中国人HLA位点分布频率

HLA特点

主要组织相容性复合物(Major Histocompatibility Complex,MHC),由一系列紧密连锁的基因座组成。其编码的产物参与抗原呈递,细胞间相互识别以及免疫应答等过程。人的MHC(HLA)位于6号染色体短臂上(6p21.31),由3.6M个碱基组成,是目前已知的人类染色体中基因密度最高,多态性最为丰富的区域。其编码产物在人群中的类型非常丰富。

数据的意义

在肿瘤与病毒的主动性免疫方面,HLA分型与抗原信息,可以为主动性免疫的治疗、机制研究提供重要的靶点信息。

在抗原信息已知的情况下,在实施了HLA检测后,研究者就可以有针对性地完成三种工作:

肿瘤/病毒/自免抗原靶点呈递的HLA类型判断:

可呈递的抗原肽需要HLA类型和蛋白氨基酸序列联合确定,并选择适合的HLA供者抗原呈递细胞体外激活靶点特异性的T细胞

肿瘤/病毒/自免抗原特异性T细胞的流式分选与流式检测:

获得HLA信息后,结合靶点信息制造抗原特异性四聚体,使用四聚体分离出T细胞表面抗原特异性TCR

中国人常见HLA分型

1、HLA-A共有4064种等位基因型蛋白,中国人中3种分型的频率合计超过50%;

2、HLA-B共有4962种等位基因型蛋白,中国人中7种分型的频率合计超过50%;

3、HLA-C共有3831种等位基因型蛋白,中国人中4种分型的频率合计超过50%;

4、HLA-DRB1共有2557种等位基因型蛋白,中国人中5种分型的频率合计超过50%;

4、HLA-DQB1共有1303种等位基因型蛋白,中国人中5种分型的频率合计超过50%;

