejeda Mora; Dennis A Hesselink; Eric Mj Bindels; Thierry Pp van den Bosch; Marian C Clahsen-van Groningen; Marjolein Dieterich; Sebastiaan Heidt; Robert C Minnee; Georges Mgm Verjans; Martin J Hoogduijn; Carla C Baan	JCI Insight	2023	Virus-specific TRM cells of both donor and recipient origin reside in human kidney transplants.
37974400	Lianghua Shen; Jiali Yang; Chijian Zuo; Jian Xu; Ling Ma; Qiaomei He; Xiao Zhou; Xiaodan Ding; Lixiang Wei; Suqin Jiang; Luanluan Ma; Benjia Zhang; Yuqin Yang; Baoxia Dong; Liping Wan; Xueying Ding; Ming Zhu; Zhenhua Sun; Pengran Wang; Xianmin Song; Yan Zhang	Mol Ther	2024	Circular mRNA-based TCR-T offers a safe and effective therapeutic strategy for treatment of cytomegalovirus infection.
38053994	Barbara Couturaud; Bastien Doix; Laura Carretero-Iglesia; Mathilde Allard; Sylvain Pradervand; Michael Hebeisen; Nathalie Rufer	Front Immunol	2023	Overall avidity declines in TCR repertoires during latent CMV but not EBV infection.
37886042	Ana C Maretti-Mira; Matthew P Salomon; Angela M Hsu; Chikako Matsuba; Lucy Golden-Mason	Front Virol	2023	Chronic HCV infection promotes cytotoxicity in antigen-specific CD8<sup>+</sup> T cells regardless of virus specificity.
38377192	Cosima Zimmermann; Gabrielle M Watson; Liane Bauersfeld; Richard Berry; Barbara Ciblis; Huan Lan; Carolin Gerke; Valerie Oberhardt; Jonas Fuchs; Maike Hofmann; Christian Freund; Jamie Rossjohn; Frank Momburg; Hartmut Hengel; Anne Halenius	Proc Natl Acad Sci U S A	2024	Diverse cytomegalovirus US11 antagonism and MHC-A evasion strategies reveal a tit-for-tat coevolutionary arms race in hominids.
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38608022	Nikolaj Pagh Kristensen; Edoardo Dionisio; Amalie Kai Bentzen; Tripti Tamhane; Janine Sophie Kemming; Grigorii Nos; Lasse Frank Voss; Ulla Kring Hansen; Georg Michael Lauer; Sine Reker Hadrup	Sci Adv	2024	Simultaneous analysis of pMHC binding and reactivity unveils virus-specific CD8 T cell immunity to a concise epitope set.
38782542	Sofie Kirial Mørk; Signe Koggersbøl Skadborg; Benedetta Albieri; Arianna Draghi; Kalijn Bol; Mohammad Kadivar; Marie Christine Wulff Westergaard; Joachim Stoltenborg Granhøj; Annie Borch; Nadia Viborg Petersen; Nikolas Thuesen; Ida Svahn Rasmussen; Lars Vibe Andreasen; Rebecca Bach Dohn; Christina Westmose Yde; Nis Noergaard; Torben Lorentzen; Anders Bundgaard Soerensen; Daniela Kleine-Kohlbrecher; Anders Jespersen; Dennis Christensen; Jens Kringelum; Marco Donia; Sine Reker Hadrup; Inge Marie Svane	J Immunother Cancer	2024	Dose escalation study of a personalized peptide-based neoantigen vaccine (EVX-01) in patients with metastatic melanoma.
39433089	Weiwen Zhang; Fernanda M Roversi; Anna B Morris; Kristina Ortiz; Grace Zhou; Annette Hadley; Xueqiong Zhang; Juliete A F Silva; Cynthia P Breeden; Zhuldyz Zhanzak; Haydn T Kissick; Christian P Larsen	Am J Transplant	2024	Major histocompatibility complex and peptide specificity underpin CD8<sup>+</sup> T cell direct alloresponse.
23143746	Daisuke Nobuoka; Toshiaki Yoshikawa; Mari Takahashi; Tatsuaki Iwama; Kazutaka Horie; Manami Shimomura; Shiro Suzuki; Noriko Sakemura; Munehide Nakatsugawa; Hiroshi Sadamori; Takahito Yagi; Toshiyoshi Fujiwara; Tetsuya Nakatsura	Cancer Immunol Immunother	2013	Intratumoral peptide injection enhances tumor cell antigenicity recognized by cytotoxic T lymphocytes: a potential option for improvement in antigen-specific cancer immunotherapy.
37133356	Helle Rus Povlsen; Amalie Kai Bentzen; Mohammad Kadivar; Leon Eyrich Jessen; Sine Reker Hadrup; Morten Nielsen	Elife	2023	Improved T cell receptor antigen pairing through data-driven filtering of sequencing information from single cells.
25245536	Petra Simon; Tana A Omokoko; Andrea Breitkreuz; Lisa Hebich; Sebastian Kreiter; Sebastian Attig; Abdo Konur; Cedrik M Britten; Claudia Paret; Karl Dhaene; Özlem Türeci; Ugur Sahin	Cancer Immunol Res	2014	Functional TCR retrieval from single antigen-specific human T cells reveals multiple novel epitopes.