Locus Allele Freq
HLA-A A*11:01 20.893%
HLA-A A*24:02 15.545%
HLA-A A*02:01 12.036%
HLA-A A*02:07 8.418%
HLA-A A*33:03 8.229%
HLA-A A*30:01 5.967%
HLA-A A*02:06 5.227%
HLA-A A*01:01 3.588%
HLA-A A*02:03 3.453%
HLA-A A*31:01 3.279%
HLA-A A*03:01 2.960%
HLA-A A*26:01 2.844%
HLA-A A*11:02 1.693%
HLA-A A*32:01 1.335%
HLA-A A*68:01 0.710%
HLA-A A*29:01 0.674%
HLA-A A*02:05 0.356%
HLA-A A*02:10 0.354%
HLA-A A*24:20 0.261%
HLA-A A*23:01 0.258%
HLA-A A*03:02 0.220%
HLA-A A*24:07 0.217%
HLA-A A*33:01 0.185%
HLA-A A*24:03 0.150%
HLA-A A*69:01 0.129%
HLA-A A*11:03 0.104%
HLA-A A*24:08 0.081%
HLA-A A*30:04 0.076%
HLA-A A*24:10 0.070%
HLA-A A*29:02 0.065%
HLA-A A*66:01 0.061%
HLA-A A*68:02 0.053%
HLA-A A*02:53N 0.050%
HLA-A A*34:01 0.042%
HLA-A A*24:04 0.038%
HLA-A A*74:02 0.037%
HLA-A A*02:09 0.037%
HLA-A A*30:02 0.032%
HLA-A A*26:03 0.022%
HLA-A A*25:01 0.021%
HLA-A A*02:11 0.018%
HLA-A A*30:18 0.018%
HLA-A A*26:02 0.014%
HLA-A A*01:03 0.013%
HLA-A A*02:48 0.010%
HLA-A A*26:18 0.007%
HLA-A A*26:20 0.007%
HLA-A A*68:24 0.007%
HLA-A A*24:68 0.007%
HLA-A A*11:04 0.006%
HLA-A A*02:02 0.006%
HLA-A A*02:17 0.005%
HLA-A A*24:30 0.005%
HLA-A A*02:93 0.005%
HLA-A A*02:90 0.004%
HLA-A A*74:03 0.004%
HLA-A A*02:20 0.004%
HLA-A A*24:85 0.003%
HLA-A A*31:13 0.003%
HLA-A A*74:01 0.003%
HLA-A A*02:189 0.002%
HLA-A A*74:05 0.002%
HLA-A A*02:264 0.002%
HLA-A A*24:64 0.002%
HLA-A A*29:10 0.002%
HLA-A A*03:77 0.002%
HLA-A A*68:38 0.002%
HLA-A A*33:08 0.002%
HLA-A A*11:36 0.002%
HLA-A A*24:144 0.002%
HLA-A A*36:02 0.002%
HLA-A A*02:108 0.002%
HLA-A A*26:36 0.002%
HLA-A A*31:17 0.002%
HLA-A A*24:28 0.002%
HLA-A A*24:59 0.002%
HLA-A A*24:128 0.002%
HLA-A A*02:12 0.001%
HLA-A A*26:08 0.001%
HLA-A A*02:99 0.001%
HLA-A A*02:08 0.001%
HLA-A A*24:52 0.001%
HLA-A A*02:42 0.001%
HLA-A A*24:132N 0.001%
HLA-A A*11:06 0.001%
HLA-A A*24:93 0.001%
HLA-A A*01:78 0.001%
HLA-A A*68:96 0.001%
HLA-A A*11:126 0.001%
HLA-A A*11:60 0.001%
HLA-A A*34:02 0.001%
HLA-A A*24:05 0.001%
HLA-A A*11:87 0.001%
HLA-A A*02:28 0.001%
HLA-A A*74:13 0.001%
HLA-A A*31:06 0.001%
HLA-A A*02:80 0.001%
HLA-A A*02:344 0.001%
HLA-A A*02:230 0.001%
HLA-A A*11:56 0.001%
HLA-A A*02:79 0.001%
HLA-A A*24:13 0.001%
HLA-A A*24:21 0.001%
HLA-A A*24:17 0.001%
HLA-A A*23:26 0.001%
HLA-A A*23:20 0.001%
HLA-A A*02:251 0.001%
HLA-A A*24:98 0.001%
HLA-A A*02:121 0.001%
HLA-A A*02:249 0.001%
HLA-A A*30:20 0.001%
HLA-A A*11:77 0.001%
HLA-A A*11:88 0.001%
HLA-A A*02:269 0.001%
HLA-A A*24:150 0.001%
HLA-A A*32:54 0.001%
HLA-A A*11:12 0.001%
HLA-A A*11:69N 0.001%
HLA-A A*24:152 0.000%
HLA-A A*11:32 0.000%
HLA-A A*11:61 0.000%
HLA-A A*33:10 0.000%
HLA-A A*02:259 0.000%
HLA-A A*33:30 0.000%
HLA-A A*02:256 0.000%
HLA-A A*26:14 0.000%
HLA-A A*03:05 0.000%
HLA-A A*02:36 0.000%
HLA-A A*24:33 0.000%
HLA-A A*11:14 0.000%
HLA-A A*03:12 0.000%
HLA-A A*11:19 0.000%
HLA-A A*30:38 0.000%
HLA-A A*26:35 0.000%
HLA-A A*24:91 0.000%
HLA-A A*24:06 0.000%
HLA-A A*31:33 0.000%
HLA-A A*02:446 0.000%
HLA-A A*26:17 0.000%
HLA-A A*02:419 0.000%
HLA-A A*31:32 0.000%
HLA-A A*24:112 0.000%
HLA-A A*02:24 0.000%
HLA-A A*26:50 0.000%
HLA-A A*02:293Q 0.000%
HLA-A A*31:30 0.000%
HLA-A A*03:20 0.000%
HLA-A A*02:478 0.000%
HLA-A A*11:163 0.000%
HLA-A A*24:225 0.000%
HLA-A A*11:100 0.000%
HLA-A A*11:27 0.000%
HLA-A A*24:141 0.000%
HLA-A A*26:09 0.000%
HLA-A A*02:426 0.000%
HLA-A »ã×Ü 100.000%
HLA-B B*46:01 10.257%
HLA-B B*40:01 9.549%
HLA-B B*13:02 6.322%
HLA-B B*58:01 6.149%
HLA-B B*51:01 5.619%
HLA-B B*13:01 5.013%
HLA-B B*15:01 4.784%
HLA-B B*15:02 3.554%
HLA-B B*40:06 3.232%
HLA-B B*54:01 3.131%
HLA-B B*52:01 2.991%
HLA-B B*44:03 2.766%
HLA-B B*38:02 2.594%
HLA-B B*55:02 2.472%
HLA-B B*48:01 2.469%
HLA-B B*35:01 2.430%
HLA-B B*07:02 2.123%
HLA-B B*40:02 1.868%
HLA-B B*15:11 1.849%
HLA-B B*39:01 1.774%
HLA-B B*37:01 1.403%
HLA-B B*15:18 1.368%
HLA-B B*57:01 1.171%
HLA-B B*35:03 1.120%
HLA-B B*51:02 1.053%
HLA-B B*27:04 0.911%
HLA-B B*08:01 0.911%
HLA-B B*44:02 0.863%
HLA-B B*15:27 0.856%
HLA-B B*27:05 0.726%
HLA-B B*67:01 0.720%
HLA-B B*50:01 0.690%
HLA-B B*15:25 0.556%
HLA-B B*07:05 0.533%
HLA-B B*38:01 0.508%
HLA-B B*56:01 0.484%
HLA-B B*18:01 0.360%
HLA-B B*15:07 0.324%
HLA-B B*14:02 0.297%
HLA-B B*35:05 0.270%
HLA-B B*15:12 0.231%
HLA-B B*35:02 0.220%
HLA-B B*40:03 0.219%
HLA-B B*15:32 0.215%
HLA-B B*15:17 0.204%
HLA-B B*15:05 0.181%
HLA-B B*49:01 0.175%
HLA-B B*39:05 0.174%
HLA-B B*48:03 0.155%
HLA-B B*27:07 0.151%
HLA-B B*35:08 0.145%
HLA-B B*45:01 0.112%
HLA-B B*41:01 0.109%
HLA-B B*55:01 0.100%
HLA-B B*59:01 0.095%
HLA-B B*15:58 0.085%
HLA-B B*56:04 0.077%
HLA-B B*81:02 0.071%
HLA-B B*18:02 0.055%
HLA-B B*27:06 0.054%
HLA-B B*15:13 0.054%
HLA-B B*14:01 0.051%
HLA-B B*55:04 0.050%
HLA-B B*15:46 0.046%
HLA-B B*07:06 0.045%
HLA-B B*40:40 0.045%
HLA-B B*51:08 0.040%
HLA-B B*56:03 0.038%
HLA-B B*55:12 0.035%
HLA-B B*53:01 0.034%
HLA-B B*51:07 0.033%
HLA-B B*15:21 0.033%
HLA-B B*39:09 0.032%
HLA-B B*27:24 0.028%
HLA-B B*15:19 0.027%
HLA-B B*15:03 0.027%
HLA-B B*15:35 0.027%
HLA-B B*55:07 0.026%
HLA-B B*41:02 0.025%
HLA-B B*47:01 0.021%
HLA-B B*27:02 0.021%
HLA-B B*40:229 0.019%
HLA-B B*15:08 0.019%
HLA-B B*15:29 0.015%
HLA-B B*39:15 0.014%
HLA-B B*42:01 0.012%
HLA-B B*73:01 0.012%
HLA-B B*39:24 0.011%
HLA-B B*51:36 0.011%
HLA-B B*40:55 0.011%
HLA-B B*40:78 0.010%
HLA-B B*27:25 0.009%
HLA-B B*51:06 0.009%
HLA-B B*15:220 0.009%
HLA-B B*15:10 0.008%
HLA-B B*15:38 0.008%
HLA-B B*27:03 0.008%
HLA-B B*44:05 0.007%
HLA-B B*40:97 0.007%
HLA-B B*07:10 0.006%
HLA-B B*39:06 0.006%
HLA-B B*15:68 0.006%
HLA-B B*56:10 0.006%
HLA-B B*27:15 0.006%
HLA-B B*27:36 0.005%
HLA-B B*57:03 0.005%
HLA-B B*40:150 0.005%
HLA-B B*54:17 0.005%
HLA-B B*15:198 0.005%
HLA-B B*39:31 0.005%
HLA-B B*81:01 0.005%
HLA-B B*42:02 0.004%
HLA-B B*15:178 0.004%
HLA-B B*37:04 0.004%
HLA-B B*35:11 0.003%
HLA-B B*40:84 0.003%
HLA-B B*44:27 0.003%
HLA-B B*51:09 0.003%
HLA-B B*51:22 0.003%
HLA-B B*48:04 0.002%
HLA-B B*57:02 0.002%
HLA-B B*40:50 0.002%
HLA-B B*40:11 0.002%
HLA-B B*55:21 0.002%
HLA-B B*27:14 0.002%
HLA-B B*56:14 0.002%
HLA-B B*15:09 0.002%
HLA-B B*51:21 0.002%
HLA-B B*38:15 0.002%
HLA-B B*27:69 0.002%
HLA-B B*51:39 0.002%
HLA-B B*35:42 0.002%
HLA-B B*35:04 0.001%
HLA-B B*15:39 0.001%
HLA-B B*51:34 0.001%
HLA-B B*18:03 0.001%
HLA-B B*40:48 0.001%
HLA-B B*15:86 0.001%
HLA-B B*55:16 0.001%
HLA-B B*13:16 0.001%
HLA-B B*57:29 0.001%
HLA-B B*39:04 0.001%
HLA-B B*35:30 0.001%
HLA-B B*15:134 0.001%
HLA-B B*40:10 0.001%
HLA-B B*40:141 0.001%
HLA-B B*15:152 0.001%
HLA-B B*40:43 0.001%
HLA-B B*07:48 0.001%
HLA-B B*52:04 0.001%
HLA-B B*55:30 0.001%
HLA-B B*56:21 0.001%
HLA-B B*56:18 0.001%
HLA-B B*40:122 0.001%
HLA-B B*39:36 0.001%
HLA-B B*35:37 0.001%
HLA-B B*46:09 0.001%
HLA-B B*35:64 0.001%
HLA-B B*52:11 0.001%
HLA-B B*15:88 0.001%
HLA-B B*54:16 0.001%
HLA-B B*07:116 0.001%
HLA-B B*46:19 0.001%
HLA-B B*15:201 0.001%
HLA-B B*15:78 0.000%
HLA-B B*56:09 0.000%
HLA-B B*55:50 0.000%
HLA-B B*40:125 0.000%
HLA-B B*40:81 0.000%
HLA-B B*78:02 0.000%
HLA-B B*15:65 0.000%
HLA-B B*39:10 0.000%
HLA-B B*39:38Q 0.000%
HLA-B B*40:70 0.000%
HLA-B B*40:140 0.000%
HLA-B B*58:12 0.000%
HLA-B B*13:38 0.000%
HLA-B B*51:59 0.000%
HLA-B B*07:08 0.000%
HLA-B B*15:192 0.000%
HLA-B B*07:81 0.000%
HLA-B B*40:49 0.000%
HLA-B B*44:29 0.000%
HLA-B B*67:03 0.000%
HLA-B B*15:227 0.000%
HLA-B B*44:118 0.000%
HLA-B B*40:268 0.000%
HLA-B B*40:153 0.000%
HLA-B B*40:75 0.000%
HLA-B B*55:34 0.000%
HLA-B B*15:15 0.000%
HLA-B B*15:16 0.000%
HLA-B B*78:01 0.000%
HLA-B B*15:30 0.000%
HLA-B B*07:18 0.000%
HLA-B B*39:58 0.000%
HLA-B B*27:61 0.000%
HLA-B B*35:28 0.000%
HLA-B B*40:207 0.000%
HLA-B B*37:02 0.000%
HLA-B B*27:01 0.000%
HLA-B B*46:18 0.000%
HLA-B B*55:26 0.000%
HLA-B B*07:91 0.000%
HLA-B B*55:43 0.000%
HLA-B B*48:06 0.000%
HLA-B B*58:58 0.000%
HLA-B B*56:27 0.000%
HLA-B B*40:25 0.000%
HLA-B B*51:130 0.000%
HLA-B B*51:05 0.000%
HLA-B B*52:20 0.000%
HLA-B B*40:255 0.000%
HLA-B B*35:29 0.000%
HLA-B B*51:04 0.000%
HLA-B B*35:189 0.000%
HLA-B B*40:69 0.000%
HLA-B »ã×Ü 100.000%
HLA-C C*01:02 15.889%
HLA-C C*07:02 15.200%
HLA-C C*03:04 9.878%
HLA-C C*06:02 8.896%
HLA-C C*08:01 8.520%
HLA-C C*03:03 6.962%
HLA-C C*03:02 5.950%
HLA-C C*04:01 5.790%
HLA-C C*14:02 4.274%
HLA-C C*15:02 3.337%
HLA-C C*12:02 3.139%
HLA-C C*12:03 1.914%
HLA-C C*14:03 1.031%
HLA-C C*04:03 1.015%
HLA-C C*08:22 0.870%
HLA-C C*07:04 0.868%
HLA-C C*05:01 0.849%
HLA-C C*07:06 0.800%
HLA-C C*08:03 0.775%
HLA-C C*15:05 0.707%
HLA-C C*02:02 0.694%
HLA-C C*01:03 0.625%
HLA-C C*07:01 0.572%
HLA-C C*08:02 0.299%
HLA-C C*04:82 0.236%
HLA-C C*16:02 0.202%
HLA-C C*17:01 0.101%
HLA-C C*01:06 0.084%
HLA-C C*16:04 0.077%
HLA-C C*07:66 0.075%
HLA-C C*15:04 0.037%
HLA-C C*04:06 0.027%
HLA-C C*07:18 0.025%
HLA-C C*03:17 0.024%
HLA-C C*17:03 0.022%
HLA-C C*01:08 0.019%
HLA-C C*15:13 0.016%
HLA-C C*03:56 0.015%
HLA-C C*07:154 0.014%
HLA-C C*15:11 0.014%
HLA-C C*07:43 0.012%
HLA-C C*07:63 0.010%
HLA-C C*08:06 0.009%
HLA-C C*03:36 0.006%
HLA-C C*15:26 0.006%
HLA-C C*03:100 0.006%
HLA-C C*07:67 0.005%
HLA-C C*16:01 0.005%
HLA-C C*08:41 0.005%
HLA-C C*12:05 0.005%
HLA-C C*07:27 0.005%
HLA-C C*04:69 0.004%
HLA-C C*03:38 0.003%
HLA-C C*08:24 0.003%
HLA-C C*08:44 0.003%
HLA-C C*15:06 0.003%
HLA-C C*14:25 0.002%
HLA-C C*04:130 0.002%
HLA-C C*07:19 0.002%
HLA-C C*07:26 0.002%
HLA-C C*03:85 0.002%
HLA-C C*15:29 0.002%
HLA-C C*03:21 0.002%
HLA-C C*15:17 0.002%
HLA-C C*04:70 0.002%
HLA-C C*06:103 0.002%
HLA-C C*18:02 0.002%
HLA-C C*04:08 0.002%
HLA-C C*01:85 0.001%
HLA-C C*03:28 0.001%
HLA-C C*07:56 0.001%
HLA-C C*03:39 0.001%
HLA-C C*08:27 0.001%
HLA-C C*01:17 0.001%
HLA-C C*17:02 0.001%
HLA-C C*07:159 0.001%
HLA-C C*15:12 0.001%
HLA-C C*15:21 0.001%
HLA-C C*07:16 0.001%
HLA-C C*03:40 0.001%
HLA-C C*03:76 0.001%
HLA-C C*14:23 0.001%
HLA-C C*04:81 0.001%
HLA-C C*03:198 0.001%
HLA-C C*08:21 0.001%
HLA-C C*14:24 0.001%
HLA-C C*12:18 0.001%
HLA-C C*02:10 0.001%
HLA-C C*07:51 0.001%
HLA-C C*06:06 0.001%
HLA-C C*01:22 0.001%
HLA-C C*01:30 0.001%
HLA-C C*06:04 0.001%
HLA-C C*03:211 0.001%
HLA-C C*08:86 0.001%
HLA-C C*14:12 0.001%
HLA-C C*01:58 0.001%
HLA-C C*03:41 0.001%
HLA-C C*15:07 0.001%
HLA-C C*01:10 0.001%
HLA-C C*07:169 0.001%
HLA-C C*01:50 0.001%
HLA-C C*03:16 0.001%
HLA-C C*03:35 0.001%
HLA-C C*08:10 0.001%
HLA-C C*03:64 0.001%
HLA-C C*12:04 0.001%
HLA-C C*03:32 0.001%
HLA-C C*01:44 0.001%
HLA-C C*03:69 0.001%
HLA-C C*03:48 0.001%
HLA-C C*03:43 0.001%
HLA-C C*14:29 0.001%
HLA-C C*07:172 0.000%
HLA-C C*06:104 0.000%
HLA-C C*03:07 0.000%
HLA-C C*03:107 0.000%
HLA-C C*15:09 0.000%
HLA-C C*12:09 0.000%
HLA-C C*01:40 0.000%
HLA-C C*06:106 0.000%
HLA-C C*03:210 0.000%
HLA-C C*03:46 0.000%
HLA-C C*06:73 0.000%
HLA-C C*03:204 0.000%
HLA-C »ã×Ü 100.000%
HLA-DQB1 DQB1*03:01 21.068%
HLA-DQB1 DQB1*03:03 15.907%
HLA-DQB1 DQB1*06:01 10.248%
HLA-DQB1 DQB1*06:02 7.571%
HLA-DQB1 DQB1*02:02 7.533%
HLA-DQB1 DQB1*05:02 7.366%
HLA-DQB1 DQB1*03:02 5.739%
HLA-DQB1 DQB1*02:01 4.968%
HLA-DQB1 DQB1*05:01 4.639%
HLA-DQB1 DQB1*04:01 4.509%
HLA-DQB1 DQB1*05:03 4.196%
HLA-DQB1 DQB1*06:09 1.693%
HLA-DQB1 DQB1*06:03 1.468%
HLA-DQB1 DQB1*06:04 1.427%
HLA-DQB1 DQB1*04:02 1.255%
HLA-DQB1 DQB1*06:10 0.101%
HLA-DQB1 DQB1*03:05 0.092%
HLA-DQB1 DQB1*03:13 0.074%
HLA-DQB1 DQB1*03:04 0.031%
HLA-DQB1 DQB1*05:10 0.031%
HLA-DQB1 DQB1*05:04 0.017%
HLA-DQB1 DQB1*06:41 0.015%
HLA-DQB1 DQB1*03:17 0.012%
HLA-DQB1 DQB1*06:07 0.010%
HLA-DQB1 DQB1*03:29 0.003%
HLA-DQB1 DQB1*03:22 0.003%
HLA-DQB1 DQB1*03:38 0.003%
HLA-DQB1 DQB1*03:27 0.002%
HLA-DQB1 DQB1*05:08 0.002%
HLA-DQB1 DQB1*03:34 0.001%
HLA-DQB1 DQB1*06:11 0.001%
HLA-DQB1 DQB1*06:103 0.001%
HLA-DQB1 DQB1*03:14 0.001%
HLA-DQB1 DQB1*06:84 0.001%
HLA-DQB1 DQB1*02:12 0.001%
HLA-DQB1 DQB1*03:50 0.001%
HLA-DQB1 DQB1*02:03 0.001%
HLA-DQB1 DQB1*03:26 0.001%
HLA-DQB1 DQB1*04:08 0.001%
HLA-DQB1 DQB1*03:19 0.001%
HLA-DQB1 DQB1*03:24 0.001%
HLA-DQB1 DQB1*03:30 0.001%
HLA-DQB1 DQB1*05:18 0.001%
HLA-DQB1 DQB1*06:05 0.001%
HLA-DQB1 DQB1*03:32 0.001%
HLA-DQB1 DQB1*05:05 0.000%
HLA-DQB1 DQB1*06:107 0.000%
HLA-DQB1 DQB1*03:44 0.000%
HLA-DQB1 DQB1*03:93 0.000%
HLA-DQB1 »ã×Ü 100.000%
HLA-DRB1 DRB1*09:01 14.787%
HLA-DRB1 DRB1*15:01 11.584%
HLA-DRB1 DRB1*07:01 9.660%
HLA-DRB1 DRB1*12:02 8.706%
HLA-DRB1 DRB1*08:03 6.312%
HLA-DRB1 DRB1*11:01 5.630%
HLA-DRB1 DRB1*03:01 5.102%
HLA-DRB1 DRB1*04:05 4.819%
HLA-DRB1 DRB1*13:02 3.340%
HLA-DRB1 DRB1*15:02 3.133%
HLA-DRB1 DRB1*16:02 3.056%
HLA-DRB1 DRB1*04:06 2.570%
HLA-DRB1 DRB1*12:01 2.412%
HLA-DRB1 DRB1*14:54 2.343%
HLA-DRB1 DRB1*14:05 2.201%
HLA-DRB1 DRB1*01:01 2.071%
HLA-DRB1 DRB1*10:01 1.588%
HLA-DRB1 DRB1*04:03 1.557%
HLA-DRB1 DRB1*13:01 1.456%
HLA-DRB1 DRB1*04:01 0.997%
HLA-DRB1 DRB1*04:04 0.740%
HLA-DRB1 DRB1*13:12 0.729%
HLA-DRB1 DRB1*08:02 0.675%
HLA-DRB1 DRB1*14:04 0.664%
HLA-DRB1 DRB1*11:04 0.604%
HLA-DRB1 DRB1*14:03 0.528%
HLA-DRB1 DRB1*04:10 0.288%
HLA-DRB1 DRB1*01:02 0.265%
HLA-DRB1 DRB1*14:07 0.237%
HLA-DRB1 DRB1*15:04 0.237%
HLA-DRB1 DRB1*12:10 0.235%
HLA-DRB1 DRB1*04:07 0.207%
HLA-DRB1 DRB1*04:02 0.174%
HLA-DRB1 DRB1*08:09 0.167%
HLA-DRB1 DRB1*04:08 0.129%
HLA-DRB1 DRB1*11:06 0.100%
HLA-DRB1 DRB1*14:18 0.090%
HLA-DRB1 DRB1*16:01 0.070%
HLA-DRB1 DRB1*13:07 0.054%
HLA-DRB1 DRB1*08:01 0.050%
HLA-DRB1 DRB1*13:03 0.050%
HLA-DRB1 DRB1*14:01 0.039%
HLA-DRB1 DRB1*14:12 0.039%
HLA-DRB1 DRB1*11:03 0.037%
HLA-DRB1 DRB1*08:04 0.036%
HLA-DRB1 DRB1*14:10 0.029%
HLA-DRB1 DRB1*14:02 0.025%
HLA-DRB1 DRB1*14:25 0.017%
HLA-DRB1 DRB1*14:06 0.013%
HLA-DRB1 DRB1*15:06 0.011%
HLA-DRB1 DRB1*11:28 0.011%
HLA-DRB1 DRB1*13:50 0.009%
HLA-DRB1 DRB1*12:08 0.008%
HLA-DRB1 DRB1*13:05 0.008%
HLA-DRB1 DRB1*11:11 0.006%
HLA-DRB1 DRB1*12:05 0.005%
HLA-DRB1 DRB1*03:27 0.005%
HLA-DRB1 DRB1*11:129 0.005%
HLA-DRB1 DRB1*09:04 0.004%
HLA-DRB1 DRB1*13:19 0.004%
HLA-DRB1 DRB1*14:22 0.004%
HLA-DRB1 DRB1*04:11 0.004%
HLA-DRB1 DRB1*14:11 0.004%
HLA-DRB1 DRB1*15:03 0.003%
HLA-DRB1 DRB1*07:13 0.003%
HLA-DRB1 DRB1*14:44 0.003%
HLA-DRB1 DRB1*14:49 0.002%
HLA-DRB1 DRB1*14:61 0.002%
HLA-DRB1 DRB1*11:19 0.002%
HLA-DRB1 DRB1*15:11 0.002%
HLA-DRB1 DRB1*11:08 0.001%
HLA-DRB1 DRB1*14:33 0.001%
HLA-DRB1 DRB1*11:20 0.001%
HLA-DRB1 DRB1*08:19 0.001%
HLA-DRB1 DRB1*13:13 0.001%
HLA-DRB1 DRB1*14:141 0.001%
HLA-DRB1 DRB1*11:101 0.001%
HLA-DRB1 DRB1*08:36 0.001%
HLA-DRB1 DRB1*01:14 0.001%
HLA-DRB1 DRB1*08:14 0.001%
HLA-DRB1 DRB1*09:10 0.001%
HLA-DRB1 DRB1*13:14 0.001%
HLA-DRB1 DRB1*16:09 0.001%
HLA-DRB1 DRB1*08:12 0.001%
HLA-DRB1 DRB1*11:39 0.001%
HLA-DRB1 DRB1*11:37 0.001%
HLA-DRB1 DRB1*11:106 0.001%
HLA-DRB1 DRB1*08:30 0.001%
HLA-DRB1 DRB1*11:02 0.001%
HLA-DRB1 DRB1*12:19 0.001%
HLA-DRB1 DRB1*04:13 0.001%
HLA-DRB1 DRB1*12:28 0.001%
HLA-DRB1 DRB1*11:75 0.001%
HLA-DRB1 DRB1*13:08 0.001%
HLA-DRB1 DRB1*15:07 0.001%
HLA-DRB1 DRB1*11:54 0.001%
HLA-DRB1 DRB1*11:57 0.001%
HLA-DRB1 DRB1*12:18 0.001%
HLA-DRB1 DRB1*12:27 0.001%
HLA-DRB1 DRB1*04:17 0.001%
HLA-DRB1 DRB1*11:15 0.001%
HLA-DRB1 DRB1*13:118 0.001%
HLA-DRB1 DRB1*08:32 0.001%
HLA-DRB1 DRB1*03:05 0.001%
HLA-DRB1 DRB1*11:23 0.001%
HLA-DRB1 DRB1*11:29 0.001%
HLA-DRB1 DRB1*07:11 0.000%
HLA-DRB1 DRB1*09:06 0.000%
HLA-DRB1 DRB1*04:38 0.000%
HLA-DRB1 DRB1*04:59 0.000%
HLA-DRB1 DRB1*16:10 0.000%
HLA-DRB1 DRB1*08:35 0.000%
HLA-DRB1 DRB1*08:18 0.000%
HLA-DRB1 DRB1*03:06 0.000%
HLA-DRB1 DRB1*11:27 0.000%
HLA-DRB1 DRB1*16:05 0.000%
HLA-DRB1 DRB1*12:14 0.000%
HLA-DRB1 DRB1*03:11 0.000%
HLA-DRB1 DRB1*11:12 0.000%
HLA-DRB1 DRB1*12:16 0.000%
HLA-DRB1 DRB1*12:20 0.000%
HLA-DRB1 DRB1*08:41 0.000%
HLA-DRB1 DRB1*04:93 0.000%
HLA-DRB1 DRB1*15:49 0.000%
HLA-DRB1 DRB1*09:07 0.000%
HLA-DRB1 DRB1*11:111 0.000%
HLA-DRB1 DRB1*15:05 0.000%
HLA-DRB1 DRB1*14:15 0.000%
HLA-DRB1 DRB1*03:08 0.000%
HLA-DRB1 DRB1*04:88 0.000%
HLA-DRB1 »ã×Ü 100.000%

参考文献

Common and well-documented (CWD) alleles of human leukocyte antigen-A, -B, -C, -DRB1, and -DQB1 loci for the Chinese Han population do not quite correlate with the ASHI CWD alleles.
He J, Li Y, Bao X, Qiu Q, Yuan X, Xu C, Shen J, Hou J.
Hum Immunol. 2012 Jan;73(1):61-6. doi: 10.1016/j.humimm.2011.06.005. Epub 2011 Jun 15.
PMID: 21712058[Identification and analysis of the rare HLA-A/B/DRB1 allele genes of 10165 bone marrow registry donors in Shaanxi region].
Liu ML, Qi J, Wang XF, Liu S, Wang TJ, Chen LP.
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2013 Dec;21(6):1602-5. doi: 10.7534/j.issn.1009-2137.2013.06.044.
PMID: 24370056 Chinese.

The CWD allele catalog in China.
Cano P, Mack SJ, Fernández-Viña M.
Hum Immunol. 2012 Jan;73(1):60. doi: 10.1016/j.humimm.2011.08.010. Epub 2011 Aug 30.

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